MX9700871A - Procedimiento para hacer compuestos antimicrobianos. - Google Patents
Procedimiento para hacer compuestos antimicrobianos.Info
- Publication number
- MX9700871A MX9700871A MX9700871A MX9700871A MX9700871A MX 9700871 A MX9700871 A MX 9700871A MX 9700871 A MX9700871 A MX 9700871A MX 9700871 A MX9700871 A MX 9700871A MX 9700871 A MX9700871 A MX 9700871A
- Authority
- MX
- Mexico
- Prior art keywords
- salt
- solvate
- formula
- structure according
- lactam
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/12—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion provee un procedimiento para hacer compuesto que tiene una estructura de conformidad con la formula I, en donde a A1, A2, y A3 son independientemente carbono o nitrogeno y R1, R3, R4 y R6 son substituyentes de quinolona conocidos; y en donde uno de R1, R3 o R6 puede ser una porcion que contiene lactama; o una forma protegida, sal, sal farmacéuticamente aceptable,éster biohidrolizable, un solvato del mismo; el procedimiento comprendiendo hacer reaccionar uno o más compuestos de organosilicio con un compuesto que tiene una estructura de conformidad con la formula II, en donde A1, A2 y A3, R1, R3 R4 y R6 son como se describio antes, en donde uno de R1, R3 o R6 puede ser una porcion que contiene lactama; y X es un grupo residual; o una forma protegida, sal, éster biohidrolizable o solvato, del mismo. Los compuestos preparados de conformidad con los procedimientos de la invencion son en sí mismos utiles como antimicrobianos, o pueden usarse como intermediarios para hacer otros intermediarios que contienen quinolilona.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28496094A | 1994-08-02 | 1994-08-02 | |
PCT/US1995/009647 WO1996004247A1 (en) | 1994-08-02 | 1995-08-01 | Process for making antimicrobial compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9700871A true MX9700871A (es) | 1997-05-31 |
Family
ID=23092187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9700871A MX9700871A (es) | 1994-08-02 | 1995-08-01 | Procedimiento para hacer compuestos antimicrobianos. |
Country Status (19)
Country | Link |
---|---|
US (1) | US5703231A (es) |
EP (1) | EP0775114B1 (es) |
JP (1) | JPH10504815A (es) |
KR (1) | KR100242355B1 (es) |
CN (1) | CN1158120A (es) |
AT (1) | ATE190972T1 (es) |
AU (1) | AU705818B2 (es) |
BR (1) | BR9508514A (es) |
CA (1) | CA2196538C (es) |
DE (1) | DE69515882T2 (es) |
DK (1) | DK0775114T3 (es) |
ES (1) | ES2143644T3 (es) |
FI (1) | FI970427A7 (es) |
GR (1) | GR3033001T3 (es) |
MX (1) | MX9700871A (es) |
NO (1) | NO311356B1 (es) |
NZ (1) | NZ290721A (es) |
PT (1) | PT775114E (es) |
WO (1) | WO1996004247A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2177945C1 (ru) * | 1995-09-22 | 2002-01-10 | Вакунага Фармасьютикал КО., Лтд. | Производное пиридонкарбоновой кислоты или его соль |
DE19926400A1 (de) | 1999-06-10 | 2000-12-14 | Bayer Ag | Verbessertes Verfahren zur Herstellung von 2,6-Dichlor-5-fluor-nicotinsäure und grobteilige und besonders reine 2,6-Dichlor-5-fluor-nicotinsäure |
CN1338455A (zh) * | 2000-08-16 | 2002-03-06 | 大连绿源实业有限公司 | 新的喹诺酮羧酸的制备方法 |
DE60112325T2 (de) * | 2000-12-14 | 2006-05-24 | The Procter & Gamble Company, Cincinnati | Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen |
KR100735587B1 (ko) | 2002-08-05 | 2007-07-04 | 더 프록터 앤드 갬블 캄파니 | 퀴놀론계 항생제 중간체의 제조 방법 |
US6803469B2 (en) * | 2002-08-05 | 2004-10-12 | The Procter & Gamble Company | Process for preparing quinolone antibiotic intermediates |
ES2255871B1 (es) * | 2004-12-31 | 2007-08-16 | Quimica Sintetica, S.A. | Procedimiento para la obtencion de levofloxacino exento de sales. |
AU2006325820B2 (en) * | 2005-12-12 | 2013-02-14 | Allaccem, Inc. | Methods and systems for preparing antimicrobial films and coatings |
CN101020647B (zh) * | 2007-02-14 | 2011-03-30 | 杭州师范学院 | 一种β-环丙胺基丙烯酸(酯)的合成方法 |
AU2008218275B2 (en) | 2007-02-21 | 2013-06-20 | Allaccem, Incorporated | Bridged polycyclic compound based compositions for the inhibition and amelioration of disease |
US20080300258A1 (en) * | 2007-05-30 | 2008-12-04 | Souza Fabio Eduardo Silva | Anhydrous ciprofloxacin hydrochloride |
US8153618B2 (en) | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for topical applications for pets |
US8153617B2 (en) | 2007-08-10 | 2012-04-10 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in humans |
US8188068B2 (en) | 2007-08-10 | 2012-05-29 | Allaccem, Inc. | Bridged polycyclic compound based compositions for coating oral surfaces in pets |
CN105566217B (zh) * | 2016-02-23 | 2019-03-01 | 青岛科技大学 | 一种氟罗沙星粗品的纯化方法 |
WO2018231747A2 (en) * | 2017-06-12 | 2018-12-20 | Virginia Commonwealth University | Streamlined syntheses of fluoroquinolones |
CN112552261B (zh) * | 2019-09-26 | 2024-11-08 | 宜昌东阳光长江药业股份有限公司 | 左氧氟沙星及其中间体的制备方法 |
CN112552260B (zh) * | 2019-09-26 | 2024-11-08 | 宜昌东阳光长江药业股份有限公司 | 左氧氟沙星及其中间体的制备方法 |
US11884658B1 (en) * | 2023-09-26 | 2024-01-30 | King Faisal University | 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((2-thioxobenzo[d]thiazol-3(2H)-yl)methyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid as an antimicrobial compound |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE279886C (es) * | ||||
US4383946A (en) * | 1980-03-27 | 1983-05-17 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals |
NL8005041A (nl) * | 1980-09-05 | 1982-04-01 | Gist Brocades Nv | Werkwijze voor de bereiding van thioethers, alsmede gesilyleerde thiolen voor toepassing bij deze werkwijze. |
US4546176A (en) * | 1982-12-14 | 1985-10-08 | Eisai Co., Ltd. | 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibacterial preparations containing the same |
EP0181521A1 (en) * | 1984-10-19 | 1986-05-21 | Otsuka Pharmaceutical Co., Ltd. | Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds |
US4755513A (en) * | 1985-01-30 | 1988-07-05 | Otsuka Pharmaceutical Company, Limited | Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds |
DE3509769A1 (de) * | 1985-03-19 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von carbapenemzwischenprodukten |
US4684648A (en) * | 1985-05-10 | 1987-08-04 | Otsuka Pharmaceutical Company Limited | Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof |
DE3542644A1 (de) * | 1985-12-03 | 1987-06-04 | Hoechst Ag | Verfahren zur herstellung von cefodizim |
JPS62215591A (ja) * | 1986-03-14 | 1987-09-22 | Dainippon Pharmaceut Co Ltd | ピリドベンズオキサジン誘導体の製造法およびその中間体 |
EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
DE3724466A1 (de) * | 1987-07-24 | 1989-02-02 | Bayer Ag | Verfahren zur herstellung von chinoloncarbonsaeuren |
US4833270A (en) * | 1987-12-21 | 1989-05-23 | American Cyanamid Company | Process for preparing 2-chloro-4,5-difluorobenzoic acid |
US4920120A (en) * | 1988-01-25 | 1990-04-24 | Warner-Lambert Company | Antibacterial agents |
EP0342849A3 (en) * | 1988-05-19 | 1990-03-14 | Pfizer Inc. | Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters |
EP0366193A3 (en) * | 1988-10-24 | 1992-01-08 | Norwich Eaton Pharmaceuticals, Inc. | Novel antimicrobial quinolonyl lactams |
ES2148135T3 (es) * | 1988-10-24 | 2000-10-16 | Norwich Eaton Pharma | Nuevos esteres antimicrobianos de quinolonil lactamas. |
ES2014560A6 (es) * | 1988-12-30 | 1990-07-16 | Marga Investigacion | Proceso para la preparacion de un nuevo reactivo organo-sililpolifosforico y su aplicacion al proceso de sontesis de 3-carboxi-quinolonas o azaquinolonas y sus sales. |
ZA912279B (en) * | 1990-04-09 | 1992-02-26 | Hoffmann La Roche | Carbapenem compounds |
KR920004385A (ko) * | 1990-08-09 | 1992-03-27 | 와꾸나가 기스께 | 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제 |
IT1248011B (it) * | 1991-06-07 | 1995-01-05 | Mediolanum Farmaceutici Spa | Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato. |
CA2120493A1 (en) * | 1991-10-01 | 1993-04-15 | Ronald E. White | Process for making antimicrobial quinolonyl lactams |
EG20543A (en) * | 1992-10-30 | 1999-07-31 | Procter & Gamble | Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones |
-
1995
- 1995-08-01 DE DE69515882T patent/DE69515882T2/de not_active Expired - Fee Related
- 1995-08-01 WO PCT/US1995/009647 patent/WO1996004247A1/en active IP Right Grant
- 1995-08-01 DK DK95927541T patent/DK0775114T3/da active
- 1995-08-01 EP EP95927541A patent/EP0775114B1/en not_active Expired - Lifetime
- 1995-08-01 MX MX9700871A patent/MX9700871A/es unknown
- 1995-08-01 AT AT95927541T patent/ATE190972T1/de not_active IP Right Cessation
- 1995-08-01 BR BR9508514A patent/BR9508514A/pt not_active Application Discontinuation
- 1995-08-01 JP JP8506673A patent/JPH10504815A/ja active Pending
- 1995-08-01 CA CA002196538A patent/CA2196538C/en not_active Expired - Fee Related
- 1995-08-01 AU AU31539/95A patent/AU705818B2/en not_active Ceased
- 1995-08-01 FI FI970427A patent/FI970427A7/fi unknown
- 1995-08-01 NZ NZ290721A patent/NZ290721A/xx unknown
- 1995-08-01 ES ES95927541T patent/ES2143644T3/es not_active Expired - Lifetime
- 1995-08-01 KR KR1019970700703A patent/KR100242355B1/ko not_active Expired - Fee Related
- 1995-08-01 CN CN95195124A patent/CN1158120A/zh active Pending
- 1995-08-01 PT PT95927541T patent/PT775114E/pt unknown
-
1996
- 1996-11-14 US US08/749,046 patent/US5703231A/en not_active Expired - Fee Related
-
1997
- 1997-01-31 NO NO19970427A patent/NO311356B1/no not_active IP Right Cessation
-
2000
- 2000-03-23 GR GR20000400607T patent/GR3033001T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO970427L (no) | 1997-03-26 |
NO311356B1 (no) | 2001-11-19 |
JPH10504815A (ja) | 1998-05-12 |
AU705818B2 (en) | 1999-06-03 |
ES2143644T3 (es) | 2000-05-16 |
EP0775114B1 (en) | 2000-03-22 |
GR3033001T3 (en) | 2000-07-31 |
FI970427L (fi) | 1997-03-26 |
KR100242355B1 (ko) | 2000-03-02 |
FI970427A7 (fi) | 1997-03-26 |
PT775114E (pt) | 2000-09-29 |
AU3153995A (en) | 1996-03-04 |
KR970704694A (ko) | 1997-09-06 |
NO970427D0 (no) | 1997-01-31 |
WO1996004247A1 (en) | 1996-02-15 |
CN1158120A (zh) | 1997-08-27 |
EP0775114A1 (en) | 1997-05-28 |
DE69515882T2 (de) | 2000-11-02 |
BR9508514A (pt) | 1997-12-23 |
NZ290721A (en) | 1999-03-29 |
US5703231A (en) | 1997-12-30 |
CA2196538A1 (en) | 1996-02-15 |
ATE190972T1 (de) | 2000-04-15 |
DK0775114T3 (da) | 2000-07-10 |
FI970427A0 (fi) | 1997-01-31 |
DE69515882D1 (de) | 2000-04-27 |
CA2196538C (en) | 2000-04-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9700871A (es) | Procedimiento para hacer compuestos antimicrobianos. | |
DE69020676D1 (de) | Tricyclische Carbapenemverbindungen. | |
CO4790091A1 (es) | Derivados sustituidos de acido 3-sulfonil-propionico | |
CA2318579A1 (en) | Nitrogen-containing heterocyclic compounds and medicaments containing the compounds | |
ATE57699T1 (de) | Pyridoncarbonsauere-derivate und verfahren zu ihrer herstellung. | |
MY123467A (en) | Preparation of sterically hindered amine ethers | |
HUT40101A (en) | Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents | |
AT379800B (de) | Verfahren zur herstellung von neuen 2-oxazetidin-derivaten | |
NZ332321A (en) | 3-Descladinose-2,3-anhydroerythromycin derivatives and medicaments | |
UY23318A1 (es) | Procedimiento para la preparacion de derivados de heteroaroilo de antibioticos de beta lactama monociclicos | |
ATE141606T1 (de) | Cephemverbindungen und verfahren zu ihrer herstellung | |
MX9605713A (es) | Procedimiento para preparar un derivado de acetoxiazetidinona e intermedio del mismo. | |
ES2075976T3 (es) | Derivados de aminoacido y su empleo como agentes antiviricos. | |
ATE375343T1 (de) | Neue beta-lactamverbindungen und verfahren zu deren herstellung | |
AR019197A1 (es) | COMPUESTOS DERIVADOS DE PIPERIDINA ANTIHISTAMINICOS, COMPUESTOS INTERMEDIOS, PROCEDIMIENTO DE PREPARACIoN DE DERIVADOS DE PIPERIDINA Y PROCEDIMIENTOS DE PREPARACIoN DE INTERMEDIARIOS. | |
ATE163184T1 (de) | Neue cephalosporinantibiotika und verfahren zu ihrer herstellung | |
ES8200689A1 (es) | Un procedimiento para la produccion de analogos de cefalosporina. | |
PT99250A (pt) | Processo para a preparacao de derivados de piperazina | |
ES2121058T3 (es) | Compuestos antibioticos de carbapenem. | |
KR950014114A (ko) | 1-(2-플루오로시클로프로필)-퀴놀론카르복실산 및 1-(2-플루오로시클로프로필)-나프티리돈카르복실산 유도체 | |
AR029004A1 (es) | Compuesto del acido 7-acilamino-3-heteroariltio-3-cefem carboxilico y su uso para la preparacion de una composicion antibacteriana | |
ES2061494T3 (es) | Proceso para la preparacion de derivados de cefalosporina. | |
AR005123A1 (es) | Derivados de acidos carboxilicos, procedimiento para su preparracion, composiciones farmaceuticas que los comprenden y empleos de dichos derivados | |
ATE258545T1 (de) | Antioxidantien, verfahren zu ihrer herstellung und ihre verwendungen | |
MX9303490A (es) | Proceso para preaparar (1'r.3s 4r) 4-aciltio-azetidinonas. |