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MA44656A - 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones et 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones en tant qu'inhibiteurs de pde1 - Google Patents

1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones et 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones en tant qu'inhibiteurs de pde1

Info

Publication number
MA44656A
MA44656A MA044656A MA44656A MA44656A MA 44656 A MA44656 A MA 44656A MA 044656 A MA044656 A MA 044656A MA 44656 A MA44656 A MA 44656A MA 44656 A MA44656 A MA 44656A
Authority
MA
Morocco
Prior art keywords
pyrazolo
dihydro
ones
pyrimidin
pyridin
Prior art date
Application number
MA044656A
Other languages
English (en)
Other versions
MA44656B1 (fr
Inventor
Mikkel Jessing
Karsten Juhl
Jan Kehler
Morten Langgård
Mauro Marigo
Lars Kyhn Rasmussen
Paulo Jorge Vieira Vital
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MA44656A publication Critical patent/MA44656A/fr
Publication of MA44656B1 publication Critical patent/MA44656B1/fr

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones et des 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones de formule (i) en tant qu'inhibiteurs de pde1 et leur utilisation en tant que médicament, en particulier pour le traitement de troubles neurodégénératifs et de troubles psychiatriques.
MA44656A 2016-04-12 2017-04-07 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones et 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones en tant qu'inhibiteurs de pde1 MA44656B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201600221 2016-04-12
PCT/EP2017/058332 WO2017178350A1 (fr) 2016-04-12 2017-04-07 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones et 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones en tant qu'inhibiteurs de pde1

Publications (2)

Publication Number Publication Date
MA44656A true MA44656A (fr) 2019-02-20
MA44656B1 MA44656B1 (fr) 2020-10-28

Family

ID=58489694

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44656A MA44656B1 (fr) 2016-04-12 2017-04-07 1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones et 1,5-dihydro-4h-pyrazolo[4,3-c]pyridin-4-ones en tant qu'inhibiteurs de pde1

Country Status (43)

Country Link
US (3) US20170291901A1 (fr)
EP (1) EP3442975B1 (fr)
JP (1) JP7093306B2 (fr)
KR (1) KR20180133413A (fr)
CN (1) CN109071549B (fr)
AR (1) AR108109A1 (fr)
AU (1) AU2017250431B2 (fr)
BR (1) BR112017026278A2 (fr)
CA (1) CA3020053A1 (fr)
CL (1) CL2018002881A1 (fr)
CO (1) CO2018010323A2 (fr)
CR (1) CR20180470A (fr)
CY (1) CY1123269T1 (fr)
DK (1) DK3442975T3 (fr)
DO (1) DOP2018000201A (fr)
EA (1) EA035197B1 (fr)
EC (1) ECSP18074641A (fr)
ES (1) ES2814289T3 (fr)
GE (1) GEP20207057B (fr)
HR (1) HRP20201331T1 (fr)
HU (1) HUE050320T2 (fr)
IL (1) IL262257B (fr)
LT (1) LT3442975T (fr)
MA (1) MA44656B1 (fr)
ME (1) ME03820B (fr)
MX (1) MX374251B (fr)
MY (1) MY194722A (fr)
NI (1) NI201800092A (fr)
PE (1) PE20181853A1 (fr)
PH (1) PH12018502168A1 (fr)
PL (1) PL3442975T3 (fr)
PT (1) PT3442975T (fr)
RS (1) RS60714B1 (fr)
RU (1) RU2018133391A (fr)
SG (1) SG11201808221QA (fr)
SI (1) SI3442975T1 (fr)
SM (1) SMT202000446T1 (fr)
SV (1) SV2018005753A (fr)
TN (1) TN2018000321A1 (fr)
TW (1) TWI729109B (fr)
UA (1) UA121925C2 (fr)
WO (1) WO2017178350A1 (fr)
ZA (1) ZA201806407B (fr)

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TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
EP3529250B1 (fr) 2016-10-18 2023-12-06 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones et pyrazolopyridinones en tant qu'inhibiteurs de pde1
MX2019004859A (es) 2016-10-28 2019-06-20 H Lundbeck As Tratamientos de combinacion que comprenden la administracion de imidazopirazinonas.
MX2019004763A (es) 2016-10-28 2019-07-01 H Lundbeck As Tratamientos de combinacion que comprenden imidazopirazinonas para el tratamiento de trastornos psiquiatricos y/o cognitivos.
KR102590848B1 (ko) 2016-12-28 2023-10-19 다트 뉴로사이언스, 엘엘씨 Pde2 억제제로서 치환된 피라졸로피리미디논 화합물
CA3120971A1 (fr) 2017-11-27 2019-05-31 Dart Neuroscience, Llc Composes furanopyrimidine substitues utilises en tant qu'inhibiteurs de pde1
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EP3529250B1 (fr) 2016-10-18 2023-12-06 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones et pyrazolopyridinones en tant qu'inhibiteurs de pde1
MX2019004763A (es) 2016-10-28 2019-07-01 H Lundbeck As Tratamientos de combinacion que comprenden imidazopirazinonas para el tratamiento de trastornos psiquiatricos y/o cognitivos.
MX2019004859A (es) 2016-10-28 2019-06-20 H Lundbeck As Tratamientos de combinacion que comprenden la administracion de imidazopirazinonas.

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EP3442975A1 (fr) 2019-02-20
CO2018010323A2 (es) 2018-12-14
ZA201806407B (en) 2019-12-18
RS60714B1 (sr) 2020-09-30
PL3442975T3 (pl) 2020-11-16
WO2017178350A1 (fr) 2017-10-19
SI3442975T1 (sl) 2020-10-30
PT3442975T (pt) 2020-09-03
US20170291901A1 (en) 2017-10-12
IL262257B (en) 2020-11-30
MX2018012496A (es) 2019-02-21
KR20180133413A (ko) 2018-12-14
TWI729109B (zh) 2021-06-01
CA3020053A1 (fr) 2017-10-19
EA035197B1 (ru) 2020-05-14
SV2018005753A (es) 2018-11-27
MX374251B (es) 2025-03-05
RU2018133391A3 (fr) 2020-06-23
EP3442975B1 (fr) 2020-07-29
IL262257A (en) 2018-11-29
EA201891897A1 (ru) 2019-03-29
CR20180470A (es) 2018-12-21
US20200102316A1 (en) 2020-04-02
SMT202000446T1 (it) 2020-09-10
AR108109A1 (es) 2018-07-18
ME03820B (fr) 2021-04-20
DOP2018000201A (es) 2018-11-15
CY1123269T1 (el) 2021-12-31
CN109071549B (zh) 2021-11-30
LT3442975T (lt) 2020-09-25
PE20181853A1 (es) 2018-12-03
BR112017026278A2 (pt) 2018-09-11
AU2017250431B2 (en) 2020-07-16
MA44656B1 (fr) 2020-10-28
CL2018002881A1 (es) 2018-12-14
TW201738242A (zh) 2017-11-01
MY194722A (en) 2022-12-15
TN2018000321A1 (en) 2020-01-16
RU2018133391A (ru) 2020-05-12
ECSP18074641A (es) 2018-10-31
JP7093306B2 (ja) 2022-06-29
JP2019517996A (ja) 2019-06-27
US11104680B2 (en) 2021-08-31
HUE050320T2 (hu) 2020-11-30
UA121925C2 (uk) 2020-08-10
SG11201808221QA (en) 2018-10-30
ES2814289T3 (es) 2021-03-26
GEP20207057B (en) 2020-01-27
PH12018502168A1 (en) 2019-08-19
NI201800092A (es) 2019-03-14
US20190194204A1 (en) 2019-06-27
CN109071549A (zh) 2018-12-21
AU2017250431A1 (en) 2018-10-11
DK3442975T3 (da) 2020-08-24
HRP20201331T1 (hr) 2020-11-27
US10538525B2 (en) 2020-01-21

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