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MX2010004878A - Derivados de tioeter y eter heterociclico y metodos de uso de los mismos. - Google Patents

Derivados de tioeter y eter heterociclico y metodos de uso de los mismos.

Info

Publication number
MX2010004878A
MX2010004878A MX2010004878A MX2010004878A MX2010004878A MX 2010004878 A MX2010004878 A MX 2010004878A MX 2010004878 A MX2010004878 A MX 2010004878A MX 2010004878 A MX2010004878 A MX 2010004878A MX 2010004878 A MX2010004878 A MX 2010004878A
Authority
MX
Mexico
Prior art keywords
treat cancer
carboxamide derivatives
heterocyclic ether
disorder
thioether derivatives
Prior art date
Application number
MX2010004878A
Other languages
English (en)
Inventor
Gerald W Shipps Jr
Matthew Richards
Xiaohua Huang
Cliff C Cheng
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2010004878A publication Critical patent/MX2010004878A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se relaciona con Derivados de Tioéter o Eter Heterocíclico novedosos, composiciones que comprenden los Derivados de Tioéter o Eter Heterocíclico, y métodos para usar los Derivados de Tioéter o Eter Heterocíclico para tratar o prevenir un trastorno proliferativo, un trastorno anti-proliferativo, inflamación, artritis, un trastorno del sistema nervioso central, una enfermedad cardiovascular, alopecia, una enfermedad neuronal, una lesión isquémica, una infección viral, una infección fúngica, o un trastorno relacionado la actividad de una proteína quinasa.
MX2010004878A 2007-10-29 2008-10-27 Derivados de tioeter y eter heterociclico y metodos de uso de los mismos. MX2010004878A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98334507P 2007-10-29 2007-10-29
PCT/US2008/081317 WO2009058729A2 (en) 2007-10-29 2008-10-27 Thiazole carboxamide derivatives and their to treat cancer

Publications (1)

Publication Number Publication Date
MX2010004878A true MX2010004878A (es) 2010-05-19

Family

ID=40585484

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004878A MX2010004878A (es) 2007-10-29 2008-10-27 Derivados de tioeter y eter heterociclico y metodos de uso de los mismos.

Country Status (7)

Country Link
US (1) US8394960B2 (es)
EP (1) EP2225235B1 (es)
JP (1) JP5224616B2 (es)
CN (1) CN101910167A (es)
CA (1) CA2703979A1 (es)
MX (1) MX2010004878A (es)
WO (1) WO2009058729A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2770252C (en) * 2009-09-08 2018-06-12 F. Hoffmann-La Roche Ag 4-substituted pyridin-3-yl-carboxamide compounds and uses thereof for treating cancer
JP2013525453A (ja) * 2010-04-30 2013-06-20 メルク・シャープ・エンド・ドーム・コーポレイション ホスホイノシチド依存性キナーゼ１（ｐｄｋ１）阻害薬
AU2011254242B2 (en) 2010-05-17 2015-10-29 Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3H-imidazo[4,5-b]pyridine and 3,5- disubstitued -3H-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
WO2012058176A1 (en) * 2010-10-29 2012-05-03 Schering Corporation Novel heteroaryl-carboxamide derivatives as pdk1 inhibitors
CN102924444B (zh) 2011-08-11 2015-07-08 上海吉铠医药科技有限公司 Pim激酶抑制剂及其制备方法与在制药中的应用
US9452995B2 (en) 2011-08-11 2016-09-27 Jikai Biosciences, Inc. Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
US9453003B2 (en) 2011-08-11 2016-09-27 Jikai Biosciences, Inc. Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
US9458151B2 (en) 2011-08-11 2016-10-04 Jikai Biosciences, Inc. Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
JP6192708B2 (ja) 2012-03-30 2017-09-06 ライゼン・ファーマシューティカルズ・エスアー Ｃ−ｍｅｔプロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−イミダゾ［４，５−ｂ］ピリジン化合物および３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物
EP3441768A3 (en) * 2013-08-26 2019-03-20 Roche Diagnostics GmbH Marker for statin treatment stratification in heart failure
WO2018218633A1 (en) 2017-06-02 2018-12-06 Beijing Percans Oncology Co. Ltd. Combination therapies for treating cancers
WO2019195959A1 (en) 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
US20230310436A1 (en) * 2019-10-09 2023-10-05 Cothera Bioscience, Inc. Combination therapy for cancers with kras mutation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
GB0102687D0 (en) * 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
WO2006008545A2 (en) * 2004-07-22 2006-01-26 Astex Therapeutics Limited Thiazole and isothiazole derivatives as protein kinase inhibitors
EP1896465A1 (en) * 2005-06-28 2008-03-12 Takeda Cambridge Limited Heterocyclic non-peptide gnrh antagonists
TWI329641B (en) * 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
AU2007314342B2 (en) * 2006-10-31 2013-02-21 Merck Sharp & Dohme Corp. Anilinopiperazine Derivatives and methods of use thereof
WO2008054701A1 (en) * 2006-10-31 2008-05-08 Schering Corporation 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors
MX2009004791A (es) * 2006-10-31 2009-08-19 Schering Corp Derivados de anilinopiperazina t metodos de uso de los mismos.
EP2209779A1 (en) * 2007-10-29 2010-07-28 Schering Corporation Heterocyclic urea and thiourea derivatives and methods of use thereof
JP5230035B2 (ja) * 2007-10-29 2013-07-10 メルク・シャープ・アンド・ドーム・コーポレーション プロテインキナーゼ阻害剤としてのチアゾール誘導体

Also Published As

Publication number Publication date
CA2703979A1 (en) 2009-05-07
JP5224616B2 (ja) 2013-07-03
EP2225235A2 (en) 2010-09-08
WO2009058729A3 (en) 2009-06-25
US8394960B2 (en) 2013-03-12
US20110044940A1 (en) 2011-02-24
CN101910167A (zh) 2010-12-08
EP2225235B1 (en) 2017-09-06
WO2009058729A2 (en) 2009-05-07
JP2011502157A (ja) 2011-01-20

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