LU87129A1 - Nouvel acide piperazinecarboxylique,sa preparation et son utilisation comme medicament - Google Patents

Nouvel acide piperazinecarboxylique,sa preparation et son utilisation comme medicament Download PDF

Info

Publication number: LU87129A1
Authority: LU; Luxembourg
Prior art keywords: compound; formula; approximately; monohydrate; pharmaceutically acceptable
Prior art date: 1987-02-18

Application number

LU87129A

Other languages

English (en)

French (fr)

Original Assignee

Sandoz Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-18

Filing date

1988-02-11

Publication date

1988-09-20

1988-02-11 Application filed by Sandoz Sa filed Critical Sandoz Sa

1988-09-20 Publication of LU87129A1 publication Critical patent/LU87129A1/fr

Links

238000002360 preparation method Methods 0.000 title claims description 8
RFIOZSIHFNEKFF-UHFFFAOYSA-N piperazine-1-carboxylic acid Chemical compound OC(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-N 0.000 title description 3
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150000003839 salts Chemical class 0.000 claims description 20
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230000008025 crystallization Effects 0.000 description 1
230000020335 dealkylation Effects 0.000 description 1
238000006900 dealkylation reaction Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000004821 distillation Methods 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
230000012173 estrus Effects 0.000 description 1
KKXWTUYDLQVOOO-UHFFFAOYSA-N ethyl 1,4-dibenzylpiperazine-2-carboxylate Chemical compound C1CN(CC=2C=CC=CC=2)C(C(=O)OCC)CN1CC1=CC=CC=C1 KKXWTUYDLQVOOO-UHFFFAOYSA-N 0.000 description 1
238000013265 extended release Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
239000012458 free base Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
238000010191 image analysis Methods 0.000 description 1
238000003384 imaging method Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
208000014674 injury Diseases 0.000 description 1
210000002570 interstitial cell Anatomy 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
230000000302 ischemic effect Effects 0.000 description 1
235000015110 jellies Nutrition 0.000 description 1
239000008274 jelly Substances 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
210000005230 lumbar spinal cord Anatomy 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
210000003657 middle cerebral artery Anatomy 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
YNAVUWVOSKDBBP-UHFFFAOYSA-O morpholinium Chemical compound [H+].C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-O 0.000 description 1
201000006417 multiple sclerosis Diseases 0.000 description 1
210000002569 neuron Anatomy 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
210000003101 oviduct Anatomy 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
230000007180 physiological regulation Effects 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
208000018198 spasticity Diseases 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
229940032330 sulfuric acid Drugs 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000029305 taxis Effects 0.000 description 1
238000010998 test method Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
230000008733 trauma Effects 0.000 description 1
FAQYAMRNWDIXMY-UHFFFAOYSA-N trichloroborane Chemical compound ClB(Cl)Cl FAQYAMRNWDIXMY-UHFFFAOYSA-N 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
238000012982 x-ray structure analysis Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

LU87129A 1987-02-18 1988-02-11 Nouvel acide piperazinecarboxylique,sa preparation et son utilisation comme medicament LU87129A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878703749A GB8703749D0 (en)	1987-02-18	1987-02-18	Piperazinecarboxylic acid
GB8703749		1987-02-18

Publications (1)

Publication Number	Publication Date
LU87129A1 true LU87129A1 (fr)	1988-09-20

Family

ID=10612501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU87129A LU87129A1 (fr)	1987-02-18	1988-02-11	Nouvel acide piperazinecarboxylique,sa preparation et son utilisation comme medicament

Country Status (28)

Country	Link
JP (1)	JPH0723387B2 (de)
KR (1)	KR960015190B1 (de)
AT (1)	AT391320B (de)
AU (1)	AU613009B2 (de)
BE (1)	BE1002427A3 (de)
CA (1)	CA1327799C (de)
CH (1)	CH675125A5 (de)
CY (1)	CY1739A (de)
DE (1)	DE3804936C2 (de)
DK (1)	DK168441B1 (de)
ES (2)	ES2011319A6 (de)
FI (1)	FI86733C (de)
FR (1)	FR2610932B1 (de)
GB (2)	GB8703749D0 (de)
GR (1)	GR1002471B (de)
HK (1)	HK142093A (de)
HU (2)	HU199858B (de)
IE (1)	IE59098B1 (de)
IL (1)	IL85436A0 (de)
IT (1)	IT1219447B (de)
LU (1)	LU87129A1 (de)
MY (1)	MY103206A (de)
NL (1)	NL8800412A (de)
NZ (1)	NZ223529A (de)
PH (1)	PH25512A (de)
PT (1)	PT86776B (de)
SE (1)	SE467256B (de)
ZA (1)	ZA881146B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU202111B (en) *	1988-03-11	1991-02-28	Sandoz Ag	Process for producing pharmaceutical compositions containing (r)-(e)-4--(3-phosphono-2-propenyl)-2-piperazine-carboxylic acid as active component
US5086072A (en) *	1990-06-18	1992-02-04	The United States Of America As Represented By The Department Of Health And Human Services	Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex
EP0488959A3 (en) *	1990-11-28	1992-08-05	Sandoz Ltd.	New uses of competitive nmda receptor antagonists
US5260286A (en) *	1992-10-16	1993-11-09	Japan Tobacco, Inc.	2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
AU5693996A (en) *	1995-05-08	1996-11-29	Lonza A.G.	Biotechnical production process of piperazine r-alpha-carbox ylic acids and piperazine s-alpha-carboxylic acid amide
ES2206928T3 (es)	1997-05-12	2004-05-16	Ortho-Mcneil Pharmaceutical, Inc.	Piperacinas sustituidas con arilo utiles en el tratamiento de la hiperplasia benigna de prostata.
GB9821179D0 (en) *	1998-09-30	1998-11-25	Merck Sharp & Dohme	Therapeutic use
JP2008124531A (ja)	2006-11-08	2008-05-29	Nec Electronics Corp	半導体装置およびオーディオプロセッサチップ
EP3427729A1 (de)	2017-07-13	2019-01-16	Paris Sciences et Lettres - Quartier Latin	Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids

1987
- 1987-02-18 GB GB878703749A patent/GB8703749D0/en active Pending
1988
- 1988-02-11 LU LU87129A patent/LU87129A1/fr unknown
- 1988-02-12 FR FR888801782A patent/FR2610932B1/fr not_active Expired - Lifetime
- 1988-02-12 BE BE8800177A patent/BE1002427A3/fr active
- 1988-02-12 IT IT47631/88A patent/IT1219447B/it active
- 1988-02-15 MY MYPI88000155A patent/MY103206A/en unknown
- 1988-02-15 GB GB8803438A patent/GB2201676B/en not_active Expired - Lifetime
- 1988-02-16 NZ NZ223529A patent/NZ223529A/xx unknown
- 1988-02-16 DK DK079688A patent/DK168441B1/da not_active IP Right Cessation
- 1988-02-16 HU HU88746A patent/HU199858B/hu not_active IP Right Cessation
- 1988-02-16 PH PH36514A patent/PH25512A/en unknown
- 1988-02-16 CH CH549/88A patent/CH675125A5/de not_active IP Right Cessation
- 1988-02-16 CA CA000559170A patent/CA1327799C/en not_active Expired - Fee Related
- 1988-02-16 IE IE41388A patent/IE59098B1/en not_active IP Right Cessation
- 1988-02-16 AU AU11758/88A patent/AU613009B2/en not_active Ceased
- 1988-02-16 GR GR880100084A patent/GR1002471B/el not_active IP Right Cessation
- 1988-02-16 IL IL85436A patent/IL85436A0/xx not_active IP Right Cessation
- 1988-02-17 JP JP63036458A patent/JPH0723387B2/ja not_active Expired - Lifetime
- 1988-02-17 FI FI880744A patent/FI86733C/fi not_active IP Right Cessation
- 1988-02-17 DE DE3804936A patent/DE3804936C2/de not_active Expired - Fee Related
- 1988-02-17 KR KR1019880001680A patent/KR960015190B1/ko not_active IP Right Cessation
- 1988-02-17 SE SE8800541A patent/SE467256B/sv not_active IP Right Cessation
- 1988-02-17 PT PT86776A patent/PT86776B/pt not_active IP Right Cessation
- 1988-02-17 AT AT0036788A patent/AT391320B/de not_active IP Right Cessation
- 1988-02-18 ZA ZA881146A patent/ZA881146B/xx unknown
- 1988-02-18 NL NL8800412A patent/NL8800412A/nl not_active Application Discontinuation
- 1988-02-18 ES ES888800466A patent/ES2011319A6/es not_active Expired - Lifetime
1989
- 1989-10-16 ES ES8903482A patent/ES2021904A6/es not_active Expired - Lifetime
1993
- 1993-12-30 HK HK1420/93A patent/HK142093A/xx not_active IP Right Cessation
1995
- 1995-06-09 HU HU95P/P00176P patent/HU211269A9/hu unknown
- 1995-10-20 CY CY173995A patent/CY1739A/xx unknown

Also Published As

Publication number	Publication date
ES2021904A6 (es)	1991-11-16
IE59098B1 (en)	1994-01-12
HK142093A (en)	1994-01-07
KR960015190B1 (ko)	1996-11-01
PH25512A (en)	1991-07-24
MY103206A (en)	1993-05-29
IT8847631A0 (it)	1988-02-12
AU613009B2 (en)	1991-07-25
FI880744A0 (fi)	1988-02-17
ATA36788A (de)	1990-03-15
CA1327799C (en)	1994-03-15
NZ223529A (en)	1991-02-26
ZA881146B (en)	1989-10-25
ES2011319A6 (es)	1990-01-01
FR2610932A1 (fr)	1988-08-19
DE3804936C2 (de)	1997-02-13
HUT49361A (en)	1989-09-28
GB8803438D0 (en)	1988-03-16
IL85436A0 (en)	1988-07-31
DK79688D0 (da)	1988-02-16
DE3804936A1 (de)	1988-09-01
HU199858B (en)	1990-03-28
CH675125A5 (de)	1990-08-31
DK79688A (da)	1988-08-19
IE880413L (en)	1988-08-18
PT86776B (pt)	1992-05-29
JPH0723387B2 (ja)	1995-03-15
GR880100084A (el)	1988-12-16
FI86733B (fi)	1992-06-30
GB2201676B (en)	1991-01-02
GB8703749D0 (en)	1987-03-25
KR880009944A (ko)	1988-10-06
IL85436A (de)	1992-12-01
IT1219447B (it)	1990-05-18
BE1002427A3 (fr)	1991-02-05
DK168441B1 (da)	1994-03-28
FI880744A (fi)	1988-08-19
AT391320B (de)	1990-09-25
GB2201676A (en)	1988-09-07
SE8800541D0 (sv)	1988-02-17
CY1739A (en)	1995-10-20
NL8800412A (nl)	1988-09-16
FR2610932B1 (fr)	1990-11-16
PT86776A (pt)	1988-03-01
HU211269A9 (en)	1995-11-28
FI86733C (fi)	1992-10-12
GR1002471B (el)	1996-11-15
SE467256B (sv)	1992-06-22
AU1175888A (en)	1988-08-25
JPS63203691A (ja)	1988-08-23

Publication	Publication Date	Title
LU86032A1 (fr)	1986-02-18	Derive d'indole
EP0752988B1 (de)	1999-05-26	5H-INDENO[1,2-b]PYRAZIN-2,3-DION-DERIVATE ANTAGONISTEN DER AMPA UND NMDA REZEPTOREN
FR2741621A1 (fr)	1997-05-30	Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
BE898278A (fr)	1984-05-22	Benzoxazines antipsychotiques.
FR2722190A1 (fr)	1996-01-12	Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
FR2707643A1 (fr)	1995-01-20	Dérivés d'imidazo[1,2-a]pyrazine-4-one, leur préparation et les médicaments les contenant.
FR2548666A1 (fr)	1985-01-11	Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
LU87129A1 (fr)	1988-09-20	Nouvel acide piperazinecarboxylique,sa preparation et son utilisation comme medicament
FR2501506A1 (fr)	1982-09-17	Compositions pharmaceutiques a action anorexigene contenant des derives de la tetrahydropyridine
FR2685918A1 (fr)	1993-07-09	Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
CH671017A5 (de)	1989-07-31
BE1009852A3 (fr)	1997-10-07	Derives 1-[2(vinyl-substitues)]-3-4-dihydro-5h-2,3-benzodiazepine.
EP0156734A2 (de)	1985-10-02	Triazolo[4,3-b]pyridazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
WO1998014444A1 (fr)	1998-04-09	Derives de n-(benzothiazol-2-yl)piperidine-1-ethanamine, leur preparation et leur application en therapeutique
FR2558158A1 (fr)	1985-07-19	Derives de l'indole ethenyl phenol, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires
EP0772615A1 (de)	1997-05-14	IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-2-CARBONSÄURE DERIVATE, IHRE HERSTELLUNG UND SIE ENTHALTENDE ARZNEIMITTEL
CH674008A5 (de)	1990-04-30
EP1476433B1 (de)	2005-11-09	Trizyklo-imidazolinen derivaten, verfahren zu deren herstellung und deren verwendung als heilmitteln
FR2522663A1 (fr)	1983-09-09	Nouveaux alcaloides ergopeptidiques, leur preparation et leur utilisation comme medicaments
FR2583047A1 (fr)	1986-12-12	Procede de preparation de derives du 4-phenylpropyl indole, et intermediaires
CH644361A5 (fr)	1984-07-31	Arylthio-3 hydroxy-4 pyrrolidines 1-substituees et leurs derives.
EP0235043B1 (de)	1991-01-23	Tetrahydrobenz[c,d]indol-Derivate, ihre Salze, Verfahren zur Herstellung, Verwendung als Arzneimittel, ihre Zusammensetzungen und Zwischenprodukte
WO2003011856A1 (fr)	2003-02-13	Derives d'aminoalkylimidazole, leur preparation et leur utilisation en therapeutique
EP0580465A1 (de)	1994-01-26	Neue therapeutische Verwendung von heterocyclischen Piperazinen als 5-HT3-Agonisten und neue Derivaten
FR2757512A1 (fr)	1998-06-26	Utilisation de benzoylalkyl-1-1,2,3,6-tetrahydropyridines