[go: up one dir, main page]

MX350164B - Composiciones para suministro pulmonar de antagonistas muscarínicos de acción prolongada y agonistas de receptor b2 adrenérgico de acción prolongada y métodos y sistemas asociados. - Google Patents

Composiciones para suministro pulmonar de antagonistas muscarínicos de acción prolongada y agonistas de receptor b2 adrenérgico de acción prolongada y métodos y sistemas asociados.

Info

Publication number
MX350164B
MX350164B MX2011012685A MX2011012685A MX350164B MX 350164 B MX350164 B MX 350164B MX 2011012685 A MX2011012685 A MX 2011012685A MX 2011012685 A MX2011012685 A MX 2011012685A MX 350164 B MX350164 B MX 350164B
Authority
MX
Mexico
Prior art keywords
long
acting
compositions
systems
receptor agonists
Prior art date
Application number
MX2011012685A
Other languages
English (en)
Other versions
MX2011012685A (es
Inventor
Vehring Reinhard
Steven Hartman Michael
Edward Smith Adrian
B Joshi Vidya
Kumar Dwivedi Sarvajna
Original Assignee
Pearl Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42269864&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX350164(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pearl Therapeutics Inc filed Critical Pearl Therapeutics Inc
Publication of MX2011012685A publication Critical patent/MX2011012685A/es
Publication of MX350164B publication Critical patent/MX350164B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1611Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/10Trunk
    • A61M2210/1025Respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se proporcionan composiciones, métodos y sistemas para el suministro pulmonar de antagonistas muscarínicos de acción prolongada y agonistas de receptor ß2 adrenérgico de acción prolongada a través de un inhalador de dosis medida. En modalidades particulares, las composiciones incluyen un modo de suspensión, partículas de agente activo y partículas de suspensión en las cuales las partículas de agente activo y las partículas de suspensión forman una co-suspensión dentro del medio de suspensión.
MX2011012685A 2009-05-29 2010-05-28 Composiciones para suministro pulmonar de antagonistas muscarínicos de acción prolongada y agonistas de receptor b2 adrenérgico de acción prolongada y métodos y sistemas asociados. MX350164B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18256509P 2009-05-29 2009-05-29
US25817209P 2009-11-04 2009-11-04
US30936510P 2010-03-01 2010-03-01
US34553610P 2010-05-17 2010-05-17
PCT/US2010/036659 WO2010138868A2 (en) 2009-05-29 2010-05-28 Compositions for pulmonary delivery of long-acting muscarinic antagonists and long-acting b2 adrenergic receptor agonists and associated methods and systems

Publications (2)

Publication Number Publication Date
MX2011012685A MX2011012685A (es) 2012-06-12
MX350164B true MX350164B (es) 2017-08-29

Family

ID=42269864

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2011012685A MX350164B (es) 2009-05-29 2010-05-28 Composiciones para suministro pulmonar de antagonistas muscarínicos de acción prolongada y agonistas de receptor b2 adrenérgico de acción prolongada y métodos y sistemas asociados.
MX2011012684A MX350163B (es) 2009-05-29 2010-05-28 Composiciones para suministro respiratorio de agentes activos y metodos y sistemas asociados.
MX2011012783A MX337126B (es) 2009-05-29 2010-05-28 Administracion respiratoria de agentes activos.
MX2020004077A MX2020004077A (es) 2009-05-29 2011-11-28 Composición farmacéutica que comprende la combinación de albuterol y budesónida, adaptada para el suministro respiratorio mediante un inhalador de dosis medida y el uso de las mismas para el tratamiento de trastornos pulmonares.

Family Applications After (3)

Application Number Title Priority Date Filing Date
MX2011012684A MX350163B (es) 2009-05-29 2010-05-28 Composiciones para suministro respiratorio de agentes activos y metodos y sistemas asociados.
MX2011012783A MX337126B (es) 2009-05-29 2010-05-28 Administracion respiratoria de agentes activos.
MX2020004077A MX2020004077A (es) 2009-05-29 2011-11-28 Composición farmacéutica que comprende la combinación de albuterol y budesónida, adaptada para el suministro respiratorio mediante un inhalador de dosis medida y el uso de las mismas para el tratamiento de trastornos pulmonares.

Country Status (32)

Country Link
US (12) US20110135737A1 (es)
EP (6) EP3111927B1 (es)
JP (10) JP5823383B2 (es)
KR (7) KR20120015334A (es)
CN (6) CN102596176B (es)
AR (3) AR076806A1 (es)
AU (3) AU2010253770B9 (es)
BR (3) BRPI1011220B1 (es)
CA (3) CA2763936C (es)
CY (8) CY1118040T1 (es)
DK (6) DK2435023T3 (es)
ES (6) ES2593429T3 (es)
FR (1) FR19C1040I2 (es)
HK (6) HK1169026A1 (es)
HR (6) HRP20161098T1 (es)
HU (8) HUE047823T2 (es)
IL (3) IL216467B (es)
LT (8) LT2435023T (es)
LU (2) LUC00124I2 (es)
ME (1) ME03631B (es)
MX (4) MX350164B (es)
NL (1) NL300995I2 (es)
NO (2) NO2019026I1 (es)
PH (1) PH12017500778A1 (es)
PL (6) PL3106149T3 (es)
PT (6) PT3106149T (es)
RU (5) RU2713404C2 (es)
SI (6) SI2435024T1 (es)
SM (6) SMT202000108T1 (es)
TW (9) TWI707700B (es)
WO (3) WO2010138884A2 (es)
ZA (4) ZA201108275B (es)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003220125B2 (en) 2002-03-20 2006-06-15 Mannkind Corporation Inhalation apparatus
DE602005024413D1 (de) 2004-08-20 2010-12-09 Mannkind Corp Katalyse der diketopiperazinsynthese
EP2322180B1 (en) 2004-08-23 2015-05-27 MannKind Corporation Diketopiperazine salts for drug delivery
US10002325B2 (en) 2005-03-30 2018-06-19 Primal Fusion Inc. Knowledge representation systems and methods incorporating inference rules
CN102614131A (zh) 2005-09-14 2012-08-01 曼金德公司 以提高结晶微粒表面对活性试剂的亲和力为基础的药物配制方法
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
IL313823A (en) 2008-06-13 2024-08-01 Mannkind Corp A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
AU2009259883B2 (en) 2008-06-20 2015-02-05 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
TWI707700B (zh) * 2009-05-29 2020-10-21 美商沛爾醫療股份有限公司 用於經由肺部遞送長效蕈毒鹼拮抗劑及長效β2腎上腺素受體激動劑之組成物,及相關方法及系統
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
KR20130117755A (ko) * 2010-06-21 2013-10-28 맨카인드 코포레이션 건조 분말 약물 운반 시스템 및 방법
US10474647B2 (en) 2010-06-22 2019-11-12 Primal Fusion Inc. Methods and devices for customizing knowledge representation systems
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
WO2012158166A1 (en) * 2011-05-17 2012-11-22 Pearl Therapeutics, Inc. Compositions, methods & systems for respiratory delivery of two or more active agents
CN105106200A (zh) * 2011-05-17 2015-12-02 珍珠治疗公司 用于呼吸递送两种或多种活性剂的组合物、方法和系统
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
GB201113662D0 (en) * 2011-08-08 2011-09-21 Prosonix Ltd Pharmaceutical compositions
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
CN104470503A (zh) * 2012-04-13 2015-03-25 葛兰素史克知识产权开发有限公司 聚集粒子
BR112015000529B1 (pt) 2012-07-12 2022-01-11 Mannkind Corporation Inalador de pó seco
CN102872027B (zh) * 2012-09-18 2014-03-12 刘晓忠 一种治疗肺部疾病的药物颗粒的制备和吸入式复方气雾剂的制备
HUE052275T2 (hu) * 2013-01-28 2021-04-28 Incozen Therapeutics Pvt Ltd Eljárások autoimmun, légzõszervi és gyulladásos rendellenességek kezelésére roflumilaszt N-oxid inhalálásával
EA201591415A1 (ru) * 2013-01-31 2016-01-29 Просоникс Лимитед Фармацевтические композиции, включающие многокомпонентные кристаллические частицы, подходящие для применения в ингаляционной терапии
GB201301721D0 (en) * 2013-01-31 2013-03-20 Prosonix Ltd Pharmaceutical Preparations
ES2804702T3 (es) * 2013-03-04 2021-02-09 Besins Healthcare Lu Sarl Composiciones farmacéuticas secas que comprenden nanopartículas de agente activo unidas a partículas de portador
JP6232079B2 (ja) * 2013-03-14 2017-11-15 ノバルティス アーゲー スプレーブレンディングによるスプレー乾燥製剤の脱アモルファス化
CA2905542C (en) * 2013-03-15 2022-05-03 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
US11554229B2 (en) 2013-03-26 2023-01-17 OptiNose Inc. Nasal administration
EP2981247B1 (en) 2013-04-01 2023-06-07 Pulmatrix Operating Company, Inc. Tiotropium dry powders
US9393202B2 (en) * 2013-04-26 2016-07-19 Chiesi Farmaceutici S.P.A Particle size reduction of an antimuscarinic compound
CN105392471A (zh) * 2013-05-22 2016-03-09 珍珠治疗公司 用于呼吸递送三种或更多种活性剂的组合物、方法和系统
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
CN105636630B (zh) * 2013-10-07 2020-05-19 梯瓦优质制药产品研发股份有限公司 干粉吸入器
CN105263473A (zh) * 2013-11-22 2016-01-20 梯瓦优质制药产品研发股份有限公司 可吸入药物
GB201321717D0 (en) * 2013-12-09 2014-01-22 Pharmachemie Bv Inhalable Medicaments
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
CN104188941B (zh) * 2014-09-02 2016-11-16 重庆和平制药有限公司 一种制备盐酸克仑特罗吸入粉雾剂的方法
US20180228818A1 (en) * 2014-10-01 2018-08-16 Chien-Hung Chen Pharmaceutical composition comprising asprin, metformin, and serotonin with non-ionic surfactant
MA41378A (fr) * 2015-01-20 2017-11-28 Teva Branded Pharmaceutical Prod R & D Inc Inhalateur de poudre sèche comprenant du propionate de fluticasone et du xinafoate de salmétérol
WO2016170518A1 (en) 2015-04-24 2016-10-27 Glenmark Specialty S.A. Pharmaceutical compositions comprising arformoterol and glycopyrronium
TW201735914A (zh) 2015-12-22 2017-10-16 阿斯特捷利康公司 用於治療慢性阻塞性肺疾病之醫藥組成物
WO2017157265A1 (zh) * 2016-03-15 2017-09-21 广东东阳光药业有限公司 喷雾剂、喷雾装置以及喷雾组件
WO2017201003A1 (en) * 2016-05-17 2017-11-23 Mayo Foundation For Medical Education And Research Materials and methods for treating chronic cough
RU2741309C2 (ru) 2016-06-30 2021-01-25 Филип Моррис Продактс С.А. Никотиносодержащие частицы
EP3610871B1 (en) 2016-09-19 2023-11-08 Mexichem Fluor S.A. de C.V. Pharmaceutical composition comprising glycopyrrolate
JP6906947B2 (ja) * 2016-12-22 2021-07-21 キヤノン株式会社 画像処理装置、撮像装置、画像処理方法およびコンピュータのプログラム
CN106943350A (zh) * 2017-03-14 2017-07-14 上海现代药物制剂工程研究中心有限公司 含毒蕈碱受体拮抗剂和β2受体激动剂的气雾剂及制备方法
CN107243080B (zh) * 2017-06-21 2021-11-12 上海上药信谊药厂有限公司 一种吸入式气雾剂、其原料组合物及制备方法
EP4091652B1 (en) * 2017-10-09 2023-11-29 Pearl Therapeutics, Inc. Aerosol delivery unit
JP7372727B2 (ja) 2017-11-20 2023-11-01 三菱重工業株式会社 系統運用者側コンピュータ、発電事業者側コンピュータ、電力システム、制御方法及びプログラム
WO2020071448A1 (ja) * 2018-10-02 2020-04-09 学校法人名城大学 吸入粉末剤、その評価方法及びその用途
CN109632555B (zh) * 2018-12-28 2021-07-27 上海新黄河制药有限公司 一种富马酸福莫特罗无定型含量的动态蒸汽吸附分析方法
WO2020229966A1 (en) * 2019-05-10 2020-11-19 Glenmark Pharmaceutical Limited Stable aerosol composition for inhalation comprising glycopyrronium
CN112137957B (zh) 2019-06-26 2022-07-29 长风药业股份有限公司 一种药用吸入气雾剂及其制备方法
WO2020263994A1 (en) * 2019-06-27 2020-12-30 Cai Gu Huang Inhalable formulation of a solution containing formoterol fumarate and aclidinium bromide
CN112972384B (zh) * 2019-12-02 2022-03-18 长风药业股份有限公司 一种格隆溴铵和茚达特罗原料药微粉混合物的制备方法
PE20230236A1 (es) * 2020-02-20 2023-02-07 Chiesi Farm Spa Inhaladores dosificadores presurizados que comprenden una formulacion farmaceutica amortiguada
ES2929818T3 (es) * 2020-05-18 2022-12-02 Orexo Ab Nueva composición farmacéutica para la administración de fármacos
US20220000767A1 (en) * 2020-07-06 2022-01-06 Sensory Cloud, Inc. Nasal hygiene compositions, antimicrobial treatments, devices, and articles for delivery of same to the nose, trachea and main bronchi
WO2022016068A1 (en) * 2020-07-16 2022-01-20 Tbd Pharma Llc Dexamethasone solution for the treatment of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infections
CN116710104A (zh) * 2021-01-08 2023-09-05 江苏恒瑞医药股份有限公司 可通过定量吸入器递送的药物组合物
JP2024049405A (ja) * 2021-02-22 2024-04-10 興和株式会社 新規吸入剤
ES2981709T3 (es) 2021-07-09 2024-10-10 Astrazeneca Pharmaceuticals Lp Composiciones, métodos y sistemas para el suministro de fármacos en aerosol
AU2022395920A1 (en) 2021-11-25 2024-05-30 Orexo Ab Pharmaceutical composition comprising adrenaline
CN118414148A (zh) 2021-12-20 2024-07-30 阿斯利康(瑞典)有限公司 用于气溶胶药物递送的组合物、方法和系统
WO2023212191A1 (en) 2022-04-28 2023-11-02 Astrazeneca Ab Combination of albuterol and budesonide for the treatment of asthma
WO2024206662A1 (en) * 2023-03-30 2024-10-03 Aerorx Therapeutics Llc Liquid formulations of indacaterol and glycopyrronium
CN117357485B (zh) * 2023-11-01 2024-09-24 山东京卫制药有限公司 一种改良的可吸入的载体颗粒及应用
CN118787617A (zh) * 2024-09-14 2024-10-18 苏州易合医药有限公司 一种吸入粉剂及其制备方法

Family Cites Families (176)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956062A (en) 1959-02-26 1960-10-11 Robins Co Inc A H Esters of amino alcohols
US3994974A (en) 1972-02-05 1976-11-30 Yamanouchi Pharmaceutical Co., Ltd. α-Aminomethylbenzyl alcohol derivatives
SE378109B (es) 1972-05-19 1975-08-18 Bofors Ab
US4187301A (en) 1978-04-05 1980-02-05 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
BE887518A (fr) * 1980-02-15 1981-08-13 Glaxo Group Ltd Cartothioates d'androstanes
DE3260474D1 (en) 1981-02-02 1984-09-06 Schering Corp Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
GB8432063D0 (en) 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
IL95590A (en) 1989-09-08 1996-06-18 Glaxo Group Ltd Medicinal preparations containing Salmetrol and Pluticasone Propionate
EP0416950B1 (en) 1989-09-08 1993-08-11 Glaxo Group Limited Medicaments
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
IE912999A1 (en) 1990-09-07 1992-03-11 Abbott Lab Phenanthridine compounds
WO1992004365A1 (en) 1990-09-10 1992-03-19 Schering Corporation Mometasone furoate monohydrate, process for making same and pharmaceutical compositions
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5635563A (en) 1991-04-01 1997-06-03 Tomoegawa Paper Co., Ltd. Polyaniline derivatives and their production process
SE9302777D0 (sv) 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
DE69232462T2 (de) 1991-12-18 2002-10-10 Astrazeneca Ab, Soedertaelje Formoterol und budesonide enthaltende zusammensetzung
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5849263A (en) 1993-03-30 1998-12-15 Charlotte-Mecklenburg Hospital Authority Pharmaceutical compositions containing alkylaryl polyether alcohol polymer
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
PT731688E (pt) 1993-12-02 2003-07-31 Abbott Lab Formulacoes de farmacos em aerossol para utilizacao com propulsores sem cfc
SE9404080L (sv) 1993-12-28 1995-06-29 Ciba Geigy Ag Förfarande för framställning av en optiskt ren enantiomer av formoterol
US5837699A (en) * 1994-01-27 1998-11-17 Schering Corporation Use of mometasone furoate for treating upper airway passage diseases
ATE165438T1 (de) * 1994-02-09 1998-05-15 Kinerton Ltd Verfahren zur trocknung eines materials aus einer lösung
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
DE4440337A1 (de) 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
EE9700138A (et) * 1994-12-22 1997-12-15 Astra Aktiebolag Aerosoolravimvormid
US5612053A (en) * 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
GB9507768D0 (en) 1995-04-13 1995-05-31 Glaxo Group Ltd Method of apparatus
KR19980703876A (ko) 1995-04-14 1998-12-05 스티븐 엘. 허스트 분산성이 개선된 분말화된 약학적 조성물
US6258341B1 (en) 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
US6309671B1 (en) * 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
US5833891A (en) 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
DE19614421C2 (de) 1996-04-12 1999-12-16 Biovision Gmbh Verfahren zur Herstellung eines biodegradierbaren Knochenersatz- und Implantatwerkstoffes und biodegradierbarer Knochenersatz- und Implantatwerkstoff
GB9610821D0 (en) 1996-05-23 1996-07-31 Glaxo Wellcome Inc Metering apparatus
GB9612297D0 (en) 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
US6054488A (en) * 1996-06-11 2000-04-25 3M Innovative Properties Company Medicinal aerosol formulations of formoterol
US5886200A (en) 1996-07-01 1999-03-23 Schering Corporation Process for the preparation of 17-esters of 9 α, 21-dihalo-pregnane-11 β, 17 α-diol-20-ones
US6068832A (en) * 1996-08-29 2000-05-30 Schering Corporation Chlorofluorocarbon-free mometasone furoate aerosol formulations
SE9603669D0 (sv) 1996-10-08 1996-10-08 Astra Ab New combination
CA2271276C (en) * 1996-11-11 2009-01-13 Christian R. Noe Pure enantiomer basic aryl-cycloalkyl-hydroxycarboxylic acid esters, process for preparing the same and their use in medicaments
US6040344A (en) 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
HU230274B1 (hu) 1997-03-20 2015-11-30 Merck Sharp & Dohme Corp. Por-agglomerátumok adagolási formája
US6129905A (en) * 1997-04-21 2000-10-10 Aeropharm Technology, Inc. Aerosol formulations containing a sugar as a dispersant
US6010935A (en) * 1997-08-21 2000-01-04 Micron Technology, Inc. Self aligned contacts
SE9703407D0 (sv) 1997-09-19 1997-09-19 Astra Ab New use
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
IL135126A0 (en) 1997-09-29 2001-05-20 Inhale Therapeutic Syst Perforated microparticles and methods of use and preparation thereof
US6946117B1 (en) * 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US20020017295A1 (en) 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
AU2745599A (en) 1998-03-05 1999-09-20 Senju Pharmaceutical Co., Ltd. Pharmaceutical composition for prophylaxis and therapy of diseases associated with ocular fundus tissue cytopathy
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
US6260549B1 (en) * 1998-06-18 2001-07-17 Clavius Devices, Inc. Breath-activated metered-dose inhaler
US6451285B2 (en) * 1998-06-19 2002-09-17 Baker Norton Pharmaceuticals, Inc. Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
JP4570251B2 (ja) 1998-07-24 2010-10-27 ヤゴテック アーゲー 医薬用エーロゾル製剤
US6475467B1 (en) * 1998-08-04 2002-11-05 Jago Research Ag Medicinal aerosol formulations
DE59914603D1 (de) * 1998-11-13 2008-02-14 Jagotec Ag Multidosis-Trockenpulverinhalator mit Pulverreservoir
GB9912639D0 (en) * 1999-05-28 1999-07-28 Britannia Pharmaceuticals Ltd Improvements in and relating to treatment of respiratory conditions
GB9826284D0 (en) 1998-12-01 1999-01-20 Rhone Poulence Rorer Limited Process
US6004537A (en) 1998-12-18 1999-12-21 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol
CA2356637C (en) 1998-12-22 2011-09-13 The University Of North Carolina At Chapel Hill Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
GB9903759D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
GB9904919D0 (en) * 1999-03-03 1999-04-28 Novartis Ag Organic compounds
HUP0200185A3 (en) 1999-03-05 2006-07-28 Chiesi Farma Spa Improved powdery pharmaceutical compositions for inhalation
SE9900833D0 (sv) * 1999-03-09 1999-03-09 Astra Ab Novel combination
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
WO2000061108A1 (en) 1999-04-14 2000-10-19 Glaxo Group Limited Pharmaceutical aerosol formulation
US20100197719A1 (en) * 1999-05-12 2010-08-05 Boehringer Ingelheim Pharma Kg Medicament compositions containing anticholinergically-effective compounds and betamimetics
EP1196236B1 (en) 1999-06-30 2007-08-29 Nektar Therapeutics Spray drying process and system for preparing dry powders
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
NZ500555A (en) 1999-08-02 2000-11-24 Hovione Int Ltd Process for the preparation of mometasone furoate
US6586008B1 (en) * 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
MXPA02004193A (es) 1999-10-29 2002-12-13 Inhale Therapeutic Syst Composiciones de polvo seco que tienen caracteristicas de dispersion mejoradas.
DE19961300A1 (de) * 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator
US6596261B1 (en) 2000-01-25 2003-07-22 Aeropharm Technology Incorporated Method of administering a medicinal aerosol formulation
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
GB0008660D0 (en) * 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
JP2003531123A (ja) 2000-04-13 2003-10-21 イノバータ・バイオミッド・リミテッド 医薬品
TWI290473B (en) * 2000-05-10 2007-12-01 Alliance Pharma Phospholipid-based powders for drug delivery
US20060257324A1 (en) * 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
AU2000265583A1 (en) 2000-08-15 2002-02-25 Carsten Berg Quaternary ammonium salts of 1,2-benzisothiazolin-3-one. preparation and use as biocides
FI20002215A0 (fi) 2000-10-06 2000-10-06 Orion Yhtymae Oyj Yhdistelmäpartikkelit
US20040081627A1 (en) * 2000-10-09 2004-04-29 Jinks Phillip A Medicinal aerosol formulations
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
PT2283817T (pt) * 2000-11-30 2016-08-22 Vectura Ltd Método de fabrico de partículas para utilização numa composição farmacêutica
AU2002222115B2 (en) * 2000-11-30 2006-09-28 Vectura Limited Method of making particles for use in a pharmaceutical composition
GB0029562D0 (en) 2000-12-04 2001-01-17 Novartis Ag Organic compounds
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
CA2433335C (en) 2000-12-29 2010-04-20 Advanced Inhalation Research, Inc. Particles for inhalation having sustained release properties
ITMI20010428A1 (it) * 2001-03-02 2002-09-02 Chemo Breath S A Composizioni ad uso inalatorio a base di formoterolo
IL157580A0 (en) * 2001-03-20 2004-03-28 Glaxo Group Ltd Inhalation drug combination
DK1372608T3 (da) * 2001-03-30 2007-12-27 Jagotec Ag Medicinske aerosolformuleringer
US20050074742A1 (en) * 2001-03-30 2005-04-07 Alain Domard Cartilaginous neo-tissue capable of being grafted
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US6848197B2 (en) 2001-04-18 2005-02-01 Advanced Inhalation Research, Inc. Control of process humidity to produce large, porous particles
DE10130371A1 (de) 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
TWI324934B (en) * 2001-08-28 2010-05-21 Schering Corp Pharmaceutical compositions for the treatment of asthma
DE10202940A1 (de) 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Patrone für einen Pulverinhalator
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214264A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen eines Anhydrats
GB0207906D0 (en) * 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and mometasone aerosol formulations
DE10216429A1 (de) 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Arzneimittel enthaltend Steroide und ein neues Anticholinergikum
EP1511500A4 (en) * 2002-06-12 2009-04-29 Epigenesis Pharmaceuticals Llc COMBINATION OF ANTI-MUSCARINIC AGENTS AND NONGLUCOCORTICOID STEROIDS
US7244742B2 (en) * 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
DE10237739A1 (de) 2002-08-17 2004-02-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalative Arzneimittel enthaltend ein neues Anticholinergikum in Kombination mit Corticosteroiden und Betamimetika
ES2388537T3 (es) 2002-08-23 2012-10-16 Merck Sharp & Dohme Corp. Inhalador dosificador que contiene una formulación en suspensión de aerosol
CN1694689A (zh) 2002-09-30 2005-11-09 阿库斯菲尔公司 供吸入的缓释多孔微粒
AU2003279976B2 (en) * 2002-10-15 2007-10-11 Cryovac, Llc A process for triggering, storing, and distributing an oxygen scavenger, and a stored oxygen scavenger
EP1452179A1 (en) 2003-02-27 2004-09-01 CHIESI FARMACEUTICI S.p.A. Novel medicament combination of a highly potent long-lasting beta2-agonist and a corticosteroid
DE10323966A1 (de) 2003-05-27 2004-12-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen
JP2007500234A (ja) 2003-05-28 2007-01-11 ネクター セラピューティクス 水に不溶な活性剤を含む医薬的成形
CA2529007C (en) * 2003-06-16 2012-03-27 Altana Pharma Ag Composition comprising a pulmonary surfactant and a pde5 inhibitor for the treatment of lung diseases
SE527190C2 (sv) * 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av en beta2-agonist, ett antikolinergiskt medel och ett antiinflammatorisk steroid
DE602004019096D1 (de) 2003-07-28 2009-03-05 Boehringer Ingelheim Pharma Medikamente zur inhalation mit betamimetika und einem anticholinergikum
CA2534128C (en) 2003-07-29 2012-10-23 Boehringer Ingelheim International Gmbh Combination of an anticholinergic and a steroid and its use to treat respiratory disorders by inhalation
ATE357258T1 (de) 2003-07-29 2007-04-15 Boehringer Ingelheim Int Medikamente zur inhalation mit betamimetika und einem anticholinergikum
EP1651224B1 (en) 2003-07-31 2011-10-05 Boehringer Ingelheim International GmbH Medicaments for inhalation comprising an anticholinergic and a betamimetic
EP1925293A3 (en) 2003-10-20 2010-01-13 Schering Corporation Pharmaceutical aerosol compositions
US9308199B2 (en) * 2004-04-29 2016-04-12 Honeywell International Inc. Medicament formulations
JP4851937B2 (ja) * 2003-11-21 2012-01-11 セラヴァンス, インコーポレーテッド β2アドレナリン作動性受容体作動薬活性およびムスカリン受容体拮抗薬活性を有する化合物
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
EP3238708A1 (en) * 2003-12-31 2017-11-01 CyDex Pharmaceuticals, Inc. Inhalant formulation containing cyclodextrin and corticosteroid
EP1713473B1 (en) 2004-02-06 2013-03-13 MEDA Pharma GmbH & Co. KG The combination of anticholinergics and glucocorticoids for the long-term treatment of asthma and copd
ES2309705T3 (es) 2004-02-06 2008-12-16 MEDA PHARMA GMBH & CO. KG Nueva combinacion de anticolinergico y beta-mimeticos para el tratamiento de enfermedades respiratorias.
US20050287077A1 (en) * 2004-02-10 2005-12-29 James E. Shipley Process for preparing stable SOL of pharmaceutical ingredients and hydrofluorocarbon
GB0411056D0 (en) * 2004-05-18 2004-06-23 Novartis Ag Organic compounds
AU2005258078B2 (en) * 2004-06-18 2010-09-30 Bgp Products Operations Gmbh Methods of treatment of endobronchial infections
GB0426301D0 (en) 2004-11-30 2004-12-29 Vectura Ltd Pharmaceutical formulations
US20060140873A1 (en) 2004-12-27 2006-06-29 Chang Heng W Aerosol pharmaceutical compositions
JP2008534480A (ja) 2005-03-24 2008-08-28 ソーセイ アールアンドディ リミテッド グリコピロニウム塩およびそれらの治療的使用
CA2603433A1 (en) 2005-03-30 2006-10-05 Schering Corporation Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist
CA2607391A1 (en) 2005-04-23 2006-11-02 Boehringer Ingelheim International Gmbh Combination of medicaments to be inhaled, containing a betamimetic agent and a steroid in addition to an anticholinergic agent
GB0523653D0 (en) 2005-11-21 2005-12-28 Novartis Ag Organic compounds
WO2006128847A2 (en) 2005-05-31 2006-12-07 Boehringer Ingelheim International Gmbh Medicament containing a betamimetic in conjunction with an anticholinergic and a pde iv inhibitor
EP1898894A1 (en) 2005-06-17 2008-03-19 Boehringer Ingelheim International GmbH Mrp iv inhibitors for the treatment of respiratory diseases
AU2006272438B2 (en) 2005-07-15 2011-08-04 Map Pharmaceuticals, Inc. Method of particle formation
CN103462943A (zh) 2005-07-15 2013-12-25 Map药物公司 在离散的吸入粒子中结合的多种活性药物成分及其制剂
CN100560598C (zh) * 2005-07-26 2009-11-18 上海奥锐特国际贸易有限公司 氟替卡松丙酸酯的合成方法
AT502396B1 (de) 2005-09-01 2007-03-15 Montanuniv Leoben Verfahren zum abtrennen von verunreinigungen aus einsatzstoffen
GB0523655D0 (en) 2005-11-21 2005-12-28 Novartis Ag Organic compounds
GB0523654D0 (en) 2005-11-21 2005-12-28 Novartis Ag Organic compounds
GB0523656D0 (en) 2005-11-21 2005-12-28 Novartis Ag Organic compounds
NZ591969A (en) 2005-12-21 2012-05-25 Meda Pharma Gmbh & Co Kg Combination of anticholinergics, glucocorticoids, beta2-adrenoceptor agonists, PDE 4 inhibitor and antileukotriene for the treatment of inflammatory diseases
US8263645B2 (en) * 2006-02-03 2012-09-11 Pari Pharma Gmbh Disodium cromoglycate compositions and methods for administering same
JP2009526063A (ja) 2006-02-09 2009-07-16 シェーリング コーポレイション 医薬製剤
US20110135580A1 (en) 2006-05-24 2011-06-09 Boehringer Ingelheim International Gmbh Novel Medicament Combinations for the Treatment of Respiratory Diseases
GB0613161D0 (en) 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
GB0614621D0 (en) * 2006-07-24 2006-08-30 3M Innovative Properties Co Metered dose dispensers
EP1894568A1 (en) * 2006-08-31 2008-03-05 Novartis AG Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases
CL2008000500A1 (es) * 2007-02-19 2008-09-05 Cipla Ltd Combinacion farmaceutica que comprende una combinacion de dos o mas broncodilatadores o una combinacion de al menos un broncodilatador y al menos un corticosteroide; uso para tratar o prevenir una enfermedad respiratoria; e inhalador que comprende di
EP1964564A1 (en) * 2007-04-19 2008-09-03 LAB International SRL Breakthrough Pain Management
EP2036572A1 (en) * 2007-09-04 2009-03-18 Novo Nordisk A/S Process for drying a protein, a protein particle and a pharmaceutical composition comprising the protein particle
CN101317821B (zh) * 2007-11-15 2012-01-04 陈晓东 适用于肺部给药的超细干粉颗粒及其制备方法
WO2009074662A2 (en) * 2007-12-13 2009-06-18 Novartis Ag Organic compounds
GB0801876D0 (en) 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations
FR2940162B1 (fr) 2008-12-22 2011-02-25 Boehm & Cie Ets Outil de frappe multi-usages a mecanisme absorbant l'energie transmise au moyen de prehension
WO2010097188A1 (en) * 2009-02-25 2010-09-02 Chiesi Farmaceutici S.P.A. Inhalation particles comprising a salt of carmoterol and a corticosteroid
TWI707700B (zh) * 2009-05-29 2020-10-21 美商沛爾醫療股份有限公司 用於經由肺部遞送長效蕈毒鹼拮抗劑及長效β2腎上腺素受體激動劑之組成物,及相關方法及系統
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
CN104257610A (zh) 2010-04-01 2015-01-07 奇斯药制品公司 用于制备可吸入干粉所用的载体颗粒的方法
JP2014504260A (ja) 2010-10-15 2014-02-20 グラクソ グループ リミテッド 集合ナノ粒子状薬物製剤、その製造及び使用
RU2018115685A (ru) 2011-02-17 2019-03-05 Сипла Лимитед Фармацевтическая композиция
JO3510B1 (ar) 2011-03-04 2020-07-05 Heptares Therapeutics Ltd استخدام جلايكوبيرولات لعلاج عدم انتظام دقات القلب
WO2012158166A1 (en) 2011-05-17 2012-11-22 Pearl Therapeutics, Inc. Compositions, methods & systems for respiratory delivery of two or more active agents
CN105392471A (zh) 2013-05-22 2016-03-09 珍珠治疗公司 用于呼吸递送三种或更多种活性剂的组合物、方法和系统

Also Published As

Publication number Publication date
EP2435023B1 (en) 2016-07-06
WO2010138862A2 (en) 2010-12-02
IL216468B (en) 2018-12-31
JP6189356B2 (ja) 2017-08-30
JP6876734B2 (ja) 2021-05-26
US9463161B2 (en) 2016-10-11
US20170112759A1 (en) 2017-04-27
SMT202000109T1 (it) 2020-03-13
RU2011152960A (ru) 2013-07-10
PH12017500778A1 (en) 2018-01-22
US20170071850A1 (en) 2017-03-16
AU2010253950C1 (en) 2015-09-17
HRP20200166T1 (hr) 2020-05-15
RU2016107464A (ru) 2018-11-22
PT2435024T (pt) 2016-10-13
HUE029532T2 (en) 2017-03-28
JP2012528200A (ja) 2012-11-12
JP2017222706A (ja) 2017-12-21
AU2010253776B2 (en) 2015-01-22
CY1122807T1 (el) 2021-05-05
JP5873012B2 (ja) 2016-03-01
ZA201208102B (en) 2013-09-25
TW201936174A (zh) 2019-09-16
LT2435024T (lt) 2016-09-26
PT3106149T (pt) 2020-02-19
LUC00124I1 (es) 2019-06-13
CN102596176B (zh) 2017-09-19
SI2435025T1 (sl) 2016-10-28
ME03631B (me) 2020-07-20
RU2016117972A3 (es) 2019-09-27
HUE047834T2 (hu) 2020-05-28
BRPI1011508A2 (pt) 2016-03-22
CN102753152A (zh) 2012-10-24
JP5873013B2 (ja) 2016-03-01
CN102596176A (zh) 2012-07-18
RU2016117972A (ru) 2018-10-29
AU2010253950B2 (en) 2014-12-04
DK3111926T3 (da) 2020-03-02
EP3111927A1 (en) 2017-01-04
EP2435023A2 (en) 2012-04-04
BRPI1011229A2 (pt) 2016-03-15
DK2435025T3 (en) 2016-10-24
BRPI1011220B1 (pt) 2020-03-10
CA2763941A1 (en) 2010-12-02
IL216467B (en) 2018-12-31
PT2435025T (pt) 2016-11-11
AR076807A1 (es) 2011-07-06
LTPA2021511I1 (es) 2021-06-25
TWI717511B (zh) 2021-02-01
RU2751771C2 (ru) 2021-07-16
LTC2435024I2 (es) 2022-06-27
HUE031283T2 (hu) 2017-07-28
DK2435023T3 (en) 2016-10-24
RU2011154083A (ru) 2013-07-10
FR19C1040I2 (fr) 2020-07-31
TW201808372A (zh) 2018-03-16
LT3106149T (lt) 2020-03-10
TWI792140B (zh) 2023-02-11
ES2592536T3 (es) 2016-11-30
TW201919730A (zh) 2019-06-01
CA2763939A1 (en) 2010-12-02
AR076806A1 (es) 2011-07-06
TW201700123A (zh) 2017-01-01
LUC00124I2 (es) 2019-12-27
BRPI1011220A2 (pt) 2016-03-15
HK1169307A1 (zh) 2013-01-25
ES2593429T3 (es) 2016-12-09
HRP20161098T1 (hr) 2016-10-21
US10716753B2 (en) 2020-07-21
HRP20200298T1 (hr) 2020-06-12
MX350163B (es) 2017-08-29
HK1244669A1 (zh) 2018-08-17
PL3111927T3 (pl) 2020-06-29
TWI539979B (zh) 2016-07-01
ZA201208100B (en) 2013-07-31
US20250009652A1 (en) 2025-01-09
IL216467A0 (en) 2012-01-31
MX337126B (es) 2016-02-12
US20180125776A1 (en) 2018-05-10
ES2774367T3 (es) 2020-07-20
HK1218867A1 (zh) 2017-03-17
PT3111927T (pt) 2020-03-03
EP3111927B1 (en) 2019-12-11
CY2019031I2 (el) 2019-11-27
HUE047803T2 (hu) 2020-05-28
KR20170070274A (ko) 2017-06-21
PL3111926T3 (pl) 2020-06-29
LUC00208I2 (es) 2022-10-07
CN102753152B (zh) 2015-09-23
JP6169639B2 (ja) 2017-07-26
WO2010138868A3 (en) 2011-04-28
JP6348645B2 (ja) 2018-06-27
HK1169026A1 (zh) 2013-01-18
KR20180130602A (ko) 2018-12-07
RU2586297C2 (ru) 2016-06-10
TW201109050A (en) 2011-03-16
TW202114642A (zh) 2021-04-16
SI3106149T1 (sl) 2020-07-31
KR20170104003A (ko) 2017-09-13
US20110132356A1 (en) 2011-06-09
CY1122749T1 (el) 2021-03-12
CY1118034T1 (el) 2017-05-17
US20110023876A1 (en) 2011-02-03
US20210186861A1 (en) 2021-06-24
JP2016041713A (ja) 2016-03-31
US20110135737A1 (en) 2011-06-09
KR101976107B1 (ko) 2019-05-09
SI2435023T1 (sl) 2016-10-28
CY1122732T1 (el) 2021-03-12
RU2020102859A (ru) 2021-07-26
RU2011154148A (ru) 2013-07-10
TWI633898B (zh) 2018-09-01
KR101748892B1 (ko) 2017-06-19
CN105193773B (zh) 2018-12-11
JP2012528199A (ja) 2012-11-12
CA2763936C (en) 2017-10-03
PL2435025T3 (pl) 2017-08-31
DK3106149T3 (da) 2020-02-24
SMT201600327B (it) 2016-11-10
CY1118040T1 (el) 2017-05-17
PT2435023T (pt) 2016-10-14
RU2015151358A (ru) 2019-01-16
NL300995I2 (nl) 2019-10-29
MX2011012684A (es) 2012-05-23
EP2435025B1 (en) 2016-07-06
RU2580315C2 (ru) 2016-04-10
FR19C1040I1 (es) 2020-07-31
AU2010253950A1 (en) 2011-12-08
JP2015187108A (ja) 2015-10-29
TW201642836A (zh) 2016-12-16
HUS2100018I1 (hu) 2021-06-28
AU2010253770B9 (en) 2015-02-12
NO2019026I1 (no) 2019-06-13
CY2019031I1 (el) 2019-11-27
AR076621A1 (es) 2011-06-22
HRP20161101T1 (hr) 2016-11-04
CN105193773A (zh) 2015-12-30
LT3111926T (lt) 2020-03-25
WO2010138884A2 (en) 2010-12-02
AU2010253770B2 (en) 2014-12-11
PL2435023T3 (pl) 2017-06-30
MX2020004077A (es) 2020-07-29
DK3111927T3 (da) 2020-03-09
JP6492124B2 (ja) 2019-03-27
RU2713404C2 (ru) 2020-02-05
KR20120034631A (ko) 2012-04-12
LTC2435025I2 (lt) 2021-02-10
MX2011012783A (es) 2012-06-28
PT3111926T (pt) 2020-02-28
KR20120026075A (ko) 2012-03-16
BRPI1011229B1 (pt) 2020-10-13
EP2435024A2 (en) 2012-04-04
EP3111926B1 (en) 2019-12-11
NL300995I1 (es) 2019-06-24
CN107669664A (zh) 2018-02-09
US20110132357A1 (en) 2011-06-09
TWI646980B (zh) 2019-01-11
LT2435023T (lt) 2016-09-26
EP2435024B1 (en) 2016-07-06
SI3111927T1 (sl) 2020-08-31
LT2435025T (lt) 2016-09-26
JP2012528792A (ja) 2012-11-15
SMT202000108T1 (it) 2020-03-13
JP2019108369A (ja) 2019-07-04
PL2435024T3 (pl) 2017-01-31
CY1118030T1 (el) 2017-05-17
EP2435025A2 (en) 2012-04-04
CY2021012I1 (el) 2021-10-15
TWI546094B (zh) 2016-08-21
RU2580315C3 (ru) 2021-06-18
AU2010253776A1 (en) 2011-11-24
LT3111927T (lt) 2020-03-25
TWI632926B (zh) 2018-08-21
KR101926060B1 (ko) 2018-12-06
TWI695723B (zh) 2020-06-11
CN102458364B (zh) 2016-11-02
HRP20200260T1 (hr) 2020-05-29
HUE047823T2 (hu) 2020-05-28
IL216466B (en) 2018-08-30
HUE031229T2 (en) 2017-06-28
US20190038548A1 (en) 2019-02-07
SI3111926T1 (sl) 2020-07-31
CN107412212B (zh) 2021-01-22
HRP20161102T1 (hr) 2016-11-04
JP5823383B2 (ja) 2015-11-25
US20150017247A1 (en) 2015-01-15
AU2010253770A1 (en) 2011-11-24
KR20120015334A (ko) 2012-02-21
SMT201600329B (it) 2016-11-10
TW201109049A (en) 2011-03-16
SMT202000077T1 (it) 2020-03-13
WO2010138868A2 (en) 2010-12-02
TW201109051A (en) 2011-03-16
LTPA2019014I1 (lt) 2019-07-10
HK1247095A1 (zh) 2018-09-21
EP3106149B1 (en) 2019-11-20
TWI707700B (zh) 2020-10-21
CN107669664B (zh) 2020-07-10
JP2018048150A (ja) 2018-03-29
IL216466A0 (en) 2012-01-31
US8808713B2 (en) 2014-08-19
ES2589135T3 (es) 2016-11-10
RU2016107464A3 (es) 2019-08-19
KR20190049943A (ko) 2019-05-09
HK1169027A1 (zh) 2013-01-18
ZA201108275B (en) 2023-04-26
PL3106149T3 (pl) 2020-06-01
US20190307676A1 (en) 2019-10-10
CA2763936A1 (en) 2010-12-02
BRPI1011229B8 (pt) 2021-05-25
IL216468A0 (en) 2012-01-31
NO2021019I1 (no) 2021-05-12
WO2010138884A3 (en) 2011-04-21
CN107412212A (zh) 2017-12-01
JP2018008942A (ja) 2018-01-18
EP3106149A1 (en) 2016-12-21
DK2435024T3 (en) 2016-10-24
MX2011012685A (es) 2012-06-12
ES2774391T3 (es) 2020-07-20
ES2772253T3 (es) 2020-07-07
HUS1900031I1 (hu) 2019-07-29
JP2015199735A (ja) 2015-11-12
EP3111926A1 (en) 2017-01-04
WO2010138862A3 (en) 2011-04-14
CN102458364A (zh) 2012-05-16
ZA201208101B (en) 2013-07-31
CY2021012I2 (el) 2021-10-15
SI2435024T1 (sl) 2016-10-28
RU2015151358A3 (es) 2019-07-29
SMT201600326B (it) 2016-11-10

Similar Documents

Publication Publication Date Title
MX350164B (es) Composiciones para suministro pulmonar de antagonistas muscarínicos de acción prolongada y agonistas de receptor b2 adrenérgico de acción prolongada y métodos y sistemas asociados.
MX2013013440A (es) Composiciones, metodos y sistemas para suministro respiratorio de dos o mas agentes activos.
CY1121373T1 (el) Μεθοδος και φαρμακοτεχνικη μορφη για εισπνοη
FI20145771L (fi) Parasitisidaalisia oraalisia eläinlääkekoostumuksia, jotka käsittävät systeemisesti vaikuttavan aktiiviaineen, menetelmiä ja käyttöjä
JO3421B1 (ar) طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية
CO7151487A2 (es) Formulación de anticuerpos
CL2014000904A1 (es) Forma de dosis farmaceutica oral resistente a la ruptura que comprende i) un ingrediente farmacologicamente activo, ii) un antagonista opioide y/o un agente repelente, iii) un oxido de polialquileno y iv) un polimero anionico.
CY1120159T1 (el) Ενωσεις που εχουν δραστικοτητα ανταγωνιστη μουσκαρινικου υποδοχεα και αγωνιστη βητα2 αδρενεργικου υποδοχεα
CL2015003422A1 (es) Composiciones, métodos y sistemas para el suministro por vía respiratoria de tres o más agentes activos
PL2958913T3 (pl) Agoniści receptora sfingozyno-1-fosforanowego, sposoby ich przygotowania i zawierające je jako środek aktywny farmaceutyczne kompozycje
PH12013502551A1 (en) Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
CL2012000737A1 (es) Composición para entregar un agente activo que comprende una matriz de carbohidrato, un agente activo volátil atrapado adentro de la matriz de carbohidrato y un agente de expulsión atrapado dentro de la matriz de carbohidrato; sustrato seco para entregar un agente activo que comprende un sustrato y dicha composición de entrega.
CL2011002002A1 (es) Uso de 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]amino}-1- hidroxietil)-8-hidroxiquinolin-2-(1h)-ona, en forma de racemato, estereoisomero o mezclas de esteroisomeros o una sal o solvato del mismo para preparar un medicamento util para tratar una enfermedad pulmonar.
TN2012000516A1 (en) Stable ready to use injectable paracetamol formulation
WO2010033167A3 (en) Anti-thrombin aptamer formulations and methods for use
MY163012A (en) Pyrazole compounds as crth2 antagonists
CO6592109A2 (es) Nueva forma cristalina de un derivado de ciclopropilbenzamida
EA201391348A8 (ru) КОМБИНАЦИИ АКТИВАТОРОВ АЛЬФА-7 НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА И АНТАГОНИСТОВ mGluR5, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ ПРИ ВЫЗВАННОЙ ДОПАМИНОМ ДИСКИНЕЗИИ, СВЯЗАННОЙ С БОЛЕЗНЬЮ ПАРКИНСОНА
DOP2013000262A (es) Composiciones, métodos y sistemas para el suministro respiratorio de dos o mas agentes activos
CR20130589A (es) Composiciones, métodos y sitemas para administracion/suministro respiratorio de dos o más agentes activos
ECSP13013082A (es) Composiciones, métodos y sistemas para administración respiratoria de dos o más agentes activos
AR122478A2 (es) COMPOSICIONES PARA EL SUMINISTRO PULMONAR DE ANTAGONISTAS MUSCARÍNICOS DE ACCIÓN PROLONGADA Y AGONISTAS DEL RECEPTOR ADRENÉRGICO b₂ DE ACCIÓN PROLONGADA, Y MÉTODOS Y SISTEMAS ASOCIADOS
Gregory et al. Eagle's Wings

Legal Events

Date Code Title Description
FG Grant or registration