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ES2143644T3 - Procedimiento para elaborar compuestos antimicrobianos. - Google Patents

Procedimiento para elaborar compuestos antimicrobianos.

Info

Publication number
ES2143644T3
ES2143644T3 ES95927541T ES95927541T ES2143644T3 ES 2143644 T3 ES2143644 T3 ES 2143644T3 ES 95927541 T ES95927541 T ES 95927541T ES 95927541 T ES95927541 T ES 95927541T ES 2143644 T3 ES2143644 T3 ES 2143644T3
Authority
ES
Spain
Prior art keywords
sup
procedure
salt
lactama
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95927541T
Other languages
English (en)
Inventor
Jared Lynn Randall
Jane Ellen Godlewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of ES2143644T3 publication Critical patent/ES2143644T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/12—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN PROCEDIMIENTO DE OBTENCION DE UN COMPUESTO QUE TIENE UNA ESTRUCTURA DE ACUERDO CON LA FORMULA (I), DONDE A{SUP,1}, A{SUP,2} Y A{SUP,3} SON INDEPENDIENTEMENTE CARBONO O NITROGENO Y R{SUP,1}, R{SUP,3}, R{SUP,4} Y R{SUP,6} SON SUSTITUYENTES DE QUINOLONA CONOCIDOS; Y DONDE UNO DE R{SUP,1}, R{SUP,3} O R{SUP,6} PUEDEN SER UNA FRACCION QUE CONTIENE LACTAMA; O UNA FORMA PROTEGIDA, SAL, SAL FARMACEUTICAMENTE ACEPTABLE, ESTER BIOHIDROLIZABLE, O SOLVATO DEL MISMO; EL PROCEDIMIENTO COMPRENDE HACER REACCIONAR UNO O MAS COMPUESTOS DE ORGANOSILICIO, CON UN COMPUESTO REPRESENTADO POR LA FORMULA (II), DONDE A{SUP,1}, A{SUP,2} Y A{SUP,3}, R{SUP,1}, R{SUP,2}, R{SUP,3}, R{SUP,4} Y R{SUP,6} SON TAL Y COMO SE LOS DESCRIBIO ANTERIORMENTE; DONDE UNO DE R{SUP,1}, R{SUP,3} O R{SUP,6} PUEDEN SER UNA FRACCION QUE CONTIENE LACTAMA; Y X ES UN GRUPO SALIENTE ; O UNA FORMA PROTEGIDA, SAL, ESTER BIOHIDROLIZABLE, O SOLVATO DEL MISMO. LOS COMPUESTOS PREPARADOS SEGUN LA INVENCION, SON EN SI MISMOS UTILES COMO ANTIMICROBIANOS, O PUEDEN SER UTILIZADOS COMO INTERMEDIARIOS PARA OBTENER OTROS ANTIMICROBIANOS QUE CONTENGAN QUINOLONAS.
ES95927541T 1994-08-02 1995-08-01 Procedimiento para elaborar compuestos antimicrobianos. Expired - Lifetime ES2143644T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28496094A 1994-08-02 1994-08-02

Publications (1)

Publication Number Publication Date
ES2143644T3 true ES2143644T3 (es) 2000-05-16

Family

ID=23092187

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95927541T Expired - Lifetime ES2143644T3 (es) 1994-08-02 1995-08-01 Procedimiento para elaborar compuestos antimicrobianos.

Country Status (19)

Country Link
US (1) US5703231A (es)
EP (1) EP0775114B1 (es)
JP (1) JPH10504815A (es)
KR (1) KR100242355B1 (es)
CN (1) CN1158120A (es)
AT (1) ATE190972T1 (es)
AU (1) AU705818B2 (es)
BR (1) BR9508514A (es)
CA (1) CA2196538C (es)
DE (1) DE69515882T2 (es)
DK (1) DK0775114T3 (es)
ES (1) ES2143644T3 (es)
FI (1) FI970427A7 (es)
GR (1) GR3033001T3 (es)
MX (1) MX9700871A (es)
NO (1) NO311356B1 (es)
NZ (1) NZ290721A (es)
PT (1) PT775114E (es)
WO (1) WO1996004247A1 (es)

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RU2177945C1 (ru) * 1995-09-22 2002-01-10 Вакунага Фармасьютикал КО., Лтд. Производное пиридонкарбоновой кислоты или его соль
DE19926400A1 (de) 1999-06-10 2000-12-14 Bayer Ag Verbessertes Verfahren zur Herstellung von 2,6-Dichlor-5-fluor-nicotinsäure und grobteilige und besonders reine 2,6-Dichlor-5-fluor-nicotinsäure
CN1338455A (zh) * 2000-08-16 2002-03-06 大连绿源实业有限公司 新的喹诺酮羧酸的制备方法
DE60112325T2 (de) * 2000-12-14 2006-05-24 The Procter & Gamble Company, Cincinnati Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen
KR100735587B1 (ko) 2002-08-05 2007-07-04 더 프록터 앤드 갬블 캄파니 퀴놀론계 항생제 중간체의 제조 방법
US6803469B2 (en) * 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
ES2255871B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la obtencion de levofloxacino exento de sales.
AU2006325820B2 (en) * 2005-12-12 2013-02-14 Allaccem, Inc. Methods and systems for preparing antimicrobial films and coatings
CN101020647B (zh) * 2007-02-14 2011-03-30 杭州师范学院 一种β-环丙胺基丙烯酸(酯)的合成方法
AU2008218275B2 (en) 2007-02-21 2013-06-20 Allaccem, Incorporated Bridged polycyclic compound based compositions for the inhibition and amelioration of disease
US20080300258A1 (en) * 2007-05-30 2008-12-04 Souza Fabio Eduardo Silva Anhydrous ciprofloxacin hydrochloride
US8153618B2 (en) 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for topical applications for pets
US8153617B2 (en) 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in humans
US8188068B2 (en) 2007-08-10 2012-05-29 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in pets
CN105566217B (zh) * 2016-02-23 2019-03-01 青岛科技大学 一种氟罗沙星粗品的纯化方法
WO2018231747A2 (en) * 2017-06-12 2018-12-20 Virginia Commonwealth University Streamlined syntheses of fluoroquinolones
CN112552261B (zh) * 2019-09-26 2024-11-08 宜昌东阳光长江药业股份有限公司 左氧氟沙星及其中间体的制备方法
CN112552260B (zh) * 2019-09-26 2024-11-08 宜昌东阳光长江药业股份有限公司 左氧氟沙星及其中间体的制备方法
US11884658B1 (en) * 2023-09-26 2024-01-30 King Faisal University 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((2-thioxobenzo[d]thiazol-3(2H)-yl)methyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid as an antimicrobial compound

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EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones

Also Published As

Publication number Publication date
NO970427L (no) 1997-03-26
NO311356B1 (no) 2001-11-19
JPH10504815A (ja) 1998-05-12
AU705818B2 (en) 1999-06-03
EP0775114B1 (en) 2000-03-22
GR3033001T3 (en) 2000-07-31
FI970427L (fi) 1997-03-26
KR100242355B1 (ko) 2000-03-02
FI970427A7 (fi) 1997-03-26
PT775114E (pt) 2000-09-29
AU3153995A (en) 1996-03-04
KR970704694A (ko) 1997-09-06
NO970427D0 (no) 1997-01-31
WO1996004247A1 (en) 1996-02-15
CN1158120A (zh) 1997-08-27
EP0775114A1 (en) 1997-05-28
DE69515882T2 (de) 2000-11-02
BR9508514A (pt) 1997-12-23
NZ290721A (en) 1999-03-29
US5703231A (en) 1997-12-30
MX9700871A (es) 1997-05-31
CA2196538A1 (en) 1996-02-15
ATE190972T1 (de) 2000-04-15
DK0775114T3 (da) 2000-07-10
FI970427A0 (fi) 1997-01-31
DE69515882D1 (de) 2000-04-27
CA2196538C (en) 2000-04-25

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