MX2009004700A - Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa. - Google Patents
Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa.Info
- Publication number
- MX2009004700A MX2009004700A MX2009004700A MX2009004700A MX2009004700A MX 2009004700 A MX2009004700 A MX 2009004700A MX 2009004700 A MX2009004700 A MX 2009004700A MX 2009004700 A MX2009004700 A MX 2009004700A MX 2009004700 A MX2009004700 A MX 2009004700A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazolo
- imidazo
- pyridazine
- protein kinase
- kinase inhibitors
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title abstract 2
- VTVRXITWWZGKHV-UHFFFAOYSA-N imidazo[1,2-b]pyridazine Chemical compound N1=CC=CC2=NC=CN21 VTVRXITWWZGKHV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003909 protein kinase inhibitor Substances 0.000 title abstract 2
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se relaciona con inhibidores de proteína cinasa que comprenden compuestos de imidazo[1,2-b]piridazina y pirazolo[1,5-a]pirimidina de la siguiente estructura (I) y (II) o un estereoisómero, fármaco precursor o una sal farmacéuticamente aceptable del mismo en donde R, R1, R2 y X son como se define en la presente. También se describen composiciones y métodos para utilizar las mismas en el tratamiento de cáncer y otras condiciones asociadas con Pim cinasa.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86456606P | 2006-11-06 | 2006-11-06 | |
US89252307P | 2007-03-01 | 2007-03-01 | |
US95798807P | 2007-08-24 | 2007-08-24 | |
PCT/US2007/083773 WO2008058126A2 (en) | 2006-11-06 | 2007-11-06 | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009004700A true MX2009004700A (es) | 2009-05-15 |
Family
ID=39277096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009004700A MX2009004700A (es) | 2006-11-06 | 2007-11-06 | Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa. |
Country Status (14)
Country | Link |
---|---|
US (3) | US7750007B2 (es) |
EP (1) | EP2086979B1 (es) |
JP (1) | JP5357763B2 (es) |
KR (1) | KR101546493B1 (es) |
CN (1) | CN101600718B (es) |
AU (1) | AU2007316417B2 (es) |
BR (1) | BRPI0718029A2 (es) |
CA (1) | CA2667487C (es) |
MX (1) | MX2009004700A (es) |
MY (1) | MY146474A (es) |
NZ (1) | NZ576234A (es) |
RU (1) | RU2487875C2 (es) |
SG (1) | SG176461A1 (es) |
WO (1) | WO2008058126A2 (es) |
Families Citing this family (115)
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JP2010509242A (ja) | 2010-03-25 |
US8710057B2 (en) | 2014-04-29 |
US7750007B2 (en) | 2010-07-06 |
AU2007316417B2 (en) | 2013-08-22 |
EP2086979A2 (en) | 2009-08-12 |
CA2667487A1 (en) | 2008-05-15 |
CN101600718A (zh) | 2009-12-09 |
EP2086979B1 (en) | 2015-06-03 |
RU2009121577A (ru) | 2010-12-20 |
CN101600718B (zh) | 2013-07-03 |
KR20090086219A (ko) | 2009-08-11 |
NZ576234A (en) | 2011-06-30 |
WO2008058126A2 (en) | 2008-05-15 |
US20080261988A1 (en) | 2008-10-23 |
US20110281863A1 (en) | 2011-11-17 |
MY146474A (en) | 2012-08-15 |
AU2007316417A1 (en) | 2008-05-15 |
KR101546493B1 (ko) | 2015-08-21 |
US20100227861A1 (en) | 2010-09-09 |
CA2667487C (en) | 2017-04-04 |
RU2487875C2 (ru) | 2013-07-20 |
BRPI0718029A2 (pt) | 2013-11-26 |
WO2008058126A3 (en) | 2008-06-26 |
SG176461A1 (en) | 2011-12-29 |
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