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KR960013391A - 다공성 뼈 대체물질 - Google Patents

다공성 뼈 대체물질 Download PDF

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KR960013391A
KR960013391A KR1019950034243A KR19950034243A KR960013391A KR 960013391 A KR960013391 A KR 960013391A KR 1019950034243 A KR1019950034243 A KR 1019950034243A KR 19950034243 A KR19950034243 A KR 19950034243A KR 960013391 A KR960013391 A KR 960013391A
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weight
particle
granules
necessary
additives
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니스 베르트홀트
트뢰스터 사비네
쉬페히트 라이너
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위르겐 호이만ㆍ라인하르트 쉬틀러
메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁
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Publication of KR960013391A publication Critical patent/KR960013391A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0036—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
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  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
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  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
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Abstract

본 발명은 용적 함량의 5 내지 60%가 부분적으로 또는 완전히 상호 연결된 공극 구조를 가지는 다공성 뼈 대체물질은 제조하는 벙법에 관한 것이다. 본 발명에 의한 뼈 대체물질은 아크릴레이트/메타크릴레이트로 된 고형 구성분 및 액상 구성분, 그리고 0.5 내지 10㎜의 최대 입자경을 가지는, 생물학적으로 혀용 가능한 조-입자을 포함하여 구성된다.

Description

다공성 뼈 대체물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 용적 함량의 5 내지 60＆가 부분적으로 또는 완전히 상호 연결된 공극 구조로 된 다공성 뼈 대체물질을 제조하는 방법에 있어서, (a)미분화된 아크릴 산 및/또는 메타크릴 산 에스테르폴리머와 필요한 경우, 폴리머화 촉매, X-선 콘트라스트 매질, 충전제 및 염료 등의 다른 첨가제를 포함하고 있는 고형 구성분 0 내지 48중량%; (b)아크릴 산 및/또는 메타크릴 산 에스테르 모노머와 필요한 경우 폴리머화 촉진제, 안정화제 등의 다른 첨가제를 포함하고 있는 액상 구성분 5 내지 50중량%; (c) 0.5 내지 10㎜의 최대 입자경을 가지는, 생물학적으로 혀용 가능한 조-입자 과립 50 내지 98중량%;를 서로 혼합한 후, 소망하는 형태로 성형하고 필요한 경우 경화시키는 것을 특징으로 하는 제조방법.
  2. 제1항에 있어서, 상기 조-입자 과립이 1 내지 5㎜, 특히 약 3㎜의 최대 입자경을 가지는 것임을 특징으로 하는 방법.
  3. 제1항 또는 2항에 있어서, 상기 조-입자 괄비이 구형, 대략 구형 또는 원통형임을 특징으로 하는 방법.
  4. 제1항 내지 3항 중의 어느 한 항에 있어서, 상기 조-입자 과립이, 미분화된 아크릴 산 및/또는 메타크릴 산 에스테르폴리머와 필요한 경우, 폴리머화 촉매, X-선 콘트라스트 매질, 충전제 및 염료 등의 다른 첨가제를 포함하고 있는 고형 구성분 5 내지 90중량%; 그리고 아크릴 산/및 또는 메타크릴 산 에스테르 모노머와 필요한 경우, 폴리머화 촉진제, 안정화제 등의 다른 첨가제를 포함하고 있는 액상 구성분 95 내지 10중량%로 경화된 혼합물임을 특징으로 하는 방법.
  5. 제1항 내지 4항 중의 어느 한 항에 있어서, 상기 조-입자 과립이 폴리올레핀, 스티렌 및/또는 부타디엔과 아크릴레이트의 공중합체 및 에폭시 수지로 된 플라스틱 물질을 포함하여 구성된 것임을 특징으로 하는 방법.
  6. 제1항 내지 5항 중의 어느 한 항에 있어서, 상기 조-입자 과립이 소결된 칼슘 포스페이트 세라믹임을 특징으로 하는 방법.
  7. 제1항 내지 6항 중의 어느 한 항에 있어서, 상기 고형 구성분/및 또는 상기 조-입자 과립이 뼈전도성 및/또는 뼈우도성 충전제를 포함하여 구성된 것을 특징으로 하는 방법.
  8. 제1항 내지 7항 중의 어느 한 항에 있어서, 상기 고형 구성분 및/또는 상기 조-입자 과립이 세포증식 억제제, 항생제, 방부제 또는 뼈 성장-촉진 물질 등의 약제학적 활성물질을 포함하여 구성된 것을 특징으로 하는 방법.
  9. (a) 미분화된 아크릴 산 및/또는 메타크릴 산 에스테르폴리머와 필요한 경우, 폴리머화 촉매, X-선 콘트라스트 매질, 충전제 및 염료 등의 다른 첨가제를 포함하여 구성된 고형 구성분을, 전체 뼈 대체물질의 0 내지 48중량%가 되도록 함유하는 팩; (b)아크릴 산 및/또는 메타크릴 산 에스테르 모노머와 필요한 경우, 폴리머화 촉진제, 안정화제 등의 다른 첨가제를 포함하여 구성된 액상 구성분을, 전체 뼈 대체물질의 2 내지 50중량%가 되도록 함유하고 있는 팩; (c) 0.5 내지 10㎜의 최대 입자경을 가지는, 생물학적으로 허용 가능한 조-입자 과립을 전체 뼈 대체물질의 50 내지 98중량%가 되도록 함유하는 팩;의 각각 분리 팩들로 구성되어 있으며, 용적 함량의 5 내지 60%가 부분적으로 또는 완전히 상호 연결된 공극 구조를 가지는 다공성 뼈 대체물질을 제조하기 위한 세트.
  10. 제9항에 있어서, 구성분(a) 및 (c)가 하나의 팩단위에 혼합되어 있는 것임을 특징으로 하는 세트.
  11. 제9항 또는 10항에 있어서, 상기 조-입자 과립이 1 내지 5㎜, 특히 약 3㎜의 최대 입자경을 가지는 것임을 특징으로 하는 세트.
  12. 제9항 내지 11항중의 어느 한 항에 있어서, 상기 조-입자 과립이 구형, 대략 규형 또는 원통형임을 특징으로 하는 세트.
  13. 제9항 내지 제12항 중의 어느 한 항에 있어서, 상기 조-입자 과립이, 미분화된 아크릴 산 및/또는 메타크릴 산 에스테르폴리머와 필요한 경우, 폴리머화 촉매, X-선 콘트라스트 매질, 충전제 및 염료 등의 다른 첨가제를 포함하여 구성된 고형 구성분 5내지 90중량%; 그리고 아크릴 산 및/또는 메타크릴 산 에스테르 모노머와 필요한 경우, 폴리머화 촉진제, 안정화제 등의 다른 첨가제를 포함하고 있는 액상 구성분 95내지 10중량%로 된 경화된 혼합물임을 특징으로 하는 세트.
  14. 제9항 내지 13항 중의 어느 한 항에 있어서, 상기 조-입자 과립이 소결된 칼슘 포스페이트 세라믹임을 특징으로 하는 세트.
  15. 제9항 내지 14항 중의 어느 한 항에 있어서, 상기 고형 구성분 및/또는 상기 조-입자 과립이 뼈전도성 및/또는 뼈유도성 충전제를 포함하여 구성된 것을 특징으로 하는 세트.
  16. 제9항 내지 제15항 중의 어느 한 항에 있어서, 상기 고형 구성분 및/또는 상기 조-입자 과립이 세포증식 역제제, 항생제, 방부제 또는 뼈 성장-촉진 물질 등의 약제학적 활성물질을 포함하여 구성된 것을 특징으로 하는 세트.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950034243A 1994-10-06 1995-10-06 다공성 뼈 대체물질 KR960013391A (ko)

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DE4435680A DE4435680A1 (de) 1994-10-06 1994-10-06 Poröse Knochenersatzmaterialien
DEP4435680.3 1994-10-06

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KR960013391A true KR960013391A (ko) 1996-05-22

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US (1) US5650108A (ko)
EP (1) EP0705609B1 (ko)
JP (1) JPH08117322A (ko)
KR (1) KR960013391A (ko)
CN (1) CN1127700A (ko)
AT (1) ATE191349T1 (ko)
AU (1) AU3300595A (ko)
BR (1) BR9504293A (ko)
CA (1) CA2159871A1 (ko)
CZ (1) CZ257495A3 (ko)
DE (2) DE4435680A1 (ko)
DK (1) DK0705609T3 (ko)
ES (1) ES2146689T3 (ko)
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DE19641775A1 (de) * 1996-08-22 1998-02-26 Merck Patent Gmbh Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen
DE19635205A1 (de) * 1996-08-30 1998-03-05 Gerd Hoermansdoerfer Knochenzement
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
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BR9504293A (pt) 1996-10-01
AU3300595A (en) 1996-04-18
JPH08117322A (ja) 1996-05-14
CA2159871A1 (en) 1996-04-07
CN1127700A (zh) 1996-07-31
DE4435680A1 (de) 1996-04-11
CZ257495A3 (en) 1996-04-17
US5650108A (en) 1997-07-22
ES2146689T3 (es) 2000-08-16
ZA958407B (en) 1996-05-08
EP0705609A2 (de) 1996-04-10
DK0705609T3 (da) 2000-08-21
EP0705609A3 (de) 1997-07-30
DE59508127D1 (de) 2000-05-11
ATE191349T1 (de) 2000-04-15
PL310793A1 (en) 1996-04-15
EP0705609B1 (de) 2000-04-05

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