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MX2015011507A - Tioesterasas y celulas para producir aceites diseñados. - Google Patents

Tioesterasas y celulas para producir aceites diseñados.

Info

Publication number
MX2015011507A
MX2015011507A MX2015011507A MX2015011507A MX2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A MX 2015011507 A MX2015011507 A MX 2015011507A
Authority
MX
Mexico
Prior art keywords
genes
cells
thioesterases
production
fatty acid
Prior art date
Application number
MX2015011507A
Other languages
English (en)
Inventor
Scott Franklin
George N Rudenko
Jason Casolari
Original Assignee
Solazyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/837,996 external-priority patent/US9290749B2/en
Application filed by Solazyme Inc filed Critical Solazyme Inc
Publication of MX2015011507A publication Critical patent/MX2015011507A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Edible Oils And Fats (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)

Abstract

La invención presenta genes de tioesterasa acil-ACP de plantas de la clase FatB, y proteínas codificadas por estos genes. Los genes son útiles para la construcción de células huésped recombinantes que tienen perfiles de ácidos grasos alterados. Se divulgan células huésped de microalgas oleaginosas con los nuevos genes o genes FatB previamente identificados. Las células de microalgas producen triglicéridos con perfiles de ácidos grasos útiles.
MX2015011507A 2013-03-15 2014-03-13 Tioesterasas y celulas para producir aceites diseñados. MX2015011507A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361791861P 2013-03-15 2013-03-15
US13/837,996 US9290749B2 (en) 2013-03-15 2013-03-15 Thioesterases and cells for production of tailored oils
US201361917217P 2013-12-17 2013-12-17
PCT/US2014/026644 WO2014151904A1 (en) 2013-03-15 2014-03-13 Thioesterases and cells for production of tailored oils

Publications (1)

Publication Number Publication Date
MX2015011507A true MX2015011507A (es) 2016-04-07

Family

ID=51581068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011507A MX2015011507A (es) 2013-03-15 2014-03-13 Tioesterasas y celulas para producir aceites diseñados.

Country Status (9)

Country Link
EP (1) EP2971024A4 (es)
JP (1) JP2016518112A (es)
KR (1) KR20150128770A (es)
CN (1) CN105143458A (es)
AU (2) AU2014236763B2 (es)
BR (1) BR112015023192A8 (es)
CA (1) CA2904395A1 (es)
MX (1) MX2015011507A (es)
WO (1) WO2014151904A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
ES2772123T3 (es) 2014-07-24 2020-07-07 Corbion Biotech Inc Variantes de tioesterasas y métodos de uso
CN107208103A (zh) * 2014-09-18 2017-09-26 泰拉瑞亚控股公司 酰基‑acp硫酯酶及其突变体
US20180142218A1 (en) 2016-10-05 2018-05-24 Terravia Holdings, Inc. Novel acyltransferases, variant thioesterases, and uses thereof
BR112019020784A2 (pt) 2017-04-03 2020-04-28 Genomatica Inc variantes de tioesterase com atividade melhorada para a produção de derivados de ácidos graxos de cadeia média
WO2021146520A1 (en) 2020-01-16 2021-07-22 Corbion Biotech, Inc. β-KETOACYL-ACP SYNTHASE IV VARIANTS

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512482A (en) * 1990-04-26 1996-04-30 Calgene, Inc. Plant thioesterases
US5344771A (en) 1990-04-26 1994-09-06 Calgene, Inc. Plant thiosterases
US5298421A (en) 1990-04-26 1994-03-29 Calgene, Inc. Plant medium-chain-preferring acyl-ACP thioesterases and related methods
US5455167A (en) 1991-05-21 1995-10-03 Calgene Inc. Medium-chain thioesterases in plants
US5639790A (en) 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
US5654495A (en) 1992-10-30 1997-08-05 Calgene, Inc. Production of myristate in plant cells
US5850022A (en) 1992-10-30 1998-12-15 Calgene, Inc. Production of myristate in plant cells
EP0716708A1 (de) * 1993-09-03 1996-06-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Mittelkettenspezifische thioesterasen
JPH09505470A (ja) 1993-11-10 1997-06-03 カルジーン，インコーポレイティド 植物アシルａｃｐチオエステラーゼ配列
US5807893A (en) 1993-11-18 1998-09-15 Voelker; Toni Alois Plant thioesterases and use for modification of fatty acid composition in plant seed oils
EP3546588A3 (en) 2007-06-01 2019-12-18 Corbion Biotech, Inc. Recombinant microalgal cell and method of producing lipids using said cell
CA2692687C (en) * 2007-07-09 2021-10-26 Bayer Bioscience N.V. Brassica plant comprising mutant fatty acyl-acp thioesterase alleles
US7982035B2 (en) 2007-08-27 2011-07-19 Duquesne University Of The Holy Spirit Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
CN103834683A (zh) * 2008-06-20 2014-06-04 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物和产生所述植物的方法
US7883882B2 (en) 2008-11-28 2011-02-08 Solazyme, Inc. Renewable chemical production from novel fatty acid feedstocks
CA2758298A1 (en) * 2009-04-10 2010-10-14 Ls9, Inc. Production of commercial biodiesel from genetically modified microorganisms
EP2575486B1 (en) 2010-05-28 2021-09-01 Corbion Biotech, Inc. Food compositions comprising tailored oils
CN110066836A (zh) 2011-02-02 2019-07-30 柯碧恩生物技术公司 产自重组产油微生物的定制油
US8951762B2 (en) * 2011-07-27 2015-02-10 Iowa State University Research Foundation, Inc. Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
CN102586350A (zh) * 2012-01-09 2012-07-18 北京化工大学 一种c8:0/c10:0/c12:0/c14:0中链脂肪酸及其乙酯的生产方法
AU2013249172C1 (en) 2012-04-18 2017-08-10 Corbion Biotech, Inc. Tailored oils

Also Published As

Publication number Publication date
CN105143458A (zh) 2015-12-09
CA2904395A1 (en) 2014-09-25
EP2971024A4 (en) 2016-11-16
AU2014236763B2 (en) 2018-08-23
JP2016518112A (ja) 2016-06-23
BR112015023192A2 (pt) 2017-11-21
BR112015023192A8 (pt) 2018-01-02
KR20150128770A (ko) 2015-11-18
AU2014236763A1 (en) 2015-10-01
EP2971024A1 (en) 2016-01-20
WO2014151904A1 (en) 2014-09-25
AU2018267601A1 (en) 2018-12-06

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