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MXPA03010440A - Derivados de 4-(fenil-(piperidin-4-il)amino)-benzamida y su uso para tratamiento del dolor, ansiedad o trastornos gastrointestinales. - Google Patents

Derivados de 4-(fenil-(piperidin-4-il)amino)-benzamida y su uso para tratamiento del dolor, ansiedad o trastornos gastrointestinales.

Info

Publication number
MXPA03010440A
MXPA03010440A MXPA03010440A MXPA03010440A MXPA03010440A MX PA03010440 A MXPA03010440 A MX PA03010440A MX PA03010440 A MXPA03010440 A MX PA03010440A MX PA03010440 A MXPA03010440 A MX PA03010440A MX PA03010440 A MXPA03010440 A MX PA03010440A
Authority
MX
Mexico
Prior art keywords
phenyl
anxiety
pain
gastrointestinal disorders
ring
Prior art date
Application number
MXPA03010440A
Other languages
English (en)
Inventor
Brown William
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MXPA03010440A publication Critical patent/MXPA03010440A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se describen y se reclaman en la presente solicitud, los compuestos de la formula general I donde R1 se selecciona de cualquiera de fenilo, piridinilo, pirrolilo, tienilo, furanilo, imidazolilo, triazolilo, piridil-N-bxido; donde cada anillo fenilo R' y anillo heteroaromatico R1 puede ser sustituido opcional e independientemente ademas por 1, 2 o 3 sustituyentes seleccionados de alquilo de 1 a 6 atomos de carbono de cadena recta o ramificada, NO2, CF3, alcoxi de 1 a atomos de carbono, cloro, fluoro, bromo y yodo. Las sustituciones en el anillo fenilo y en el anillo heteroaromatico pueden tomar lugar en cualquier posicion en los sistemas de anillos; asi como tambien sus sales farmaceuticamente aceptables y composiciones farmaceuticas que comprenden los compuestos novedosos y su uso en la terapia, en particular en el manejo del dolor, ansiedad y trastornos gastrointestinales, funcionales.
MXPA03010440A 2001-05-18 2002-05-16 Derivados de 4-(fenil-(piperidin-4-il)amino)-benzamida y su uso para tratamiento del dolor, ansiedad o trastornos gastrointestinales. MXPA03010440A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0101769A SE0101769D0 (sv) 2001-05-18 2001-05-18 Novel compounds
PCT/SE2002/000944 WO2002094782A1 (en) 2001-05-18 2002-05-16 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derativatives and their use for the treatment of pain, anxiety or gastrointestinal disorders

Publications (1)

Publication Number Publication Date
MXPA03010440A true MXPA03010440A (es) 2004-03-09

Family

ID=20284172

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03010440A MXPA03010440A (es) 2001-05-18 2002-05-16 Derivados de 4-(fenil-(piperidin-4-il)amino)-benzamida y su uso para tratamiento del dolor, ansiedad o trastornos gastrointestinales.

Country Status (26)

Country Link
US (1) US7226933B2 (es)
EP (1) EP1395555B1 (es)
JP (1) JP2005508289A (es)
KR (1) KR20030094425A (es)
CN (1) CN1639123A (es)
AR (1) AR033758A1 (es)
AT (1) ATE313528T1 (es)
BG (1) BG108330A (es)
BR (1) BR0209670A (es)
CA (1) CA2446311A1 (es)
CO (1) CO5540317A2 (es)
CZ (1) CZ20033089A3 (es)
DE (1) DE60208192T2 (es)
EE (1) EE200300554A (es)
HU (1) HUP0401328A2 (es)
IL (1) IL158628A0 (es)
IS (1) IS7028A (es)
MX (1) MXPA03010440A (es)
NO (1) NO20035113D0 (es)
NZ (1) NZ529398A (es)
PL (1) PL366387A1 (es)
RU (1) RU2003131966A (es)
SE (1) SE0101769D0 (es)
SK (1) SK13912003A3 (es)
WO (1) WO2002094782A1 (es)
ZA (1) ZA200308631B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4836405B2 (ja) * 2002-03-13 2011-12-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのアミノカルボニル誘導体
SE0300987D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2063886A2 (en) * 2006-09-12 2009-06-03 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091096A (en) * 1976-03-19 1978-05-23 Eli Lilly And Company Dinitroanilines for the control of phytopathogens
EG12406A (en) * 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
US4252812A (en) * 1977-05-23 1981-02-24 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
SE441448B (sv) 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
EP0181793B1 (fr) * 1984-10-16 1988-07-27 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
KR940003491B1 (ko) * 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
ZA9811842B (en) 1997-12-24 2000-06-23 Ortho Mcneil Pharm Inc 4-[aryl(piperidin-4-yl)]aminobenzamides.
CA2683097A1 (en) 1998-03-10 1999-09-16 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
JP2003525938A (ja) * 2000-03-03 2003-09-02 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ３−（ジアリールメチレン）−８−アザビシクロ［３．２．１］オクタン誘導体
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
JPWO2009028275A1 (ja) * 2007-08-28 2010-11-25 コニカミノルタエムジー株式会社 シンチレータパネル

Also Published As

Publication number Publication date
PL366387A1 (en) 2005-01-24
IS7028A (is) 2003-11-12
US7226933B2 (en) 2007-06-05
CZ20033089A3 (en) 2004-06-16
WO2002094782A1 (en) 2002-11-28
CO5540317A2 (es) 2005-07-29
JP2005508289A (ja) 2005-03-31
BG108330A (bg) 2004-12-30
EE200300554A (et) 2004-02-16
RU2003131966A (ru) 2005-05-10
NO20035113D0 (no) 2003-11-17
SE0101769D0 (sv) 2001-05-18
CA2446311A1 (en) 2002-11-28
ATE313528T1 (de) 2006-01-15
HUP0401328A2 (hu) 2004-12-28
DE60208192D1 (de) 2006-01-26
DE60208192T2 (de) 2006-07-13
EP1395555B1 (en) 2005-12-21
SK13912003A3 (sk) 2004-04-06
EP1395555A1 (en) 2004-03-10
BR0209670A (pt) 2004-04-20
AR033758A1 (es) 2004-01-07
IL158628A0 (en) 2004-05-12
ZA200308631B (en) 2005-02-07
NZ529398A (en) 2005-08-26
KR20030094425A (ko) 2003-12-11
US20040235897A1 (en) 2004-11-25
CN1639123A (zh) 2005-07-13

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