KR970702024A - 점도가 감소된 안용 조성물 (ophthalmic composition with decreased viscosity) - Google Patents
점도가 감소된 안용 조성물 (ophthalmic composition with decreased viscosity)Info
- Publication number
- KR970702024A KR970702024A KR1019960705391A KR19960705391A KR970702024A KR 970702024 A KR970702024 A KR 970702024A KR 1019960705391 A KR1019960705391 A KR 1019960705391A KR 19960705391 A KR19960705391 A KR 19960705391A KR 970702024 A KR970702024 A KR 970702024A
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- composition
- amount
- viscosity
- sodium
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 16
- 230000003247 decreasing effect Effects 0.000 title 1
- 229960004605 timolol Drugs 0.000 claims description 5
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- 235000002639 sodium chloride Nutrition 0.000 claims 5
- 239000003002 pH adjusting agent Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 2
- 239000001488 sodium phosphate Substances 0.000 claims 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 2
- 230000002889 sympathetic effect Effects 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 claims 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 claims 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000030 antiglaucoma agent Substances 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 229910021538 borax Inorganic materials 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 229960002704 metipranolol Drugs 0.000 claims 1
- BLWNYSZZZWQCKO-UHFFFAOYSA-N metipranolol hydrochloride Chemical compound [Cl-].CC(C)[NH2+]CC(O)COC1=CC(C)=C(OC(C)=O)C(C)=C1C BLWNYSZZZWQCKO-UHFFFAOYSA-N 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 229960001416 pilocarpine Drugs 0.000 claims 1
- 229960002508 pindolol Drugs 0.000 claims 1
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 229960003712 propranolol Drugs 0.000 claims 1
- 239000001632 sodium acetate Substances 0.000 claims 1
- 235000017281 sodium acetate Nutrition 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 235000011083 sodium citrates Nutrition 0.000 claims 1
- 235000011008 sodium phosphates Nutrition 0.000 claims 1
- 235000010339 sodium tetraborate Nutrition 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
본 발명은 필수적으로 활성 안약 성분, 이온 민감성 및 친수성 고분자 0.004~1.5중량%, 완충제 및 무기염 중에서 선택된 한가지 이상의 염 총 0.01~2.0중량%, 물, 및 임의로 조성물의 pH가 4.0~8.0이 되기에 충분한 양의 pH조절제로 이루어지며, 여기서 염과 고분자 성분 사이의 비율은 용액의 점도가 1000mPas 미만이 되도록 조정된, 국소용 수용액 형태의 안용 조성물에 관한 것이다. 이 조성물은 약물이 눈에 조절적으로 흡수되도록 하기에 충분한 양으로 고분자를 함유하며, 그 점도는 취급이 용이하도록 감소된 특징을 갖는다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 전단 속도에 대한 조성물의 점도 곡선을 나타낸다,
제2도는 토끼 눈에서의 티몰롤 농도를 본 발명에 의한 조성물과 대조 생성물로 비교하여 나타낸다.
Claims (12)
- 활성 안약 성분, 이온 민감성, 친수성 고분자 0.004~1.5중량%, 완충제 및 무기염 중에서 선택된 한 가지 이상의 염 총 0.01중량%~2.0중량%, 습윤제 0~3.0중량%, 방부제 0~0.02중량%, 물, 그리고 임의적으로 조성물의 pH를 4.0~8.0으로 만들기에 충분한 양의 pH조절제로 구성되는 국소용 수용액 형태의 안용 조성물로서, 그 염과 고분자 성분의 비율은 용액의 점도가 1000mPas 미만으로 되도록 조정된 안용 조성물.
- 제1항에 있어서, 고분자가 0.01~0.8중량%, 바람직하게는 0.01~0.4중량%, 더욱 바람직하게는 0.04~0.4중량%의 양으로 존재하고, 카르보풀 907, 910, 934, 934P, 940, 971, 971P, 974, 974P, 980, 981 중에서 선택되는 조성물.
- 제1항 또는 제2항에 있어서, 습윤제가 글리세롤인 조성물.
- 제3항에 있어서, 글리세롤의 양이 0.5~2.5중량%인 조성물.
- 전술한 항 중 어느 한 항에 있어서, 염이 염화나트륨, 염화칼륨, 인산나트륨, 붕산나트륨, 아세트산나트륨, 시트르산나트륨, 그들의 등가물 및 혼합물 중에서 선택되고, 그 양이 바람직하게 0.01~1.5중량%가 되는 조성물.
- 전술한 항 중 한 항에 있어서, 점도가 800mPas 미만인 조성물.
- 전술한 항 중 한 항에 있어서, pH가 5.0~8.0, 바람직하게는 6.5~8.0인 조성물.
- 전술한 항 중 한 항에 있어서, 활성 안약 성분이 교감신경차단제, 교감신경흥분제, 항녹내장제, 예컨대 β-블로커, 탄산탈수효소억제인자, 항생제, 소염제, 항알레르기제 또는 그들의 조합물 중에서 선택되는 조성물.
- 제8항에 있어서, 약리 활성제가 베타솔롤, 카테올롤, 레보부놀롤, 메티프라놀롤, 핀돌롤, 프로프라놀롤 및 티몰롤, 그 뿐만 아니라 필로카르핀과의 그의 혼합물, 바람직하게는 특히 S-티몰롤, 그의 말레산염 또는 반수화물 중에서 선택되는 조성물.
- 제1항에 있어서, 자유 염기로서 선출할 경우, 0.1~0.5중량% 양의 말레산염 또는 반수화물 형태의 티몰롤, 특히 S-티몰롤, 폴리아크릴산 0.04~0.4중량%, 글리세롤 0.5~2.5중량%, 인산나트늄 0.01~1.5중량%, 방부제 0~0.02중량%, 물, 그리고 임의적으로 조성물의 pH를 6.5~8로 만들기에 충분한 양의 pH조절제로 구성되고, 용액의 점도가 800mPas 미만인 조성물.
- 전술한 항 중 한 항에 있어서, 유기 및 무기 염기 및 산 중에서 선택된 pH조절제를 첨가하여 용액의 pH를 조정한, 특히 pH 6.5~8.0으로 조성한 조성물.
- 제11항에 있어서, pH조절제가 수산화나트륨인 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9401108A SE9401108D0 (sv) | 1994-03-31 | 1994-03-31 | Ophthalmic composition I |
| SE9401108-7 | 1994-03-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR970702024A true KR970702024A (ko) | 1997-05-13 |
| KR100365914B1 KR100365914B1 (ko) | 2003-04-16 |
Family
ID=20393511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019960705391A KR100365914B1 (ko) | 1994-03-31 | 1995-03-29 | 점도가감소된안약조성물 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5710182A (ko) |
| EP (1) | EP0752847B1 (ko) |
| JP (1) | JPH10503470A (ko) |
| KR (1) | KR100365914B1 (ko) |
| CN (1) | CN1112918C (ko) |
| AT (1) | ATE202921T1 (ko) |
| AU (1) | AU694497B2 (ko) |
| BG (1) | BG63145B1 (ko) |
| BR (1) | BR9507438A (ko) |
| CA (1) | CA2186734A1 (ko) |
| CZ (1) | CZ290987B6 (ko) |
| DE (2) | DE752847T1 (ko) |
| DK (1) | DK0752847T3 (ko) |
| EE (1) | EE03661B1 (ko) |
| ES (1) | ES2161874T3 (ko) |
| GR (1) | GR3036763T3 (ko) |
| HK (1) | HK1013953A1 (ko) |
| HU (1) | HU223071B1 (ko) |
| MX (1) | MX9603918A (ko) |
| NO (1) | NO314434B1 (ko) |
| PL (1) | PL179433B1 (ko) |
| PT (1) | PT752847E (ko) |
| RO (1) | RO115409B1 (ko) |
| RU (1) | RU2139016C1 (ko) |
| SE (1) | SE9401108D0 (ko) |
| SK (1) | SK280492B6 (ko) |
| WO (1) | WO1995026711A1 (ko) |
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| GB9718568D0 (en) | 1997-09-03 | 1997-11-05 | Chauvin Pharmaceuticals Limite | Compositions |
| WO2000064528A1 (en) | 1999-04-28 | 2000-11-02 | Situs Corporation | Drug delivery system |
| US6852688B2 (en) | 2000-03-10 | 2005-02-08 | University Of Florida | Compositions for treating diabetic retinopathy and methods of using same |
| EP1484054B1 (en) * | 2002-02-22 | 2012-08-29 | Santen Pharmaceutical Co., Ltd. | Drug delivery system for the subconjunctival administration of fine grains |
| CA2477044A1 (en) * | 2002-02-22 | 2003-09-04 | Pharmacia Corporation | Ophthalmic formulation with gum system |
| JP2004196787A (ja) * | 2002-12-04 | 2004-07-15 | Santen Pharmaceut Co Ltd | 結膜下デポによるドラッグデリバリーシステム |
| CN100453066C (zh) * | 2002-12-04 | 2009-01-21 | 参天制药株式会社 | 利用结膜下储存库的药物释放系统 |
| JP4860475B2 (ja) * | 2003-06-13 | 2012-01-25 | アルコン，インコーポレイテッド | ２種のポリマーの相乗作用的組み合わせを含む眼科用組成物 |
| US7947295B2 (en) * | 2003-06-13 | 2011-05-24 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| EP1666025A4 (en) * | 2003-08-20 | 2011-08-31 | Santen Pharmaceutical Co Ltd | DRUG DELIVERY SYSTEM FOR THE SUBTENOIN DELIVERY OF FINE GRAINS |
| TWI367098B (en) * | 2004-12-23 | 2012-07-01 | Kowa Co | Treating agent for glaucoma |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| DE102005035986B4 (de) * | 2005-07-28 | 2009-10-15 | Bausch & Lomb Incorporated | Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat |
| US20110190323A1 (en) * | 2008-08-28 | 2011-08-04 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses thereof |
| EP2383286A1 (en) | 2010-04-30 | 2011-11-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of retinal degenerative diseases |
| JP2012180346A (ja) * | 2011-02-10 | 2012-09-20 | Santen Pharmaceut Co Ltd | 親水性薬物の薬物移行性を改善した水性組成物 |
| WO2013124477A1 (en) | 2012-02-24 | 2013-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treatment of retinal degenerative diseases |
| SG11201605178WA (en) | 2013-12-24 | 2016-07-28 | Harvard College | Cortistatin analogues and syntheses and uses thereof |
| WO2016182932A1 (en) | 2015-05-08 | 2016-11-17 | President And Fellows Of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| US11052094B2 (en) | 2015-05-29 | 2021-07-06 | Sydnexis, Inc. | D2O stabilized pharmaceutical formulations |
| WO2017004411A1 (en) | 2015-07-01 | 2017-01-05 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| CA3014774A1 (en) | 2016-02-17 | 2017-08-24 | Children's Medical Center Corporation | Ffa1 (gpr40) as a therapeutic target for neural angiogenesis diseases or disorders |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| KR20190036520A (ko) | 2016-06-27 | 2019-04-04 | 아칠리온 파르마세우티칼스 인코포레이티드 | 의학적 장애를 치료하기 위한 퀴나졸린 및 인돌 화합물 |
| WO2018033854A1 (en) * | 2016-08-15 | 2018-02-22 | Santen Pharmaceutical Co., Ltd. | Ophthalmic composition and a method for treating ocular hypertension and glaucoma |
| IL264664B2 (en) | 2016-08-19 | 2023-03-01 | Orasis Pharmaceuticals Ltd | Ophthalmic pharmaceutical preparations and uses related to them |
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| MX2022010952A (es) | 2020-03-05 | 2022-10-07 | C4 Therapeutics Inc | Compuestos para la degradacion dirigida de brd9. |
| CA3205883A1 (en) * | 2021-02-04 | 2022-08-11 | Gregory I. Ostrow | Ophthalmic compositions for presbyopia |
| EP4088714A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| EP4088713A1 (en) | 2021-05-10 | 2022-11-16 | Warszawskie Zaklady Farmaceutyczne Polfa S.A. | Ophthalmic pharmaceutical composition comprising atropine |
| CN113786380A (zh) * | 2021-09-18 | 2021-12-14 | 华北制药股份有限公司 | 一种硝酸毛果芸香碱眼用凝胶及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6056684B2 (ja) * | 1977-11-07 | 1985-12-11 | 東興薬品工業株式会社 | 点眼剤 |
| US5252318A (en) * | 1990-06-15 | 1993-10-12 | Allergan, Inc. | Reversible gelation compositions and methods of use |
| FR2678832B1 (fr) * | 1991-07-10 | 1995-03-17 | Europhta Sa Laboratoire | Nouvelles compositions ophtalmiques a resorption amelioree et leurs procedes de preparation. |
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1994
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1995
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1998
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