[go: up one dir, main page]

KR930017916A - 황산화 디오스민 유도체 - Google Patents

황산화 디오스민 유도체 Download PDF

Info

Publication number
KR930017916A
KR930017916A KR1019930002682A KR930002682A KR930017916A KR 930017916 A KR930017916 A KR 930017916A KR 1019930002682 A KR1019930002682 A KR 1019930002682A KR 930002682 A KR930002682 A KR 930002682A KR 930017916 A KR930017916 A KR 930017916A
Authority
KR
South Korea
Prior art keywords
diosmin
hydrogen sulphate
heptakis
sulfated
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019930002682A
Other languages
English (en)
Other versions
KR100272646B1 (ko
Inventor
오르할레스-베네로 아우렐리오
모스께라-페스타냐 라몬
Original Assignee
자비엘 가르시아 데 라마
파브리까 에스파뇨라 데 쁘로독또스 끼미꼬스 이 빠르마세우띠꼬스 소시에다드 아노니마
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 자비엘 가르시아 데 라마, 파브리까 에스파뇨라 데 쁘로독또스 끼미꼬스 이 빠르마세우띠꼬스 소시에다드 아노니마 filed Critical 자비엘 가르시아 데 라마
Publication of KR930017916A publication Critical patent/KR930017916A/ko
Application granted granted Critical
Publication of KR100272646B1 publication Critical patent/KR100272646B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Ceramic Products (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Seasonings (AREA)

Abstract

디오스민 헵타키스(황산수소)알루미늄 착체가 기재되어 있고 1몰의 디오스민과 7몰의 황상화제를 건조매질중에서 반응시키고 이렇게 얻은 디어스민 헵타키스(황산수소) 나트륨염을 알루미늄 히드록시클로라이드 수용액으로 처리하는 것을 특징으로 하는 그것의 제조방법도 기재되어 있다.
이 생성물의 세포보호 작용을 확인하기 위해 수행되는 약리학적 분석에 대해서도 기술되어 있다.

Description

황산화 디오스민 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 분자식의 디오스민 헵타키스(황산수소) 알루미늄 착체
    상기식에서 R은 SO3〔Al2(OH)5〕를 나타낸다.
  2. 궤양 질병의 치료에 유용한, 효과적인 양의 디오스민 헵타키스(황산수소)알루미늄 착체를 투여하는 것에 의한 세포보호 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930002682A 1992-02-25 1993-02-25 황산화 디오스민 유도체 Expired - Fee Related KR100272646B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9200414 1992-02-25
ES09200414A ES2041216B1 (es) 1992-02-25 1992-02-25 Procedimiento de preparacion de un nuevo derivado sulfatado de diosmina.

Publications (2)

Publication Number Publication Date
KR930017916A true KR930017916A (ko) 1993-09-20
KR100272646B1 KR100272646B1 (ko) 2000-11-15

Family

ID=8276183

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930002682A Expired - Fee Related KR100272646B1 (ko) 1992-02-25 1993-02-25 황산화 디오스민 유도체

Country Status (16)

Country Link
US (1) US5296469A (ko)
EP (1) EP0558435B1 (ko)
JP (1) JPH069677A (ko)
KR (1) KR100272646B1 (ko)
AT (1) ATE184014T1 (ko)
AU (1) AU661553B2 (ko)
CA (1) CA2090301C (ko)
DE (1) DE69326176T2 (ko)
DK (1) DK0558435T3 (ko)
ES (1) ES2041216B1 (ko)
FI (1) FI930812L (ko)
GR (1) GR3031972T3 (ko)
MX (1) MX9301042A (ko)
NO (1) NO179709C (ko)
TW (1) TW305845B (ko)
ZA (1) ZA931300B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1975297A (en) * 1996-02-21 1997-09-10 Glycomed Incorporated Sialyl lewisx mimetics containing flavanoid backbones
ES2158774B1 (es) * 1999-04-12 2002-03-16 Faes Fabrica Espanola De Produ Nuevo procedimiento para la preparacion industrial de dosmalfato en povo.
US7034054B2 (en) * 2000-12-15 2006-04-25 Galileo Pharmaceuticals, Inc. Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols
CN102272129B (zh) * 2009-01-03 2014-10-08 静冈县公立大学法人 硫酸化c-糖苷及其分离方法以及合成方法
EP3949972A4 (en) * 2019-05-05 2022-06-15 Guangzhou Century Clinical Research Co., Ltd COMPOUND FOR REGULATING AN IMBALANCE OF BODY WEIGHT, COMPOSITION THEREOF AND APPLICATION THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58513A (en) * 1978-12-04 1982-11-30 American Cyanamid Co Rutin poly(h-)sulfate salts and the preparation thereof
US4334058A (en) * 1979-07-31 1982-06-08 American Cyanamid Company Rutin poly(H--)sulfate salts and related compounds
US4414207A (en) * 1980-08-25 1983-11-08 American Cyanamid Company Rutin poly(H-)sulfate salts and related compounds
ES8707969A1 (es) * 1986-05-09 1987-10-01 Espanola Prod Quimicos Procedimiento de preparacion de una mezcla estandar de o-(b-hidroxietil)-diosminas
IT1245371B (it) * 1991-03-28 1994-09-20 Geymonat Spa Derivati di flavoni, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
NO179709B (no) 1996-08-26
MX9301042A (es) 1993-12-01
ES2041216B1 (es) 1994-06-16
ATE184014T1 (de) 1999-09-15
NO179709C (no) 1996-12-04
FI930812A0 (fi) 1993-02-24
CA2090301A1 (en) 1993-08-26
EP0558435B1 (en) 1999-09-01
GR3031972T3 (en) 2000-03-31
DE69326176D1 (de) 1999-10-07
ZA931300B (en) 1993-12-20
NO930670L (no) 1993-08-26
CA2090301C (en) 2000-04-11
KR100272646B1 (ko) 2000-11-15
FI930812L (fi) 1993-08-26
JPH069677A (ja) 1994-01-18
TW305845B (ko) 1997-05-21
AU3378793A (en) 1993-08-26
NO930670D0 (no) 1993-02-25
DK0558435T3 (da) 2000-03-27
US5296469A (en) 1994-03-22
ES2041216A1 (es) 1993-11-01
EP0558435A1 (en) 1993-09-01
DE69326176T2 (de) 2000-04-20
AU661553B2 (en) 1995-07-27

Similar Documents

Publication Publication Date Title
KR900018129A (ko) 콘드로이틴 황산염, 데르마탄황산염 및 히알루론산의 술포아미노 유도체와 그 약제학적 성질
CA2266523A1 (en) Aqueous disinfecting agent containing performic acid and peracetic acid
KR840000236A (ko) 포유류의 국부용 제형의 수분 손실량을 극소화시키는 방법
ES8603480A1 (es) Procedimiento para preparar nuevos imidazoles
KR930004330A (ko) β-시클로덱스트린 유도체의 폴리술페이트 및 그의 제조방법
KR930017916A (ko) 황산화 디오스민 유도체
KR900000070A (ko) 화장제 조성물
KR850001731A (ko) 아줄렌 유도체의 제조방법
KR970707086A (ko) 제이철 이온을 첨가하여 아연 및 망간 메티오닌 착염의 용해도를 향상시키는 방법(enhanced solubilization of zinc and manganese methionine complex salts byaddition of ferric ion)
KR940011415A (ko) 1,1-디클로로-1-플루오로에탄의 정제방법
KR900018012A (ko) 아실 시아나이드의 합성 방법
KR870006192A (ko) 항생제 tan-749관련 화합물의 제조방법
KR930700397A (ko) 레졸신올 제조방법
KR870006024A (ko) 니자티딘의 제조방법
KR840003262A (ko) 안트리사이클린 글리코시드의 제조방법
KR890014086A (ko) 구상 위생 증진용 치약 조성물
KR890017259A (ko) 모액으로부터의 항생물질 회수방법 및 그의 약학적으로 허용할 수 있는 신규한 염
KR910006223A (ko) 2-알킬아미노-4-아미노벤젤술폰산의 제조방법
KR940005557A (ko) 아미노포르마잔의 제조방법
PT101446A (pt) Metodo para aumentar a solubilidade e estabilidade do cloranfenicol, atraves da formacao de complexos de inclusao com ciclodextrinas, solucoes contendo o referido complexo de inclusao e processo para a preparacao dessas solucoes.
KR870007844A (ko) 알루미늄 마그네슘 하이드록시 카보네이트의 제조방법
KR910000786A (ko) 콜레스타디엔 유도체, 이의 제조방법 및 HMG-CoA 환원제를 저해하는 작용을 하는 약제로서의 이의 용도
KR870010062A (ko) 세파로스포린 유도체의 제조방법
KR910019993A (ko) 디히드로후리논 유도체의 제조방법
KR970011158A (ko) 폴리에스테르 섬유의 감량처리방법

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19930225

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19980220

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19930225

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19991129

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20000615

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20000828

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20000829

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20030812

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20030812

Start annual number: 4

End annual number: 4

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

Termination category: Default of registration fee

Termination date: 20050510