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MA26976A1 - Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules - Google Patents

Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules

Info

Publication number
MA26976A1
MA26976A1 MA27207A MA27207A MA26976A1 MA 26976 A1 MA26976 A1 MA 26976A1 MA 27207 A MA27207 A MA 27207A MA 27207 A MA27207 A MA 27207A MA 26976 A1 MA26976 A1 MA 26976A1
Authority
MA
Morocco
Prior art keywords
preparation
cell proliferation
proliferation inhibitors
tetrahydropyridine derivatives
tetrahydropyridine
Prior art date
Application number
MA27207A
Other languages
English (en)
Inventor
Guy Georges
Adelbert Grossmann
Olaf Mundigl
Der Saal Wolfgang Von
Tim Sattelkau
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26976A1 publication Critical patent/MA26976A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
MA27207A 2000-12-23 2003-06-20 Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules MA26976A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00128487 2000-12-23

Publications (1)

Publication Number Publication Date
MA26976A1 true MA26976A1 (fr) 2004-12-20

Family

ID=8170814

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27207A MA26976A1 (fr) 2000-12-23 2003-06-20 Derives du tetrahydropyridine, leur preparation et leur utilisation comme inhibiteur de proliferation de cellules

Country Status (27)

Country Link
US (1) US6800638B2 (fr)
EP (1) EP1353921B1 (fr)
JP (1) JP2004516325A (fr)
KR (1) KR100836545B1 (fr)
CN (1) CN1213046C (fr)
AR (1) AR035513A1 (fr)
AT (1) ATE323700T1 (fr)
AU (1) AU2002226397B2 (fr)
BG (1) BG107935A (fr)
BR (1) BR0116402A (fr)
CA (1) CA2431471A1 (fr)
CZ (1) CZ20031940A3 (fr)
DE (1) DE60118975T2 (fr)
EC (1) ECSP034664A (fr)
ES (1) ES2261519T3 (fr)
HU (1) HUP0400554A2 (fr)
IL (1) IL156131A0 (fr)
MA (1) MA26976A1 (fr)
MX (1) MXPA03005713A (fr)
NO (1) NO20032830L (fr)
NZ (1) NZ526189A (fr)
PL (1) PL365531A1 (fr)
RU (1) RU2276140C2 (fr)
SK (1) SK9122003A3 (fr)
WO (1) WO2002051842A1 (fr)
YU (1) YU48803A (fr)
ZA (1) ZA200304264B (fr)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
WO2003032921A2 (fr) 2001-10-16 2003-04-24 Sloan-Kettering Institute For Cancer Research Traitement des maladies neurodegeneratives et du cancer du cerveau
WO2003083323A1 (fr) 2002-04-01 2003-10-09 Ranko Rakanovic Élément élastique en caoutchouc
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
AU2003900608A0 (en) * 2003-02-11 2003-02-27 Fujisawa Pharmaceutical Co., Ltd. Hdac inhibitor
US7169801B2 (en) 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20060235012A1 (en) * 2003-06-16 2006-10-19 Chroma Therapeutics Limited Carboline and betacarboline derivatives for use as hdac enzyme inhibitors
JP2007512367A (ja) * 2003-11-26 2007-05-17 エートン ファーマ インコーポレーティッド ジアミンおよびイミノ二酢酸ヒドロキサム酸誘導体
WO2005065681A1 (fr) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Derives de n-hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide et composes associes en tant qu'inhibiteurs d'histone deacetylase pour le traitement du cancer
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
WO2006066133A2 (fr) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
JP2008530136A (ja) 2005-02-14 2008-08-07 ミイカナ セラピューティクス インコーポレイテッド ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
EP1896436A2 (fr) * 2005-05-11 2008-03-12 Takeda San Diego, Inc. Inhibiteurs d'histone deacetylase
JP2009501236A (ja) * 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
EP1928437A2 (fr) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenese par modulation du recepteur muscarinique
CA2625153A1 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
JP2009525955A (ja) * 2006-01-13 2009-07-16 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (fr) 2006-05-09 2011-10-19 Braincells, Inc. Neurogénèse par modulation de l'angiotensine
CA2651862A1 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenese induite par le recepteur 5ht
EP2068872A1 (fr) 2006-09-08 2009-06-17 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TWI425945B (zh) * 2007-05-28 2014-02-11 Seldar Pharma Inc 四氫異喹啉－１－酮衍生物或其鹽
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
JP5838157B2 (ja) * 2009-07-22 2015-12-24 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ Ｈｄａｃ阻害剤およびそれを用いる治療法
CN102153549B (zh) * 2010-12-14 2012-11-14 华东理工大学 γ咔啉化合物、制备方法和用途
MY184756A (en) 2013-04-29 2021-04-20 Chong Kun Dang Pharmaceutical Corp Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same
WO2015051035A1 (fr) 2013-10-01 2015-04-09 The J. David Gladstone Institutes Compositions, systèmes et procédés pour le criblage de médicament de bruit d'expression génétique et leurs utilisations
CN108084178B (zh) * 2018-01-04 2020-09-01 济南大学 一类含有四氢-β-咔碄结构的异羟肟酸类化合物的用途
CN108558653A (zh) * 2018-05-14 2018-09-21 湖南华腾制药有限公司 赛乐西帕中间体及赛乐西帕的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002119A1 (fr) * 1988-08-18 1990-03-08 Banyu Pharmaceutical Co., Ltd. Derives de 1,2,3,4-tetrahydro-isoquinoline
US5369108A (en) * 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
WO1998007421A1 (fr) 1996-08-16 1998-02-26 Ishihara Sangyo Kaisha, Ltd. Composition medicinale
WO1998015525A1 (fr) * 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Acides hydroxamiques
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
US6465468B1 (en) * 1999-03-22 2002-10-15 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives

Also Published As

Publication number Publication date
BG107935A (bg) 2004-08-31
KR100836545B1 (ko) 2008-06-10
KR20030063424A (ko) 2003-07-28
PL365531A1 (en) 2005-01-10
US6800638B2 (en) 2004-10-05
ES2261519T3 (es) 2006-11-16
ECSP034664A (es) 2003-07-25
CN1483033A (zh) 2004-03-17
CA2431471A1 (fr) 2002-07-04
NO20032830D0 (no) 2003-06-20
HUP0400554A2 (hu) 2004-06-28
AR035513A1 (es) 2004-06-02
JP2004516325A (ja) 2004-06-03
NO20032830L (no) 2003-08-04
AU2002226397B2 (en) 2006-10-05
CN1213046C (zh) 2005-08-03
ZA200304264B (en) 2004-08-30
SK9122003A3 (en) 2004-02-03
EP1353921A1 (fr) 2003-10-22
CZ20031940A3 (cs) 2003-10-15
RU2276140C2 (ru) 2006-05-10
YU48803A (sh) 2006-05-25
EP1353921B1 (fr) 2006-04-19
BR0116402A (pt) 2003-11-11
DE60118975T2 (de) 2006-12-21
IL156131A0 (en) 2003-12-23
DE60118975D1 (de) 2006-05-24
WO2002051842A1 (fr) 2002-07-04
ATE323700T1 (de) 2006-05-15
NZ526189A (en) 2004-10-29
MXPA03005713A (es) 2003-10-06
RU2003122190A (ru) 2005-02-27
US20040053960A1 (en) 2004-03-18

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