[go: up one dir, main page]

MX2018006286A - Inhibidores de acc pirazolicos y usos de los mismos. - Google Patents

Inhibidores de acc pirazolicos y usos de los mismos.

Info

Publication number
MX2018006286A
MX2018006286A MX2018006286A MX2018006286A MX2018006286A MX 2018006286 A MX2018006286 A MX 2018006286A MX 2018006286 A MX2018006286 A MX 2018006286A MX 2018006286 A MX2018006286 A MX 2018006286A MX 2018006286 A MX2018006286 A MX 2018006286A
Authority
MX
Mexico
Prior art keywords
pyrazole
acc inhibitors
acc
inhibitors
fungicides
Prior art date
Application number
MX2018006286A
Other languages
English (en)
Inventor
C Harriman Geraldine
Ghosh Shomir
robert greenwood Jeremy
Marcel Leit De Moradei Silvana
Original Assignee
Gilead Apollo Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Apollo Llc filed Critical Gilead Apollo Llc
Publication of MX2018006286A publication Critical patent/MX2018006286A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención provee compuestos pirazólicos de la fórmula I que inhiben la Acetil-CoA carboxilasa (ACC), composiciones y usos de los mismos para el tratramiento de obesidad o como fungidas.
MX2018006286A 2015-11-25 2016-11-22 Inhibidores de acc pirazolicos y usos de los mismos. MX2018006286A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562259973P 2015-11-25 2015-11-25
PCT/US2016/063386 WO2017091600A1 (en) 2015-11-25 2016-11-22 Pyrazole acc inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
MX2018006286A true MX2018006286A (es) 2018-09-07

Family

ID=57543206

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018006286A MX2018006286A (es) 2015-11-25 2016-11-22 Inhibidores de acc pirazolicos y usos de los mismos.

Country Status (18)

Country Link
US (2) US20170166582A1 (es)
EP (1) EP3380480B1 (es)
JP (1) JP2019502660A (es)
KR (1) KR20180082556A (es)
CN (1) CN108349995B (es)
AR (1) AR106798A1 (es)
AU (1) AU2016361412A1 (es)
BR (1) BR112018010113B1 (es)
CA (1) CA3004796C (es)
CL (1) CL2018001356A1 (es)
CO (1) CO2018005368A2 (es)
EA (1) EA201890913A1 (es)
ES (1) ES2939833T3 (es)
MX (1) MX2018006286A (es)
PL (1) PL3380480T3 (es)
PT (1) PT3380480T (es)
SI (1) SI3380480T1 (es)
WO (1) WO2017091600A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2776038T (lt) 2011-11-11 2018-04-25 Gilead Apollo, Llc Acc inhibitoriai ir jų panaudojimas
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
MX2016009974A (es) 2014-01-31 2016-10-31 Dana Farber Cancer Inst Inc Derivados de diaminopirimidina bencensulfona y sus usos.
CA2996977A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazolodiazepines and uses thereof
KR20180049058A (ko) 2015-09-11 2018-05-10 다나-파버 캔서 인스티튜트 인크. 시아노 티에노트리아졸로디아제핀 및 그의 용도
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
MX2018006287A (es) 2015-11-25 2018-09-07 Gilead Apollo Llc Inhibidores de acc de triazol y usos de los mismos.
EA201890913A1 (ru) 2015-11-25 2018-11-30 Джилид Аполло, Ллс Пиразоловые соединения в качестве ингибиторов акк и их применение
WO2017091602A1 (en) 2015-11-25 2017-06-01 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
CN108347939B (zh) 2015-11-25 2021-09-28 吉利德阿波罗公司 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物
SG10201913450PA (en) 2015-11-25 2020-03-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
BR112018067408A2 (pt) 2016-03-02 2018-12-26 Gilead Apollo Llc formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas
KR102577824B1 (ko) 2017-01-22 2023-09-13 선샤인 레이크 파르마 컴퍼니 리미티드 티에노피리미딘 유도체 및 의약에서 이의 용도
JP2020509038A (ja) 2017-03-03 2020-03-26 ギリアド アポロ， エルエルシー 殺真菌剤化合物を調製するための方法
WO2018171698A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物及其制备方法和用途
EP4122464B1 (en) 2017-03-28 2024-05-15 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases
CN110709402B (zh) * 2017-06-15 2022-05-10 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
WO2019015583A1 (en) 2017-07-17 2019-01-24 Nanjing Ruijie Pharmatech Co., Ltd. NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS
CN110950884B (zh) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
TW202033511A (zh) 2018-10-29 2020-09-16 美商基利阿波羅有限責任公司 用於製備殺真菌化合物之方法
CN111484504B (zh) * 2019-01-25 2024-05-10 南京圣和药业股份有限公司 Acc抑制剂的光学异构体及其应用
WO2021000242A1 (zh) 2019-07-02 2021-01-07 广东东阳光药业有限公司 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
CN110746439B (zh) * 2019-10-18 2020-10-30 南京瑞捷医药科技有限公司 一种噻吩并嘧啶二酮化合物的制备方法
CN111039880B (zh) * 2019-12-10 2022-06-21 河南大学 咪康唑及其衍生物作为tgr5激动剂的应用
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN113968871A (zh) * 2020-07-25 2022-01-25 南京圣和药业股份有限公司 苯基取代类acc抑制剂的晶型
US20220192956A1 (en) * 2020-12-18 2022-06-23 The Procter & Gamble Company Superior efficacy of azoxystrobin and other strobilurins

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3325503A (en) 1965-02-18 1967-06-13 Diamond Alkali Co Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en) 1965-04-01 1967-01-03 Dow Chemical Co Sulfinyl- and sulfonylpyridines
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
DE3338292A1 (de) 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
CA1249832A (en) 1984-02-03 1989-02-07 Shionogi & Co., Ltd. Azolyl cycloalkanol derivatives and agricultural fungicides
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
BR8600161A (pt) 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
DE3545319A1 (de) 1985-12-20 1987-06-25 Basf Ag Acrylsaeureester und fungizide, die diese verbindungen enthalten
ATE57390T1 (de) 1986-03-11 1990-10-15 Plant Genetic Systems Nv Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen.
US4670560A (en) 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
CN1015981B (zh) 1986-05-02 1992-03-25 施托福化学公司 吡啶基亚胺酸酯的制备方法
DE256503T1 (de) 1986-08-12 1990-02-08 Mitsubishi Kasei Corp., Tokio/Tokyo Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel.
FR2629098B1 (fr) 1988-03-23 1990-08-10 Rhone Poulenc Agrochimie Gene chimerique de resistance herbicide
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
EP0374753A3 (de) 1988-12-19 1991-05-29 American Cyanamid Company Insektizide Toxine, Gene, die diese Toxine kodieren, Antikörper, die sie binden, sowie transgene Pflanzenzellen und transgene Pflanzen, die diese Toxine exprimieren
JPH02225485A (ja) 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk チエノピリミジン―３―酢酸誘導体
ES2199931T3 (es) 1989-03-24 2004-03-01 Syngenta Participations Ag Plantas transgenicas resistentes a enfermedades.
ZW13690A1 (en) 1989-08-30 1990-11-21 Aeci Ltd Active ingredient dosage device
ES2074547T3 (es) 1989-11-07 1995-09-16 Pioneer Hi Bred Int Lectinas larvicidas, y resistencia inducida de las plantas a los insectos.
AU628229B2 (en) 1989-11-10 1992-09-10 Agro-Kanesho Co. Ltd. Hexahydrotriazine compounds and insecticides
AU651335B2 (en) 1990-03-12 1994-07-21 E.I. Du Pont De Nemours And Company Water-dispersible or water-soluble pesticide granules from heat-activated binders
WO1992000377A1 (en) 1990-06-25 1992-01-09 Monsanto Company Glyphosate tolerant plants
EP0480679B1 (en) 1990-10-11 1996-09-18 Sumitomo Chemical Company Limited Pesticidal composition
JP2828186B2 (ja) 1991-09-13 1998-11-25 宇部興産株式会社 アクリレート系化合物、その製法及び殺菌剤
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
DE4322211A1 (de) 1993-07-03 1995-01-12 Basf Ag Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
JP3811196B2 (ja) 1993-08-26 2006-08-16 武田薬品工業株式会社 エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法
TW276256B (es) 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
JPH09110873A (ja) 1995-08-17 1997-04-28 Takeda Chem Ind Ltd チエノピリミジン誘導体、その製造法および用途
CA2227384A1 (en) 1995-08-17 1997-02-27 Toshifumi Watanabe Thienopyrimidine derivatives, their production and use
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
CA2250908C (en) 1996-04-30 2012-03-13 Takeda Chemical Industries, Ltd. Combined use of gnrh agonist and antagonist
JP2007302703A (ja) 1996-04-30 2007-11-22 Takeda Chem Ind Ltd 医薬組成物
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
AU3596697A (en) 1996-07-17 1998-02-09 Michigan State University Imidazolinone herbicide resistant sugar beet plants
DE19650197A1 (de) 1996-12-04 1998-06-10 Bayer Ag 3-Thiocarbamoylpyrazol-Derivate
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6984644B2 (en) 1997-05-28 2006-01-10 Astrazeneca Ab Treatment of skin disorders using thieno[2,3-D]pyrimidinediones
SE9702001D0 (sv) 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
NZ503594A (en) 1997-09-18 2001-08-31 Basf Ag (Phenyl, thienyl or pyrazolyl)-substituted and alkyl-substituted benzamidoxime derivatives, and benzonitrile intermediates, useful as fungicides
DE19750012A1 (de) 1997-11-12 1999-05-20 Bayer Ag Isothiazolcarbonsäureamide
AU1621799A (en) 1997-12-04 1999-06-16 Dow Agrosciences Llc Fungicidal compositions and methods, and compounds and methods for the preparation thereof
DE19754082A1 (de) 1997-12-05 1999-06-10 Knoll Ag Methode zur Bekämpfung der Fettleibigkeit
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
AU755538B2 (en) 1998-11-17 2002-12-12 Ihara Chemical Industry Co. Ltd. Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural fungicides
IT1303800B1 (it) 1998-11-30 2001-02-23 Isagro Ricerca Srl Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico.
JP3417862B2 (ja) 1999-02-02 2003-06-16 新東工業株式会社 酸化チタン光触媒高担持シリカゲルおよびその製造方法
AU770077B2 (en) 1999-03-11 2004-02-12 Dow Agrosciences Llc Heterocyclic substituted isoxazolidines and their use as fungicides
EP1171442B1 (en) 1999-04-09 2005-12-07 Cell Therapeutics, Inc. Xanthine derivatives and analogs as cell signalling inhibitors
US6586617B1 (en) 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
UA73307C2 (uk) 1999-08-05 2005-07-15 Куміаі Кемікал Індастрі Ко., Лтд. Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення
DE10021412A1 (de) 1999-12-13 2001-06-21 Bayer Ag Fungizide Wirkstoffkombinationen
DK1250047T3 (da) 2000-01-25 2005-05-30 Syngenta Participations Ag Herbicidt middel
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
IL167957A (en) 2000-02-04 2009-07-20 Sumitomo Chemical Co Hydroxypyridine compounds
MX233208B (es) 2000-04-28 2005-12-20 Basf Ag Uso del gen mutante ahas 2 del maiz xi12 y herbicidas de imidazolinona para la seleccion de plantas de maiz, arroz y trigo, monocotiledoneas transgenicas, resistentes a los herbicidas de imidazolinona.
CN100353846C (zh) 2000-08-25 2007-12-12 辛根塔参与股份公司 新的来自苏云金芽孢杆菌杀虫晶体蛋白的杀虫毒素
MXPA03002338A (es) 2000-09-18 2003-09-10 Du Pont Piridinilamidas y piridinilimidas para uso como fungicidas.
NZ525744A (en) 2000-11-17 2004-10-29 Dow Agrosciences Llc Compounds having fungicidal activity and processes to make and use same
EP1370562A1 (en) 2001-02-14 2003-12-17 Warner-Lambert Company LLC Thieno[2,3-d]pyrimidindione derivatives as matrix metalloproteinase inhibitors
JP5034142B2 (ja) 2001-04-20 2012-09-26 住友化学株式会社 植物病害防除剤組成物
DE10136065A1 (de) 2001-07-25 2003-02-13 Bayer Cropscience Ag Pyrazolylcarboxanilide
AR037228A1 (es) 2001-07-30 2004-11-03 Dow Agrosciences Llc Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada
FR2828196A1 (fr) 2001-08-03 2003-02-07 Aventis Cropscience Sa Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture
US7897845B2 (en) 2001-08-09 2011-03-01 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
RU2337532C2 (ru) 2001-08-09 2008-11-10 Юниверсити Оф Саскачеван Растения пшеницы с повышенной устойчивостью к имидазолиноновым гербицидам
ES2417012T3 (es) 2001-08-09 2013-08-05 Northwest Plant Breeding Co. Plantas de trigo que exhiben resistencia aumentada a los herbicidas de imidazolinona
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
JPWO2003016286A1 (ja) 2001-08-17 2004-12-02 三共アグロ株式会社 ３−フェノキシ−４−ピリダジノール誘導体及びそれを含有する除草剤組成物
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
WO2003052073A2 (en) 2001-12-17 2003-06-26 Syngenta Participations Ag Novel corn event
WO2003053145A1 (en) 2001-12-21 2003-07-03 Nissan Chemical Industries, Ltd. Bactericidal composition
TWI327462B (en) 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (de) 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituierte Thiazolylcarboxanilide
PL372887A1 (en) 2002-02-27 2005-08-08 Pfizer Products Inc. Acc inhibitors
HK1079785B (zh) 2002-03-05 2007-08-10 辛根塔参与股份公司 邻环丙基-n-甲酰苯胺及其作为杀菌剂的用途
EP1551218B1 (en) 2002-07-10 2017-05-17 The Department of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
AU2003253165A1 (en) 2002-08-13 2004-02-25 Warner-Lambert Company Llc Pyrimidine fused bicyclic metalloproteinase inhibitors
GB0227966D0 (en) 2002-11-29 2003-01-08 Syngenta Participations Ag Organic Compounds
DE602004020052D1 (de) 2003-01-06 2009-04-30 Israel State Pflanzliche acetyl-coa carboxylase-hemmende herbizide als pestizide
CA2514407C (en) 2003-01-29 2012-01-03 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
WO2004083193A1 (ja) 2003-03-17 2004-09-30 Sumitomo Chemical Company, Limited アミド化合物およびこれを含有する殺菌剤組成物
MXPA05012733A (es) 2003-05-28 2006-05-17 Basf Ag Plantas de trigo que tienen tolerancia incrementada a los herbicidas de imidazolinona.
ES2743420T3 (es) 2003-08-29 2020-02-19 Instituto Nac De Tecnologia Agropecuaria Plantas de arroz que tienen tolerancia incrementada frente a herbicidas de imidazolinona
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
JP2007527886A (ja) 2004-03-10 2007-10-04 ビーエーエスエフ　アクチェンゲゼルシャフト ５，６−ジアルキル−７−アミノトリアゾロピリミジン、その調製、および有害真菌を防除するためのその使用、ならびにそれらの化合物を含む組成物
HRP20100538T1 (hr) 2004-03-10 2010-12-31 Basf Se 5,6-dialkil-7-aminotriazolopirimidini, postupci za njihovo dobijanje, njihova primjena za kontrolu patogenih gljiva, kao i sredstva koja sadrže spomenute spojeve
WO2005120234A2 (en) 2004-06-03 2005-12-22 E.I. Dupont De Nemours And Company Fungicidal mixtures of amidinylphenyl compounds
EP1761498A1 (de) 2004-06-18 2007-03-14 Basf Aktiengesellschaft 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid
ATE458722T1 (de) 2004-06-18 2010-03-15 Basf Se 1-methyl-3-trifluormethyl-pyrazol-4-carbonsäure (ortho-phenyl)-anilide und ihre verwendung als fungizid
WO2006014647A2 (en) 2004-07-21 2006-02-09 Athersys, Inc. Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof
GB0418048D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
WO2006087325A1 (de) 2005-02-16 2006-08-24 Basf Aktiengesellschaft 5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
DE102005007160A1 (de) 2005-02-16 2006-08-24 Basf Ag Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
DE102005009458A1 (de) 2005-03-02 2006-09-07 Bayer Cropscience Ag Pyrazolylcarboxanilide
KR101288144B1 (ko) 2005-06-14 2013-07-18 아스카 세이야쿠 가부시키가이샤 티에노피리미딘 유도체
PL1973881T3 (pl) 2006-01-13 2010-04-30 Dow Agrosciences Llc 6-(wielo-podstawione arylo)-4-aminopikoliniany i ich zastosowanie jako herbicydy
EP1983832A2 (en) 2006-02-09 2008-10-29 Syngeta Participations AG A method of protecting a plant propagation material, a plant, and/or plant organs
US20070208040A1 (en) 2006-03-02 2007-09-06 Elfatih Elzein A2a adenosine receptor antagonists
JPWO2008143262A1 (ja) 2007-05-21 2010-08-12 武田薬品工業株式会社 複素環化合物およびその用途
JP5535931B2 (ja) 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
US8623880B2 (en) 2009-03-23 2014-01-07 Glenmark Pharmaceuticals S.A. Fused pyrimidine-dione derivatives as TRPA1 modulators
HRP20140035T1 (hr) 2009-12-29 2014-02-14 Poxel Tieno[2,3-b]piridindion aktivatori ampk i njihove terapijske uporabe
AU2011252874A1 (en) 2010-05-14 2012-11-29 University Of Rochester Compositions and methods for targeting A3G:RNA complexes
WO2012030887A1 (en) 2010-09-02 2012-03-08 Divergence, Inc. New compositions and methods for controlling nematode pests
LT2776038T (lt) 2011-11-11 2018-04-25 Gilead Apollo, Llc Acc inhibitoriai ir jų panaudojimas
US9988399B2 (en) 2013-05-10 2018-06-05 Gilead Apollo, Llc Bicyclic compounds as ACC inhibitors and uses thereof
CA2911818A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
MX2015015422A (es) 2013-05-10 2016-06-21 Nimbus Apollo Inc Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos.
EP2994141A4 (en) 2013-05-10 2016-11-23 Nimbus Apollo Inc ACC-HEMMER AND USES THEREOF
TWI652012B (zh) 2013-05-20 2019-03-01 杜邦股份有限公司 殺真菌吡唑的固態形式
WO2015003881A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
WO2015003879A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicylic derivatives
WO2015007451A1 (en) * 2013-07-15 2015-01-22 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
HK1243369A1 (zh) * 2015-01-09 2018-07-13 吉利德阿波罗公司 用於治疗非酒精性脂肪肝病的acc抑制剂组合治疗
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
CN108347939B (zh) 2015-11-25 2021-09-28 吉利德阿波罗公司 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物
EA201890913A1 (ru) 2015-11-25 2018-11-30 Джилид Аполло, Ллс Пиразоловые соединения в качестве ингибиторов акк и их применение
WO2017091602A1 (en) 2015-11-25 2017-06-01 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
SG10201913450PA (en) 2015-11-25 2020-03-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
MX2018006287A (es) 2015-11-25 2018-09-07 Gilead Apollo Llc Inhibidores de acc de triazol y usos de los mismos.
JP7105691B2 (ja) 2015-11-25 2022-07-25 イーフェクター セラピューティクス， インコーポレイテッド Ｅｉｆ４ａ－阻害化合物およびそれに関連する方法
BR112018067408A2 (pt) 2016-03-02 2018-12-26 Gilead Apollo Llc formas sólidas de um inibidor de acc de tienopirimidinadiona e métodos para a produção das mesmas
SG10201911221RA (en) 2016-12-16 2020-02-27 Cystic Fibrosis Found Bicyclic heteroaryl derivatives as cftr potentiators

Also Published As

Publication number Publication date
CL2018001356A1 (es) 2018-08-17
PL3380480T3 (pl) 2023-05-08
CA3004796C (en) 2023-11-14
EP3380480A1 (en) 2018-10-03
US20170166582A1 (en) 2017-06-15
US10941158B2 (en) 2021-03-09
PT3380480T (pt) 2023-03-14
KR20180082556A (ko) 2018-07-18
AR106798A1 (es) 2018-02-21
AU2016361412A9 (en) 2018-12-06
CN108349995A (zh) 2018-07-31
EP3380480B1 (en) 2022-12-14
WO2017091600A9 (en) 2018-07-19
JP2019502660A (ja) 2019-01-31
CO2018005368A2 (es) 2018-05-31
ES2939833T3 (es) 2023-04-27
AU2016361412A1 (en) 2018-05-24
WO2017091600A1 (en) 2017-06-01
CA3004796A1 (en) 2017-06-01
BR112018010113A2 (pt) 2018-11-21
SI3380480T1 (sl) 2023-04-28
EA201890913A1 (ru) 2018-11-30
CN108349995B (zh) 2021-08-03
BR112018010113B1 (pt) 2022-06-14
US20190375759A1 (en) 2019-12-12

Similar Documents

Publication Publication Date Title
MX2018006286A (es) Inhibidores de acc pirazolicos y usos de los mismos.
MX2018006287A (es) Inhibidores de acc de triazol y usos de los mismos.
MX2018005292A (es) Inhibidores de acc y usos de los mismos.
MX2018006288A (es) Inhibidores de acc tipo ester y usos de los mismos.
MX2018009773A (es) Heteroarilos inhibidores de peptidilarginina desiminasa 4 (pad4).
NZ739676A (en) Heteroaryl compounds as irak inhibitors and uses thereof
EA201691916A1 (ru) Биарильные ингибиторы киназы
MY189454A (en) 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists
TW201613886A (en) 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones
MY201783A (en) Compositions and methods for inhibiting arginase activity
MX2015015421A (es) Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos.
EA201790170A1 (ru) Терапевтические соединения-ингибиторы
NZ729005A (en) Aminopyrimidinyl compounds as jak inhibitors
MX2018001890A (es) Compuestos biciclicos como inhibidores de autotaxina (atx).
PH12018500408A1 (en) Bicyclic compounds as atx inhibitors
MX2015015417A (es) Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos.
EP4327809A3 (en) Tyk2 inhibitors and uses thereof
EA033163B1 (ru) Ингибиторы глутаминазы
SG10201908839QA (en) 2,4-dihydroxy-nicotinamides as apj agonists
MX2015015416A (es) Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos.
NZ725917A (en) Novel polymerase-i inhibitors, uses and methods for making them
MX2018006700A (es) Inhibidores aza-bencimidazol de peptidilarginina desiminasa (pad4).
PH12017502051A1 (en) TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF
TW201613892A (en) Forms and compositions of an ERK inhibitor
EA201691397A1 (ru) Хинолиновые ингибиторы киназы