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ES2054667T3 - Anticuerpos monoclonales contra c5a y des-arg74-c5a, su produccion y uso. - Google Patents

Anticuerpos monoclonales contra c5a y des-arg74-c5a, su produccion y uso.

Info

Publication number
ES2054667T3
ES2054667T3 ES87303762T ES87303762T ES2054667T3 ES 2054667 T3 ES2054667 T3 ES 2054667T3 ES 87303762 T ES87303762 T ES 87303762T ES 87303762 T ES87303762 T ES 87303762T ES 2054667 T3 ES2054667 T3 ES 2054667T3
Authority
ES
Spain
Prior art keywords
arg74
des
monoclonal antibodies
production
antibodies against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87303762T
Other languages
English (en)
Inventor
James W Larrick
Brian M Fendly
Tracey E Deinhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cetus Oncology Corp
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Application granted granted Critical
Publication of ES2054667T3 publication Critical patent/ES2054667T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE PRODUCEN ANTICUERPOS MONOCLONALES QUE SE CARACTERIZA POR SU APTITUD PARA COMBINARSE CON EL COMPONENTE DEL COMPLEMENTO HUMANO C5A. ESTOS ANTICUERPOS SON PARTICULARMENTE UTILES PARA EL TRATAMIENTO DE ESTADOS ASOCIADOS CON LA ACTIVACION DEL COMPLEMENTO INTRAVASCULAR NOCIVA O CAUSADOS POR ELLA. ADEMAS, ESTOS ANTICUERPOS PUEDEN UTILIZARSE EN UN METODO INMUNOLOGICO O DE INMUNODIAGNOSTICO PARA DETECTAR C5A O DES-ARG74-C5A EN HUMANOS EN FLUIDOS.
ES87303762T 1986-04-28 1987-04-28 Anticuerpos monoclonales contra c5a y des-arg74-c5a, su produccion y uso. Expired - Lifetime ES2054667T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85678086A 1986-04-28 1986-04-28
US94783986A 1986-12-30 1986-12-30

Publications (1)

Publication Number Publication Date
ES2054667T3 true ES2054667T3 (es) 1994-08-16

Family

ID=27127377

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87303762T Expired - Lifetime ES2054667T3 (es) 1986-04-28 1987-04-28 Anticuerpos monoclonales contra c5a y des-arg74-c5a, su produccion y uso.

Country Status (4)

Country Link
EP (1) EP0245993B1 (es)
JP (2) JP2703764B2 (es)
DE (1) DE3785967T2 (es)
ES (1) ES2054667T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO162210C (no) * 1987-07-20 1989-11-22 Fasting Biotech As Monoklonale antistoffer mot c5a for in-vitro anvendelse ved immunologiske kvantitative teknikker eller ved isolering av c5a.
DE3924924A1 (de) * 1989-07-27 1991-02-07 Goetze Otto Verfahren zum nachweis und/oder der quantitativen bestimmung von komplementpeptid c5a und/oder c5adesarg
US5837499A (en) * 1993-12-06 1998-11-17 Ciba-Geigy Corporation DNA encoding C5A receptor antagonists having substantially no agonist activity and methods of expressing same
HUT75990A (en) * 1993-12-06 1997-05-28 Ciba Geigy Ag C5a receptor antagonists having substantially no agonist activity
US5807824A (en) * 1993-12-06 1998-09-15 Ciba-Geigy Corporation C5A receptor antagonists having substantially no agonist activity
EP0777474B1 (en) 1994-09-23 2005-12-21 Alexion Pharmaceuticals, Inc. Methods for the treatment of inflammatory joint disease
US6673346B1 (en) 1999-08-31 2004-01-06 The Regents Of The University Of Michigan Compositions and methods for the treatment of sepsis
US7432356B2 (en) * 2001-08-17 2008-10-07 Genentech, Inc. Complement pathway inhibitors binding to C5 and C5a without preventing formation of C5b
WO2004043223A2 (en) * 2002-11-05 2004-05-27 The Regents Of The University Of Michigan Compositions and methods for the diagnosis and treatment of sepsis
ES2387275T3 (es) 2003-05-15 2012-09-19 Genentech, Inc. Métodos y composiciones para la prevención y el tratamiento de la sepsis
PT2563813E (pt) 2010-04-30 2015-11-26 Alexion Pharma Inc Anticorpos anti-c5a e métodos para utilização dos anticorpos
EP2468295A1 (en) 2010-12-21 2012-06-27 Affiris AG Vaccines based on peptides of the complement protein C5a
EP2666785A1 (en) 2012-05-23 2013-11-27 Affiris AG Complement component C5a-based vaccine
JP6463359B2 (ja) 2013-08-12 2019-01-30 ジェネンテック， インコーポレイテッド 補体関連病態を治療するための組成物及び方法
NZ711451A (en) * 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
MX2016014160A (es) 2014-05-01 2017-02-16 Genentech Inc Variantes del anticuerpo anti-factor d y sus usos.
EP3368090A1 (en) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
EP3368074A2 (en) 2015-10-30 2018-09-05 Hoffmann-La Roche AG Anti-factor d antibodies and conjugates
JP6923212B2 (ja) * 2016-02-17 2021-08-18 国立大学法人 東京医科歯科大学 動脈硬化性疾患の発症の予測因子および検査方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0776240B2 (ja) * 1983-05-06 1995-08-16 ベロス グル−プ エンドトキシンコア−と反応性のモノクロ−ナル抗体

Also Published As

Publication number Publication date
JPH10130167A (ja) 1998-05-19
DE3785967D1 (de) 1993-07-01
JPS62269699A (ja) 1987-11-24
EP0245993A3 (en) 1989-07-26
DE3785967T2 (de) 1993-12-02
JP2820402B2 (ja) 1998-11-05
EP0245993B1 (en) 1993-05-26
EP0245993A2 (en) 1987-11-19
JP2703764B2 (ja) 1998-01-26

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