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MX345764B - Métodos para preparar glicoesfingolípidos y usos de los mismos. - Google Patents

Métodos para preparar glicoesfingolípidos y usos de los mismos.

Info

Publication number
MX345764B
MX345764B MX2013007888A MX2013007888A MX345764B MX 345764 B MX345764 B MX 345764B MX 2013007888 A MX2013007888 A MX 2013007888A MX 2013007888 A MX2013007888 A MX 2013007888A MX 345764 B MX345764 B MX 345764B
Authority
MX
Mexico
Prior art keywords
sub
glycosphingolipids
heteroaryl
aryl
methods
Prior art date
Application number
MX2013007888A
Other languages
English (en)
Other versions
MX2013007888A (es
Inventor
Liang Pi-Hui
Original Assignee
Univ Nat Taiwan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nat Taiwan filed Critical Univ Nat Taiwan
Publication of MX2013007888A publication Critical patent/MX2013007888A/es
Publication of MX345764B publication Critical patent/MX345764B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a métodos para la síntesis y preparación de alfa-glicoesfingolípidos. Se proporcionan métodos para la síntesis de a-galactosil ceramida, y análogos y variantes farmacéuticamente activos del mismo. Se proporcionan alfa-glicoesfingolípidos novedosos, en donde los compuestos son compuestos inmunogénicos los cuales sirven como ligandos para las células NKT (T asesinas naturales).
MX2013007888A 2011-01-05 2012-01-05 Métodos para preparar glicoesfingolípidos y usos de los mismos. MX345764B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161430117P 2011-01-05 2011-01-05
PCT/US2012/020388 WO2012094540A2 (en) 2011-01-05 2012-01-05 Methods for preparation of glycosphingolipids and uses thereof

Publications (2)

Publication Number Publication Date
MX2013007888A MX2013007888A (es) 2014-09-11
MX345764B true MX345764B (es) 2017-02-15

Family

ID=45688966

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007888A MX345764B (es) 2011-01-05 2012-01-05 Métodos para preparar glicoesfingolípidos y usos de los mismos.

Country Status (15)

Country Link
US (2) US9181292B2 (es)
EP (1) EP2661440B1 (es)
JP (2) JP6057300B2 (es)
KR (1) KR102005003B1 (es)
CN (1) CN103748103A (es)
AU (2) AU2012204336C1 (es)
BR (1) BR112013017382B1 (es)
CA (1) CA2854725C (es)
CO (1) CO6761397A2 (es)
ES (1) ES2654382T3 (es)
HK (1) HK1197068A1 (es)
IL (1) IL227333B (es)
MX (1) MX345764B (es)
RU (1) RU2636587C2 (es)
WO (1) WO2012094540A2 (es)

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US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
EP2975409B1 (en) 2010-05-10 2018-10-31 Academia Sinica Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
BR112013017382B1 (pt) 2011-01-05 2021-03-16 National Taiwan University método de preparação de um composto de fórmula (5)
WO2013119857A1 (en) 2012-02-07 2013-08-15 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
CA2880701A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
EP2888238A4 (en) 2012-08-21 2016-01-27 Academia Sinica BENZOCYCLOOCTYN COMPOUNDS AND USES THEREOF
EP2727929A1 (en) * 2012-10-30 2014-05-07 Wittycell Method of preparation of alpha galactosyl ceramides compounds
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
EP3013347B1 (en) 2013-06-27 2019-12-11 Academia Sinica Glycan conjugates and use thereof
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TWI797430B (zh) 2014-03-27 2023-04-01 中央研究院 反應性標記化合物及其用途
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TWI745275B (zh) * 2014-09-08 2021-11-11 中央研究院 使用醣脂激活人類ｉＮＫＴ細胞
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JP6956719B2 (ja) 2015-12-29 2021-11-02 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーＯｐｋｏ Ｄｉａｇｎｏｓｔｉｃｓ，Ｌｌｃ 流体の収集のための物品
US10336784B2 (en) 2016-03-08 2019-07-02 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
JP7213549B2 (ja) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド 抗体、結合性断片、および使用の方法
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Also Published As

Publication number Publication date
HK1197068A1 (en) 2015-01-02
IL227333A0 (en) 2013-09-30
KR102005003B1 (ko) 2019-07-29
AU2017206277A1 (en) 2017-08-10
EP2661440B1 (en) 2017-09-27
AU2017206277B2 (en) 2019-05-02
BR112013017382B1 (pt) 2021-03-16
CO6761397A2 (es) 2013-09-30
RU2636587C2 (ru) 2017-11-24
EP2661440A2 (en) 2013-11-13
JP2017061481A (ja) 2017-03-30
WO2012094540A3 (en) 2012-08-30
WO2012094540A2 (en) 2012-07-12
US10654880B2 (en) 2020-05-19
JP6259887B2 (ja) 2018-01-10
KR20140036147A (ko) 2014-03-25
ES2654382T3 (es) 2018-02-13
RU2013136531A (ru) 2015-02-10
IL227333B (en) 2018-01-31
AU2012204336B2 (en) 2017-05-04
JP6057300B2 (ja) 2017-01-11
US20160229881A1 (en) 2016-08-11
JP2014504593A (ja) 2014-02-24
MX2013007888A (es) 2014-09-11
CA2854725C (en) 2019-10-22
US9181292B2 (en) 2015-11-10
US20120178705A1 (en) 2012-07-12
BR112013017382A2 (pt) 2016-10-04
AU2012204336A1 (en) 2013-08-22
CN103748103A (zh) 2014-04-23
CA2854725A1 (en) 2013-07-12
AU2012204336C1 (en) 2017-08-03

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