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MA38859B1 - Anticorps anti-c5 présentant une pharmacocinétique améliorée - Google Patents

Anticorps anti-c5 présentant une pharmacocinétique améliorée

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Publication number
MA38859B1
MA38859B1 MA38859A MA38859A MA38859B1 MA 38859 B1 MA38859 B1 MA 38859B1 MA 38859 A MA38859 A MA 38859A MA 38859 A MA38859 A MA 38859A MA 38859 B1 MA38859 B1 MA 38859B1
Authority
MA
Morocco
Prior art keywords
antibodies
improved pharmacokinetics
complement
anaphylatoxin
inhibiting
Prior art date
Application number
MA38859A
Other languages
English (en)
Other versions
MA38859A (fr
Inventor
Douglas L Sheridan
Bruce A Andrien
Paul P Tamburini
Original Assignee
Alexion Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Publication of MA38859A publication Critical patent/MA38859A/fr
Publication of MA38859B1 publication Critical patent/MA38859B1/fr

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Abstract

La présente invention concerne des anticorps qui sont utiles, entre autres, pour inhiber la fraction terminale du complément (par exemple l'assemblage et/ou l'activité du c5b -9 tcc) et l'inflammation médiée par l'anaphylatoxine c5a et, par conséquent, le traitement de troubles associés au complément. Les anticorps ont un certain nombre de propriétés améliorées par rapport à l'eculizumab, comprenant, par exemple, demi-vie sérique accrue dans un être humain.
MA38859A 2014-03-07 2015-03-06 Anticorps anti-c5 présentant une pharmacocinétique améliorée MA38859B1 (fr)

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