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ES8603480A1 - Procedimiento para preparar nuevos imidazoles - Google Patents

Procedimiento para preparar nuevos imidazoles

Info

Publication number
ES8603480A1
ES8603480A1 ES541662A ES541662A ES8603480A1 ES 8603480 A1 ES8603480 A1 ES 8603480A1 ES 541662 A ES541662 A ES 541662A ES 541662 A ES541662 A ES 541662A ES 8603480 A1 ES8603480 A1 ES 8603480A1
Authority
ES
Spain
Prior art keywords
procedure
acid
formula
preparing new
new imidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541662A
Other languages
English (en)
Other versions
ES541662A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8603480A1 publication Critical patent/ES8603480A1/es
Publication of ES541662A0 publication Critical patent/ES541662A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS IMIDAZOLES. CONSISTE EN HACER REACIONAR UN COMPUESTO DE FORMULA (II) CON UN HALOGENURO DE FORMULA (III) PARA OBTENER UN COMPUESTO DE FORMULA (I), QUE ES TRANSFORMADO EN SU SAL POR ADICION DE ACIDO, ESPECIALMENTE EN SU SAL POR ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLE CON UN ACIDO INORGANICO U ORGANICO. LA REACCION SE LLEVA A CABO EN PRESENCIA DE UN AGENTE FIJADOR DE ACIDOS Y UN DISOLVENTE Y A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 100JC, PREFERENTEMENTE ENTRE 20 Y 50JC. APLICACION FARMACOLOGICA.
ES541662A 1983-07-05 1985-03-28 Procedimiento para preparar nuevos imidazoles Granted ES541662A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833324115 DE3324115A1 (de) 1983-07-05 1983-07-05 Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8603480A1 true ES8603480A1 (es) 1985-12-16
ES541662A0 ES541662A0 (es) 1985-12-16

Family

ID=6203136

Family Applications (4)

Application Number Title Priority Date Filing Date
ES533995A Granted ES533995A0 (es) 1983-07-05 1984-07-04 Procedimiento para preparar imidasoles
ES541662A Granted ES541662A0 (es) 1983-07-05 1985-03-28 Procedimiento para preparar nuevos imidazoles
ES541661A Expired ES8603479A1 (es) 1983-07-05 1985-03-28 Procedimiento para preparar nuevos imidazoles
ES541660A Expired ES8603478A1 (es) 1983-07-05 1985-03-28 Procedimiento para preparar nuevos imidazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES533995A Granted ES533995A0 (es) 1983-07-05 1984-07-04 Procedimiento para preparar imidasoles

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES541661A Expired ES8603479A1 (es) 1983-07-05 1985-03-28 Procedimiento para preparar nuevos imidazoles
ES541660A Expired ES8603478A1 (es) 1983-07-05 1985-03-28 Procedimiento para preparar nuevos imidazoles

Country Status (18)

Country Link
US (2) US4670438A (es)
EP (1) EP0130461A3 (es)
JP (1) JPS6036486A (es)
KR (1) KR850001208A (es)
AU (1) AU3032384A (es)
DD (1) DD224851A5 (es)
DE (1) DE3324115A1 (es)
DK (1) DK326484A (es)
ES (4) ES533995A0 (es)
FI (1) FI842666A (es)
GR (1) GR82380B (es)
HU (1) HU194878B (es)
IL (1) IL72298A0 (es)
NO (1) NO842684L (es)
NZ (1) NZ208779A (es)
PH (1) PH21496A (es)
PT (1) PT78836B (es)
ZA (1) ZA845103B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346640A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4783530A (en) * 1986-11-13 1988-11-08 Marion Laboratories, Inc. 8-arylxanthines
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
DE3929864A1 (de) * 1989-09-08 1991-03-14 Nordmark Arzneimittel Gmbh Verfahren zur herstellung von theophyllin-pellets
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
US5877176A (en) * 1991-12-26 1999-03-02 Cornell Research Foundation, Inc. Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis
JP2534423B2 (ja) * 1991-12-26 1996-09-18 コーネル・リサーチ・ファンデーション・インコーポレイテッド 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤
EP0577025A3 (de) * 1992-07-01 1998-02-04 Hoechst Aktiengesellschaft Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen
JPH08507068A (ja) * 1993-02-26 1996-07-30 シェリング・コーポレーション ２−ベンジル−多環式グアニン誘導体およびそれらの製造方法
CA2131134A1 (en) * 1993-09-17 1995-03-18 Gerhard Stucky Process for preparing imidazopyridine derivatives
CA2131680C (en) * 1993-09-17 2006-11-07 Gerhard Stucky Process for preparing imidazopyridine derivatives
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
US6887690B2 (en) * 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
EP1991226B1 (en) * 2006-02-28 2013-03-20 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
AU2008271170A1 (en) * 2007-06-27 2009-01-08 Merck Sharp & Dohme Corp. Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors
US20090197880A1 (en) * 2007-07-13 2009-08-06 Genelabs Technologies, Inc. Anti-viral compounds, compositions, and methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660397A (en) * 1970-04-17 1972-05-02 Merck & Co Inc Imidazo(4 5-b)pyrazines
US3922345A (en) * 1971-10-29 1975-11-25 Pfizer Pyrimidinones and hydroxy pyrimidines
DE2305339C3 (de) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
EP0011399A1 (en) * 1978-11-11 1980-05-28 FISONS plc N-substituted theophyllines, processes for their preparation and pharmaceutical compositions containing them
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DE3037464A1 (de) * 1980-10-03 1982-05-19 Dr. Karl Thomae Gmbh, 7950 Biberach 6-hydroxy-2-phenyl-imidazo 4,5-b zu pyridine, ihre herstellung und diese sie enthaltende arzneimittel
DE3044497A1 (de) * 1980-11-26 1982-06-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neues verfahren zur herstellung von imidazo(4,5-b)pyridinen und -pyrimidinen
GB2091249A (en) * 1980-12-23 1982-07-28 Fordonal Sa Xanthine derivatives
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4452788A (en) * 1982-04-21 1984-06-05 Warner-Lambert Company Substituted 8-phenylxanthines
RO86850B (ro) * 1982-05-03 1985-05-31 Eli Lilly And Company Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine
DE3217583A1 (de) * 1982-05-11 1983-11-17 Merck Patent Gmbh, 6100 Darmstadt 2-aryl-tetraazaindene
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
EP0130461A3 (de) 1987-05-06
NO842684L (no) 1985-01-07
DK326484D0 (da) 1984-07-03
EP0130461A2 (de) 1985-01-09
FI842666A0 (fi) 1984-07-03
NZ208779A (en) 1988-02-29
US4766130A (en) 1988-08-23
KR850001208A (ko) 1985-03-16
DK326484A (da) 1985-01-06
ES541661A0 (es) 1985-12-16
ES8506017A1 (es) 1985-06-16
DD224851A5 (de) 1985-07-17
PT78836A (de) 1984-08-01
ES8603479A1 (es) 1985-12-16
US4670438A (en) 1987-06-02
ES541660A0 (es) 1985-12-16
IL72298A0 (en) 1984-11-30
ES8603478A1 (es) 1985-12-16
AU3032384A (en) 1985-01-10
HU194878B (en) 1988-03-28
JPS6036486A (ja) 1985-02-25
HUT34475A (en) 1985-03-28
DE3324115A1 (de) 1985-01-17
PH21496A (en) 1987-11-10
ES533995A0 (es) 1985-06-16
ES541662A0 (es) 1985-12-16
FI842666A (fi) 1985-01-06
ZA845103B (en) 1986-03-26
PT78836B (de) 1986-10-21
GR82380B (es) 1984-12-13

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