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KR880001630A - 5-플루오로우라실 유도체 및 그의 용도 - Google Patents

5-플루오로우라실 유도체 및 그의 용도 Download PDF

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Publication number
KR880001630A
KR880001630A KR1019870006895A KR870006895A KR880001630A KR 880001630 A KR880001630 A KR 880001630A KR 1019870006895 A KR1019870006895 A KR 1019870006895A KR 870006895 A KR870006895 A KR 870006895A KR 880001630 A KR880001630 A KR 880001630A
Authority
KR
South Korea
Prior art keywords
fluorouracil
fluorouracil derivative
pyridyloxycarbonyl
benzoyloxy
ethoxymethyl
Prior art date
Application number
KR1019870006895A
Other languages
English (en)
Other versions
KR950011394B1 (ko
Inventor
세쓰로 후지이
Original Assignee
오오쓰까 아끼히꼬
오오쓰까세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61181027A external-priority patent/JPS63301880A/ja
Priority claimed from JP62034161A external-priority patent/JPS63201127A/ja
Application filed by 오오쓰까 아끼히꼬, 오오쓰까세이야꾸 가부시끼가이샤 filed Critical 오오쓰까 아끼히꼬
Publication of KR880001630A publication Critical patent/KR880001630A/ko
Application granted granted Critical
Publication of KR950011394B1 publication Critical patent/KR950011394B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

5-플루오로우라실 유도체 및 그의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(I)로 표시되는 5-플루오로우라실 유도체.
    [상기 식중, Ra는 C1~C6알콕시메틸기이다].
  2. 제1항에 있어서, 5-플루오로우라실 유도체가 3-[3-(6-벤조일옥시-3-시아노-2-피리딜옥시카르보닐)벤조일]-1-에톡시메틸-5-플루오로우라실인 화합물.
  3. 하기 일반식(I)로 표시되는 5-플루오로우라실 유도체의 유효량 및 약학적으로 허용 가능한 담체로 구성되는 항암 조성물.
    [상기 식중, Ra는 C1~C6알콕시메틸기이다].
  4. 제3항에 있어서, 5-플루오로우라실 유도체가 3-[3-(6-벤조일옥시-3-시아노-2-피리딜옥시카르보닐) 벤조일]-1-에톡시메틸-5-플루오로우라실인 항암 조성물.
  5. 하기 일반식(1)로 표시되는 5-플루오로우라실 유도체의 유효량을 환자에게 투여함을 특징으로 하는 환자에 있어서 암의 치료방법.
    [상기 식중, Ra는 C1~C6알콕시메틸기이다].
  6. 제5항에 있어서, 5-플루오로우라실 유도체가 3-[3-6-벤조일옥시-3-시아노-2-피리딜옥시카르보닐)벤조일]-1-에톡시메틸-5-플루오로우라실인 암의 치료방법.
  7. 암 치료용 조성물을 제조하기 위한 하기 일반식(I)로 표시되는 5-플루오로우라실 유도체의 용도.
    [상기 식중, Ra는 C1~C6알콕시메틸기이다].
  8. 제7항에 있어서, 5-플루오로우라실 유도체가 3-[3-(6-벤조일옥시-3-시아노-2-피리딜옥시카르보닐)벤조일]-1-에톡시메틸-5-플루오로우라실인 암 치료용 조성물을 제조하기 위한 5-플루오로우라실 유도체의 용도.
  9. 암을 치료하기 위한 하기 일반식(1)로 표시되는 5-플루오로우라실 유도체의 용도.
    [상기 식중, Ra는 C1~C6알콕시메틸기이다].
  10. 제9항에 있어서, 5-플루오로우라실 유도체가 3-[3-(6-벤조일옥시-3-시아노-2-피리딜옥시카르보닐)벤조일]-1-에톡시메틸-5-플루오로우라실인 암을 치료하기 위한 5-플루오로우라실 유도체의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870006895A 1986-07-25 1987-07-01 5-플루오로우라실 유도체 및 그의 용도 KR950011394B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP176464/1986 1986-07-25
JP17646486 1986-07-25
JP86-176464 1986-07-25
JP86-181072 1986-07-30
JP181027/1986 1986-07-30
JP61181027A JPS63301880A (ja) 1985-09-03 1986-07-30 ５−フルオロウラシル誘導体
JP34161/1987 1987-02-17
JP87-34161 1987-02-17
JP62034161A JPS63201127A (ja) 1987-02-17 1987-02-17 ５−フルオロウラシル誘導体を含有する制癌剤

Publications (2)

Publication Number Publication Date
KR880001630A true KR880001630A (ko) 1988-04-25
KR950011394B1 KR950011394B1 (ko) 1995-10-02

Family

ID=27288338

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019870002961A KR950009857B1 (ko) 1986-07-25 1987-03-30 5-플루오로우라실 유도체의 제조방법
KR1019870006895A KR950011394B1 (ko) 1986-07-25 1987-07-01 5-플루오로우라실 유도체 및 그의 용도

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019870002961A KR950009857B1 (ko) 1986-07-25 1987-03-30 5-플루오로우라실 유도체의 제조방법

Country Status (10)

Country Link
KR (2) KR950009857B1 (ko)
CH (1) CH671578A5 (ko)
DE (1) DE3709699C2 (ko)
DK (1) DK169520B1 (ko)
ES (1) ES2004904A6 (ko)
FR (1) FR2605006B1 (ko)
GB (1) GB2192880B (ko)
IT (1) IT1207785B (ko)
NL (1) NL194043C (ko)
SE (1) SE464303B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
WO1990007334A1 (en) 1989-01-05 1990-07-12 Otsuka Pharmaceutical Co., Ltd. Non-injection carcinostatic agent for suppressing occurrence of inflammation due to 5-fluorouracil and method for curing cancer
EP0489181B1 (en) * 1990-07-19 1996-10-02 Otsuka Pharmaceutical Co., Ltd. Solid preparation
CN102574837B (zh) * 2009-10-27 2013-11-27 德尔塔菲制药股份有限公司 新的5-氟尿嘧啶衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323441B1 (en) * 1984-10-30 1996-04-24 Otsuka Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
JPS61114739A (ja) * 1984-11-08 1986-06-02 Mitsubishi Rayon Co Ltd 不飽和カルボン酸製造用触媒の調製法

Also Published As

Publication number Publication date
GB8706972D0 (en) 1987-04-29
FR2605006B1 (fr) 1990-01-12
FR2605006A1 (fr) 1988-04-15
KR950009857B1 (ko) 1995-08-29
DE3709699A1 (de) 1988-02-04
ES2004904A6 (es) 1989-02-16
SE8701118D0 (sv) 1987-03-18
DK133387D0 (da) 1987-03-16
GB2192880A (en) 1988-01-27
NL8700742A (nl) 1988-02-16
DK133387A (da) 1988-01-26
IT1207785B (it) 1989-06-01
KR950011394B1 (ko) 1995-10-02
DK169520B1 (da) 1994-11-21
NL194043B (nl) 2001-01-02
KR880001635A (ko) 1988-04-25
NL194043C (nl) 2001-05-03
SE464303B (sv) 1991-04-08
IT8705150A0 (it) 1987-03-30
GB2192880B (en) 1990-05-09
DE3709699C2 (de) 1996-09-05
SE8701118L (sv) 1988-01-26
CH671578A5 (ko) 1989-09-15

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