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MX2009009447A - Dihidro y tetrahidro oxazolopirimidinonas sustituidas, preparacion y uso de las mismas. - Google Patents

Dihidro y tetrahidro oxazolopirimidinonas sustituidas, preparacion y uso de las mismas.

Info

Publication number
MX2009009447A
MX2009009447A MX2009009447A MX2009009447A MX2009009447A MX 2009009447 A MX2009009447 A MX 2009009447A MX 2009009447 A MX2009009447 A MX 2009009447A MX 2009009447 A MX2009009447 A MX 2009009447A MX 2009009447 A MX2009009447 A MX 2009009447A
Authority
MX
Mexico
Prior art keywords
substituted
compounds
dihydro
oxazolo
pyrimidin
Prior art date
Application number
MX2009009447A
Other languages
English (en)
Inventor
Bin Cao
Rosy Sher
Raymond W Kosley Jr
Sathapana Kongsamut
Vieroslava Gurunian
Ryan E Hartung
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2009009447A publication Critical patent/MX2009009447A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención se refiere a una serie de dihidro y tetrahidro oxazolopirimidinonas sustituidas, específicamente, a una serie de 2,3-dihidro-oxazolo[3,2-a]pirimidin-7-onas 2-sustituidas y 2,3,5,6-tetrahidro-oxazolo[3,2-a]pirimidin-7-onas 2- sustituidas de fórmula (I): (ver fórmula I) en la que p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 y R8 son como se han definido en este documento. Esta invención también se refiere a métodos para preparar estos compuestos, incluyendo nuevos intermedios. Los compuestos de esta invención son moduladores alostéricos de receptores de glutamato metabotrópico (mGluR), particularmente, el receptor mGluR2. Por lo tanto, los compuestos de esta invención son útiles como agentes farmacéuticos, especialmente en el tratamiento y/o prevención de una diversidad de trastornos del sistema nervioso central (SNC), incluyendo, pero sin limitación, afecciones neurodegenerativas agudas y crónicas, psicosis, convulsiones, ansiedad, depresión, migraña, dolor, trastornos del sueño y emesis.
MX2009009447A 2007-03-09 2008-03-06 Dihidro y tetrahidro oxazolopirimidinonas sustituidas, preparacion y uso de las mismas. MX2009009447A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89399107P 2007-03-09 2007-03-09
PCT/US2008/056002 WO2008112483A2 (en) 2007-03-09 2008-03-06 Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof

Publications (1)

Publication Number Publication Date
MX2009009447A true MX2009009447A (es) 2009-09-14

Family

ID=39760318

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009447A MX2009009447A (es) 2007-03-09 2008-03-06 Dihidro y tetrahidro oxazolopirimidinonas sustituidas, preparacion y uso de las mismas.

Country Status (23)

Country Link
US (1) US8642603B2 (es)
EP (1) EP2137193B1 (es)
JP (1) JP5351056B2 (es)
KR (1) KR101547573B1 (es)
CN (2) CN101675060A (es)
AR (1) AR065651A1 (es)
AU (1) AU2008226649B2 (es)
BR (1) BRPI0808678A2 (es)
CA (1) CA2680262C (es)
CL (1) CL2008000691A1 (es)
CO (1) CO6231034A2 (es)
IL (1) IL200695A (es)
MA (1) MA31285B1 (es)
MX (1) MX2009009447A (es)
MY (1) MY147757A (es)
NZ (1) NZ579431A (es)
PE (1) PE20090158A1 (es)
RU (1) RU2470937C2 (es)
SG (2) SG10201506994RA (es)
TW (1) TWI417296B (es)
UY (1) UY30954A1 (es)
WO (1) WO2008112483A2 (es)
ZA (1) ZA200905564B (es)

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AR078171A1 (es) * 2009-09-15 2011-10-19 Sanofi Aventis Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas
AR078173A1 (es) 2009-09-15 2011-10-19 Sanofi Aventis Bifeniloximetil dihidro oxazolopirimidinonas sustituidas, su preparacion y su uso
AR078172A1 (es) 2009-09-15 2011-10-19 Sanofi Aventis Fenoximetil dihidro oxazolopirimidinonas sustituidas y uso de las mismas como moduladores de receptores metabotropicos de mglur
US20130035332A1 (en) 2010-04-29 2013-02-07 Layton Mark E Substituted 1,3-Benzothiazol-2(3H)-Ones and [1,3]Thiazolo[5,4-B]Pyridin-2(IH)-Ones as Positive Allosteric Modulators of MGLUR2
WO2012031024A1 (en) * 2010-08-31 2012-03-08 Vanderbilt University Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mglur5 receptors
CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
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Also Published As

Publication number Publication date
PE20090158A1 (es) 2009-04-23
SG10201506994RA (en) 2015-10-29
TWI417296B (zh) 2013-12-01
CN104447792A (zh) 2015-03-25
NZ579431A (en) 2012-04-27
TW200900409A (en) 2009-01-01
WO2008112483A2 (en) 2008-09-18
BRPI0808678A2 (pt) 2014-08-12
AR065651A1 (es) 2009-06-24
AU2008226649B2 (en) 2013-08-01
US20100075994A1 (en) 2010-03-25
US8642603B2 (en) 2014-02-04
CA2680262A1 (en) 2008-09-18
MA31285B1 (fr) 2010-04-01
JP5351056B2 (ja) 2013-11-27
MY147757A (en) 2013-01-15
SG179453A1 (en) 2012-04-27
JP2010520880A (ja) 2010-06-17
IL200695A (en) 2014-11-30
CN101675060A (zh) 2010-03-17
EP2137193B1 (en) 2017-08-09
RU2009137369A (ru) 2011-04-20
KR20090121381A (ko) 2009-11-25
EP2137193A2 (en) 2009-12-30
CA2680262C (en) 2012-11-13
CO6231034A2 (es) 2010-12-20
RU2470937C2 (ru) 2012-12-27
WO2008112483A3 (en) 2009-01-15
AU2008226649A1 (en) 2008-09-18
ZA200905564B (en) 2010-05-26
UY30954A1 (es) 2008-10-31
IL200695A0 (en) 2010-05-17
KR101547573B1 (ko) 2015-08-26
CL2008000691A1 (es) 2008-09-12

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