MX2007010331A - Procedimiento de preparacion del docetaxel. - Google Patents
Procedimiento de preparacion del docetaxel.Info
- Publication number
- MX2007010331A MX2007010331A MX2007010331A MX2007010331A MX2007010331A MX 2007010331 A MX2007010331 A MX 2007010331A MX 2007010331 A MX2007010331 A MX 2007010331A MX 2007010331 A MX2007010331 A MX 2007010331A MX 2007010331 A MX2007010331 A MX 2007010331A
- Authority
- MX
- Mexico
- Prior art keywords
- docetaxel
- hydroxy functions
- amine
- paclitaxel
- protecting
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 3
- 229960003668 docetaxel Drugs 0.000 title abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229930012538 Paclitaxel Natural products 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 229960001592 paclitaxel Drugs 0.000 abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 2
- 150000004625 docetaxel anhydrous derivatives Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La invencion se refiere a un metodo para preparar docetaxel a partir de paclitaxel, en el que se incluyen los siguientes pasos: a)desacetilar el paclitaxel, b)proteger las funciones hidroxi libres, en las posiciones 7-, 10- y 2'- respectivamente, c)desbenzoilar la amina en la posicion 3'- en una amina primaria derivada del 10- diacetilbacatina en donde se protegen las funciones hidroxi en las posiciones 7-, 10, y 2', d)funcionalizar la amina por un radical ter-butoxicarbonilo para obtener el derivado de docetaxel de la formula general (1), en la cual X representa radicales o atomos de hidrogeno protegidos, y posteriormente, si se requiere e)liberar las funciones hidroxi inicialmente protegidas para obtener docetaxel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0501882A FR2882363B1 (fr) | 2005-02-24 | 2005-02-24 | Procede de preparation du docetaxel |
| PCT/FR2006/000386 WO2006090056A1 (fr) | 2005-02-24 | 2006-02-21 | Procede de preparation du docetaxel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007010331A true MX2007010331A (es) | 2008-03-04 |
Family
ID=35106645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007010331A MX2007010331A (es) | 2005-02-24 | 2006-02-21 | Procedimiento de preparacion del docetaxel. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20080200699A1 (es) |
| EP (1) | EP1856080B1 (es) |
| JP (1) | JP2008531527A (es) |
| KR (1) | KR20070108188A (es) |
| CN (1) | CN101128449A (es) |
| AT (1) | ATE490245T1 (es) |
| AU (1) | AU2006217803A1 (es) |
| BR (1) | BRPI0607989A2 (es) |
| CA (1) | CA2596696A1 (es) |
| DE (1) | DE602006018584D1 (es) |
| FR (1) | FR2882363B1 (es) |
| IL (1) | IL185464A0 (es) |
| MX (1) | MX2007010331A (es) |
| NO (1) | NO20074861L (es) |
| RU (1) | RU2007134454A (es) |
| WO (1) | WO2006090056A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2914642B1 (fr) * | 2007-04-03 | 2009-10-16 | Seripharm | Procede de preparation de taxanes 3'-n-substitues a partir du paclitaxel |
| PL388144A1 (pl) | 2009-05-29 | 2010-12-06 | Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością | Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie |
| CN103808851A (zh) * | 2012-11-15 | 2014-05-21 | 刘胜远 | 一种红豆杉中10-去乙酰基紫杉醇的薄层色谱检测方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679807A (en) * | 1995-01-30 | 1997-10-21 | Hauser, Inc. | Preparation of taxol and docetaxel through primary amines |
| US6891050B2 (en) * | 2001-08-10 | 2005-05-10 | Dabur India Limited | Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs |
| WO2004033442A2 (en) * | 2002-10-09 | 2004-04-22 | Chatham Biotec Ltd. | Novel taxanes and methods related to use and preparation thereof |
-
2005
- 2005-02-24 FR FR0501882A patent/FR2882363B1/fr not_active Expired - Fee Related
-
2006
- 2006-02-21 MX MX2007010331A patent/MX2007010331A/es unknown
- 2006-02-21 RU RU2007134454/04A patent/RU2007134454A/ru not_active Application Discontinuation
- 2006-02-21 WO PCT/FR2006/000386 patent/WO2006090056A1/fr active Application Filing
- 2006-02-21 US US11/816,915 patent/US20080200699A1/en not_active Abandoned
- 2006-02-21 AU AU2006217803A patent/AU2006217803A1/en not_active Abandoned
- 2006-02-21 AT AT06709352T patent/ATE490245T1/de not_active IP Right Cessation
- 2006-02-21 DE DE602006018584T patent/DE602006018584D1/de active Active
- 2006-02-21 JP JP2007556632A patent/JP2008531527A/ja active Pending
- 2006-02-21 CN CNA2006800059812A patent/CN101128449A/zh active Pending
- 2006-02-21 EP EP06709352A patent/EP1856080B1/fr not_active Revoked
- 2006-02-21 KR KR1020077019470A patent/KR20070108188A/ko not_active Withdrawn
- 2006-02-21 CA CA002596696A patent/CA2596696A1/fr not_active Abandoned
- 2006-02-21 BR BRPI0607989-0A patent/BRPI0607989A2/pt not_active Application Discontinuation
-
2007
- 2007-08-22 IL IL185464A patent/IL185464A0/en unknown
- 2007-09-24 NO NO20074861A patent/NO20074861L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2596696A1 (fr) | 2006-08-31 |
| WO2006090056A1 (fr) | 2006-08-31 |
| JP2008531527A (ja) | 2008-08-14 |
| NO20074861L (no) | 2007-11-26 |
| EP1856080A1 (fr) | 2007-11-21 |
| FR2882363B1 (fr) | 2007-05-11 |
| FR2882363A1 (fr) | 2006-08-25 |
| US20080200699A1 (en) | 2008-08-21 |
| DE602006018584D1 (de) | 2011-01-13 |
| EP1856080B1 (fr) | 2010-12-01 |
| KR20070108188A (ko) | 2007-11-08 |
| IL185464A0 (en) | 2008-01-06 |
| RU2007134454A (ru) | 2009-03-27 |
| CN101128449A (zh) | 2008-02-20 |
| BRPI0607989A2 (pt) | 2009-10-27 |
| ATE490245T1 (de) | 2010-12-15 |
| AU2006217803A1 (en) | 2006-08-31 |
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