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MX2007001337A - Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos. - Google Patents

Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos.

Info

Publication number
MX2007001337A
MX2007001337A MX2007001337A MX2007001337A MX2007001337A MX 2007001337 A MX2007001337 A MX 2007001337A MX 2007001337 A MX2007001337 A MX 2007001337A MX 2007001337 A MX2007001337 A MX 2007001337A MX 2007001337 A MX2007001337 A MX 2007001337A
Authority
MX
Mexico
Prior art keywords
containing amine
compounds
amine oxidases
inhibiting copper
copper
Prior art date
Application number
MX2007001337A
Other languages
English (en)
Inventor
Fernando Albericio Palomera
Miriam Royo Exposito
Luc Marti Clauzel
Silvia Garcia Vicente
Antonio Zorzano Olarte
Francesc Yraola Font
Original Assignee
Genmedica Therapeutics Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genmedica Therapeutics Sl filed Critical Genmedica Therapeutics Sl
Publication of MX2007001337A publication Critical patent/MX2007001337A/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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Abstract

Esta invencion se refiere a inhibidores de amina-oxidasas que contienen cobre (E.C.1.4.3.6) que incluyen amina-oxidasa sensible a semicarbazida (SSAO; tambien conocida como proteina-1 de adhesion vascular, VAP-1), y su uso farmaceutico en enfermedades inflamatorios, diabetes y sus complicaciones asociadas, aterosclerosis, enfermedades neurodegenerativas, obesidad, hipertension y cancer.
MX2007001337A 2004-08-02 2005-08-02 Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos. MX2007001337A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59801004P 2004-08-02 2004-08-02
PCT/EP2005/053778 WO2006013209A2 (en) 2004-08-02 2005-08-02 Compounds for inhibiting copper-containing amine oxidases and uses thereof

Publications (1)

Publication Number Publication Date
MX2007001337A true MX2007001337A (es) 2008-03-13

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MX2007001337A MX2007001337A (es) 2004-08-02 2005-08-02 Compuestos para inhibir amina-oxidasas que contienen cobre y usos de los mismos.

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Country Link
US (1) US20080269282A1 (es)
EP (1) EP1796681A2 (es)
JP (1) JP2008508348A (es)
CN (1) CN101087601A (es)
AU (1) AU2005268781A1 (es)
CA (1) CA2575928A1 (es)
MX (1) MX2007001337A (es)
WO (1) WO2006013209A2 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP2332919A3 (en) 2003-06-17 2011-10-19 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
ES2332009T3 (es) 2004-12-21 2010-01-22 Arena Pharmaceuticals, Inc. Formas cristalinas de hidrocloruro de (r)-8-cloro-1-metil-2,3,4,5-tetrahidro-1h-3-benzazepina.
EA015012B1 (ru) 2004-12-23 2011-04-29 Арена Фармасьютикалз, Инк. Композиция, содержащая фентермин и избирательный агонист рецептора 5ht, и ее применение
WO2006071960A2 (en) 2004-12-28 2006-07-06 Kinex Pharmaceuticals, Llc Compositions and methods of treating cell proliferation disorders
US7968574B2 (en) * 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
WO2007030617A1 (en) * 2005-09-09 2007-03-15 Vertex Pharmaceuticals Incorporated Inhibitors of bacterial impdh
WO2007069020A2 (en) * 2005-12-15 2007-06-21 Vicuron Pharmaceuticals Inc. N-hydroxyamide derivatives possessing antibacterial activity
EP2471779A1 (en) 2006-04-03 2012-07-04 Arena Pharmaceuticals, Inc. Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP2041071B1 (en) 2006-06-29 2014-06-18 Kinex Pharmaceuticals, LLC Biaryl compositions and methods for modulating a kinase cascade
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
FI20070820A0 (fi) * 2007-10-30 2007-10-30 Faron Ventures Oy Menetelmä angiogeneesin estoon tai syövän hoitoon
US20090170770A1 (en) * 2007-11-06 2009-07-02 Ali Hafezi-Moghadam Methods and compositions for treating conditions associated with angiogenesis using a vascular adhesion protein-1 (vap 1) inhibitor
KR20100117137A (ko) * 2008-02-27 2010-11-02 메르크 파텐트 게엠베하 당뇨병 치료를 위한 카르복사마이드-헤테로아릴유도체
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
AU2009248057B2 (en) * 2008-05-13 2013-02-21 Genmedica Therapeutics Sl Salicylate conjugates useful for treating metabolic disorders
EA201100187A1 (ru) * 2008-07-14 2011-10-31 Новартис Аг Селективные ингибиторы ммр-12 и ммр-13 на основе гидроксамовой кислоты
RU2499790C2 (ru) * 2008-09-18 2013-11-27 Ниппон Дзоки Фармасьютикал Ко., Лтд. Производное аминокислоты
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
UA112154C2 (uk) 2009-09-08 2016-08-10 Біоті Терапіс Корп. Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів
PT2479165T (pt) 2009-09-16 2017-12-19 Astellas Pharma Inc Composto de glicina
US8524909B2 (en) * 2010-02-02 2013-09-03 Hoffmann-La Roche Inc. Tetrahydro-pyran derivatives
US8575170B2 (en) 2010-02-26 2013-11-05 The Regents Of The Unversity Of Colorado, A Body Corporate Flurbiprofen analogs and methods of use in treating cancer
JP5210405B2 (ja) * 2010-03-17 2013-06-12 日本臓器製薬株式会社 アミノ酸誘導体を含有する医薬及び該誘導体の製造方法
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
EA201390335A1 (ru) 2010-09-01 2013-09-30 Арена Фармасьютикалз, Инк. Введение лоркасерина индивидуумам с почечной недостаточностью
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
AU2011296014A1 (en) 2010-09-01 2013-04-04 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
AU2011296003B2 (en) 2010-09-01 2015-11-12 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-HT2C agonist useful for weight management
FR2985259B1 (fr) 2012-01-03 2016-12-09 Centre Nat De La Rech Scient - Cnrs - Peptides c-alpha-amides, leurs procedes de preparation et leurs utilisations comme precurseurs de peptides c-alpha-thioesters pour la synthese de proteines.
US9409858B2 (en) 2012-03-07 2016-08-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. Selective histone deactylase 6 inhibitors
WO2013134467A1 (en) * 2012-03-07 2013-09-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Selective histone deactylase 6 inhibitors
JP2015534563A (ja) 2012-10-09 2015-12-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 体重管理の方法
GB201304526D0 (en) 2013-03-13 2013-04-24 Proximagen Ltd New compounds
CA2915163A1 (en) 2013-06-12 2014-12-18 Proximagen Limited New therapeutic uses of enzyme inhibitors
WO2015017546A1 (en) 2013-07-30 2015-02-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Selective histone deactylase 6 inhibitors
ES2714125T3 (es) 2014-04-15 2019-05-27 Pecsi Tudomanyegyetem Inhibidores de la amino oxidasa sensible a la semicarbazida para uso como analgésicos en una neuropatía traumática y una inflamación neurogénica
WO2015189534A1 (en) 2014-06-12 2015-12-17 Proximagen Limited Vap-1 inhibitors for treating muscular dystrophy
CN104402785A (zh) * 2014-09-26 2015-03-11 南开大学 新型双酰胺衍生物及其制备和应用
WO2017098236A1 (en) 2015-12-07 2017-06-15 Proximagen Limited Vap-1 inhibitors for treating pain
EP3967679B1 (en) * 2016-04-18 2025-02-19 Vivoryon Therapeutics AG Novel inhibitors of meprin alpha and beta
WO2018048930A1 (en) * 2016-09-07 2018-03-15 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
GB201709136D0 (en) * 2017-06-08 2017-07-26 Proximagen Ltd New therapeutic uses of enzyme inhibitors
WO2019169011A1 (en) * 2018-02-28 2019-09-06 Bioxiness Pharmaceuticals, Inc. Chemotherapeutic oligopeptide mimetics
CN108821999A (zh) * 2018-04-26 2018-11-16 南昌大学 一种氨基酸异羟肟酸类氨肽酶n抑制剂及制备方法
WO2023191425A1 (ko) * 2022-03-28 2023-10-05 주식회사 비엔에이치리서치 약물의 전기생리학적 스크리닝 방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839580A (en) * 1972-08-14 1974-10-01 Morton Norwich Products Inc 2-p-(nitrobenzamido)acetohydroxamic for treating urinary tract infections
US5055451A (en) * 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
FR2669029B1 (fr) * 1990-11-14 1994-09-02 Adir Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US6124333A (en) * 1995-06-22 2000-09-26 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
CA2242416C (en) * 1996-01-23 2006-03-21 Shionogi & Co., Ltd. Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
AU737117B2 (en) * 1996-12-17 2001-08-09 Warner-Lambert Company Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing
AU746877B2 (en) * 1997-07-31 2002-05-02 Procter & Gamble Company, The Acyclic metalloprotease inhibitors
DE69808518T2 (de) * 1997-12-23 2003-06-26 Warner-Lambert Co., Morris Plains Ace hemmer/matrix metalloproteinase hemmer-arzneimittelkombinationen
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6211384B1 (en) * 1999-08-30 2001-04-03 Novartis Pharmaceuticals Corp. Methods for the acylation of amine compounds
KR20030030036A (ko) * 2000-09-29 2003-04-16 시오노기세이야쿠가부시키가이샤 티아졸 또는 옥사졸 유도체
JP2007523955A (ja) * 2004-02-25 2007-08-23 ラ ホヤ ファーマシューティカル カンパニー 疾患の治療のためのアミンおよびアミド
US20070066646A1 (en) * 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof

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