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LU93229I2 - "pitolisant et ses sels pharmaceutiquement acceptables, tel que chlorhydrate" - Google Patents

"pitolisant et ses sels pharmaceutiquement acceptables, tel que chlorhydrate" Download PDF

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Publication number
LU93229I2
LU93229I2 LU93229C LU93229C LU93229I2 LU 93229 I2 LU93229 I2 LU 93229I2 LU 93229 C LU93229 C LU 93229C LU 93229 C LU93229 C LU 93229C LU 93229 I2 LU93229 I2 LU 93229I2
Authority
LU
Luxembourg
Prior art keywords
pitolisant
hydrochloride
pharmaceutically acceptable
acceptable salts
histamine
Prior art date
Application number
LU93229C
Other languages
English (en)
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98401944A external-priority patent/EP0978512A1/fr
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Publication of LU93229I2 publication Critical patent/LU93229I2/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/38—Nitrogen atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • C07C2602/00—Systems containing two condensed rings
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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LU93229C 1998-07-29 2016-09-21 "pitolisant et ses sels pharmaceutiquement acceptables, tel que chlorhydrate" LU93229I2 (fr)

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EP98401944A EP0978512A1 (fr) 1998-07-29 1998-07-29 Non-imidazole aryloxy- (ou arylthio)alkylamines comme antagonistes du recepteur H3 et leur application thérapeutique
EP98403351A EP0982300A3 (fr) 1998-07-29 1998-12-31 Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique
EP04003944A EP1428820B1 (fr) 1998-07-29 1999-07-29 Alkylamines sans imidazoles comme ligands de récepteur H-3 d'histamine et leurs applications therapeutiques
EP99941543A EP1100503B1 (fr) 1998-07-29 1999-07-29 Alkylamines sans imidazoles comme ligands de recepteur h 3? d'histamine et leurs applications therapeutiques

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Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0982300A3 (fr) * 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique
US6620839B2 (en) 2000-07-13 2003-09-16 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
US6515013B2 (en) 2000-07-13 2003-02-04 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
US7186732B2 (en) 2000-08-08 2007-03-06 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxyalkylamines
HUP0302893A3 (en) 2000-08-08 2006-04-28 Ortho Mcneil Pharm Inc Non-imidazole aryloxypiperidines and pharmaceutical compositions containing them and their use
AU2001281119A1 (en) 2000-08-08 2002-02-18 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic compounds as h3 receptor ligands
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
US6316475B1 (en) 2000-11-17 2001-11-13 Abbott Laboratories Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
EP2258694A1 (fr) * 2001-03-16 2010-12-08 Abbott Laboratories Amines en tant que ligands des recepteurs de l'histamine-3 et leurs applications thérapeutiques
US6969730B2 (en) 2001-03-16 2005-11-29 Abbott Laboratories Amines as histamine-3 receptor ligands and their therapeutic applications
AU2002254114A1 (en) * 2001-03-23 2002-10-08 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
JP4563675B2 (ja) * 2001-10-12 2010-10-13 ハイ・ポイント・ファーマスーティカルズ、エルエルシー 置換ピペリジン類、およびヒスタミンｈ３受容体関連疾患の治療のためのその使用
WO2003045920A1 (fr) * 2001-11-27 2003-06-05 Merck & Co., Inc. Composes 4-aminoquinoleines
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
US20060089347A1 (en) * 2002-08-20 2006-04-27 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
AU2003274053A1 (en) * 2002-10-22 2004-05-13 Glaxo Group Limited Aryloxyalkylamine derivates as h3 receptor ligands
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
JP4820094B2 (ja) * 2002-11-12 2011-11-24 アボット・ラボラトリーズ ヒスタミン−３受容体リガンドとしての２環式置換アミン
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
GB0229820D0 (en) * 2002-12-20 2003-01-29 Glaxo Group Ltd Novel compounds
AU2003294909B2 (en) 2002-12-20 2007-05-17 Glaxo Group Limited Benzazepine derivatives for the treatment of neurological disorders
WO2004078114A2 (fr) * 2003-02-28 2004-09-16 Encysive Pharmaceuticals Inc. Pyridine, pyrimidine, quinoline, quinazoline et naphtalene, antagonistes du recepteur de l'urotensine ii
CA2521000A1 (fr) * 2003-04-03 2004-10-21 Kyowa Hakko Kogyo Co., Ltd. Agent therapeutique et/ou curatif pour les douleurs nevropathiques
US7094790B2 (en) 2003-05-07 2006-08-22 Abbott Laboratories Fused bicyclic-substituted amines as histamine-3 receptor ligands
FR2856596B1 (fr) * 2003-06-27 2007-04-27 Bioprojet Soc Civ Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes.
FR2874215B1 (fr) * 2004-08-11 2006-09-29 Sanofi Synthelabo Derives de cyclopropylmethanones, leur preparation et leur utilisation en therapeutique
US7902191B2 (en) 2004-02-25 2011-03-08 Eli Lilly And Company Histamine H3 receptor antagonists, preparation and therapeutic uses
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
US7145005B2 (en) 2004-05-12 2006-12-05 Abbott Laboratories 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
EP1595881A1 (fr) 2004-05-12 2005-11-16 Pfizer Limited Dérivés de tetrahydronaphthyridine en tant que ligands de récepteur H3 d'histamine
US7205316B2 (en) 2004-05-12 2007-04-17 Abbott Laboratories Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
US20050256309A1 (en) * 2004-05-12 2005-11-17 Altenbach Robert J Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands
WO2005123723A1 (fr) * 2004-06-18 2005-12-29 Glaxo Group Limited 3-cycloalkylbenzazepines utilisees en tant qu'antagonistes de h3 l'histamine
CA2578016A1 (fr) * 2004-09-01 2006-03-09 Pfizer Products Inc. Antagonistes des recepteurs d'amine histamine-3 azabicycliques
US20060141072A1 (en) * 2004-12-29 2006-06-29 Arvanitidou Evangelia S Oxidation resistant dentifrice compositions
EP1690858B1 (fr) * 2005-02-10 2008-04-09 Bioprojet Sel de monohydrochloride de 1-[3-[3-(4-chlorophenyl)propoxy[propyl]-piperidine
EP1707203A1 (fr) * 2005-04-01 2006-10-04 Bioprojet Utilization des allkylamines sans imidazoles comme ligandes du recepteur histamine H3 pour le traitement de la maladie de Parkinson, de l'apnee obstructive du sommeil, de la demence vasculaire et de la demence avec corps de Lewy
EP1707204A1 (fr) * 2005-04-01 2006-10-04 Bioprojet Utilization des allkylamines sans imidazoles comme ligandes du recepteur histamine H3 pour le traitement de l'epilepsie
EP1717234A1 (fr) * 2005-04-29 2006-11-02 Bioprojet Phenoxypropylpiperidines and -pyrrolidines et leur utilisation comme ligands du récepteur histaminique H3
EP1717233A1 (fr) * 2005-04-29 2006-11-02 Bioprojet Ligands du récepteur histaminique H3 et leur application thérapeutique
US9063015B2 (en) * 2005-04-29 2015-06-23 Prasidiux Llp Stimulus indication employing polymer gels
EP1717235A3 (fr) * 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines et leur utilisation comme ligands du récepteur histaminique H3
AR054530A1 (es) * 2005-07-08 2007-06-27 Ferrer Int Procedimiento para la preparacion de 1-[3-[3-(4-clorofenil)-propoxi]propil]-piperidina
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
RU2449989C2 (ru) 2006-06-23 2012-05-10 Эбботт Лэборетриз Производные циклопропиламина в качестве модуляторов h3-гистаминового рецептора
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2011002984A1 (fr) * 2009-07-02 2011-01-06 Cephalon, Inc. Dérivés de phénoxypropylcycloamine substitués en tant que ligands de récepteur d'histamine-3 (h3)
WO2013151982A1 (fr) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés
WO2013173768A1 (fr) 2012-05-17 2013-11-21 Array Biopharma Inc. Procédé de fabrication de composés de cyclopentylpyrimidine hydroxylée
KR102074535B1 (ko) 2012-05-17 2020-02-06 제넨테크, 인크. 아미노산 화합물의 제조 방법
WO2013173736A1 (fr) 2012-05-17 2013-11-21 Array Biopharma Inc. Procédé de fabrication de composés cyclopentylpyrimidines hydroxylées
MX354373B (es) 2012-05-17 2018-02-28 Genentech Inc Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales.
ES2799512T3 (es) 2012-05-17 2020-12-18 Genentech Inc Forma amorfa de un compuesto de pirimidinil-ciclopentano inhibidor de la AKT, composiciones y métodos de la misma
DK2950649T3 (da) * 2013-02-01 2020-05-04 Wellstat Therapeutics Corp Aminforbindelser med antiinflammations-, antisvampe-, antiparasit- og anticanceraktivitet
CN103435575A (zh) * 2013-08-06 2013-12-11 中国人民解放军军事医学科学院毒物药物研究所 1-（ 3-（ 3-（ 4-氯苯基）丙氧基）丙基）哌啶盐酸盐的制备方法
EP3239138A1 (fr) * 2016-04-25 2017-11-01 Sandoz Ag Sel de fumarate d'hydrogène de 1-[3-[3-(4-chlorophényl)propoxy]propyl]pipéridine
EP3378477A1 (fr) * 2017-03-21 2018-09-26 BIOPROJET Pharma Nouvelles utilisations thérapeutiques de ligands h3
ES2840253T3 (es) 2018-07-27 2021-07-06 Bioprojet Soc Civ Combinaciones novedosas de un antagonista de H3 y un inhibidor de la recaptación de noradrenalina y usos terapéuticos de los mismos
WO2020092604A1 (fr) * 2018-10-30 2020-05-07 Concert Pharmaceuticals, Inc. Pitolisant deutéré
KR102669877B1 (ko) * 2019-12-19 2024-05-29 삼성전자주식회사 통신 장치 및 통신 방법
WO2022113008A1 (fr) 2020-11-27 2022-06-02 Richter Gedeon Nyrt. Antagonistes/agonistes inverses du récepteur h3 de l'histamine pour le traitement d'un trouble du spectre autistique
US11623920B2 (en) 2021-06-07 2023-04-11 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
US11945788B2 (en) 2021-06-07 2024-04-02 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
EP4374854A1 (fr) 2022-11-28 2024-05-29 Alfred E. Tiefenbacher (GmbH & Co. KG) Mélange pharmaceutique comprenant un pitolisant amorphe
WO2024201139A1 (fr) 2023-03-31 2024-10-03 Bioprojet Pharma Forme polymorphe de chlorhydrate de pitolisant

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE184968C (fr) *
US2870151A (en) * 1959-01-20 Mqrpholine -ethers
DE965813C (de) * 1950-09-29 1957-06-19 Abbott Lab Verfahren zur Herstellung von AEthern von Morpholinoalkanolen
DE1007774B (de) * 1954-09-08 1957-05-09 Hoffmann La Roche Verfahren zur Herstellung von substituierten therapeutisch wirksamen 2, 6, 6-Trimethylcyclohexen-(1)-yl-(1)-propyl- oder -butylaminen bzw. deren Salzen oder quaternaerenAmmoniumverbindungen
BE588558A (fr) * 1959-03-13 1960-09-12
DE1269134B (de) * 1962-12-18 1968-05-30 Hydrierwerk Rodleben Veb Verfahren zur Herstellung von Dialkylaminoalkylaethern von Phenolen
US3312696A (en) * 1964-02-20 1967-04-04 Turbanti Luigi 2-tertiary amino alkoxy-betaphenyl-propiophenones
US3947434A (en) * 1973-06-06 1976-03-30 Morton-Norwich Products, Inc. 9-(P-phenylazoanilino)-7-methyl-1H-imidazo[4,5-f]quinolines
DE2408530A1 (de) * 1974-02-22 1975-09-04 Basf Ag Verfahren zur herstellung von betahalogenalkylaminosulfonylhalogeniden
GB1513092A (en) * 1975-06-05 1978-06-07 Bottu O-aminophenol derivatives
DE2627227A1 (de) * 1975-06-19 1976-12-30 Mitsubishi Chem Ind Orthosubstituierte phenoxyalkylamino-derivate
EP0090972B1 (fr) * 1982-03-17 1990-05-30 Asahi Kasei Kogyo Kabushiki Kaisha Dérivés de l'indazole
DK368687A (da) * 1986-11-21 1988-05-22 Cheminova As Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider
US5348964A (en) * 1990-07-25 1994-09-20 Merrell Dow Pharmaceuticals Inc. Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis
EP0982300A3 (fr) * 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique
FR2788775B1 (fr) * 1999-01-22 2001-04-13 Pf Medicament Nouvelles n-alcoyl-n-[1-(omega-(arylalcoyloxy)alcoyl] piperidin-4-yl]-4h-3,1-benzo(thia/oxa)zines-2-amines substituees, leur preparation et leur application en therapeutique

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EP2000462A3 (fr) 2011-05-04
DK1100503T3 (da) 2004-10-18
WO2000006254A3 (fr) 2000-05-04
DK1428820T3 (da) 2006-08-28
US7138413B1 (en) 2006-11-21
DE69920472D1 (de) 2004-10-28
CA2321881C (fr) 2011-01-18
ATE326446T1 (de) 2006-06-15
PT1100503E (pt) 2005-01-31
ATE276751T1 (de) 2004-10-15
FR16C0038I1 (fr) 2016-11-11
PT1428820E (pt) 2006-09-29
EP0982300A3 (fr) 2000-03-08
CY2016032I2 (el) 2017-03-15
AU5511999A (en) 2000-02-21
JP2010189441A (ja) 2010-09-02
JP5301501B2 (ja) 2013-09-25
EP1100503A2 (fr) 2001-05-23
DE69920472T2 (de) 2005-10-06
FR16C0038I2 (fr) 2017-09-22
EP1100503B1 (fr) 2004-09-22
JP4553487B2 (ja) 2010-09-29
CY2016032I1 (el) 2017-03-15
CA2321881A1 (fr) 2000-02-10
BE2016C048I2 (fr) 2018-12-04
JP2002521463A (ja) 2002-07-16
US7910605B2 (en) 2011-03-22
EP2000462A2 (fr) 2008-12-10
US20040220225A1 (en) 2004-11-04
ES2226423T3 (es) 2005-03-16
DE69931409D1 (de) 2006-06-22
EP0982300A2 (fr) 2000-03-01
ES2260703T3 (es) 2006-11-01
EP1428820B1 (fr) 2006-05-17
US7169928B2 (en) 2007-01-30
US20110281844A1 (en) 2011-11-17
US20060247223A1 (en) 2006-11-02
EP1428820A1 (fr) 2004-06-16
DE69931409T2 (de) 2006-11-02
WO2000006254A2 (fr) 2000-02-10

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