MX363258B - Compuestos piridinilpirazoloquinolina. - Google Patents
Compuestos piridinilpirazoloquinolina.Info
- Publication number
- MX363258B MX363258B MX2015013446A MX2015013446A MX363258B MX 363258 B MX363258 B MX 363258B MX 2015013446 A MX2015013446 A MX 2015013446A MX 2015013446 A MX2015013446 A MX 2015013446A MX 363258 B MX363258 B MX 363258B
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compound
- pyridinylpyrazoloquinoline
- group
- represented
- Prior art date
Links
- -1 Pyridinylpyrazoloquinoline compound Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto representado por la fórmula (I), o una sal farmacéuticamente aceptable del mismo: (ver Fórmula) donde R1 es un grupo representado por la fórmula: (ver Fórmula) un grupo representado por la fórmula: (ver Fórmula) o un grupo representado por la fórmula: (ver Fórmula) y R2 es un grupo 3-metiltetrahidro-2H-piran-4-ilo o un grupo 4-metoxiciclohexilo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809118P | 2013-04-05 | 2013-04-05 | |
| US201361809095P | 2013-04-05 | 2013-04-05 | |
| PCT/JP2014/059852 WO2014163146A1 (ja) | 2013-04-05 | 2014-04-03 | ピリジニルピラゾロキノリン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015013446A MX2015013446A (es) | 2016-01-12 |
| MX363258B true MX363258B (es) | 2019-03-19 |
Family
ID=51658437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015013446A MX363258B (es) | 2013-04-05 | 2014-04-03 | Compuestos piridinilpirazoloquinolina. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9550776B2 (es) |
| EP (1) | EP2982674B1 (es) |
| JP (1) | JP6244353B2 (es) |
| KR (1) | KR102234131B1 (es) |
| CN (1) | CN105189496B (es) |
| AU (1) | AU2014250391B2 (es) |
| BR (1) | BR112015024075B1 (es) |
| CA (1) | CA2904820C (es) |
| CL (1) | CL2015002837A1 (es) |
| ES (1) | ES2654094T3 (es) |
| HK (1) | HK1219100A1 (es) |
| IL (1) | IL241695B (es) |
| MX (1) | MX363258B (es) |
| PE (1) | PE20151718A1 (es) |
| PH (1) | PH12015502178A1 (es) |
| RU (1) | RU2655172C2 (es) |
| SG (1) | SG11201507733YA (es) |
| TW (1) | TW201439091A (es) |
| WO (1) | WO2014163146A1 (es) |
| ZA (1) | ZA201507044B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201406486D0 (en) | 2014-04-10 | 2014-05-28 | Redx Pharma Ltd | Antibacterial compounds |
| WO2017046606A1 (en) * | 2015-09-18 | 2017-03-23 | Redx Pharma Plc | Antibacterial compounds |
| JP7269875B2 (ja) | 2017-06-01 | 2023-05-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロキノリン誘導体を含有するレビー小体病治療剤 |
| BR112020005174A2 (pt) | 2017-09-14 | 2020-11-10 | Daiichi Sankyo Company,Limited | composto que possui estrutura cíclica |
| US11530218B2 (en) | 2020-01-20 | 2022-12-20 | Incyte Corporation | Spiro compounds as inhibitors of KRAS |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| WO2022047093A1 (en) | 2020-08-28 | 2022-03-03 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of kras |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| US12030883B2 (en) | 2021-09-21 | 2024-07-09 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of KRAS |
| WO2023056421A1 (en) | 2021-10-01 | 2023-04-06 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
| CR20240197A (es) | 2021-10-14 | 2024-08-07 | Incyte Corp | Compuestos de quinolina como inhibidores de kras |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05132484A (ja) | 1991-04-26 | 1993-05-28 | Otsuka Pharmaceut Factory Inc | ピラゾロキノリン及びピラゾロナフチリジン誘導体 |
| JP2828506B2 (ja) | 1994-05-24 | 1998-11-25 | エフ・ホフマン−ラ ロシュ アーゲー | 三環式ジカルボニル誘導体 |
| DE102004004142A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
| WO2005118583A1 (en) | 2004-05-28 | 2005-12-15 | Millennium Pharmaceuticals, Inc. | 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors |
| JP2006045118A (ja) | 2004-08-04 | 2006-02-16 | Mochida Pharmaceut Co Ltd | 新規ピラゾロキノロン誘導体 |
| CN101268073B (zh) | 2005-09-15 | 2011-10-19 | Aska制药株式会社 | 杂环化合物、制备方法及其用途 |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| EP2103613B1 (en) | 2006-12-13 | 2016-02-17 | ASKA Pharmaceutical Co., Ltd. | Quinoxaline derivative |
| MY147330A (en) * | 2007-05-11 | 2012-11-30 | Pfizer | Amino-heterocyclic compounds |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| KR20110132559A (ko) | 2009-03-05 | 2011-12-08 | 아스텔라스세이야쿠 가부시키가이샤 | 퀴녹살린 화합물 |
| PE20120505A1 (es) | 2009-03-31 | 2012-05-09 | Boehringer Ingelheim Int | Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona como moduladores de pde9a |
| PL2615089T3 (pl) | 2010-09-07 | 2016-10-31 | Związki pirazolochinolinowe | |
| SI2573073T1 (sl) * | 2011-09-26 | 2015-02-27 | Sanofi | Pirazolokinolinonski derivati, njihova priprava in njihova terapevtska uporaba |
| JP6042060B2 (ja) | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| JP5546693B2 (ja) | 2011-10-07 | 2014-07-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロキノリン誘導体 |
-
2014
- 2014-04-03 CN CN201480016592.4A patent/CN105189496B/zh active Active
- 2014-04-03 EP EP14780073.4A patent/EP2982674B1/en active Active
- 2014-04-03 MX MX2015013446A patent/MX363258B/es unknown
- 2014-04-03 US US14/778,202 patent/US9550776B2/en active Active
- 2014-04-03 WO PCT/JP2014/059852 patent/WO2014163146A1/ja active Application Filing
- 2014-04-03 SG SG11201507733YA patent/SG11201507733YA/en unknown
- 2014-04-03 KR KR1020157026010A patent/KR102234131B1/ko active Active
- 2014-04-03 CA CA2904820A patent/CA2904820C/en active Active
- 2014-04-03 JP JP2015510131A patent/JP6244353B2/ja active Active
- 2014-04-03 AU AU2014250391A patent/AU2014250391B2/en active Active
- 2014-04-03 BR BR112015024075-5A patent/BR112015024075B1/pt active IP Right Grant
- 2014-04-03 PE PE2015001977A patent/PE20151718A1/es not_active Application Discontinuation
- 2014-04-03 RU RU2015140669A patent/RU2655172C2/ru active
- 2014-04-03 ES ES14780073.4T patent/ES2654094T3/es active Active
- 2014-04-03 TW TW103112618A patent/TW201439091A/zh unknown
-
2015
- 2015-09-17 PH PH12015502178A patent/PH12015502178A1/en unknown
- 2015-09-17 IL IL241695A patent/IL241695B/en active IP Right Grant
- 2015-09-22 ZA ZA2015/07044A patent/ZA201507044B/en unknown
- 2015-09-23 CL CL2015002837A patent/CL2015002837A1/es unknown
-
2016
- 2016-06-21 HK HK16107121.9A patent/HK1219100A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2982674A1 (en) | 2016-02-10 |
| ES2654094T3 (es) | 2018-02-12 |
| BR112015024075B1 (pt) | 2022-05-03 |
| TW201439091A (zh) | 2014-10-16 |
| CN105189496B (zh) | 2017-03-29 |
| ZA201507044B (en) | 2017-02-22 |
| CN105189496A (zh) | 2015-12-23 |
| RU2015140669A (ru) | 2017-05-11 |
| IL241695B (en) | 2019-06-30 |
| US9550776B2 (en) | 2017-01-24 |
| CA2904820A1 (en) | 2014-10-09 |
| CL2015002837A1 (es) | 2016-04-22 |
| AU2014250391A1 (en) | 2015-10-15 |
| KR102234131B1 (ko) | 2021-04-01 |
| KR20150138204A (ko) | 2015-12-09 |
| CA2904820C (en) | 2021-05-18 |
| HK1219100A1 (zh) | 2017-03-24 |
| US20160289225A1 (en) | 2016-10-06 |
| JP6244353B2 (ja) | 2017-12-06 |
| WO2014163146A1 (ja) | 2014-10-09 |
| JPWO2014163146A1 (ja) | 2017-02-16 |
| AU2014250391B2 (en) | 2017-11-02 |
| BR112015024075A2 (pt) | 2017-10-24 |
| RU2015140669A3 (es) | 2018-03-21 |
| MX2015013446A (es) | 2016-01-12 |
| PH12015502178A1 (en) | 2016-01-25 |
| EP2982674A4 (en) | 2016-08-31 |
| PE20151718A1 (es) | 2015-11-22 |
| EP2982674B1 (en) | 2017-10-25 |
| RU2655172C2 (ru) | 2018-05-24 |
| SG11201507733YA (en) | 2015-10-29 |
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