[go: up one dir, main page]

MX2009005054A - Disacaridos de beta 1,6 glucosamina funcionalizados y procedimiento para su preparacion. - Google Patents

Disacaridos de beta 1,6 glucosamina funcionalizados y procedimiento para su preparacion.

Info

Publication number
MX2009005054A
MX2009005054A MX2009005054A MX2009005054A MX2009005054A MX 2009005054 A MX2009005054 A MX 2009005054A MX 2009005054 A MX2009005054 A MX 2009005054A MX 2009005054 A MX2009005054 A MX 2009005054A MX 2009005054 A MX2009005054 A MX 2009005054A
Authority
MX
Mexico
Prior art keywords
preparation
disaccharides
glucosamine disaccharides
functionalized beta
compounds
Prior art date
Application number
MX2009005054A
Other languages
English (en)
Inventor
Stephane Moutel
Jacques Bauer
Carlo Chiavaroli
Original Assignee
Om Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Om Pharma filed Critical Om Pharma
Publication of MX2009005054A publication Critical patent/MX2009005054A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un nuevo procedimiento para la síntesis química de disacáridos de glucosamina enlazados a ß-(1?6) de fórmula (1) y compuestos (intermediarios) relacionados con el procedimiento. De acuerdo con aspectos adicionales, la invención se refiere a composiciones que comprenden los compuestos y el uso de los compuestos en la síntesis de disacáridos y medicina.
MX2009005054A 2006-11-16 2007-11-15 Disacaridos de beta 1,6 glucosamina funcionalizados y procedimiento para su preparacion. MX2009005054A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2006/003244 WO2008059307A2 (en) 2006-11-16 2006-11-16 Functionalized beta 1,6 glucosamine disaccharides and process for their preparation
PCT/EP2007/062424 WO2008059035A2 (en) 2006-11-16 2007-11-15 Functionalized beta 1,6 glucosamine disaccharides and process for their preparation

Publications (1)

Publication Number Publication Date
MX2009005054A true MX2009005054A (es) 2009-12-18

Family

ID=39093051

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005054A MX2009005054A (es) 2006-11-16 2007-11-15 Disacaridos de beta 1,6 glucosamina funcionalizados y procedimiento para su preparacion.

Country Status (15)

Country Link
US (2) US20100168054A1 (es)
EP (1) EP2106403A2 (es)
JP (1) JP2010510190A (es)
KR (1) KR20090101162A (es)
CN (1) CN101627048A (es)
AR (1) AR063854A1 (es)
AU (1) AU2007321172A1 (es)
BR (1) BRPI0721482A2 (es)
CA (1) CA2669401A1 (es)
IL (1) IL198748A0 (es)
MX (1) MX2009005054A (es)
RU (1) RU2481352C2 (es)
TW (1) TW200838546A (es)
WO (2) WO2008059307A2 (es)
ZA (1) ZA200903340B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009034779A1 (de) 2009-07-25 2011-02-03 Emc Microcollections Gmbh Synthetische Analoga bakterieller Lipopeptide und ihre Anwendung zur Therapie und Prophylaxe allergischer Erkrankungen
WO2013033602A2 (en) * 2011-08-31 2013-03-07 Milne Jill C Fatty acid amides, compositions and methods of use
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
US9518078B2 (en) * 2012-04-12 2016-12-13 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
US20150133551A1 (en) * 2012-05-03 2015-05-14 Beth Israel Deaconess Medical Center, Inc. Lipids That Increase Insulin Sensitivity And Methods Of Using The Same
CN102977159A (zh) * 2012-11-18 2013-03-20 大连九信生物化工科技有限公司 一种苄醚保护d-氨基葡萄糖衍生物c3位上羟基的制备方法
EP3041478A4 (en) * 2013-09-05 2017-04-26 Immune Design Corp. Vaccine compositions for drug addiction
CN105461767B (zh) * 2014-08-07 2019-03-12 富力 一种连翘苷的化学合成方法
US11013711B2 (en) 2016-06-10 2021-05-25 Beth Israel Deaconess Medical Center, Inc. Fatty acid esters of hydroxy fatty acids (FAHFAs) for use in the treatment of type 1 diabetes
CN106496987A (zh) * 2016-12-09 2017-03-15 南京林业大学 一种聚乳酸/纤维低聚糖共混物材料及其制备方法
US20220339283A1 (en) * 2019-09-10 2022-10-27 The Penn State Research Foundation Lipopolysaccharide molecules for enhancing immune responses
CN111345426B (zh) * 2020-04-15 2023-06-30 中山市南方新元食品生物工程有限公司 一种食品保鲜剂
CN112175023A (zh) * 2020-10-31 2021-01-05 江南大学 一种脂肪醇乙酰壳二糖和脂肪醇n-乙酰葡糖胺的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4912094B1 (en) * 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
AU700485B2 (en) * 1993-11-17 1999-01-07 Om Pharma Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use
US5750664A (en) * 1995-06-05 1998-05-12 Eisai Co., Ltd. Substituted liposaccharides useful in the treatment and prevention of endotoxemia
JP2000226397A (ja) * 1998-11-30 2000-08-15 Otsuka Pharmaceut Factory Inc リピドａ中間体、その製法、リピドａ及びその誘導体の製法
BR0008146A (pt) * 1999-02-10 2002-01-15 Sankyo Co Composto, agente e uso de um composto
JP2000297096A (ja) * 1999-02-10 2000-10-24 Sankyo Co Ltd エーテル型リピッドａ１位カルボン酸類縁体
US7491707B1 (en) * 1999-11-15 2009-02-17 Biomira, Inc. Synthetic lipid-a-analogs and uses thereof
WO2006095270A1 (en) * 2005-03-10 2006-09-14 Om Pharma Combination anticancer therapy or om-174 and pharmaceutical compositions therefor

Also Published As

Publication number Publication date
AR063854A1 (es) 2009-02-25
CN101627048A (zh) 2010-01-13
TW200838546A (en) 2008-10-01
RU2009122714A (ru) 2010-12-27
EP2106403A2 (en) 2009-10-07
CA2669401A1 (en) 2008-05-22
ZA200903340B (en) 2010-10-27
IL198748A0 (en) 2010-02-17
US20100168054A1 (en) 2010-07-01
WO2008059035A3 (en) 2009-09-24
WO2008059307A2 (en) 2008-05-22
AU2007321172A1 (en) 2008-05-22
BRPI0721482A2 (pt) 2015-08-04
RU2481352C2 (ru) 2013-05-10
US20130035479A1 (en) 2013-02-07
KR20090101162A (ko) 2009-09-24
JP2010510190A (ja) 2010-04-02
WO2008059035A2 (en) 2008-05-22

Similar Documents

Publication Publication Date Title
MX2009005054A (es) Disacaridos de beta 1,6 glucosamina funcionalizados y procedimiento para su preparacion.
TNSN07360A1 (en) Substituted pyrrolo-pyridines, composition containing them, method for their producing and use thereof
TW200716121A (en) Acetylenyl-pyrazolo-pyrimidine derivatives as mGluR2 antagonists
IL265947A (en) Preparation of stansoporfin with a high degree of purification on a large scale
MY154464A (en) Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
TW200609235A (en) Tetraazabenzo[e]azulene derivatives and analogs thereof
JO2770B1 (en) Organic compounds
TW200702330A (en) 3,4,5-Substituted piperidines
BRPI0908926A2 (pt) Compostos de policarbonato-poliorganosiloxano e/ou poliuretano-poliorganosiloxano
HK1148517A1 (en) Tricyclic triazolic compounds
UA98623C2 (ru) Соединения диосметина, способ их получения и фармацевтическая композиция, которая их содержит
TW200714598A (en) Urea derivatives, methods for their manufacture, and uses therefor
UA89769C2 (ru) Каучуковая смесь, способ ее получения и применение
TW200640857A (en) Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefor and use thereof
WO2007083060A3 (fr) Derives de chalcone a activite antimitotique
MX2009004343A (es) Compuestos organicos.
MX2009008324A (es) Compuestos 6´-sustituidos que tienen afinidad con el receptor de 5-hidroxitriptamina-6.
SI1831239T1 (sl) Postopek za pripravo gamma laktona hidroksi beta beta beta beta bismetilen alfa pregn en on karboksilne kisline in ključniintermediati za ta postopek
WO2008059513A3 (en) Compounds suitable as modulators of hdl
TW200613315A (en) Estradiol prodrugs
MX2009013336A (es) Sintesis de 3-aminopirazoles sustituidos.
UA99904C2 (ru) Производство станнсопорфина высокой чистоты
HK1136288A1 (es)
WO2008010764A3 (en) A process for the preparation of substituted 2-acetylamino-alkoxyphenyl
WO2009156938A3 (en) A cost effective process for preparing 6,9-imino ether

Legal Events

Date Code Title Description
FA Abandonment or withdrawal