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MX2017016213A - Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia y metodos para crear soportes para el uso contra el cancer de pancreas y otros tipos de cancer. - Google Patents

Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia y metodos para crear soportes para el uso contra el cancer de pancreas y otros tipos de cancer.

Info

Publication number
MX2017016213A
MX2017016213A MX2017016213A MX2017016213A MX2017016213A MX 2017016213 A MX2017016213 A MX 2017016213A MX 2017016213 A MX2017016213 A MX 2017016213A MX 2017016213 A MX2017016213 A MX 2017016213A MX 2017016213 A MX2017016213 A MX 2017016213A
Authority
MX
Mexico
Prior art keywords
peptides
cancer
new
immunotherapy
methods
Prior art date
Application number
MX2017016213A
Other languages
English (en)
Inventor
Singh Harpreet
Weinschenk Toni
fritsche Jens
Schoor Oliver
Mahr Andrea
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1510771.7A external-priority patent/GB201510771D0/en
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MX2017016213A publication Critical patent/MX2017016213A/es

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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

La presente invención se refiere a péptidos, proteínas, ácidos nucleicos y células destinados a la utilización en métodos inmunoterapéuticos. En particular, la presente invención se refiere a la inmunoterapia contra el cáncer. La presente invención se refiere asimismo a epítopos peptídicos para linfocitos T asociados a tumores, solos o en combinación con otros péptidos asociados a tumores que, por ejemplo, pueden servir como principios activos farmacéuticos en composiciones de vacuna destinadas a estimular respuestas inmunitarias antitumorales, o a estimular ex vivo linfocitos T que después serán transferidos a los pacientes. Los péptidos unidos a moléculas del complejo mayor de histocompatibilidad (MHC), o los péptidos como tales, también pueden ser dianas de anticuerpos, de receptores de linfocitos T solubles, y de otras moléculas de unión.
MX2017016213A 2015-06-19 2016-06-17 Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia y metodos para crear soportes para el uso contra el cancer de pancreas y otros tipos de cancer. MX2017016213A (es)

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US201562182026P 2015-06-19 2015-06-19
GBGB1510771.7A GB201510771D0 (en) 2015-06-19 2015-06-19 Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer
PCT/EP2016/063976 WO2016202963A2 (en) 2015-06-19 2016-06-17 Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer and other cancers

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MX2020012772A MX2020012772A (es) 2015-06-19 2017-12-13 Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia y metodos para crear soportes para el uso contra el cancer de pancreas y otros tipos de cancer.
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MX2020012773A MX2020012773A (es) 2015-06-19 2017-12-13 Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia y metodos para crear soportes para el uso contra el cancer de pancreas y otros tipos de cancer.
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20200523A (es) * 2015-06-19 2020-12-23 Immatics Biotechnologies Gmbh NUEVOS PÉPTIDOS Y NUEVAS COMBINACIONES DE PÉPTIDOS PARA EL USO EN LA INMUNOTERAPIA Y MÉTODOS PARA CREAR SOPORTES PARA EL USO CONTRA EL CÁNCER DE PÁNCREAS Y OTROS TIPOS DE CÁNCER (Divisional 2018-0040)
PH12022551111A1 (en) 2015-10-05 2023-08-23 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
CN109116024B (zh) * 2018-06-14 2021-04-23 郑州大学第一附属医院 一种肺癌标志物抗-actr3自身抗体及其应用
CN111781356A (zh) * 2019-04-04 2020-10-16 清华大学 一种胃癌极早期细胞标志和胃癌前病变早期细胞标志及其在诊断试剂盒中的应用
CN110791566B (zh) * 2019-10-29 2023-06-27 徐州市中心医院 人shcbp1基因的用途及相关产品
CN111333710B (zh) * 2020-03-04 2021-12-03 暨南大学 C20orf24蛋白缺失突变体及其应用
CN113539365B (zh) * 2020-04-16 2024-03-01 腾辰生物科技(上海)有限公司 用于早期诊断心脑血管疾病的甲基化标志物
CN112522209A (zh) * 2020-12-29 2021-03-19 郑州大学 肿瘤相关抗原p62/IMP2对食管鳞癌影响的研究方法
CN113176408B (zh) * 2021-06-02 2022-10-11 四川大学华西医院 一种甲状腺癌预后情况判断的方法
CN115491369B (zh) * 2021-06-18 2025-06-03 佛山热休生物技术有限公司 Pdia3的表位肽及所述表位肽与热休克蛋白的复合物
CN113337514B (zh) * 2021-08-05 2021-10-29 卡瑞济(北京)生命科技有限公司 Tcr表达构建体以及其制备方法和用途
CN116139277B (zh) * 2021-11-23 2025-06-24 中国科学院大连化学物理研究所 肝癌药物的辅助治疗药物及应用和治疗肝癌药物混合物
CN114195903B (zh) * 2021-12-10 2023-02-03 中国人民解放军空军军医大学 一种重组融合蛋白及其制备治疗炎症性肠病药物的应用
CN114377135B (zh) * 2022-03-15 2023-11-24 河南大学 Ppm1g在诊治肺癌中的应用
CN115558021B (zh) * 2022-12-01 2023-03-17 山东大学 一种转录因子、重组细胞及其在制备肿瘤治疗药物的应用
CN115612745B (zh) * 2022-12-19 2023-03-21 北京大学人民医院 Ipo7在结直肠癌治疗及预后预测中的应用
CN117130645A (zh) * 2023-10-25 2023-11-28 山东大学 基于大型语言模型和补全引擎的自动程序修复方法及系统
CN119555940A (zh) * 2024-12-13 2025-03-04 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种与肿瘤骨转移及疼痛相关的血浆多肽标志物col1a2及应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003010327A2 (en) 2001-02-21 2003-02-06 Curagen Corporation Novel proteins and nucleic acids encoding same
AU2002320264B2 (en) * 2001-06-05 2008-05-01 Exelixis, Inc. GFATs as modifiers of the p53 pathway and methods of use
AU2003223766A1 (en) * 2002-04-30 2003-11-17 University Of North Carolina At Chapel Hill Secretion signal vectors
US7332281B2 (en) 2004-04-27 2008-02-19 Sagres Discovery, Inc. Therapeutic targets in cancer
DK1806359T3 (da) * 2005-09-05 2010-06-14 Immatics Biotechnologies Gmbh Tumorassocierede peptider, der bindes promiskuøst til Humant Leukocyt-Antigen (HLA) klasse II molekyler
DE602005016112D1 (de) 2005-09-05 2009-10-01 Immatics Biotechnologies Gmbh Tumorassoziierte Peptide, die HLA Klasse I oder II-Moleküle binden, und anti-Tumor Impfstoffe
ES2689851T3 (es) * 2007-07-27 2018-11-16 Immatics Biotechnologies Gmbh Nuevos epítopos inmunogénicos para inmunoterapia
ATE462442T1 (de) * 2008-04-30 2010-04-15 Immatics Biotechnologies Gmbh Neuartige formulierungen von tumor-assoziierten peptiden, welche an menschliche leukozytenantigene der klasse i oder ii für impfungen binden
JP5475355B2 (ja) 2009-07-31 2014-04-16 ユニ・チャーム株式会社 超音波接合装置及び吸収性物品の製造装置
WO2011060821A1 (de) 2009-11-19 2011-05-26 Robert Bosch Gmbh Angleichen elektrischer spannungen elektrischer speichereinheiten
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
GB201009222D0 (en) 2010-06-02 2010-07-21 Immatics Biotechnologies Gmbh Improved cancer therapy based on tumour associated antigens derived from cyclin D1
CA2868469A1 (en) * 2012-03-26 2013-10-03 Pronutria, Inc. Nutritive fragments, proteins and methods
CA2868393A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
EP3004141A4 (en) * 2013-06-03 2017-05-31 Acetylon Pharmaceuticals, Inc. Histone deacetylase ( hdac) biomarkers in multiple myeloma
TWI819228B (zh) * 2013-08-05 2023-10-21 德商伊瑪提克斯生物科技有限公司 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（八）
GB201319446D0 (en) * 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
CR20200523A (es) * 2015-06-19 2020-12-23 Immatics Biotechnologies Gmbh NUEVOS PÉPTIDOS Y NUEVAS COMBINACIONES DE PÉPTIDOS PARA EL USO EN LA INMUNOTERAPIA Y MÉTODOS PARA CREAR SOPORTES PARA EL USO CONTRA EL CÁNCER DE PÁNCREAS Y OTROS TIPOS DE CÁNCER (Divisional 2018-0040)

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