[go: up one dir, main page]

AU2003900608A0 - Hdac inhibitor - Google Patents

Hdac inhibitor

Info

Publication number
AU2003900608A0
AU2003900608A0 AU2003900608A AU2003900608A AU2003900608A0 AU 2003900608 A0 AU2003900608 A0 AU 2003900608A0 AU 2003900608 A AU2003900608 A AU 2003900608A AU 2003900608 A AU2003900608 A AU 2003900608A AU 2003900608 A0 AU2003900608 A0 AU 2003900608A0
Authority
AU
Australia
Prior art keywords
hdac inhibitor
hdac
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003900608A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to AU2003900608A priority Critical patent/AU2003900608A0/en
Publication of AU2003900608A0 publication Critical patent/AU2003900608A0/en
Priority to PCT/JP2004/001438 priority patent/WO2004072047A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2003900608A 2003-02-11 2003-02-11 Hdac inhibitor Abandoned AU2003900608A0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003900608A AU2003900608A0 (en) 2003-02-11 2003-02-11 Hdac inhibitor
PCT/JP2004/001438 WO2004072047A1 (en) 2003-02-11 2004-02-10 Indoles, benzimidazoles or naphhimidazoles as histone deacetylase (hdac) inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU2003900608A AU2003900608A0 (en) 2003-02-11 2003-02-11 Hdac inhibitor

Publications (1)

Publication Number Publication Date
AU2003900608A0 true AU2003900608A0 (en) 2003-02-27

Family

ID=30005308

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003900608A Abandoned AU2003900608A0 (en) 2003-02-11 2003-02-11 Hdac inhibitor

Country Status (2)

Country Link
AU (1) AU2003900608A0 (en)
WO (1) WO2004072047A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007099B1 (en) 2002-03-13 2006-06-30 Янссен Фармацевтика Н. В. Sulfonylamino-derivatives as inhibitors of histone deacetylase
ATE521592T1 (en) 2002-03-13 2011-09-15 Janssen Pharmaceutica Nv HISTONE DEACETYLASE INHIBITORS
US7446109B2 (en) 2002-03-13 2008-11-04 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
MXPA04008795A (en) 2002-03-13 2004-11-26 Janssen Pharmaceutica Nv Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase.
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7169801B2 (en) 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP1768955A1 (en) * 2004-07-12 2007-04-04 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Amide derivatives as inhibitors of histone deacetylase
UA86066C2 (en) 2004-07-28 2009-03-25 Янссен Фармацевтика Н.В. Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase
NZ552865A (en) 2004-07-28 2009-09-25 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
KR20070072598A (en) * 2004-10-19 2007-07-04 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 Indole and benzimidazole derivatives
US7863294B2 (en) 2004-12-10 2011-01-04 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Heterocycle derivatives as histone deacetylase (HDAC) inhibitors
WO2006066133A2 (en) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
EP2522396A1 (en) 2005-02-03 2012-11-14 TopoTarget UK Limited Combination therapies using HDAC inhibitors
US7642253B2 (en) 2005-05-11 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
ZA200710313B (en) 2005-05-13 2009-05-27 Topotarget Uk Ltd Pharmaceutical formulations of HDAC inhibitors
ES2553178T3 (en) 2005-05-18 2015-12-04 Janssen Pharmaceutica N.V. Substituted derivatives of aminopropenyl piperidine or morpholine as new histone deacetylase inhibitors
WO2007011626A2 (en) 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors
DK1943232T3 (en) 2005-10-27 2011-08-29 Janssen Pharmaceutica Nv Quadric acid derivatives as inhibitors of histone deacetylase
GB0522130D0 (en) * 2005-10-31 2005-12-07 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2627923C (en) 2005-11-10 2016-01-12 Topotarget Uk Limited Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer
GB0526107D0 (en) 2005-12-22 2006-02-01 Angeletti P Ist Richerche Bio Therapeutic Compounds
DK1979326T3 (en) 2006-01-19 2013-01-07 Janssen Pharmaceutica Nv PYRIDINE AND PYRIMIDINE DERIVATIVES AS INHIBITORS OF HISTONDEACETYLASE
US7834011B2 (en) 2006-01-19 2010-11-16 Janssen Pharmaceutica N.V. Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase
JP5225104B2 (en) 2006-01-19 2013-07-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Aminophenyl derivatives as new inhibitors of histone deacetylase
EP1979327A1 (en) 2006-01-19 2008-10-15 Janssen Pharmaceutica, N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
EP1979328B1 (en) 2006-01-19 2012-12-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
CA2635015C (en) 2006-01-19 2014-06-03 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
CN101868446A (en) 2007-09-25 2010-10-20 托波塔吉特英国有限公司 Synthetic method of some hydroxamic acid compounds
DK2274301T3 (en) 2008-03-27 2013-01-02 Janssen Pharmaceutica Nv AZABICYCLOHEXYL SUBSTITUTED INDOLYLALKYLAMINODE DERIVATIVES AS UNKNOWN INHIBITORS OF HISTONDEACETYLASE
JP5535931B2 (en) 2008-10-27 2014-07-02 武田薬品工業株式会社 Bicyclic compound
ES2650810T3 (en) * 2009-01-28 2018-01-22 Karus Therapeutics Limited Scriptaid isosteros and their use in therapy
US9827212B2 (en) 2009-03-18 2017-11-28 The Trustees Of The University Of Pennsylvania Compositions and methods for treating asthma and other lung diseases
WO2014072714A1 (en) 2012-11-07 2014-05-15 Karus Therapeutics Ltd Novel histone deacetylase inhibitors and their use in therapy
WO2014181137A1 (en) 2013-05-10 2014-11-13 Karus Therapeutics Ltd Novel histone deacetylase inhibitors
WO2015058106A1 (en) 2013-10-18 2015-04-23 The General Hospital Corporation Imaging histone deacetylases with a radiotracer using positron emission tomography
BR112016026518A2 (en) * 2014-05-14 2017-08-15 Univ Colorado Regents HETEROCYCLIC HYDROXAMIC ACIDS AS PROTEIN DEACETYLASE INHIBITORS AND DUAL PROTEIN DEACETYLASE-PROTEIN KINASE INHIBITORS AND METHODS OF USE THEREOF
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
CN108976200B (en) * 2018-09-19 2022-09-20 青岛农业大学 Method for preparing pimobendan from side product of pimobendan synthesis
WO2024089227A1 (en) 2022-10-28 2024-05-02 Boehringer Ingelheim International Gmbh Novel substituted pyrazine-carboxamide derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726192A (en) * 1992-12-29 1998-03-10 Smithkline Beecham Corporation Platelet aggregation inhibiting compounds
US7288567B2 (en) * 2000-03-24 2007-10-30 Methylgene Inc. Inhibitors of histone deacetylase
PE20020354A1 (en) * 2000-09-01 2002-06-12 Novartis Ag HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS
EP1598067B1 (en) * 2000-09-29 2009-05-06 TopoTarget UK Limited Carbamic acid compounds comprising an amide linkage for the treatment of malaria
AR035513A1 (en) * 2000-12-23 2004-06-02 Hoffmann La Roche DERIVATIVES OF TETRAHYDROPIRIDINE, PROCESS TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE OF SUCH COMPOUNDS IN THE PREPARATION OF MEDICINES

Also Published As

Publication number Publication date
WO2004072047A1 (en) 2004-08-26
WO2004072047A8 (en) 2005-01-13

Similar Documents

Publication Publication Date Title
AU2003900608A0 (en) Hdac inhibitor
AU2003202263A1 (en) Roh-kinase inhibitors
AU2003225523A1 (en) Functional pipelines
AU2003272930A1 (en) Footwere
AU2003238042A1 (en) Cyclooxygenase-2 inhibitors
AU2003249683A1 (en) Nf-:b inhibitors
AU2003233426A1 (en) Corrosion inhibitor
AU2003900587A0 (en) Hdac inhibitor
AU2003215635A1 (en) Thiazol-2-yl-imine compounds as pde-7 inhibitors
AU2002343940A1 (en) Anticorrosive
AU2003274573A1 (en) Deburrer
AU2003242559A1 (en) Alkylaminosiloxanes as corrosion inhibitors
AU2003234859A1 (en) Description
AU2003905406A0 (en) HDAC Inhibitor
AU2003900116A0 (en) Hdac inhibitor
AU2003227952A1 (en) Metalloproteinase inhibitors
AU2003241210A1 (en) Videocomputer
AU2004907228A0 (en) HDAC Inhibitor
AU2004904487A0 (en) HDAC Inhibitor
AU2004100967A4 (en) Pro-Cutter
AU2003252417A1 (en) Protease inhibitor
HK1085644A (en) Diffusion-enabled ingestion inhibitor
AU2003100006A4 (en) Adcaster
AU2003100325A4 (en) Freez-A-Cube
AU2003100198A4 (en) Colourband Browbands