KR910000125A - 피리도 [1,2-a] 피리미딘 화합물의 에어로졸 - Google Patents
피리도 [1,2-a] 피리미딘 화합물의 에어로졸 Download PDFInfo
- Publication number
- KR910000125A KR910000125A KR1019900008833A KR900008833A KR910000125A KR 910000125 A KR910000125 A KR 910000125A KR 1019900008833 A KR1019900008833 A KR 1019900008833A KR 900008833 A KR900008833 A KR 900008833A KR 910000125 A KR910000125 A KR 910000125A
- Authority
- KR
- South Korea
- Prior art keywords
- pyrido
- decaglyceryl
- fatty acid
- acid ester
- sorbitan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000443 aerosol Substances 0.000 title claims 5
- VFMCUTPRJLZEEW-UHFFFAOYSA-N 4h-pyrido[1,2-a]pyrimidine Chemical class C1=CC=CN2CC=CN=C21 VFMCUTPRJLZEEW-UHFFFAOYSA-N 0.000 title 1
- -1 pyrido [1,2-a] pyrimidine compound Chemical class 0.000 claims 9
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- 229930195729 fatty acid Natural products 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- RVRGDCZGEKSIRW-UHFFFAOYSA-N 9-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]-3-(2h-tetrazol-5-yl)pyrido[1,2-a]pyrimidin-4-one Chemical compound C1=CC(C(C)=O)=C(O)C(CCC)=C1OCC1=CC=CN2C(=O)C(C3=NNN=N3)=CN=C12 RVRGDCZGEKSIRW-UHFFFAOYSA-N 0.000 claims 1
- FIWFSFADIWXCKO-UHFFFAOYSA-N 9-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]-3-[2-(2h-tetrazol-5-yl)ethyl]pyrido[1,2-a]pyrimidin-4-one Chemical compound C1=CC(C(C)=O)=C(O)C(CCC)=C1OCC1=CC=CN2C(=O)C(CCC=3NN=NN=3)=CN=C12 FIWFSFADIWXCKO-UHFFFAOYSA-N 0.000 claims 1
- 239000004147 Sorbitan trioleate Substances 0.000 claims 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 1
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000001593 sorbitan monooleate Substances 0.000 claims 1
- 235000011069 sorbitan monooleate Nutrition 0.000 claims 1
- 229940035049 sorbitan monooleate Drugs 0.000 claims 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 claims 1
- 235000019337 sorbitan trioleate Nutrition 0.000 claims 1
- 229960000391 sorbitan trioleate Drugs 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- (a) 하기 일반식의 피리도〔1,2-a〕피리미딘 화합물 0.015~5.00%(w/v) 및 (b) 지방산 에스테르 0.015~5.00%(w/v)를 함유하는 에어로졸 조성물.[상기 식중, R은 n-프로필 또는 알릴기이고, A는 테트라졸릴 또는 카르복실기이며, n은 0~2의 정수이다.〕
- 제1항에 있어서, 지방산 에스테르가 소르비탄 지방산 에스테르 또는 데카글리세린 지방산 에스테르인 에어로졸 조성물.
- 제2항에 있어서, 소르비탄 지방산 에스테르가 소르비탄 세스퀴올레이트, 소르비탄 모노올레이트, 소르비탄 트리올레이트 또는 소르비탄 모노이소스테아레이트인 에어로졸 조성물.
- 제2항에 있어서, 데카글리세린 지방산 에스테르가 데카글리세릴 데카올레이트, 데카글리세릴 데카스테아레이터, 데카글리세릴 헵타올레이트, 데카글리세릴 펜타올레이트, 데카글리세릴 트리올레이트, 데카글리세릴 디올레이트 또는 데카글리세릴 디이소스테아레이트인 에어로졸 조성물.
- 제1항, 2항, 3항 또는 4항에 있어서, 피리도〔1,2-a〕피리미딘 화합물이 9-〔(4-아세틸-3-히드록시-2-n-프로필페녹시)메틸〕-3-(1H-테트라졸-5-일)-4H-피리도〔1,2-a〕피리미딘-4-온, 9-〔(4-아세틸-3-히드록시-2-n-프로필페녹시)메틸〕-3-〔2-(1H-테트라졸-5-일)에틸〕-4H-피리도〔1,2-a〕피리미딘-4-온, 9-〔(4-아세틸-3-히드록시-2-알릴페녹시)메틸〕-3-(1H-테트라졸-5-일)-4H-피리도〔1,2-a〕-피리미딘-4-온 또는 9-〔(4-아세틸-3-히드록시-2-n-프로필페녹시)메틸〕-4-옥소-피리도〔1,2-a〕피리미딘-3-일〕아세트산인 에어로졸 조성물.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1-150540 | 1989-06-15 | ||
| JP15054089 | 1989-06-15 | ||
| JP1-155798 | 1989-06-20 | ||
| JP15579889 | 1989-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR910000125A true KR910000125A (ko) | 1991-01-29 |
Family
ID=26480107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900008833A Ceased KR910000125A (ko) | 1989-06-15 | 1990-06-15 | 피리도 [1,2-a] 피리미딘 화합물의 에어로졸 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US5158775A (ko) |
| JP (1) | JPH0386825A (ko) |
| KR (1) | KR910000125A (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6006745A (en) * | 1990-12-21 | 1999-12-28 | Minnesota Mining And Manufacturing Company | Device for delivering an aerosol |
| JP4064574B2 (ja) | 1998-07-29 | 2008-03-19 | 株式会社資生堂 | 抗糖尿病用皮膚外用剤 |
| JP4178829B2 (ja) * | 2002-05-02 | 2008-11-12 | 株式会社Ｊ−オイルミルズ | 抗アレルギー性組成物 |
| GB0520794D0 (en) * | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63183581A (ja) * | 1985-10-03 | 1988-07-28 | Tokyo Tanabe Co Ltd | ピリド〔１，２−ａ〕ピリミジン誘導体、その製造法及びそれを有効成分とするアレルギ−疾患治療薬 |
| JPS62242682A (ja) * | 1986-04-16 | 1987-10-23 | Tokyo Tanabe Co Ltd | 新規なピリド［１，２―ａ］ピリミジン誘導体及びその製造法 |
| JPS62243082A (ja) * | 1986-04-16 | 1987-10-23 | Sharp Corp | 読取り方式 |
| JPS62246374A (ja) * | 1986-04-21 | 1987-10-27 | 住友ベークライト株式会社 | 医療用吸引排液装置 |
| JPS62246375A (ja) * | 1986-04-21 | 1987-10-27 | 旭メデイカル株式会社 | 低流量用血液浄化装置 |
-
1990
- 1990-05-14 JP JP2121140A patent/JPH0386825A/ja active Pending
- 1990-06-14 US US07/538,104 patent/US5158775A/en not_active Expired - Fee Related
- 1990-06-15 KR KR1019900008833A patent/KR910000125A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0386825A (ja) | 1991-04-11 |
| US5158775A (en) | 1992-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19900615 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19950524 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19900615 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19980305 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19980603 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19980305 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |