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MX2012008260A - Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa. - Google Patents

Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa.

Info

Publication number
MX2012008260A
MX2012008260A MX2012008260A MX2012008260A MX2012008260A MX 2012008260 A MX2012008260 A MX 2012008260A MX 2012008260 A MX2012008260 A MX 2012008260A MX 2012008260 A MX2012008260 A MX 2012008260A MX 2012008260 A MX2012008260 A MX 2012008260A
Authority
MX
Mexico
Prior art keywords
triazole derivatives
gamma secretase
substituted triazole
novel substituted
secretase modulators
Prior art date
Application number
MX2012008260A
Other languages
English (en)
Inventor
Michel Surkyn
Henricus Jacobus Maria Gijsen
Sven Franciscus Anna Van Brandt
Didier Jean-Claude Berthelot
Cleyn Michel Anna Jozef De
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43569255&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012008260(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of MX2012008260A publication Critical patent/MX2012008260A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona con novedosos derivados de triazol sustituidos de la Fórmula (I) (ver fórmula) en donde Het1, R1, R2, A1, A2, A3, A4, L1, y L2 poseen el significado definido en las reivindicaciones; los compuestos de acuerdo con la presente invención son útiles como moduladores de la gamma secretasa; la invención se refiere adicionalmente a procesos para la preparación de dichos compuestos novedosos, las composiciones farmacéuticas que comprenden dichos compuestos como un ingrediente activo así como también al uso de dichos compuestos como medicamento.
MX2012008260A 2010-01-15 2011-01-12 Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa. MX2012008260A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10150892 2010-01-15
EP10171292 2010-07-29
PCT/EP2011/050350 WO2011086099A1 (en) 2010-01-15 2011-01-12 Novel substituted triazole derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
MX2012008260A true MX2012008260A (es) 2012-08-17

Family

ID=43569255

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012008259A MX2012008259A (es) 2010-01-15 2011-01-12 Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa.
MX2012008260A MX2012008260A (es) 2010-01-15 2011-01-12 Novedosos derivados de triazol sustituidos como moduladores de la gamma secretasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012008259A MX2012008259A (es) 2010-01-15 2011-01-12 Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa.

Country Status (21)

Country Link
US (2) US9145399B2 (es)
EP (2) EP2523955B1 (es)
JP (2) JP5824464B2 (es)
KR (2) KR20120123677A (es)
CN (2) CN102803261A (es)
AR (2) AR079905A1 (es)
AU (2) AU2011206635B2 (es)
BR (2) BR112012017442A2 (es)
CA (2) CA2784769A1 (es)
CL (2) CL2012001956A1 (es)
EA (2) EA021776B1 (es)
ES (2) ES2512840T3 (es)
IL (2) IL220838A0 (es)
MX (2) MX2012008259A (es)
NZ (2) NZ601150A (es)
PE (2) PE20121511A1 (es)
PH (2) PH12012501381A1 (es)
SG (2) SG182506A1 (es)
TW (2) TWI473807B (es)
WO (2) WO2011086099A1 (es)
ZA (2) ZA201205240B (es)

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CN102803261A (zh) 2012-11-28
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