KR950702942A - 암의 간전이 억제용 의약 조성물 및 간암 치료용 의약 조성물(pharmaceutical compositions for preventing liver metastasis of cancer and pharmaceutical composition for the treatment of liver cancer) - Google Patents
암의 간전이 억제용 의약 조성물 및 간암 치료용 의약 조성물(pharmaceutical compositions for preventing liver metastasis of cancer and pharmaceutical composition for the treatment of liver cancer) Download PDFInfo
- Publication number
- KR950702942A KR950702942A KR1019950700434A KR19950700434A KR950702942A KR 950702942 A KR950702942 A KR 950702942A KR 1019950700434 A KR1019950700434 A KR 1019950700434A KR 19950700434 A KR19950700434 A KR 19950700434A KR 950702942 A KR950702942 A KR 950702942A
- Authority
- KR
- South Korea
- Prior art keywords
- cancer
- pharmaceutical composition
- liver
- metastasis
- treatment
- Prior art date
Links
- 206010027476 Metastases Diseases 0.000 title claims abstract 6
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 6
- 201000011510 cancer Diseases 0.000 title claims abstract 6
- 210000004185 liver Anatomy 0.000 title claims abstract 6
- 230000009401 metastasis Effects 0.000 title claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title claims 8
- 201000007270 liver cancer Diseases 0.000 title claims 5
- 208000014018 liver neoplasm Diseases 0.000 title claims 5
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims abstract 6
- 229960000684 cytarabine Drugs 0.000 claims abstract 6
- 230000002401 inhibitory effect Effects 0.000 claims abstract 5
- 239000004480 active ingredient Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- YJTVZHOYBAOUTO-URBBEOKESA-N cytarabine ocfosfate Chemical compound O[C@H]1[C@H](O)[C@@H](COP(O)(=O)OCCCCCCCCCCCCCCCCCC)O[C@H]1N1C(=O)N=C(N)C=C1 YJTVZHOYBAOUTO-URBBEOKESA-N 0.000 abstract 1
- 229950006614 cytarabine ocfosfate Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
아래의 식(I)으로 나타내어지는 시타라빈 옥포스페이트(Cytarabine Ocfosfate)는 암세포의 간장에의 전이를 억제하는 효과를 가지므로 암의 치료약으로 유효한 것으로 기대된다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 아래의 식(I)으로 나타내어지는 시타라빈 옥포스페이트를 유효 성분으로 함유하는 암의 간전이 억제용 의약 조성물 및 간암 치료용 의약 조성물.
- 식(I)으로 나타내어지는 시타라빈 옥포스페이트의 유효량을 투여하는 것을 포함하는 암의 간전이 억제 방법 및 간암 치료 방법.
- 식(I)으로 나타내어지는 시타라빈 옥포스페이트를 유효 성분으로 함유하는 암의 간전이 억제용 의약 조성물 및 간암 치료용 의약 조성물을 제조하기 위한 시타라빈 옥포스페이트의 용도.
- 유효 성분인 시타라빈 옥포스페이트와 부형제 혹은 담체를 혼합하는 것을 포함하는 암의 간전이 억제용 의약 조성물 및 간암 치료용 의약 조성물의 제조 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP92-232699 | 1992-08-10 | ||
| JP23269992 | 1992-08-10 | ||
| JP5170850A JPH06107548A (ja) | 1992-08-10 | 1993-06-18 | 癌の肝転移抑制剤及び肝癌の治療剤 |
| JP93-170850 | 1993-06-18 | ||
| PCT/JP1993/001100 WO1994003183A1 (en) | 1992-08-10 | 1993-08-05 | Medicinal composition for inhibiting cancer metastasis to liver and medicinal composition for curing hepatoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950702942A true KR950702942A (ko) | 1995-08-23 |
Family
ID=26493731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950700434A KR950702942A (ko) | 1992-08-10 | 1993-08-05 | 암의 간전이 억제용 의약 조성물 및 간암 치료용 의약 조성물(pharmaceutical compositions for preventing liver metastasis of cancer and pharmaceutical composition for the treatment of liver cancer) |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0654269A4 (ko) |
| JP (1) | JPH06107548A (ko) |
| KR (1) | KR950702942A (ko) |
| CN (1) | CN1086421A (ko) |
| AU (1) | AU4760593A (ko) |
| CA (1) | CA2140762A1 (ko) |
| CZ (1) | CZ33795A3 (ko) |
| HU (1) | HUT72602A (ko) |
| PL (1) | PL307353A1 (ko) |
| WO (1) | WO1994003183A1 (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2874902A (en) | 2000-10-18 | 2002-04-29 | Pharmasset Ltd | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62221696A (ja) * | 1986-03-24 | 1987-09-29 | Nippon Kayaku Co Ltd | １−β−Ｄ−アラビノフラノシルシトシン−５′−ステアリルりん酸モノナトリウム塩・１水和物 |
-
1993
- 1993-06-18 JP JP5170850A patent/JPH06107548A/ja active Pending
- 1993-08-05 EP EP94906768A patent/EP0654269A4/en not_active Withdrawn
- 1993-08-05 PL PL93307353A patent/PL307353A1/xx unknown
- 1993-08-05 HU HU9500397A patent/HUT72602A/hu unknown
- 1993-08-05 AU AU47605/93A patent/AU4760593A/en not_active Abandoned
- 1993-08-05 WO PCT/JP1993/001100 patent/WO1994003183A1/ja not_active Application Discontinuation
- 1993-08-05 KR KR1019950700434A patent/KR950702942A/ko not_active Application Discontinuation
- 1993-08-05 CZ CZ95337A patent/CZ33795A3/cs unknown
- 1993-08-05 CA CA002140762A patent/CA2140762A1/en not_active Abandoned
- 1993-08-09 CN CN93116240A patent/CN1086421A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994003183A1 (en) | 1994-02-17 |
| HU9500397D0 (en) | 1995-03-28 |
| CA2140762A1 (en) | 1994-02-17 |
| CN1086421A (zh) | 1994-05-11 |
| HUT72602A (en) | 1996-05-28 |
| PL307353A1 (en) | 1995-05-15 |
| EP0654269A4 (en) | 1995-08-23 |
| AU4760593A (en) | 1994-03-03 |
| EP0654269A1 (en) | 1995-05-24 |
| JPH06107548A (ja) | 1994-04-19 |
| CZ33795A3 (en) | 1995-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19950206 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |