CY1109092T1 - Παραγωγα 1-(4-πιπεριδινυλ)-1,3-διυδρο-2η-βενζοξαζολο-2-ονης και σχετικες ενωσεις ως αναλογα νοσισεπτινης και προσδεματα orl1 για τη θεραπευτικη αγωγη του πονου - Google Patents
Παραγωγα 1-(4-πιπεριδινυλ)-1,3-διυδρο-2η-βενζοξαζολο-2-ονης και σχετικες ενωσεις ως αναλογα νοσισεπτινης και προσδεματα orl1 για τη θεραπευτικη αγωγη του πονουInfo
- Publication number
- CY1109092T1 CY1109092T1 CY20091100552T CY091100552T CY1109092T1 CY 1109092 T1 CY1109092 T1 CY 1109092T1 CY 20091100552 T CY20091100552 T CY 20091100552T CY 091100552 T CY091100552 T CY 091100552T CY 1109092 T1 CY1109092 T1 CY 1109092T1
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- Prior art keywords
- agents
- compounds
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- modulators
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Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 101001122499 Homo sapiens Nociceptin receptor Proteins 0.000 title 1
- 102100028646 Nociceptin receptor Human genes 0.000 title 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 6
- 102000005962 receptors Human genes 0.000 abstract 3
- 108020003175 receptors Proteins 0.000 abstract 3
- 239000005557 antagonist Substances 0.000 abstract 2
- 239000001961 anticonvulsive agent Substances 0.000 abstract 2
- 230000004044 response Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000027796 Blood pressure disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 229940035674 anesthetics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000003556 anti-epileptic effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- -1 anti-inflammatory Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 235000021407 appetite control Nutrition 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 230000029142 excretion Effects 0.000 abstract 1
- 239000003193 general anesthetic agent Substances 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000003907 kidney function Effects 0.000 abstract 1
- 230000006984 memory degeneration Effects 0.000 abstract 1
- 208000023060 memory loss Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000037023 motor activity Effects 0.000 abstract 1
- 239000002756 mu opiate receptor agonist Substances 0.000 abstract 1
- 239000004090 neuroprotective agent Substances 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 230000029865 regulation of blood pressure Effects 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
Ένα αντικείμενο ορισμένων ενσωματώσεων της παρούσας εφεύρεσης είναι η παροχή ενώσεων χρήσιμων ως αναλγητικά, αντι-φλεγμονώδη, διουρητικά, αναισθητικά και ως νευροπροστατευτικοί παράγοντες, αντι-υπερτασικά, αντι-αγχολυτικά, ως παράγοντες ελέγχου της όρεξης· ως ρυθμιστές της ακοής· ως αντι-βηχικά· αντι-ασθματικά· ως διαμορφωτές της κινητικής δραστηριότητας, ως διαμορφωτές της εκμάθησης και της μνήμης, ως ρυθμιστές της έκλυσης νευροδιαβιβαστών και ορμονών, ως διαμορφωτές της νεφρικής λειτουργίας, ως αντι-καταθλιπτικά, ως παράγοντες για τη θεραπεία της απώλειας της μνήμης λόγω νόσου του Αλτσχάιμερ, ή άλλων ανοιών, ως αντι-επιληπτικά, αντισπασμωδικά, ως παράγοντες για τη θεραπεία της στέρησης από αλκοόλ και εθιστικές ουσίες, ως παράγοντες για τον έλεγχο του ισοζυγίου του ύδατος, ως παράγοντες για τον έλεγχο της απέκκρισης νατρίου και ως παράγοντες για τον έλεγχο διαταραχών της αρτηριακής πίεσης του αίματος και μεθόδων για τη χορήγηση των ρηθέντων ενώσεων. Οι ενώσεις της παρούσας εφεύρεσης είναι χρήσιμες για τη διαμόρφωση μιας φαρμακοδυναμικής απόκρισης από έναν ή περισσότερους οπιοειδείς υποδοχείς (ORL-1, μ, δ και κ) κεντρικώς ή/και περιφερικώς. Η απόκριση μπορεί να αποδοθεί στην ένωση που διεγείρει (αγωνιστής) ή αναστέλλει (ανταγωνιστής) τον ένα ή περισσότερους υποδοχείς. Ορισμένες ενώσεις μπορούν να διεγείρουν έναν υποδοχέα (π.χ., έναν μ αγωνιστή) και να αναστείλουν ένα διαφορετικό υποδοχέα (π.χ., έναν ανταγωνιστή του ORL-1). Άλλα αντικείμενα και πλεονεκτήματα της παρούσας εφεύρεσης θα καταστούν προφανή από την ακόλουθη λεπτομερή περιγραφή αυτής. Η παρούσα εφεύρεση σε ορισμένες ενσωματώσεις περιλαμβάνει ενώσεις που έχουν το γενικό τύπο (I):
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28466901P | 2001-04-18 | 2001-04-18 | |
| US28466801P | 2001-04-18 | 2001-04-18 | |
| US28466601P | 2001-04-18 | 2001-04-18 | |
| US28466701P | 2001-04-18 | 2001-04-18 | |
| EP05014117A EP1598340B1 (en) | 2001-04-18 | 2002-04-18 | 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109092T1 true CY1109092T1 (el) | 2014-07-02 |
Family
ID=27501377
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100010T CY1108707T1 (el) | 2001-04-18 | 2009-01-08 | Αναλογα νοσισεπτινης |
| CY20091100475T CY1109053T1 (el) | 2001-04-18 | 2009-04-29 | Παραγωγα 1-(4-πιπεριδινυλ)-1,3-διυδρο-2η-ινδολο-2-ονης και σχετικες ενωσεις ως αναλογα νοσισεπτινης και προσδεματα orl1 για τη θεραπευτικη αγωγη του πονου |
| CY20091100552T CY1109092T1 (el) | 2001-04-18 | 2009-05-22 | Παραγωγα 1-(4-πιπεριδινυλ)-1,3-διυδρο-2η-βενζοξαζολο-2-ονης και σχετικες ενωσεις ως αναλογα νοσισεπτινης και προσδεματα orl1 για τη θεραπευτικη αγωγη του πονου |
| CY20091100940T CY1109352T1 (el) | 2001-04-18 | 2009-09-10 | Παραγωγα 1-(4-αμινο-κυκλοεξυλ)-1,3-διυδρο-2η-βενζιμιδαζολ-2-ονης και σχετικες ενωσεις ως αναλογα νοσισεπτινης και προσδεματα orl1 για τη θεραπευτικη αγωγη του πονου |
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| EP (7) | EP1598339B1 (el) |
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| AT (4) | ATE410165T1 (el) |
| AU (1) | AU2002307416B2 (el) |
| BR (1) | BR0209129A (el) |
| CA (1) | CA2444198C (el) |
| CL (2) | CL2009001279A1 (el) |
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| SI (4) | SI1379246T1 (el) |
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