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MXPA03009600A - Analogos de nociceptina. - Google Patents

Analogos de nociceptina.

Info

Publication number
MXPA03009600A
MXPA03009600A MXPA03009600A MXPA03009600A MXPA03009600A MX PA03009600 A MXPA03009600 A MX PA03009600A MX PA03009600 A MXPA03009600 A MX PA03009600A MX PA03009600 A MXPA03009600 A MX PA03009600A MX PA03009600 A MXPA03009600 A MX PA03009600A
Authority
MX
Mexico
Prior art keywords
nociceptin
analogs
nociceptin analogs
iii
compound
Prior art date
Application number
MXPA03009600A
Other languages
English (en)
Inventor
Sun Qun
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27501377&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA03009600(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of MXPA03009600A publication Critical patent/MXPA03009600A/es

Links

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
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    • A61P25/22Anxiolytics
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/32Alcohol-abuse
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms
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    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Finishing Walls (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Un compuesto de la formula (I), (II), (III) o (IV), donde Z, A, B, C, R, R1, R2, Q y N estan descritos en la presente.(Ver formula(I), (II), (III) o (IV).
MXPA03009600A 2001-04-18 2002-04-18 Analogos de nociceptina. MXPA03009600A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28466801P 2001-04-18 2001-04-18
US28466701P 2001-04-18 2001-04-18
US28466901P 2001-04-18 2001-04-18
US28466601P 2001-04-18 2001-04-18
PCT/US2002/012351 WO2002085357A1 (en) 2001-04-18 2002-04-18 Nociceptin analogs

Publications (1)

Publication Number Publication Date
MXPA03009600A true MXPA03009600A (es) 2004-04-02

Family

ID=27501377

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03009600A MXPA03009600A (es) 2001-04-18 2002-04-18 Analogos de nociceptina.

Country Status (25)

Country Link
US (4) US6867222B2 (es)
EP (7) EP1930322A1 (es)
JP (4) JP4364513B2 (es)
KR (2) KR100878774B1 (es)
CN (1) CN100352816C (es)
AT (4) ATE410165T1 (es)
AU (1) AU2002307416B2 (es)
BR (1) BR0209129A (es)
CA (1) CA2444198C (es)
CL (2) CL2009001278A1 (es)
CY (4) CY1108707T1 (es)
CZ (1) CZ20032850A3 (es)
DE (4) DE60232752D1 (es)
DK (4) DK1598338T5 (es)
ES (4) ES2323876T3 (es)
HU (1) HUP0401109A3 (es)
IL (4) IL158484A0 (es)
MX (1) MXPA03009600A (es)
NO (1) NO20034661L (es)
NZ (5) NZ540234A (es)
PL (1) PL367310A1 (es)
PT (4) PT1598340E (es)
SI (4) SI1379246T1 (es)
WO (1) WO2002085357A1 (es)
YU (1) YU82303A (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6615189B1 (en) * 1998-06-22 2003-09-02 Bank One, Delaware, National Association Debit purchasing of stored value card for use by and/or delivery to others
IL158484A0 (en) * 2001-04-18 2004-05-12 Euro Celtique Sa Nociceptin analogs
DE10252665A1 (de) 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
WO2004064835A1 (en) * 2003-01-17 2004-08-05 Neurosearch A/S Use of ion channel modulating agents for treating pain
JP5229853B2 (ja) 2003-02-28 2013-07-03 ニッポネックス インコーポレイテッド 癌その他の疾患の治療に有用な新規な二環尿素誘導体
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20080214827A1 (en) * 2004-02-03 2008-09-04 Euro-Celtique S.A. Synthesis of Cyanoimino-Benzoimidazoles
WO2006080519A1 (ja) * 2005-01-31 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. ジアミン誘導体
EP1934199B1 (en) * 2005-09-30 2009-04-22 F.Hoffmann-La Roche Ag Indane derivatives as mch receptor antagonists
CA2637674A1 (en) * 2006-01-19 2007-07-26 Abbott Laboratories 2-imino-benzimidazoles
EP1987009A1 (en) * 2006-01-30 2008-11-05 Euro-Celtique S.A. Cyclourea compounds as calcium channel blockers
TW200813018A (en) 2006-06-09 2008-03-16 Astrazeneca Ab Novel compounds
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US20080287479A1 (en) * 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase
WO2008089201A2 (en) * 2007-01-16 2008-07-24 Purdue Pharma L.P. Heterocyclic-substituted piperidine as orl-1 ligands
EP2128154B1 (en) * 2007-03-01 2015-04-08 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
NZ582940A (en) 2007-08-31 2013-01-25 Purdue Pharma Lp Substituted-quinoxaline-type piperidine compounds and the uses thereof
US8119661B2 (en) 2007-09-11 2012-02-21 Astrazeneca Ab Piperidine derivatives and their use as muscarinic receptor modulators
JP2010538985A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 抗hiv剤としての副甲状腺ホルモン(1−34)の使用
US8697722B2 (en) 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
SI2324013T1 (sl) 2008-07-21 2012-12-31 Purdue Pharma L.P. Premoščene piperidinske spojine tipa substituiranih kinoksalinov in njihove uporabe
GB0817982D0 (en) * 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
MX2012008082A (es) 2010-01-11 2013-02-07 Astraea Therapeutics Llc Moduladores del receptor nicotinico de acetilcolina.
JP2014532660A (ja) * 2011-10-28 2014-12-08 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 電位作動型ナトリウムチャネルにおける選択活性を有するベンゾオキサゾリノン化合物
TW201348231A (zh) * 2012-02-29 2013-12-01 Amgen Inc 雜雙環化合物
WO2014102594A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
WO2014102590A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
US9884844B2 (en) 2012-12-31 2018-02-06 Sunovion Pharmaceuticals, Inc. Heterocyclic compounds and methods of use thereof
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
EP3383390A4 (en) 2015-12-02 2019-11-20 Astraea Therapeutics, LLC PIPERIDINYL-nociceptin RECEPTOR COMPOUNDS
PL3490560T3 (pl) 2016-07-29 2025-03-24 Janssen Pharmaceutica, N.V. Niraparyb do stosowania w sposobie leczenia nowotworu prostaty

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US49212A (en) * 1865-08-08 Improvement in submerged force-pumps
US171360A (en) * 1875-12-21 Improvement in mortising-machines
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
US3325499A (en) * 1964-11-02 1967-06-13 Mcneilab Inc 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone
US3325490A (en) * 1965-02-23 1967-06-13 Rexall Drug Chemical Substituted 1-hydroxydibenzopyrans
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
EP0029707B1 (en) * 1979-11-21 1984-02-01 Kyowa Hakko Kogyo Co., Ltd Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
US4410528A (en) 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
JPS60120872A (ja) 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
DE3827641A1 (de) * 1988-08-16 1990-03-08 Basf Ag 2,6-polyalkylpiperidinsubstituierte bislactame und deren verwendung zum stabilisieren von organischem material, insbesondere von kunststoffen und damit stabilisiertes material
DE4332168A1 (de) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0714299B1 (en) * 1993-07-16 2002-04-24 Merck & Co. Inc. Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
FR2708608B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant.
GB9325074D0 (en) 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
EP0755392A4 (en) * 1994-04-14 1997-05-02 Merck & Co Inc ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS
FR2722190B1 (fr) * 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
WO1996005166A1 (fr) * 1994-08-11 1996-02-22 Yamanouchi Pharmaceutical Co., Ltd. Derive d'amine substitue et composition medicamenteuse le contenant
US5767118A (en) * 1994-10-26 1998-06-16 Merck & Co., Inc. 4-Heterocyclic peperidines promote release of growth hormone
US5574044A (en) * 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
JP2002515008A (ja) * 1994-10-27 2002-05-21 メルク エンド カンパニー インコーポレーテッド ムスカリン・アンタゴニスト
US5789402A (en) * 1995-01-17 1998-08-04 Eli Lilly Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
GB9603457D0 (es) * 1996-02-19 1996-04-17 Merck & Co Inc
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
AU6111796A (en) 1995-06-12 1997-01-09 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5 -lipoxygenase inhibitor
AU6943996A (en) 1995-09-13 1997-04-01 Kyowa Hakko Kogyo Co. Ltd. Phenylpiperidine derivatives
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
BR9708475A (pt) * 1996-03-30 1999-04-13 Boehringer Mannheim Gmbh Derivados oxazolidina processos para sua produção e agentes farmacéuticos contendo estes compostos
CA2249601A1 (en) * 1996-04-03 1997-10-23 Thorsten E. Fisher Inhibitors of farnesyl-protein transferase
US5891889A (en) * 1996-04-03 1999-04-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
EP0898568B1 (en) 1996-04-19 2006-10-04 Neurosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
ATE266673T1 (de) * 1996-09-10 2004-05-15 Boehringer Ingelheim Pharma Abgewandelte aminosäuren, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5977134A (en) 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CN1217660C (zh) 1997-01-23 2005-09-07 史密丝克莱恩比彻姆公司 Il-8受体拮抗剂
US6117973A (en) * 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
TWI242011B (en) * 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US6063796A (en) * 1997-04-04 2000-05-16 Merck & Co., Inc. Somatostatin agonists
WO1998054168A1 (fr) 1997-05-30 1998-12-03 Banyu Pharmaceutical Co., Ltd. Derives de 2-0xoimidazole
JPH10330377A (ja) 1997-06-02 1998-12-15 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
AU9206798A (en) * 1997-08-28 1999-03-16 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
EP0921125B1 (en) 1997-12-05 2002-01-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro[4,5]decan-4-on derivatives
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
WO1999032481A1 (en) * 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
DE69901934T2 (de) * 1998-01-19 2002-11-07 Pfizer Inc., New York 4-(2-keto-1-benzimidazolinyl)piperidin derivate als orl1-rezeptor agoniste
SK11082000A3 (sk) 1998-01-27 2001-01-18 Aventis Pharmaceuticals Products Inc. Substituované oxoazaheterocyklické inhibítory faktora xa, farmaceutický prostriedok s ich obsahom a ich použitie
CA2325638A1 (en) 1998-03-26 1999-09-30 Hideki Yamada Amide derivatives and nociceptin antagonists
JP2002515503A (ja) 1998-05-18 2002-05-28 ノボ ノルディスク アクティーゼルスカブ オピオイド受容体のサブタイプへの高い親和性を有する新規1,3,8−トリアザスピロ〔4,5〕デカノン
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
MA26659A1 (fr) * 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
ID28692A (id) 1998-09-09 2001-06-28 Ishihara Sangyo Kaisha Turunan benzena dilebur yang berguna sebagai herbisida
US6204265B1 (en) * 1998-12-23 2001-03-20 Schering Corporation Substituted oximes and hydrazones as neurokinin antagonists
WO2000039114A2 (en) 1998-12-23 2000-07-06 Schering Corporation Substituted oximes and hydrazones as neurokinin antagonists
CA2356269A1 (en) * 1998-12-24 2000-07-06 Yoshihisa Akiyama Pain control agent
JP4011819B2 (ja) * 1999-04-12 2007-11-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 インドール誘導体の製造法およびその中間体
US6642228B1 (en) 1999-06-24 2003-11-04 Toray Industries, Inc. α1b-adrenergic receptor antagonists
US6340681B1 (en) 1999-07-16 2002-01-22 Pfizer Inc 2-benzimidazolylamine compounds as ORL-1-receptor agonists
KR20020020788A (ko) * 1999-07-21 2002-03-15 후지야마 아키라 벤즈이미다졸론 유도체 및 포스포디에스테라제억제제로서의 이의 용도
US7456198B2 (en) * 1999-12-06 2008-11-25 Purdue Pharma L.P. Benzimidazole compounds having nociceptin receptor affinity
SE9904652D0 (sv) * 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
EP1122257B1 (en) 2000-01-05 2005-10-12 Pfizer Inc. Benzimidazole compounds as ORL1-receptor agonists
CA2400640A1 (en) * 2000-02-18 2001-08-23 Meiji Seika Kaisha, Ltd. Phenoxyalkylamine derivatives useful as opioid .delta. receptor ligands
AU2001238690A1 (en) * 2000-03-14 2001-09-24 Sepracor, Inc. 3-substituted piperidines comprising urea functionality, and methods of use thereof
AU2001242744B2 (en) * 2000-03-24 2005-07-21 Meiji Seika Kaisha Ltd Diphenylalkylamine derivatives useful as opioid delta receptor ligands
TWI295293B (en) 2000-05-29 2008-04-01 Chugai Pharmaceutical Co Ltd Method for preparing nitrogen-containing compounds
EP1167969A2 (en) 2000-06-14 2002-01-02 Pfizer Inc. Method and system for predicting pharmacokinetic properties
BRPI0113286B8 (pt) * 2000-08-14 2021-05-25 Johnson & Johnson pirazóis substituídos e composição farmacêutica compreendendo os mesmos.
EP1315490B1 (en) * 2000-09-06 2008-11-12 Ortho-McNeil Pharmaceutical, Inc. A method for treating allergies using substituted pyrazoles
US20040267010A1 (en) * 2001-02-02 2004-12-30 Forbes Ian Thomson Sulfonamide compounds, their preparation and use
AR035230A1 (es) * 2001-03-19 2004-05-05 Astrazeneca Ab Compuestos de bencimidazol, proceso para su preparacion, composicion farmaceutica, proceso para la preparacion de dicha composicion farmaceutica, y usos de estos compuestos para la elaboracion de medicamentos
IL158484A0 (en) * 2001-04-18 2004-05-12 Euro Celtique Sa Nociceptin analogs
CA2446924C (en) 2001-04-19 2011-02-08 Eisai Co., Ltd. 2-iminopyrrolidine derivatives
EP1440059B1 (en) 2001-10-22 2008-04-16 Pfizer Products Inc. 3-azabicyclo(3.1.0)hexane derivatives as opioid receptor antagonists
US7244744B2 (en) 2001-11-01 2007-07-17 Icagen, Inc. Piperidines

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