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MX2015017599A - Compuestos biciclicos utiles para el tratamiento de enfermedades causadas por retrovirus. - Google Patents

Compuestos biciclicos utiles para el tratamiento de enfermedades causadas por retrovirus.

Info

Publication number
MX2015017599A
MX2015017599A MX2015017599A MX2015017599A MX2015017599A MX 2015017599 A MX2015017599 A MX 2015017599A MX 2015017599 A MX2015017599 A MX 2015017599A MX 2015017599 A MX2015017599 A MX 2015017599A MX 2015017599 A MX2015017599 A MX 2015017599A
Authority
MX
Mexico
Prior art keywords
group
retroviral infection
treating
preventing
disease caused
Prior art date
Application number
MX2015017599A
Other languages
English (en)
Inventor
Romain Najman
Jamal Tazi
Didier Scherrer
Aude Garcel
Noëlie Campos
Florence Mahuteau-Betzer
Original Assignee
Abivax
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abivax filed Critical Abivax
Publication of MX2015017599A publication Critical patent/MX2015017599A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describe en la presente métodos para prevenir o tratar una infección retrovírica y/o para prevenir, inhibir o tratar una enfermedad causada por la infección retrovírica. En ciertos aspectos, los métodos descritos en la presente incluyen poner en contacto una célula que necesita del mismo con el compuesto (1) (ver Fórmula) en donde: (ver Fórmula) significa a grupo piridazina, pirimidina o pirazina, R representa independientemente un átomo de hidrógeno, un átomo de halógeno o un grupo elegido de entre un grupo - CN, un grupo hidroxilo, un grupo -COOR1, un grupo fluoroalquilo(C1-C3), un grupo fluoroalcoxi(C1-C3), un grupo - NO2, un grupo -NR1R2, un grupo alcoxi (C1-C4), un grupo fenoxi y un grupo alquilo (C1-C3), el alquilo siendo opcionalmente mono-sustituido por un grupo hidroxilo, n es 1, 2 o 3, n´ es 1 o 2, R´ es un átomo de hidrógeno, un átomo de halógeno o un grupo elegido de entre un grupo alquilo (C1-C3), , un grupo hidroxilo, un grupo -COOR1, un grupo -NO2, un grupo -NR1R2, un grupo morfolinilo o uno morfolino, un grupo N-metilpiperazinilo, un grupo fluoroalquilo(C1-C3), un grupo alcoxi(C1-C4) y un grupo -CN, Z es N o C, Y es N o C, X es N o C, W es N o C, T es N o C, U es N o C, Para prevenir o tratar la infección retrovírica y/o para prevenir, inhibir o tratar una enfermedad causada por la infección retrovírica, en donde la infección retrovírica no es VIH y la enfermedad causada por infección retrovírica que no es SIDA.
MX2015017599A 2013-07-05 2014-07-04 Compuestos biciclicos utiles para el tratamiento de enfermedades causadas por retrovirus. MX2015017599A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361843155P 2013-07-05 2013-07-05
PCT/IB2014/062849 WO2015001518A1 (en) 2013-07-05 2014-07-04 Bicyclic compounds useful for treating diseases caused by retroviruses

Publications (1)

Publication Number Publication Date
MX2015017599A true MX2015017599A (es) 2016-04-07

Family

ID=51453778

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015017599A MX2015017599A (es) 2013-07-05 2014-07-04 Compuestos biciclicos utiles para el tratamiento de enfermedades causadas por retrovirus.

Country Status (17)

Country Link
US (1) US9827237B2 (es)
EP (1) EP3016656B1 (es)
JP (2) JP6895251B2 (es)
KR (1) KR102326068B1 (es)
CN (1) CN105530938B (es)
AU (1) AU2014285733B2 (es)
BR (1) BR112016000127B1 (es)
CA (1) CA2916623C (es)
ES (1) ES2898385T3 (es)
HK (1) HK1217447A1 (es)
HR (1) HRP20211839T1 (es)
MX (1) MX2015017599A (es)
PL (1) PL3016656T3 (es)
PT (1) PT3016656T (es)
RU (1) RU2681943C9 (es)
WO (1) WO2015001518A1 (es)
ZA (1) ZA201600317B (es)

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Also Published As

Publication number Publication date
BR112016000127B1 (pt) 2022-02-15
HRP20211839T1 (hr) 2022-03-04
US9827237B2 (en) 2017-11-28
KR20160032724A (ko) 2016-03-24
US20160151348A1 (en) 2016-06-02
RU2016103217A (ru) 2017-08-10
PT3016656T (pt) 2021-11-26
JP6895251B2 (ja) 2021-06-30
JP2016523893A (ja) 2016-08-12
RU2681943C2 (ru) 2019-03-14
KR102326068B1 (ko) 2021-11-11
ZA201600317B (en) 2018-07-25
CN105530938A (zh) 2016-04-27
CA2916623C (en) 2021-09-14
AU2014285733A1 (en) 2016-01-21
CA2916623A1 (en) 2015-01-08
JP2019142946A (ja) 2019-08-29
EP3016656A1 (en) 2016-05-11
PL3016656T3 (pl) 2022-02-21
EP3016656B1 (en) 2021-09-08
RU2681943C9 (ru) 2019-05-16
CN105530938B (zh) 2019-10-22
WO2015001518A1 (en) 2015-01-08
BR112016000127A8 (pt) 2018-01-23
ES2898385T3 (es) 2022-03-07
HK1217447A1 (zh) 2017-01-13
AU2014285733B2 (en) 2019-05-16

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