KR920008003A - 내부 기생충을 구제하기 위한 치환된 2- 머캅토니코틴산 유도체의 용도, 신규한 치환된 2- 머캅토니코틴산 유도체 및 그의 제조방법 - Google Patents
내부 기생충을 구제하기 위한 치환된 2- 머캅토니코틴산 유도체의 용도, 신규한 치환된 2- 머캅토니코틴산 유도체 및 그의 제조방법 Download PDFInfo
- Publication number
- KR920008003A KR920008003A KR1019910017565A KR910017565A KR920008003A KR 920008003 A KR920008003 A KR 920008003A KR 1019910017565 A KR1019910017565 A KR 1019910017565A KR 910017565 A KR910017565 A KR 910017565A KR 920008003 A KR920008003 A KR 920008003A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- alkyl
- compound
- substituted
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- WYKHFQKONWMWQM-UHFFFAOYSA-N 2-sulfanylidene-1h-pyridine-3-carboxylic acid Chemical class OC(=O)C1=CC=CN=C1S WYKHFQKONWMWQM-UHFFFAOYSA-N 0.000 title claims 4
- 244000045947 parasite Species 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 title claims 2
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 8
- -1 cyano, nitro, amino Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000005110 aryl thio group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000003139 biocide Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000003071 parasitic effect Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 의학 또는 수의학 분야에서 내부 기생충을 구제하기 위한 하기 일반식(I)의 화합물의 용도.상기식에서, R1은 할로겐, 시아노, 니트로, 아미노, 알킬아미노, 아미노아실, 알킬, 아르알킬, 할로게노알킬, 알콕시, 아릴옥시, 할로게노알콕시, 알킬티오, 아릴티오, 알킬술피닐, 아릴술피닐, 아릴술포닐, 할로게노알킬티오, 할로게노알킬술피닐, 할로게노알킬술포닐 또는 카르보닐 아릴에 의해 임의 치환된 C1-C8-알킬, 아르알킬, 아릴 또는 헤테로 아릴 기를 나타내고, X는 0또는를 나타내고, R2는 C1-5-알킬, 아르알킬, 알케닐 또는 알키닐을 나타내고, R3는 H 또는 알킬을 나타내거나, R1과 R3가 인접한 N원자와 함께는, 추가의 헤테로원자로서 0 또는 N을 함유할 수 있고, C1-4-알킬에 의해 임의 치환되는 5 또는 6-원헤테로사이클을 나타내고, R4는 수소, 할로겐, 또는 임의 치환된 알킬, 할로게노알킬, 시아노, 니트로, 아미노, 아미노아실, 페닐, 알콕시, 아릴옥시, 티오알킬 또는 아릴티오를 나타낸다.
- 하기 일반식(I)의 치환된 2-머캅토니코틴산 유도체.상기식에서, R1은 할로겐, 시아노, 니트로, 아미노, 알킬, 아미노, 아미노알킬, 알킬, 아르알킬, 할로게노알킬, 알콕시, 아릴옥시, 할로게노알콕시, 알킬티오, 아릴티오, 알킬술피닐, 아릴술피닐, 아릴술포닐, 할로게노알킬티오, 할로게노알킬술피닐, 할로게노알킬술포닐 또는 카르보닐 아릴에 의해 임의 치환된 아릴 또는 헤테로아릴기를 나타내고 X는 0또는를 나타내고, R2는 C2-5-알킬, 아르알킬, 알케닐 또는 알키닐을 나타내고, R3는 H또는 알킬을 나타내거나, R1과 R3가 인접한 N원자와 함께는, 추가의 헤테로원자로서 0 또는 N을 함유할수 있고, C1-4-알킬에 의해 임의 치환되는 5 또는 6-원 헤테로사이클을 나타내고, R4는 수소, 할로겐, 또는 임의 치환된 알킬, 할로게노알킬, 니트로, 아미노, 아미노아실, 시아노, 알콕시, 아릴옥시, 티오알킬, 아릴티오 또는 페닐을 나타낸다.
- a)하기 일반식(Ⅱ)의 화합물을 하기 일반식(Ⅲ)의 화합물과 반응시키거나, b)하기 일반식(Ia)의 화합물을 하기 일반식(Ⅳ)의 화합물과 반응시키거나, c)하기 일반식(Ⅴ)의 화합물을 염기의 존재하에서 하기 일반식(Ⅵ)의 화합물과 반응시킴을 특징으로 하여, 하기 일반식(I)의 화합물을 제조하는 방법.상기식에서, X, R1, R2및 R4는 제2항에서 정의된 의미를 가지며, 단, 일반식(Ⅵ)에서 R2는 수소를 나타내지는 않고, Y는 할로겐을 나타내며, A는 할로겐을 나타낸다.
- 적어도 하나의 제1항에 따른 일반식(I)의 치환된-머캅토 니코틴산 유도체를 함유함을 특징으로 하는 내부 기생충 사멸제.
- 제1항에 따른 일반식(I)의 치환된 2-머캅토니코틴산 유도체를 중량제 및/또는 계면활성제와 혼합시킴을 특징으로 하여, 내부 기생충 사멸제를 제조하는 방법.
- 내부 기생충 사멸제의 제조를 위한 제1항에 따른 일반식(I)의 치환된 2-머캅토니코틴산 유니체의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4032147A DE4032147A1 (de) | 1990-10-10 | 1990-10-10 | Verwendung von substituierten 2-mercaptonicotinsaeurederivaten zur bekaempfung von endoparasiten, neue substituierte 2-mercaptonicotinsaeurederivate und verfahren zu ihrer herstellung |
| DEP4032147.9 | 1990-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920008003A true KR920008003A (ko) | 1992-05-27 |
Family
ID=6416011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019910017565A Withdrawn KR920008003A (ko) | 1990-10-10 | 1991-10-08 | 내부 기생충을 구제하기 위한 치환된 2- 머캅토니코틴산 유도체의 용도, 신규한 치환된 2- 머캅토니코틴산 유도체 및 그의 제조방법 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0480258A3 (ko) |
| JP (1) | JPH0532631A (ko) |
| KR (1) | KR920008003A (ko) |
| AU (1) | AU634424B2 (ko) |
| BR (1) | BR9104365A (ko) |
| CA (1) | CA2052894A1 (ko) |
| CS (1) | CS305891A3 (ko) |
| DE (1) | DE4032147A1 (ko) |
| HU (1) | HUT59671A (ko) |
| MX (1) | MX9101265A (ko) |
| ZA (1) | ZA918069B (ko) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0533130A1 (de) * | 1991-09-19 | 1993-03-24 | Hoechst Aktiengesellschaft | 2-Hydroxymethylpyridine, die entsprechenden Pyridin-N-oxide und ihre Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung |
| IL103614A (en) * | 1991-11-22 | 1998-09-24 | Basf Ag | Carboxamides for controlling botrytis and certain novel such compounds |
| DE4200323A1 (de) * | 1992-01-09 | 1993-07-15 | Bayer Ag | Herbizide und pflanzennematizide mittel auf basis von mercaptonicotinsaeurederivaten |
| DE4331181A1 (de) * | 1993-09-14 | 1995-03-16 | Hoechst Schering Agrevo Gmbh | Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| DE4331179A1 (de) * | 1993-09-14 | 1995-03-16 | Hoechst Schering Agrevo Gmbh | Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| AR037233A1 (es) | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| AR036873A1 (es) | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
| CA2455999A1 (en) | 2001-10-04 | 2003-04-17 | Novartis Ag | Carbonyloxy-cyanomethyl compounds as antiparasitic agents |
| US20060100245A1 (en) * | 2002-12-19 | 2006-05-11 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues |
| JP5497650B2 (ja) * | 2007-10-19 | 2014-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１０アンタゴニスト |
| TWI504395B (zh) | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| EP2550264B1 (en) | 2010-03-23 | 2016-06-08 | Basf Se | Pyridazine compounds for controlling invertebrate pests |
| JP5837933B2 (ja) | 2010-08-27 | 2015-12-24 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Ｋｃｎｑ２／３調節因子としての置換された２−オキシ−キノリン−３−カルボキサミド |
| MX2013000748A (es) | 2010-08-27 | 2013-03-05 | Gruenenthal Gmbh | 2-amino-quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| PE20140214A1 (es) | 2010-08-27 | 2014-02-19 | Gruenenthal Chemie | 2-oxo- y 2-tioxo-dihidroquinolina-3-carboxamidas sustituidos como moduladores kcnq2/3 |
| CA2807886A1 (en) | 2010-09-01 | 2012-03-08 | Gruenenthal Gmbh | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
| WO2012034959A2 (en) | 2010-09-13 | 2012-03-22 | Basf Se | Pyridine compounds for controlling invertebrate pests iii |
| EP2648518A2 (en) | 2010-12-10 | 2013-10-16 | Basf Se | Pyrazole compounds for controlling invertebrate pests |
| EP2782565B1 (de) | 2011-11-25 | 2019-11-06 | Bayer Intellectual Property GmbH | Verwendung von aryl- und hetarylcarboxamiden als endoparasitizide |
| PT2891492T (pt) * | 2012-08-30 | 2022-12-13 | Univ Tokyo | Agente de controlo de endoparasitas |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3965107A (en) * | 1974-07-08 | 1976-06-22 | Rohm And Haas Company | Isothiazolopyridinones |
| BR8701302A (pt) * | 1986-03-25 | 1987-12-22 | Sankyo Co | Compostos macrolideos,sua preparacao e seu uso |
-
1990
- 1990-10-10 DE DE4032147A patent/DE4032147A1/de not_active Withdrawn
-
1991
- 1991-09-25 MX MX9101265A patent/MX9101265A/es unknown
- 1991-09-27 EP EP19910116492 patent/EP0480258A3/de not_active Withdrawn
- 1991-10-03 JP JP3283554A patent/JPH0532631A/ja active Pending
- 1991-10-07 CA CA002052894A patent/CA2052894A1/en not_active Abandoned
- 1991-10-08 CS CS913058A patent/CS305891A3/cs unknown
- 1991-10-08 KR KR1019910017565A patent/KR920008003A/ko not_active Withdrawn
- 1991-10-09 ZA ZA918069A patent/ZA918069B/xx unknown
- 1991-10-09 AU AU85692/91A patent/AU634424B2/en not_active Ceased
- 1991-10-09 BR BR919104365A patent/BR9104365A/pt unknown
- 1991-10-10 HU HU913213A patent/HUT59671A/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9101265A (es) | 1992-06-05 |
| CS305891A3 (en) | 1992-10-14 |
| CA2052894A1 (en) | 1992-04-11 |
| BR9104365A (pt) | 1992-06-09 |
| AU8569291A (en) | 1992-04-16 |
| HUT59671A (en) | 1992-06-29 |
| DE4032147A1 (de) | 1992-04-16 |
| JPH0532631A (ja) | 1993-02-09 |
| AU634424B2 (en) | 1993-02-18 |
| EP0480258A3 (en) | 1992-09-30 |
| ZA918069B (en) | 1992-07-29 |
| HU913213D0 (en) | 1992-01-28 |
| EP0480258A2 (de) | 1992-04-15 |
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