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MX2021007833A - Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer. - Google Patents

Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer.

Info

Publication number
MX2021007833A
MX2021007833A MX2021007833A MX2021007833A MX2021007833A MX 2021007833 A MX2021007833 A MX 2021007833A MX 2021007833 A MX2021007833 A MX 2021007833A MX 2021007833 A MX2021007833 A MX 2021007833A MX 2021007833 A MX2021007833 A MX 2021007833A
Authority
MX
Mexico
Prior art keywords
mat2a
inhibitors
methods
heterobiciclic
aza
Prior art date
Application number
MX2021007833A
Other languages
English (en)
Inventor
Zenon D Konteatis
Jeremy M Travins
Samuel K Reznik
Li Mingzong
Sui Zhihua
Original Assignee
Les Laboratoires Servier Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier Sas filed Critical Les Laboratoires Servier Sas
Publication of MX2021007833A publication Critical patent/MX2021007833A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente descripción proporciona compuestos de acuerdo con la Fórmula I, Fórmula II, y sus sales, tautómeros y/o isotopólogos farmacéuticamente aceptables como se describe en la descripción. Los compuestos son inhibidores de la isoforma 2A de la metionina adenosiltransferasa (MAT2A). También se proporcionan composiciones farmacéuticas y métodos para usar los compuestos para tratar cánceres, que incluyen algunos cánceres en los que se elimina el gen que codifica la metiltioadenosina fosforilasa (MTAP).
MX2021007833A 2018-12-27 2019-12-27 Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer. MX2021007833A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862785574P 2018-12-27 2018-12-27
PCT/US2019/068653 WO2020139992A1 (en) 2018-12-27 2019-12-27 Aza-heterobicyclic inhibitors of mat2a and methods of use for treating cancer

Publications (1)

Publication Number Publication Date
MX2021007833A true MX2021007833A (es) 2021-10-26

Family

ID=69400626

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021007833A MX2021007833A (es) 2018-12-27 2019-12-27 Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer.

Country Status (22)

Country Link
US (1) US20220098203A1 (es)
EP (1) EP3902804A1 (es)
JP (1) JP2022516882A (es)
KR (1) KR20220050832A (es)
CN (1) CN113474347A (es)
AR (1) AR115296A1 (es)
AU (1) AU2019414446A1 (es)
BR (1) BR112021012599A2 (es)
CA (1) CA3124678A1 (es)
CL (1) CL2021001722A1 (es)
CO (1) CO2021009882A2 (es)
CR (1) CR20210409A (es)
EA (1) EA202191800A1 (es)
IL (1) IL284324A (es)
JO (1) JOP20210171A1 (es)
MA (1) MA54609A (es)
MX (1) MX2021007833A (es)
PE (1) PE20212303A1 (es)
PH (1) PH12021551493A1 (es)
SG (1) SG11202106627WA (es)
TW (1) TW202039489A (es)
WO (1) WO2020139992A1 (es)

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SG11202105469YA (en) 2018-12-10 2021-06-29 Ideaya Biosciences Inc 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors
US12077534B2 (en) * 2018-12-27 2024-09-03 Les Laboratoires Servier Aza-heterobicyclic inhibitors of MAT2A and methods of use for treating cancer
WO2021219731A2 (en) * 2020-04-28 2021-11-04 Iomx Therapeutics Ag Bicyclic kinase inhibitors and uses thereof
EP4168394A1 (en) * 2020-06-22 2023-04-26 F. Hoffmann-La Roche AG Amidopyrimidone derivatives
CN115960098A (zh) * 2020-09-11 2023-04-14 上海凌达生物医药有限公司 一类含氮稠环类化合物的制备方法和用途
EP4273146A4 (en) * 2020-12-31 2024-12-11 Nanjing Zaiming Pharmaceutical Co., Ltd. TRICYCLIC COMPOUND AND ITS USE
WO2022206730A1 (zh) * 2021-03-29 2022-10-06 武汉人福创新药物研发中心有限公司 嘧啶并吡嗪酮化合物及其用途
CA3234810A1 (en) 2021-10-20 2023-04-27 Chiachun Chen Methionine adenosyltransferase 2a (mat2a) inhibitors and uses thereof
AU2022423231A1 (en) * 2021-12-21 2024-07-11 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Methionine adenosyltransferase 2a heterocyclic inhibitor
JP2025503186A (ja) * 2022-01-26 2025-01-30 勤浩医▲葯▼（▲蘇▼州）有限公司 Ｍｔａｐ欠失型がん治療用メチオニンアデノシルトランスフェラーゼ２ａ阻害剤
WO2023169554A1 (zh) * 2022-03-11 2023-09-14 赛诺哈勃药业（成都）有限公司 甲硫氨酸腺苷转移酶抑制剂、其制备方法及应用
GB202204913D0 (en) 2022-04-04 2022-05-18 Cambridge Entpr Ltd antiviral therapy
WO2024002024A1 (zh) 2022-06-27 2024-01-04 石药集团中奇制药技术（石家庄）有限公司 三环类化合物及其用途
WO2024080788A1 (ko) 2022-10-13 2024-04-18 한미약품 주식회사 신규한 트리사이클 유도체 화합물 및 이의 용도
WO2024183778A1 (zh) * 2023-03-06 2024-09-12 甘李药业股份有限公司 一种甲硫氨酸腺苷转移酶2a抑制剂及其医药用途
WO2024255805A1 (zh) * 2023-06-14 2024-12-19 南京正大天晴制药有限公司 蛋氨酸腺苷转移酶2a杂环抑制剂的晶型、其制备方法及用途
WO2025000265A1 (en) * 2023-06-28 2025-01-02 Silexon Ai Technology Co., Ltd. Heterocyclic compounds usefull as sos1 inhibitor

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CN1150195C (zh) * 1998-10-23 2004-05-19 霍夫曼-拉罗奇有限公司 双环氮杂环
JP3961830B2 (ja) * 1999-10-21 2007-08-22 エフ．ホフマン−ラ ロシュ アーゲー ｐ３８プロテインキナーゼのインヒビターとしてのヘテロアルキルアミノ置換二環式窒素複素環
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US7084270B2 (en) * 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
US7112676B2 (en) * 2002-11-04 2006-09-26 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
JP2006522756A (ja) * 2003-04-10 2006-10-05 エフ．ホフマン−ラ　ロシュ　アーゲー ピリミド化合物
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Also Published As

Publication number Publication date
KR20220050832A (ko) 2022-04-25
US20220098203A1 (en) 2022-03-31
MA54609A (fr) 2022-04-06
TW202039489A (zh) 2020-11-01
AU2019414446A1 (en) 2021-07-15
AR115296A1 (es) 2020-12-16
PE20212303A1 (es) 2021-12-10
IL284324A (en) 2021-08-31
CA3124678A1 (en) 2020-07-02
BR112021012599A2 (pt) 2021-09-08
SG11202106627WA (en) 2021-07-29
JP2022516882A (ja) 2022-03-03
WO2020139992A1 (en) 2020-07-02
CR20210409A (es) 2022-01-24
EA202191800A1 (ru) 2021-09-13
CO2021009882A2 (es) 2021-10-29
PH12021551493A1 (en) 2022-04-11
JOP20210171A1 (ar) 2023-01-30
CN113474347A (zh) 2021-10-01
EP3902804A1 (en) 2021-11-03
CL2021001722A1 (es) 2022-02-18

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