MX2016015015A - Compuesto de pirrolopirimidina novedoso o sal del mismo, composicion farmaceutica que lo contiene, agente especialmente para la prevencion y/o el tratamiento de tumores, etc. con base en el efecto inhibidor de enzima activadora de nedd8 (nae). - Google Patents
Compuesto de pirrolopirimidina novedoso o sal del mismo, composicion farmaceutica que lo contiene, agente especialmente para la prevencion y/o el tratamiento de tumores, etc. con base en el efecto inhibidor de enzima activadora de nedd8 (nae).Info
- Publication number
- MX2016015015A MX2016015015A MX2016015015A MX2016015015A MX2016015015A MX 2016015015 A MX2016015015 A MX 2016015015A MX 2016015015 A MX2016015015 A MX 2016015015A MX 2016015015 A MX2016015015 A MX 2016015015A MX 2016015015 A MX2016015015 A MX 2016015015A
- Authority
- MX
- Mexico
- Prior art keywords
- salt
- pharmaceutical composition
- inhibitory effect
- prevention
- treatment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un objeto a ser resuelto por la presente invención es proporcionar un compuesto de pirrolopirimidina novedoso o una sal del mismo que tiene una acción inhibidora de NAE y un efecto inhibidor del crecimiento celular; la presente invención proporciona un compuesto o una sal del mismo representado por la Fórmula (A), así como un inhibidor de NAE, una composición farmacéutica, y un agente antitumoral que comprende el compuesto o una sal del mismo como un ingrediente activo. (ver Fórmula).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014129740 | 2014-06-24 | ||
| JP2015024785 | 2015-02-10 | ||
| PCT/JP2015/068218 WO2015199136A1 (ja) | 2014-06-24 | 2015-06-24 | 新規ピロロピリミジン化合物又はその塩、及びこれを含有する医薬組成物、特にｎａｅ阻害作用に基づく腫瘍等の予防剤及び／又は治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016015015A true MX2016015015A (es) | 2017-02-27 |
Family
ID=54938214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016015015A MX2016015015A (es) | 2014-06-24 | 2015-06-24 | Compuesto de pirrolopirimidina novedoso o sal del mismo, composicion farmaceutica que lo contiene, agente especialmente para la prevencion y/o el tratamiento de tumores, etc. con base en el efecto inhibidor de enzima activadora de nedd8 (nae). |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9963456B2 (es) |
| EP (1) | EP3103802B1 (es) |
| JP (1) | JP6192741B2 (es) |
| KR (1) | KR101947289B1 (es) |
| CN (1) | CN106661031B (es) |
| AU (1) | AU2015281155B9 (es) |
| BR (1) | BR112016025835B1 (es) |
| CA (1) | CA2946833C (es) |
| DK (1) | DK3103802T3 (es) |
| ES (1) | ES2656772T3 (es) |
| HU (1) | HUE037266T2 (es) |
| MX (1) | MX2016015015A (es) |
| MY (1) | MY183327A (es) |
| NO (1) | NO3103802T3 (es) |
| PH (1) | PH12016502130A1 (es) |
| PL (1) | PL3103802T3 (es) |
| PT (1) | PT3103802T (es) |
| RU (1) | RU2658008C2 (es) |
| SG (1) | SG11201608441YA (es) |
| TW (1) | TWI605048B (es) |
| WO (1) | WO2015199136A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI623316B (zh) * | 2015-12-22 | 2018-05-11 | Taiho Pharmaceutical Co Ltd | Antitumor effect enhancer derived from pyrrolopyrimidine compound |
| WO2018085833A2 (en) * | 2016-11-07 | 2018-05-11 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyl transferase 5 (prmt5) |
| WO2018085818A1 (en) * | 2016-11-07 | 2018-05-11 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
| US10865208B2 (en) | 2016-11-11 | 2020-12-15 | Millennium Pharmaceuticals, Inc. | ATG7 inhibitors and the uses thereof |
| WO2018110591A1 (ja) * | 2016-12-13 | 2018-06-21 | ヤマサ醤油株式会社 | 抗ウイルス活性を有する２'－デオキシ－７－デアザプリンヌクレオシド誘導体 |
| JP7060694B2 (ja) * | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物 |
| CN108822145B (zh) * | 2018-06-11 | 2020-10-23 | 广东工业大学 | 一种磺酰胺类化合物及其制备方法和应用 |
| CN108640945B (zh) * | 2018-06-11 | 2020-10-23 | 广东工业大学 | 一种酰胺类化合物及其制备方法与应用 |
| CN113382754A (zh) * | 2018-07-13 | 2021-09-10 | Il-2Rx公司 | 治疗癌症和免疫病症的化合物、组合物、方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5048520B2 (ja) * | 2005-02-04 | 2012-10-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｅ１活性化酵素の阻害剤 |
| US7989430B2 (en) * | 2005-12-06 | 2011-08-02 | Regents Of The University Of Minnesota | Antibacterial agents |
| US8207177B2 (en) | 2006-02-02 | 2012-06-26 | Millennium Pharmaceuticals, Inc. | Inhibitors of E1 activating enzymes |
| WO2012061551A1 (en) * | 2010-11-05 | 2012-05-10 | Millennium Pharmaceuticals, Inc. | Administration of nedd8-activating enzyme inhibitor |
| MX2013007792A (es) | 2011-01-07 | 2013-07-30 | Leo Pharma As | Nuevos derivados de sulfamida piperazina como inhibidores de proteina tirosina cinasa y uso farmaceutico de los mismos. |
| WO2013016906A1 (zh) * | 2011-07-29 | 2013-02-07 | 深圳光启高等理工研究院 | 人工复合材料和人工复合材料天线 |
| WO2013108809A1 (ja) * | 2012-01-19 | 2013-07-25 | 大鵬薬品工業株式会社 | ３，５－二置換ベンゼンアルキニル化合物及びその塩 |
-
2015
- 2015-06-24 NO NO15811341A patent/NO3103802T3/no unknown
- 2015-06-24 KR KR1020177002160A patent/KR101947289B1/ko not_active Expired - Fee Related
- 2015-06-24 PL PL15811341T patent/PL3103802T3/pl unknown
- 2015-06-24 US US15/122,863 patent/US9963456B2/en active Active
- 2015-06-24 ES ES15811341.5T patent/ES2656772T3/es active Active
- 2015-06-24 CN CN201580034466.6A patent/CN106661031B/zh not_active Expired - Fee Related
- 2015-06-24 HU HUE15811341A patent/HUE037266T2/hu unknown
- 2015-06-24 BR BR112016025835-5A patent/BR112016025835B1/pt not_active IP Right Cessation
- 2015-06-24 TW TW104120451A patent/TWI605048B/zh not_active IP Right Cessation
- 2015-06-24 PT PT158113415T patent/PT3103802T/pt unknown
- 2015-06-24 JP JP2015555474A patent/JP6192741B2/ja not_active Expired - Fee Related
- 2015-06-24 AU AU2015281155A patent/AU2015281155B9/en not_active Ceased
- 2015-06-24 SG SG11201608441YA patent/SG11201608441YA/en unknown
- 2015-06-24 EP EP15811341.5A patent/EP3103802B1/en active Active
- 2015-06-24 MX MX2016015015A patent/MX2016015015A/es active IP Right Grant
- 2015-06-24 MY MYPI2016704032A patent/MY183327A/en unknown
- 2015-06-24 RU RU2016149319A patent/RU2658008C2/ru active
- 2015-06-24 DK DK15811341.5T patent/DK3103802T3/en active
- 2015-06-24 WO PCT/JP2015/068218 patent/WO2015199136A1/ja active Application Filing
- 2015-06-24 CA CA2946833A patent/CA2946833C/en active Active
-
2016
- 2016-10-25 PH PH12016502130A patent/PH12016502130A1/en unknown
-
2018
- 2018-02-07 US US15/890,470 patent/US10174040B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |