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MX2009003468A - Anticuerpo humanizado contra beta amiloide. - Google Patents

Anticuerpo humanizado contra beta amiloide.

Info

Publication number
MX2009003468A
MX2009003468A MX2009003468A MX2009003468A MX2009003468A MX 2009003468 A MX2009003468 A MX 2009003468A MX 2009003468 A MX2009003468 A MX 2009003468A MX 2009003468 A MX2009003468 A MX 2009003468A MX 2009003468 A MX2009003468 A MX 2009003468A
Authority
MX
Mexico
Prior art keywords
amyloid
disorders
amyloidosis
diseases
present
Prior art date
Application number
MX2009003468A
Other languages
English (en)
Inventor
Andrea Pfeifer
Andreas Muhs
Maria Pihlgren
Ryan Watts
Original Assignee
Ac Immune Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43063574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009003468(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2006/011862 external-priority patent/WO2007068412A2/en
Application filed by Ac Immune Sa filed Critical Ac Immune Sa
Priority claimed from PCT/US2007/021134 external-priority patent/WO2008060364A2/en
Publication of MX2009003468A publication Critical patent/MX2009003468A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a métodos y composiciones para uso terapéutico y de diagnóstico en el tratamiento de enfermedades y trastornos que se causan por o se asocian con proteínas amiloides o tipo amiloide que incluyen amidiosis, un grupo de trastornos y anormalidades asociadas con proteína amiloide tal como enfermedad de Alzheimer. La presente invención proporciona métodos novedosos y composiciones que comprenden anticuerpos altamente específicos y altamente efectivos que tienen la capacidad para reconocer específicamente y unirse a epítopos específicos de un intervalo de proteínas ß-amiloide. Los anticuerpos capacitados por la enseñanza de la presente invención son particularmente útiles par el tratamiento de enfermedades y trastornos que se cuasan por o se asocian con proteínas amiloides o tipo amiloides que incluyen amiloidosis, un grupo de enfermedades y trastornos asociados con formación de placa amiloide que incluye amiloidosis secundaria y amiloidosis relacionada con la edad que incluye, pero no se limita a, trastornos neurológicos tal como Enfermedad de Alzheimer (AD).
MX2009003468A 2006-07-14 2007-10-02 Anticuerpo humanizado contra beta amiloide. MX2009003468A (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP06014730 2006-07-14
EP06020765 2006-10-02
EP06020766 2006-10-02
PCT/EP2006/011862 WO2007068412A2 (en) 2005-12-12 2006-12-08 A beta 1-42 specific monoclonal antibodies with therapeutic properties
US94328907P 2007-06-11 2007-06-11
US94349907P 2007-06-12 2007-06-12
PCT/US2007/073504 WO2008011348A2 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
PCT/US2007/021134 WO2008060364A2 (en) 2006-10-02 2007-10-02 Humani zed antibody against amyloid beta

Publications (1)

Publication Number Publication Date
MX2009003468A true MX2009003468A (es) 2009-04-15

Family

ID=43063574

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009000476A MX2009000476A (es) 2006-07-14 2007-07-13 Anticuerpo humanizado contra beta amiloide.
MX2009003468A MX2009003468A (es) 2006-07-14 2007-10-02 Anticuerpo humanizado contra beta amiloide.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2009000476A MX2009000476A (es) 2006-07-14 2007-07-13 Anticuerpo humanizado contra beta amiloide.

Country Status (21)

Country Link
US (5) US7892544B2 (es)
EP (2) EP2468770B1 (es)
JP (1) JP5641737B2 (es)
KR (2) KR101605207B1 (es)
AR (1) AR062065A1 (es)
AU (1) AU2007275467B2 (es)
CA (1) CA2657681C (es)
CL (1) CL2007002070A1 (es)
CO (1) CO6150201A2 (es)
CR (1) CR10556A (es)
HR (1) HRP20090221B1 (es)
IL (1) IL196478B (es)
MA (1) MA30632B1 (es)
MX (2) MX2009000476A (es)
NO (2) NO344963B1 (es)
NZ (1) NZ574188A (es)
PL (2) PL2468770T3 (es)
RU (1) RU2498999C2 (es)
SG (1) SG173385A1 (es)
TW (1) TWI551607B (es)
WO (1) WO2008011348A2 (es)

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