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KR910009684A - 방향족 아민 화합물, 이의 제조방법 및 이들의 존재하는 약제학적 조성물 - Google Patents

방향족 아민 화합물, 이의 제조방법 및 이들의 존재하는 약제학적 조성물 Download PDF

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Publication number
KR910009684A
KR910009684A KR1019900017897A KR900017897A KR910009684A KR 910009684 A KR910009684 A KR 910009684A KR 1019900017897 A KR1019900017897 A KR 1019900017897A KR 900017897 A KR900017897 A KR 900017897A KR 910009684 A KR910009684 A KR 910009684A
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KR
South Korea
Prior art keywords
group
formula
compound
benzylpiperidin
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019900017897A
Other languages
English (en)
Inventor
에몽잘 그자비에
굴라우이크 삐에르
프로이에또 빈센쬬
반 브뢰크 디디에
Original Assignee
미쉘드 아스
소시에떼 아노님 사노피
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8914517A external-priority patent/FR2654100B1/fr
Priority claimed from FR9007534A external-priority patent/FR2663329B1/fr
Application filed by 미쉘드 아스, 소시에떼 아노님 사노피 filed Critical 미쉘드 아스
Publication of KR910009684A publication Critical patent/KR910009684A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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Abstract

내용 없음

Description

방향족 아민 화합물, 이의 제조방법 및 이들이 존재하는 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (23)

  1. 일반식(Ⅰ)의 화합물 또는 이의 무기산 또는 유기산과의 염.
    상기식에서, m은 1∼3의 정수이고;Ar 및 Ar′는 각각 티에닐기;치환되지 않은 페닐기이거나 할로겐원자,C1-C3알킬, 트리플로오로메틸, 알콕시(여기서, 알킬은 C1-C3이다);히드록실 또는 메틸렌디옥시기에 의해 일- 또는 이치환된 페닐기; 또는 이미다졸릴기이며, Ar′은 치환되지 않았거나 할로겐에 의해 치환된 벤조티에닐기;치환되지 않았거나 할로겐에 의해 치환된 나프틸기;비페닐기;또는 치환 되지 않았거나 질소에 벤질기가 치환된 인돌릴기일 수 있으며-X는 수소이고-X′는 수소 또는 히드록실기이거나 하기의 X′와 결합하여 탄소-탄소 결합을 형성하며, 또는 X및X′가 함께 옥소기 또는 =N-O(CH2)P-Am의기(식에서, P는 2또는 3이며 Am은 디알킬아미노기이다)의 디알킬아미노알콕시아미노기를 형성하며, 각 알킬기는 탄소수가 1 내지 4일수 있고-Y는 질소원자 또는 C(X″)기(식에서, X″는 수소원자이거나 X′와 탄소-탄소 결합을 형성한다)이며-Q는 수소원자, C1-C4알킬기 또는 -(CH2)q-Am′의기(식에서, q는 2 또는 3이고 Am′은 피페리디노, 4-벤질과 페리디노 또는 디알킬아미노기이다)의 아미노알킬이고, 각 알킬기는 탄소수가 1 내지 4일수 있으며;R은 수소, 메틸기 또는 (CH2)n-L의기(식에서, n은 2∼6의 정수이고 L은 수소 또는 아미노기이다)이고;-T는및(식에서, W는 산소 또는 황원자 이다)로부터 선택된 기이며;-Z는 수소원자이거나, 혹은 T가 -C(=O)-의 기이면 M이거나 OM이며, 또는 T가 -C(=W)-NH-의 기이면 M이고, 여기에서, M은 수소;직쇄 또는 축쇄의 C1-C6알킬;치환되지 않은 페닐알킬기이거나 방향족 고리상에 할로겐, 히드록실, 탄소수 1 내지 4의 알콕시 또는 탄소수 1 내지 4의 알킬기로 일-또는 다치환된, 알킬기와 탄소수가 1 내지 3인 페닐알킬;알킬기의 탄소수가 1 내지 3인 피리딜알킬;알킬기의 탄소수가 1 내지 3인 나프틸알킬;알킬기의 탄소수가 1 내지 3인 피리딜티오알킬;스티릴;알킬기의 탄소수가 1 내지 3인 1-메틸아미다졸-2-일티오알킬;1-옥소페닐-3-인단-2-일;또는 치환되지 않았거나 일-또는 다치환된 방향족기 혹은 헤테로 방향족기이다.
  2. 일반식(Ⅰ*)의 광학적으로 순수한 화합물 또는 이의 무기산 또는 유기산과의 염.
    상기식에서, -n*n-n*n는 이 기호로 표시된 탄소원자가 제한된(+) 또는 (-)절대 배열을 가짐을 의미하며;-m,Ar,X,x′,Y,Q,R,T 및 M은 제1항에서 정의 한 바와 같다.
  3. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-디클로로페닐)부틸]-2,4-디클로로벤즈 아미드 또는 이의 약제학적 허용가능염.
  4. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-디플루오로페닐)부틸]-2,4-디클로로벤즈 아미드 또는 이의 약제학적 허용가능염.
  5. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-디클로로페닐)부틸]-4-플루오로나프탈렌-1-카르복스아미드 또는 이의 약제학적 허용가능염.
  6. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-디플루오로페닐)부틸]-2,4-디클로로벤즈 아미드(+) 또는 이의 약제학적 허용가능염.
  7. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-미클로로페닐)부틸]-2,4-디클로로벤즈 아미드(-) 또는 이의 약제학적 허용가능염.
  8. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-디플루오로페닐)부틸]-2,4-디클로로벤즈 아미드(+) 또는 이의 약제학적 허용가능염.
  9. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-디플로오로페닐)부틸]-2,4-디클로로벤즈 아미드(-) 또는 이의 약제학적 허용가능염.
  10. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-미클로로페닐)부틸]-4-플루오로나프탈렌-1-카르복스아미드(+) 또는 이의 약제학적 허용가능염.
  11. N-[4-(4-벤질피페리딘-1-일)-2-(3,4-디클로로페닐)부틸]-4-플루오로나프탈렌-1-카르복스아미드(-) 또는 이의 약제학적 허용가능염.
  12. a)일반식(Ⅲ)의 유리 아민을 일반식(Ⅲ)의 산 작용성 유도체(T가 -CO-인, 일반식(Ⅰ)의 화합물을 제조하고자 하는 것이다) 또는 일반식(Ⅲ′)의 이소(티오)시아네이트(T가-C(W)-NH-인, 일반식(Ⅰ)의 화합물을 제조하고자 하는 것이다)로 처리하여 일반식(Ⅳ)의 화합물을 형성시키고,
    [상기식에서 m,Ar′ 및 Q는 제1항에서 정의한 바와 같고;R0는 수소, 메틸기 또는 (CH2)n-L0의기(식에서, n은 제1항에서 정의한 바와 같고 L0은 수소원자 또는 N-보호기에 의해 보호된 아미노기이다)이며;E는 히드록실기, 테트라이히드로피틴-2-일옥시기와 같은 O-보호기, 또는
    의 기(식에서, Ar,X 및 Y는 제1항에서 정의한 바와 같고 X0는 제1항의 X′기와 같으며, 여기에서 히드록실기는 0-보호기에 의해 보호된것)이다]
    HO-CO-Z (Ⅲ)
    (상기식에서, Z는 제1항에서 정의한 바와같다)
    W=C=N-Z (Ⅲ′)
    (상기식에서, W와 Z는 제1항에서 정의한 바와같다)
    (Ⅳ)
    b)E가 테트라이히드로피라닐옥시면, 단계,a)에서 일반식(Ⅱ)의 출발 아민상에서 선택적으로 수행하는 산 가수분해에 의해 테트라히드로피라닐기를 제거하고, (c)생성된 일반식 (Ⅴ)의 N-치환 알칸을아민을 메탄솔포닐 클로라이드로 처리하고,
    (Ⅴ)
    d)생성된 일반식(Ⅵ)의 메실레이트를 일반식(Ⅶ)의 아치 아민과 반응시키고,
    (Ⅵ)
    (Ⅶ)
    (상기식에서, Ar,Y,X 및 X′는 제1항에서 정의한 바와 같다)
    e)존재하는 특정한 O-보호기와 N-보호기를 제거하고, 적당하다면, 생성물을 그의 염으로 전환시킴을 특징으로 하는, 제1항의 화합물의 제조방법.
  13. 일반식(ⅩⅤⅠⅠ*)의 화합물을 산매질내, 용매내에서 처리하여, 산매질 내에서, 알칸올 AIKOH(여기에서, AIK는 탄소수 1내지 4의 알킬기이다)내에서 에스테르화되는 일반식(ⅩⅤⅠⅠ*)의 아미노산을 수득한 다음;
    상응하는 일반식(ⅩⅤⅠⅠ*)의 에스테르를 일반식(Ⅲ)의 산 작용성 유도체를 또는 일반식(Ⅲ′)의 이소(티오)시아네이트로 처리하고;
    (상기식에서, AIK는 상기에서 정의한 바와같고, Q,Ar′및 m은 제1항에서 정의한 바와 같으며 R0는 제12항에서 정의한 바와 같다)
    HO-CO-Z (Ⅲ)
    W=C=N-Z (Ⅲ′)
    (상기식에서, Z및 W는 제2항에서 정의한 바와같다)생성된 일반식(XX*)의 에스테르에 환원제를 작용시키고;
    (XX*)
    일반식(V*)의 상응 알콜을 일반식(Ⅵ*)의 메탄술포네이트에 스테르(이는 일반식(Ⅶ)의 아민으로 처리하고, 적당하다면 탑보호시켜 적당하다면 그의 염으로 전환되는 일반식(Ⅰ*)의 화합물이 얻어진다)로 전환시킴을 특징으로 하는 제2항의 광학적으로 순수한 일반식(Ⅰ*)의 화합물의 입체 선택적 제조방법.
    (상기식에서, Ar,x,x′및 Y는 제1항에서 정의한 바와 같다)
  14. 일반식(XVI)의 화합물 또는 그의 염.
    상기식에서, Enn은 테트라히드로피라닐옥시기 히드록실기 또는
    의기이고;
    -X0는 수소원자 또는 유리되어 있거나 O-보호기로 보호되어 있는 히드록실기이거나, 하기의 X″와 결합하여 탄소-탄소 결합을 형성하며, 또는 X와 X0가 함께 옥소기 또는 일반식=N-O-(CH2)-Am(식에서, P는 2 또는 3이고, Am은 디알킬아미노기이다)의 디알킬아미노알콕시이미노기를 형성하며, 각 알킬기는 탄소수 1내지 4일수 있고-Y는 질소원자 또는 C(X″)의 기(식에서, X″는 수소원자이거나 X0와 탄소-탄소 결합을 형성한다)이며;-R0는 수소, 메틸기 또는 (CH2)n-L0기(식에서, n은 2∼6이며 L0는 수소원자 또는 유리되어 있거나 N-보호기로 보호되어 있는 아미노기이다)이고;m,Ar,Ar′,X 및 Q는 제1항에서 정의한 바와 같다.
  15. 제14항에 있어서, 광학적으로 순수한 일반식(XVI)의 화합물의 m,Q 및 Ar′가 제1항에서 정의한 바와 같고 E0가 히드록실기이며 R0가 제12항에서 정의한 바와 같은 R0인 화합물.
  16. 일반식(V′)의 화합물 또는 이의 염.
    상기식에서, G는 수소원자, 테트라히드로피라닐기 또는 메탄술포닐기며;R0는 수소원자, 메틸기 또는 (CH2)n-L0의 기(식에서, n은 2∼6이고 L0는 수소원자 또는 유리되어 있거나 N-보호기로 보호되어 있는 아미노기이다)이고;m,Ar,Ar′,X 및 Q는 제1항에서 정의한 바와 같다.
  17. 제16항에 있어서, 광학적으로 순수한 일반식(V′)의 화합물의 m,Q,T,Ar′ 및 Z가 1항에서 정의한 바와 같으며 G가 수소원자이고 R0가 제12항에서 정의한 바와 같은 R0인 화합물.
  18. 제16항에 있어서, 광학적으로 순수한 일반식(V′)의 화합물의 m,Q,T,Ar′ 및 Z가 1항에서 정의한 바와 같으며 G가 메탄술포닐기이고 R0가 제12항에서 정의한 바와 같은 R0인 화합물.
  19. 활성 성분으로 제1항 또는 제2항에 따른 일반식(I) 또는 (I*)의 화합물을 함유하는 약제학적 조성물.
  20. 제19항에 있어서, 활성 성분을 한가지 이상의 약제학적 부형제와 혼합하여 투여단위 형태로 만들어진 약제학적 조성물.
  21. 제20항에 있어서, 활성 성분을 2.5내지 1000㎎ 함유하는 약제학적 조성물.
  22. 제14항에 있어서, E00가 히드록실기이고 R00가 수소원자인 화합물.
  23. N-메틸-N[4-(4-벤질피페리딘-1-일)-2-(3,4-디클로로페닐)부틸]페닐 아세트 아미드.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900017897A 1989-11-06 1990-11-06 방향족 아민 화합물, 이의 제조방법 및 이들의 존재하는 약제학적 조성물 Ceased KR910009684A (ko)

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FR8914517A FR2654100B1 (fr) 1989-11-06 1989-11-06 Arylalkylenediamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
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FR9007534A FR2663329B1 (fr) 1990-06-15 1990-06-15 Composes aromatiques amines, procede pour leur preparation et compositions pharmaceutiques les contenant.

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Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218364B1 (en) 1988-06-20 2001-04-17 Scott L. Harbeson Fluorinated neurokinin A antagonists
US5830863A (en) * 1988-06-20 1998-11-03 Merrell Pharmaceuticals Inc. Neurokinin A antagonists
ZA906188B (en) * 1989-08-10 1991-06-26 Merrell Dow Pharma Cyclic neurokinin a antagonists
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2678267B1 (fr) * 1991-06-25 1994-02-04 Elf Sanofi Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
CZ284993B6 (cs) * 1991-03-29 1999-04-14 Eli Lilly And Company Derivát piperidinu
US5250542A (en) * 1991-03-29 1993-10-05 Eli Lilly And Company Peripherally selective piperidine carboxylate opioid antagonists
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
DK0533280T4 (da) * 1991-09-20 2005-02-28 Glaxo Group Ltd Ny medicinsk anvendelse af tachykininantagonister
GB9201179D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
KR100269756B1 (ko) * 1992-02-13 2000-10-16 슈테펜엘.네스비트 피페리디닐티아시클릭유도체(Piperidinyl Thiacyclic Derivatives)
TW224462B (ko) * 1992-02-24 1994-06-01 Squibb & Sons Inc
FR2688218A1 (fr) * 1992-03-03 1993-09-10 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
ES2043557B1 (es) * 1992-06-04 1994-07-01 Ferrer Int Procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina.
ES2060547B1 (es) * 1992-06-04 1995-06-16 Ferrer Int Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
JP3507494B2 (ja) * 1992-08-13 2004-03-15 ワーナー−ランバート・コンパニー タキキニン拮抗薬
FR2696178B1 (fr) * 1992-09-30 1994-12-30 Sanofi Elf Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.
US5391819A (en) * 1992-09-30 1995-02-21 Merck & Co., Inc. Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists
US5583134A (en) * 1992-09-30 1996-12-10 Sanofi 1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
US5830854A (en) * 1992-12-14 1998-11-03 Merck Sharp & Dohme, Limited Method of treating cystic fibrosis using a tachykinin receptor antagonist
CN1042335C (zh) * 1993-01-03 1999-03-03 诺瓦提斯公司 1－酰基哌啶化合物、其制备方法、药物组合物及用途
FR2700472B1 (fr) 1993-01-19 1995-02-17 Rhone Poulenc Rorer Sa Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
ATE169001T1 (de) * 1993-01-28 1998-08-15 Merck & Co Inc Substituierte spiro-azaringen als tachykinine rezeptor antagonisten
US5512680A (en) * 1993-02-26 1996-04-30 Sanofi Process for the preparation of an optically pure aminoalcohol
FR2701946B1 (fr) * 1993-02-26 1995-05-24 Sanofi Elf Procédé pour la préparation d'un aminoalcool optiquement pur.
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
US5589489A (en) * 1993-12-15 1996-12-31 Zeneca Limited Cyclic amide derivatives for treating asthma
FR2717802B1 (fr) * 1994-03-25 1996-06-21 Sanofi Sa Nouveaux composés aromatiques, procédé pour leur préparation et compositions pharmaceutiques en contenant.
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
GB9408872D0 (en) * 1994-05-03 1994-06-22 Zeneca Ltd Heterocyclic compounds
DE69508093T2 (de) 1994-08-25 1999-07-15 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Substituierte piperidine für die behandlung von allergischen krankheiten
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
TW397825B (en) * 1994-10-14 2000-07-11 Novartis Ag Aroyl-piperidine derivatives
FR2725900B1 (fr) * 1994-10-21 1997-07-18 Sanofi Sa Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
DE69534213T2 (de) * 1994-10-25 2006-01-12 Astrazeneca Ab Therapeutisch wirksame Heterocyclen
US5998444A (en) * 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9421709D0 (en) * 1994-10-27 1994-12-14 Zeneca Ltd Therapeutic compounds
CA2162786A1 (en) * 1994-11-22 1996-05-23 Philip Arthur Hipskind Heterocyclic tachykinin receptor antagonists
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729952B1 (fr) * 1995-01-30 1997-04-18 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9502644D0 (en) * 1995-02-10 1995-03-29 Zeneca Ltd Heterocyclic derivatives
EP0815105B1 (en) * 1995-03-15 2001-10-04 Aventis Pharmaceuticals Inc. Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists
MX9707879A (es) * 1995-04-13 1997-11-29 Hoechst Marion Roussel Inc Derivados de piperazina sustituidos novedosos que tienen actividad antagonista de receptor de taquinina.
GB9508786D0 (en) 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
ATE243204T1 (de) * 1995-08-24 2003-07-15 Basf Ag Isoxazole- und isothiazole-5-carboxamid derivate, deren herstellung und deren verwendung als herbizide
FR2738245B1 (fr) * 1995-08-28 1997-11-21 Sanofi Sa Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2738819B1 (fr) * 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
HU224225B1 (hu) 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
DE19624704A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalkansäureamide
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
MY132550A (en) * 1996-08-22 2007-10-31 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists
US5977139A (en) * 1996-12-15 1999-11-02 Hoechst Marion Roussel, Inc. Carboxysubstituted cyclic carboxamide derivatives
US5861417A (en) * 1996-12-19 1999-01-19 Hoechst Marion Roussel, Inc. Heterocyclic substituted pyrrolidine amide derivatives
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
DE19756235A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756261A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
DE19756212A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
PT1058683E (pt) * 1998-02-02 2003-04-30 Lg Chemical Ltd Inibidores da farnesil-transferase com uma estrutura de piperidina e seu processo de preparacao
US5928783A (en) * 1998-03-09 1999-07-27 National Starch And Chemical Investment Holding Corporation Pressure sensitive adhesive compositions
US6316445B1 (en) 1998-05-15 2001-11-13 Aventis Pharmaceuticals Inc. Carboxy substituted acylic carboxamide derivatives
FR2779429B1 (fr) * 1998-06-03 2000-07-13 Synthelabo Derives d'oxindole, leurs preparations et leurs applications en therapeutique
CN1309638A (zh) * 1998-07-10 2001-08-22 阿斯特拉曾尼卡有限公司 作为神经激肽受体拮抗剂的n－取代的萘甲酰胺
GB9922519D0 (en) 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9922521D0 (en) * 1998-10-07 1999-11-24 Zeneca Ltd Compounds
US6194458B1 (en) 1998-10-30 2001-02-27 Merck & Co., Inc. Benzamide potassium channel inhibitors
US6303637B1 (en) 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
US6632836B1 (en) 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors
CA2350722A1 (en) * 1998-11-17 2000-05-25 Leyi Gong 4-aroyl-piperidin-ccr-3 receptor antagonists iii
DE69938193D1 (de) 1998-11-20 2008-04-03 Hoffmann La Roche Piperidin ccr-3 rezeptor-hemmer
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2482100A (en) * 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
WO2000035451A1 (en) * 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6605623B1 (en) * 1998-12-18 2003-08-12 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1158980B1 (en) * 1998-12-18 2005-08-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
GB9907571D0 (en) * 1999-04-06 1999-05-26 Zeneca Ltd Compounds
US6365591B1 (en) 1999-10-18 2002-04-02 Recordati, S.A., Chemical And Pharmacueticals Company Isoxazolecarboxamide derivatives
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
RU2309953C2 (ru) 1999-11-03 2007-11-10 Эймр Текнолоджи, Инк. Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе
CA2399791A1 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
JP2004517805A (ja) 2000-06-30 2004-06-17 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体活性調節剤としてのｎ−ウレイドヘテロシクロアルキル−ピペリジン
BR0112350A (pt) 2000-07-11 2003-06-24 Albany Molecular Res Inc Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico
KR20030093257A (ko) 2001-03-21 2003-12-06 파마코페이아, 인크. Ｍｃｈ 조정 활성을 지닌 아릴 및 바이아릴 화합물
US6815451B2 (en) * 2001-03-27 2004-11-09 Actelion Pharmaceuticals Ltd. 1,2,3,4-Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists
WO2002083134A1 (en) 2001-04-12 2002-10-24 Pharmacopeia, Inc. Aryl and biaryl piperidines used as mch antagonists
DZ3292A1 (fr) * 2001-09-13 2005-05-14 Solvay Pharm Gmbh Nouveaux composes de type 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]piperazine, methodes pour les preparer et medicaments renfermant cescomposes
NZ534046A (en) 2001-12-04 2006-02-24 Actelion Pharmaceuticals Ltd 4-(piperidyl-and pyrrolidyl-alkyl-ureido) -quinolines as urotensin II receptor antagonists
TW200508221A (en) * 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds
MXPA06003264A (es) 2003-09-26 2006-06-08 Actelion Pharmaceuticals Ltd Derivados de piridina y uso de los mismos como antagonistas de la urotensina ii.
US7291744B2 (en) * 2003-11-13 2007-11-06 Bristol-Myers Squibb Company N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
CN103880827B (zh) 2004-07-15 2017-01-04 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
JP5139066B2 (ja) 2004-10-12 2013-02-06 アクテリオン ファーマシューティカルズ リミテッド 結晶性硫酸塩としての１−［２−（４−ベンジル−４−ヒドロキシ−ピペリジン−１−イル）−エチル］−３−（２−メチル−キノリン−４−イル）−尿素
WO2006123182A2 (en) 2005-05-17 2006-11-23 Merck Sharp & Dohme Limited Cyclohexyl sulphones for treatment of cancer
JP5258561B2 (ja) 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ， インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
US7592344B2 (en) * 2005-11-30 2009-09-22 Solvay Pharmaceuticals Gmbh NK1 and NK2-antagonists and compositions and methods of using the same
ATE550324T1 (de) * 2005-11-30 2012-04-15 Abbott Products Gmbh Neue nk1- und nk2-antagonisten
EP1979319A1 (en) * 2006-02-01 2008-10-15 Solvay Pharmaceuticals GmbH Novel dual nk2/nk3-antagonists, pharmaceutical compositions comprising them and processes for their preparations
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007136323A1 (en) * 2006-05-18 2007-11-29 Albireo Ab A novel process suitable for large-scale production of phenyl propan derivatives of formula i
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt) 2007-01-10 2022-01-25 Msd Italia S.R.L. Compostos de fórmula i e seus usos
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 ｒ(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 ｎｋ1을 포함하는 제약 조성물
CA2690191C (en) 2007-06-27 2015-07-28 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
PE20120373A1 (es) 2009-05-12 2012-05-17 Albany Molecular Res Inc 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina
ES2528404T3 (es) 2009-05-12 2015-02-10 Bristol-Myers Squibb Company Formas cristalinas de (S)-7-([1,2,4]triazol[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y sus usos
MX2011011901A (es) 2009-05-12 2012-01-20 Albany Molecular Res Inc Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
NZ599343A (en) 2009-10-14 2014-05-30 Merck Sharp & Dohme Substituted piperidines that increase p53 activity and the uses thereof
CA2805265A1 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
US9029341B2 (en) 2010-08-17 2015-05-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2608669B1 (en) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
WO2012036997A1 (en) 2010-09-16 2012-03-22 Schering Corporation Fused pyrazole derivatives as novel erk inhibitors
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US20140046059A1 (en) 2011-04-21 2014-02-13 Piramal Enterprises Limited Process for the preparation of morpholino sulfonyl indole derivatives
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
WO2013165816A2 (en) 2012-05-02 2013-11-07 Merck Sharp & Dohme Corp. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
MX2015002231A (es) 2012-08-23 2015-07-17 Alios Biopharma Inc Compuestos antivirales.
JP6280554B2 (ja) 2012-09-28 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｅｒｋ阻害剤である新規化合物
AU2013352568B2 (en) 2012-11-28 2019-09-19 Merck Sharp & Dohme Llc Compositions and methods for treating cancer
JP6387013B2 (ja) 2012-12-20 2018-09-12 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｄｍ２阻害薬としての置換されたイミダゾピリジン類
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
AU2014308991B2 (en) * 2013-08-21 2019-02-14 Janssen Biopharma, Inc. Antiviral compounds
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
EP3706747A4 (en) 2017-11-08 2021-08-04 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors
KR20210046009A (ko) 2018-08-07 2021-04-27 머크 샤프 앤드 돔 코포레이션 Prmt5 억제제

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1151516B (de) * 1960-08-03 1963-07-18 Krewel Leuffen Gmbh Verfahren zur Herstellung von ª†-Aminoalkoholen mit quartaerem ª‰-C-Atom
DE1261862B (de) * 1965-03-11 1968-02-29 Bayer Ag Verfahren zur Herstellung von N-substituierten 3-Aminopropanolen
GB1213166A (en) * 1967-07-19 1970-11-18 Aspro Nicholas Ltd Novel cyanoethanols, their synthesis and their conversion to derivatives
NL7112938A (ko) * 1970-09-30 1972-04-05
GB1374366A (en) * 1972-07-21 1974-11-20 Science Union & Cie Propanol derivatives and a process for their preparation
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
DE2944150A1 (de) * 1979-11-02 1981-05-14 Bayer Ag, 5090 Leverkusen Gummifederreifen und verfahren zu seiner herstellung
DE3276313D1 (en) * 1981-09-24 1987-06-19 Beecham Wuelfing Gmbh & Co Kg Sulphonamides
DK159420C (da) * 1983-03-09 1991-03-11 Ciba Geigy Ag N-(piperidinyl-alkyl)-carboxamider og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af antipsykotiske farmaceutiske praeparater
JPH0660160B2 (ja) * 1985-12-13 1994-08-10 テルモ株式会社 アミド誘導体およびこれを含有する抗アレルギ−剤
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
IT1182010B (it) * 1985-12-30 1987-09-30 Consiglio Nazionale Ricerche Procedimento per ottenere, in films epitessial di granati magnetici strati aventi diverse proprieta di anisotropia magnetica
FR2613719B1 (fr) * 1987-04-10 1991-03-22 Sanofi Sa Derives aromatiques, leur preparation et leur utilisation comme antimicrobiens
FR2620704B1 (fr) * 1987-09-17 1991-04-26 Sanofi Sa Derives de (benzyl-4 piperidino)-1 propanol-2, leur preparation, leur utilisation comme antimicrobiens et les produits les contenant
US5278316A (en) * 1989-06-29 1994-01-11 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives

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HU907027D0 (en) 1991-05-28
FI905444A0 (fi) 1990-11-02
AU668018B2 (en) 1996-04-18
PL166565B1 (pl) 1995-06-30
EP0428434A2 (fr) 1991-05-22
IL96241A (en) 1996-03-31
EP0428434A3 (en) 1991-10-09
PL293823A1 (en) 1993-01-25
PL287644A1 (en) 1992-07-27
AU649973B2 (en) 1994-06-09
NZ235985A (en) 1993-10-26
CA2029275A1 (en) 1991-05-07
FI97540C (fi) 1997-01-10
HUT56543A (en) 1991-09-30
FI97540B (fi) 1996-09-30
HU913347D0 (en) 1992-01-28
JPH03206086A (ja) 1991-09-09
PL166582B1 (pl) 1995-06-30
US5317020A (en) 1994-05-31
NO904802D0 (no) 1990-11-05
IL96241A0 (en) 1991-08-16
AU6583890A (en) 1991-05-23
AU5924594A (en) 1994-06-02
NO177299C (no) 1995-08-23
NO904802L (no) 1991-05-07
MY141603A (en) 2010-05-31
IE903957A1 (en) 1991-05-08
US5618938A (en) 1997-04-08
NO177299B (no) 1995-05-15
HU913346D0 (en) 1992-01-28
LV10713A (lv) 1995-06-20
PT95790A (pt) 1991-09-13
LV10713B (en) 1995-10-20
US5686609A (en) 1997-11-11
PL165758B1 (pl) 1995-02-28
RU2084453C1 (ru) 1997-07-20

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