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KR920702361A - 10(1-히드록시에틸)-11-옥소-1-아자트리시클로[7.2.0.0.3.8]운데스-2-엔-2-카르복실산 에스테르 및 그의 제조 방법 - Google Patents

10(1-히드록시에틸)-11-옥소-1-아자트리시클로[7.2.0.0.3.8]운데스-2-엔-2-카르복실산 에스테르 및 그의 제조 방법

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Publication number
KR920702361A
KR920702361A KR1019920700916A KR920700916A KR920702361A KR 920702361 A KR920702361 A KR 920702361A KR 1019920700916 A KR1019920700916 A KR 1019920700916A KR 920700916 A KR920700916 A KR 920700916A KR 920702361 A KR920702361 A KR 920702361A
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KR
South Korea
Prior art keywords
group
compound
methoxy
alkyl
hydrogen atom
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KR1019920700916A
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English (en)
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KR0169147B1 (en
Inventor
알시드 페르보니
티노 로시
지오반니 가비라기
안토넬라 우르시니
지오르지오 타르지아
Original Assignee
원본미기재
글락소 에스.피.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from GB909018330A external-priority patent/GB9018330D0/en
Priority claimed from GB919104770A external-priority patent/GB9104770D0/en
Application filed by 원본미기재, 글락소 에스.피.에이. filed Critical 원본미기재
Publication of KR920702361A publication Critical patent/KR920702361A/ko
Application granted granted Critical
Publication of KR0169147B1 publication Critical patent/KR0169147B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

20(1-히드록시에틸)-11-옥소-1-아자트리시클로[7.2.0.0.3.8]운데스-2-엔-2-카르복실산 에스테르 및 그의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기 일반식(Ⅰ)의 화합물.
    상기 식중, R1은기 (상기 식중, R4는 수소 원자 또는 C1-4알킬기를 나타내고; p는 0 또는 1을 나타내고; R5는 C1-4알킬, C1-4알킬기에 의해 치환된 C1-4알킬을 나타냄)를 나타내고, R2는 OR3기(여기서, R3은 C1-4알킬기를 나타냄)를 나타낸다.
  2. 제1항에 있어서, 하기 배위를 가진 화합물.
    상기 식중, R1및 R2는 제1항에 정의한 바와 같다.
  3. 제1항 또는 제2항에 있어서, R4가 수소 원자 또는 메틸기를 나타내는 화합물.
  4. 제1항 내지 제3항중 어느 한항에 있어서, R2가 메톡시 또는 에톡시기를 나타내는 화합물.
  5. 제1항 내지 제4항중 어느 한항에 있어서, R5가 메틸, 에틸, 이소프로필, t-부틸, 1-메톡시-1-메틸에틸, 페닐, 시클로헥실 또는 4-에틸시클로헥실기를 나타내는 화합물.
  6. 제2항에 있어서, R4가 수소 원자 또는 메틸기를 나타내고; R5가 C1-4알킬, C1-2알킬기에 의해 치환될 수 있는 C5-6시클로알킬, 페닐 및 메톡시에 의해 치환된 C1-4알킬로 부터 선택된 기이고; R2가 메톡시기인 화합물.
  7. (4S,8S,9R,10S,12R)-4-메톡시-10-(1-히드록시에틸)-11-옥소-1-아자트리시클로[7.2.0.03,8]운데스-2-엔-2-카르복실산의 피발로일옥시메틸, 1-피발로일옥시에틸, 아세톡시메틸, 1-아세톡시에틸, 1-메톡시-1-메틸에틸카르보닐옥시메틸, 1-(1-메톡시-메틸에틸카르보닐옥시메틸, 1-벤조일옥시에틸, 1-이소프로폭시카르보닐옥시에틸, 시클로헥실옥시카르보닐옥시메틸 및 1-(4-에틸시클로헥실옥시카르보닐옥시)에틸 에스테르.
  8. 1-시클로헥실옥시카르보닐옥시메틸 (4S,8S,9R,10S,12R)-4-메톡시-10-(1-히드록시에틸)-11-옥소-1-아자트리시클로[7.2.0.03,8]운데스-2-엔-2-카르복실레이트.
  9. 제1항 내지 제8항중 어느 한항에 있어서, 인간 또는 동물에 있어서 전신 박테리아 감염증의 치료 또는 예방용의 화합물.
  10. 인간 또는 동물 채내에서의 전신 박테리아 감염증의 치료 또는 예방을 위한 치료제의 제조에 있어서의 제1항 내지 제8항중 어느 한항에 정의한 화합물의 용도.
  11. 1종 이상의 생리학적 허용되는 담체 또는 부형제와 혼합된 제1항 내지 제8항 중 어느 한항에 있어서, 화합물로 이루어진 제약학적 조성물.
  12. 제1항 내지 제8항중 어느 한항에 정의된 화합물 유료량을 인간 또는 비인간의 체내에 투여하는 것을 이루어지는 바테리아 감영증을 억제하기 위한 인간 또는 비인간의 치료 방법.
  13. (a) 하기 일반식(Ⅱ)의 화합물 또는 그의 염 또는 반응성 유도체를 에스테르화제와 반응시켜 제1항에 정의된 R1기를 도입하거나
    (상기 식중, R2는 제1항에 정의한 바와 같고, Ra는 수소 원자 또는 히드록시 보호기를 나타냄), 또는 (b)하기 일반식(Ⅲ)의 화합물을 고리화시키고, 그후에 필요 또는 소망에 따라 히드록실 보호기 Ra를 수소 원자에 의해 치환 반응시키고 및(또는) 일반식(Ⅰ)의 화합물의 1종 이상의 다른 이성질체로부터의 그의 특별히 목적하는 이성질체를 분리시키는 것.
    (상기 식중, R1및 R2는 제1항에 정의한 바와 같고, Ra는 수소 원자 또는 히드록실 보호기이고, Y는 산소 원자 또는 포스핀기를 나타냄)으로 이루어지는 제1항에 정의된 일반식(Ⅰ)의 화합물의 제조 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920700916A 1990-08-21 1992-04-20 10-(1-hydroxyethyl)-11-oxo-1-azatricyclo(7,2,0,0(3,8))undec-2-ene-2-carboxylic acid esters and a proces for preparing thereof Expired - Fee Related KR0169147B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB91047704 1990-03-07
GB90183302 1990-08-21
GB909018330A GB9018330D0 (en) 1990-08-21 1990-08-21 Heterocyclic compounds
GB919104770A GB9104770D0 (en) 1991-03-07 1991-03-07 Heterocyclic compounds
PCT/EP1991/001589 WO1992003437A1 (en) 1990-08-21 1991-08-20 10(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3.8]undec-2-ene-2-carboxylic acid esters and a process for preparing thereof

Publications (2)

Publication Number Publication Date
KR920702361A true KR920702361A (ko) 1992-09-03
KR0169147B1 KR0169147B1 (en) 1999-01-15

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KR1019920700916A Expired - Fee Related KR0169147B1 (en) 1990-08-21 1992-04-20 10-(1-hydroxyethyl)-11-oxo-1-azatricyclo(7,2,0,0(3,8))undec-2-ene-2-carboxylic acid esters and a proces for preparing thereof

Country Status (32)

Country Link
US (1) US5587374A (ko)
EP (1) EP0495953B1 (ko)
JP (2) JP3151215B2 (ko)
KR (1) KR0169147B1 (ko)
CN (1) CN1030917C (ko)
AP (1) AP238A (ko)
AT (1) ATE106887T1 (ko)
AU (1) AU647178B2 (ko)
CA (1) CA2067741C (ko)
CY (1) CY2037A (ko)
CZ (1) CZ280942B6 (ko)
DE (1) DE69102415T2 (ko)
DK (1) DK0495953T3 (ko)
ES (1) ES2054502T3 (ko)
FI (1) FI97136C (ko)
HK (1) HK19495A (ko)
HR (1) HRP940556B1 (ko)
HU (2) HUT61024A (ko)
IE (1) IE66122B1 (ko)
IL (1) IL99248A (ko)
MX (1) MX9100743A (ko)
MY (1) MY106997A (ko)
NO (1) NO300176B1 (ko)
NZ (1) NZ239474A (ko)
OA (1) OA09578A (ko)
PL (1) PL169425B1 (ko)
PT (1) PT98729B (ko)
SG (1) SG169494G (ko)
SI (1) SI9111427B (ko)
SK (1) SK121392A3 (ko)
WO (1) WO1992003437A1 (ko)
YU (1) YU48079B (ko)

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GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
AP294A (en) * 1992-08-31 1993-12-28 Glaxo Spa "10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo-(7.2.0.0.3.8) undec-2-ene-2-carboxylic acid derivatives".
GB9218781D0 (en) * 1992-09-04 1992-10-21 Glaxo Spa Heterocyclic derivatives
IN188720B (ko) * 1997-11-06 2002-11-02 Panacea Biotec Ltd
KR100945706B1 (ko) * 2001-11-05 2010-03-05 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규 카르바페넴 화합물
WO2004089954A1 (ja) * 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. 新規なカルバペネム化合物
EP1785426A4 (en) * 2004-09-03 2008-02-20 Dainippon Sumitomo Pharma Co NEW CARBAPENEM DERIVATIVE
JPWO2006103999A1 (ja) * 2005-03-25 2008-09-04 大日本住友製薬株式会社 新規なカルバペネム化合物
EP2085084A1 (en) 2008-01-29 2009-08-05 LEK Pharmaceuticals D.D. Use of inhibitor of beta-lactamases and its combination with beta-lactam antibiotics
EP2135871A1 (en) * 2008-06-18 2009-12-23 LEK Pharmaceuticals D.D. New trinem antibiotics and inhibitors of beta-lactamases
EP3621609B1 (en) 2017-05-08 2022-07-27 GlaxoSmithKline Intellectual Property Development Limited Sanfetrinem or a salt or ester thereof for use in treating mycobacterial infection

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DE2811514A1 (de) * 1977-03-19 1978-09-21 Beecham Group Ltd Ester der 7-oxo-1-azabicyclo eckige klammer auf 3.2.0 eckige klammer zu hept- 2-en-2-carbonsaeure und deren derivate, verfahren zur herstellung dieser verbindungen und diese verbindungen enthaltende pharmazeutische zubereitungen
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AU636913B2 (en) * 1989-10-11 1993-05-13 Takeda Chemical Industries Ltd. Tricyclic carbapenem compounds
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GB9104832D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
SI9111427B (sl) 2000-10-31
FI97136C (fi) 1996-10-25
FI97136B (fi) 1996-07-15
EP0495953B1 (en) 1994-06-08
JP3461786B2 (ja) 2003-10-27
HK19495A (en) 1995-02-17
HRP940556B1 (en) 2000-06-30
PL169425B1 (pl) 1996-07-31
US5587374A (en) 1996-12-24
KR0169147B1 (en) 1999-01-15
SG169494G (en) 1995-04-28
NO300176B1 (no) 1997-04-21
PT98729A (pt) 1992-07-31
AP238A (en) 1993-02-04
SK278470B6 (en) 1997-06-04
SI9111427A (en) 1996-12-31
CA2067741A1 (en) 1992-02-22
DK0495953T3 (da) 1994-07-18
ES2054502T3 (es) 1994-08-01
WO1992003437A1 (en) 1992-03-05
JP3151215B2 (ja) 2001-04-03
IL99248A0 (en) 1992-07-15
HRP940556A2 (en) 1996-06-30
FI921717A0 (fi) 1992-04-16
HUT61024A (en) 1992-11-30
CN1060094A (zh) 1992-04-08
MX9100743A (es) 1992-04-01
PT98729B (pt) 1999-01-29
AP9100320A0 (en) 1991-10-31
CY2037A (en) 1998-02-20
AU8421291A (en) 1992-03-17
HU9201303D0 (en) 1992-07-28
CZ121392A3 (en) 1993-04-14
OA09578A (en) 1993-01-31
CA2067741C (en) 2002-01-01
DE69102415T2 (de) 1994-10-13
YU142791A (sh) 1994-01-20
IE66122B1 (en) 1995-12-13
IL99248A (en) 1996-01-31
JP2000351730A (ja) 2000-12-19
EP0495953A1 (en) 1992-07-29
NO921521D0 (no) 1992-04-15
FI921717L (fi) 1992-04-16
MY106997A (en) 1995-08-30
NZ239474A (en) 1994-06-27
IE912944A1 (en) 1992-02-26
CZ280942B6 (cs) 1996-05-15
YU48079B (sh) 1997-01-08
SK121392A3 (en) 1997-06-04
DE69102415D1 (de) 1994-07-14
CN1030917C (zh) 1996-02-07
NO921521L (no) 1992-06-22
JPH05502044A (ja) 1993-04-15
AU647178B2 (en) 1994-03-17
ATE106887T1 (de) 1994-06-15
HU211584A9 (en) 1995-12-28

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