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MX2010003949A - N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. - Google Patents

N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas.

Info

Publication number
MX2010003949A
MX2010003949A MX2010003949A MX2010003949A MX2010003949A MX 2010003949 A MX2010003949 A MX 2010003949A MX 2010003949 A MX2010003949 A MX 2010003949A MX 2010003949 A MX2010003949 A MX 2010003949A MX 2010003949 A MX2010003949 A MX 2010003949A
Authority
MX
Mexico
Prior art keywords
phenyl
substituted
therapeutic use
bipyrrolidine carboxamides
bipyrrolidine
Prior art date
Application number
MX2010003949A
Other languages
English (en)
Inventor
Siegfried Stengelin
Lothar Schwink
William J Hurst
Zhongli Gao
Werngard Czechtizky
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2010003949A publication Critical patent/MX2010003949A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invenci?n describe y reivindica una serie de N-fenil-bipirrolidina carboxamidas sustituidas de f?rmula (I). (Ver f?rmula I) en la que R, R1, R2, R3 y R4 son como se describen en la presente memoria. M?s espec?ficamente, los compuestos de esta invenci?n son moduladores de los receptores H3 y, por lo tanto, son ?tiles como agentes farmac?uticos, especialmente en el tratamiento y/o prevenci?n de una variedad de enfermedades moduladas por los receptores H3, incluyendo enfermedades asociadas con el sistema nervioso central. Adem?s, la presente invenci?n tambi?n describe m?todos para la preparaci?n de N-fenil-bipirrolidina carboxamidas sustituidas e intermedios para ello.
MX2010003949A 2007-10-17 2008-10-14 N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. MX2010003949A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98059907P 2007-10-17 2007-10-17
PCT/US2008/079757 WO2009052062A1 (en) 2007-10-17 2008-10-14 Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

Publications (1)

Publication Number Publication Date
MX2010003949A true MX2010003949A (es) 2010-04-30

Family

ID=40247942

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003949A MX2010003949A (es) 2007-10-17 2008-10-14 N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas.

Country Status (25)

Country Link
US (2) US8088808B2 (es)
EP (1) EP2212283B1 (es)
JP (1) JP5377503B2 (es)
KR (1) KR20100072077A (es)
CN (1) CN101903340B (es)
AT (1) ATE525351T1 (es)
AU (1) AU2008312635B2 (es)
BR (1) BRPI0818581A2 (es)
CA (1) CA2702467C (es)
CY (1) CY1112083T1 (es)
DK (1) DK2212283T3 (es)
ES (1) ES2372332T3 (es)
HR (1) HRP20110762T1 (es)
IL (1) IL205001A (es)
MA (1) MA31858B1 (es)
MX (1) MX2010003949A (es)
MY (1) MY151348A (es)
NZ (1) NZ584690A (es)
PL (1) PL2212283T3 (es)
PT (1) PT2212283E (es)
RS (1) RS52235B (es)
RU (1) RU2477720C2 (es)
SI (1) SI2212283T1 (es)
WO (1) WO2009052062A1 (es)
ZA (1) ZA201002115B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE534625T1 (de) 2007-10-17 2011-12-15 Sanofi Sa Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung
HRP20110762T1 (hr) * 2007-10-17 2011-11-30 Sanofi Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji
HRP20110953T1 (hr) * 2007-10-17 2012-01-31 Sanofi Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji
AU2008312636B2 (en) 2007-10-17 2013-03-14 Sanofi-Aventis Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine H3 receptor modulators
AR074467A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
AR074466A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
SA110310332B1 (ar) 2009-05-01 2013-12-10 Astrazeneca Ab مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
TW201206889A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
JP5784110B2 (ja) * 2010-05-11 2015-09-24 サノフイ 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用
AR083718A1 (es) * 2010-05-11 2013-03-20 Sanofi Aventis Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas
JP2013529198A (ja) 2010-05-11 2013-07-18 サノフイ 置換されたｎ−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用
JP2013526530A (ja) * 2010-05-11 2013-06-24 サノフイ 置換されたｎ−フェニルスピロラクタムビピロリジン、その製造及び治療上の使用
TW201202251A (en) * 2010-05-11 2012-01-16 Sanofi Aventis Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
TW201206901A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
AU2011275547B2 (en) 2010-07-06 2015-10-29 Astrazeneca Ab Therapeutic agents 976
UY34194A (es) 2011-07-15 2013-02-28 Astrazeneca Ab ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
JP2013232564A (ja) * 2012-04-27 2013-11-14 National Institute Of Advanced Industrial & Technology 半導体装置および半導体装置の製造方法
CN103694163A (zh) * 2012-09-27 2014-04-02 上海先声药物研究有限公司 作为钾通道调节剂的化合物
CA2897562A1 (en) 2013-01-10 2014-07-17 Grunenthal Gmbh Pyrazolyl-based carboxamides i as crac channel inhibitors
MX2015008912A (es) 2013-01-10 2015-10-22 Gruenenthal Gmbh Carboxamidas basadas en pirazolilo ii como inhibidores del canal de calcio activado por liberacion de calcio (crac).
EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
JP2006505590A (ja) * 2002-10-23 2006-02-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ３受容体調節物質としてのフェニルピペリジンおよびフェニルピロリジン
US7223788B2 (en) * 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2006101808A1 (en) 2005-03-17 2006-09-28 Eli Lilly And Company Pyrrolidine derivatives as histamine h3 receptor antagonists
WO2006107661A1 (en) * 2005-04-01 2006-10-12 Eli Lilly And Company Histamine h3 receptor agents, preparation and therapeutic uses
US8008296B2 (en) * 2005-07-01 2011-08-30 Eli Lilly And Company Histamine H3 receptor agents, preparation and therapeutic uses
TW200804274A (en) * 2005-10-27 2008-01-16 Ucb Sa Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses
CA2636873A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
ATE534625T1 (de) * 2007-10-17 2011-12-15 Sanofi Sa Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung
AU2008312636B2 (en) 2007-10-17 2013-03-14 Sanofi-Aventis Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine H3 receptor modulators
HRP20110953T1 (hr) 2007-10-17 2012-01-31 Sanofi Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji
HRP20110762T1 (hr) * 2007-10-17 2011-11-30 Sanofi Supstituirani n-fenilbipirolidinkarboksamidi i njihova upotreba u terapiji

Also Published As

Publication number Publication date
NZ584690A (en) 2011-09-30
PT2212283E (pt) 2011-11-03
US8252824B2 (en) 2012-08-28
IL205001A0 (en) 2010-11-30
HRP20110762T1 (hr) 2011-11-30
PL2212283T3 (pl) 2012-01-31
ES2372332T3 (es) 2012-01-18
CN101903340A (zh) 2010-12-01
IL205001A (en) 2014-06-30
BRPI0818581A2 (pt) 2015-07-21
RU2010119528A (ru) 2011-11-27
US20120065234A1 (en) 2012-03-15
US8088808B2 (en) 2012-01-03
MA31858B1 (fr) 2010-11-01
AU2008312635A1 (en) 2009-04-23
KR20100072077A (ko) 2010-06-29
CN101903340B (zh) 2013-03-27
EP2212283A1 (en) 2010-08-04
ZA201002115B (en) 2010-12-29
HK1146053A1 (en) 2011-05-13
ATE525351T1 (de) 2011-10-15
AU2008312635B2 (en) 2013-05-16
WO2009052062A1 (en) 2009-04-23
MY151348A (en) 2014-05-15
US20100173949A1 (en) 2010-07-08
RS52235B (en) 2012-10-31
DK2212283T3 (da) 2011-12-19
JP2011500693A (ja) 2011-01-06
EP2212283B1 (en) 2011-09-21
CA2702467C (en) 2012-11-27
CY1112083T1 (el) 2015-11-04
JP5377503B2 (ja) 2013-12-25
SI2212283T1 (sl) 2011-12-30
CA2702467A1 (en) 2009-04-23
RU2477720C2 (ru) 2013-03-20

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