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KR900700448A - 불포화 측쇄를 갖는 1α-히드로시비타민 D동족체 - Google Patents

불포화 측쇄를 갖는 1α-히드로시비타민 D동족체

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Publication number
KR900700448A
KR900700448A KR1019890702480A KR890702480A KR900700448A KR 900700448 A KR900700448 A KR 900700448A KR 1019890702480 A KR1019890702480 A KR 1019890702480A KR 890702480 A KR890702480 A KR 890702480A KR 900700448 A KR900700448 A KR 900700448A
Authority
KR
South Korea
Prior art keywords
vitamin
alpha
dihydroxy
hydroxy
pharmaceutical composition
Prior art date
Application number
KR1019890702480A
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English (en)
Other versions
KR940003360B1 (ko
Inventor
헥터 에프. 드루카
하인리히 케이. 쉬노에스
캐토 엘. 펄먼
Original Assignee
위스콘신 알럼나이 리써취 파운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 위스콘신 알럼나이 리써취 파운데이션 filed Critical 위스콘신 알럼나이 리써취 파운데이션
Publication of KR900700448A publication Critical patent/KR900700448A/ko
Application granted granted Critical
Publication of KR940003360B1 publication Critical patent/KR940003360B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

불포화 측쇄를 갖는 1α-히드로시비타민 D동족체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. 다음 구조식을 갖는 화합물.
    위 식에서, X,Y 및 Z는 서로 동일하거나 또는 상이한 것으로서 수소 원자 및 히드록시-보호기로 구성되는 군 중에서 선택되고, n은 3 또는 4이다.
  2. 제1항 있어서, X,Y 및 Z가 수소 원자인 화합물.
  3. 24-디호모-1α,25-디히드록시-22-데히드로비타민 D3.
  4. 24-트리호모-1α,25-디히드록시-22-데히드로비타민 D3.
  5. 다음 구조식을 갖는 화합물.
    위 식에서 X,Y 및 Z는 서로 동일하거나 또는 상이한 것으로서, 수소 원자 및 히드록시 보호기로 구성되는 군중에서 선택되고, n은 3 또는 4이다.
  6. 적어도 1종의 제1항에 의한 화합물과 제약학상 허용되는 부형제를 함유하는 제약 조성물.
  7. 제6항에 있어서, 상기 화합물이 24-디호모-1α,25-디히드록시-22-데히드로비타민 D3인 것을 특징으로 하는 제약 조성물.
  8. 제6항에 있어서, 상기 화합물이 24-트리호모-1α,25-디히드록시-22-데히드로비타민 D3인 것을 특징으로 하는 제약 조성물.
  9. 제7항에 있어서, 비타민 동족체를 약 0.5내지 약 50㎍양으로 함유하는 것을 특징으로 하는 제약 조성물.
  10. 제8항에 있어서, 비타민 동족체를 약 0.5내지 약 50㎍양으로 함유하는 것을 특징으로 하는 제약 조성물.
  11. 종양 세포를 적어도 1종의 제1항에서 정의한 1α-히드록시 비타민 D동족체에 노출시키는 것을 특징으로 하는 종양 세포에 있어서 세포 분화를 유발 및 증대시키는 방법.
  12. 제11항에 있어서, 상기 1α-히드록시비타민 D동족체가 24-디호모-1α,25-디히드록시-22-데히드로 비타민 D3인 방법.
  13. 제11항에 있어서, 상기 1α-히드록시비타민 D동족체가 24-트리호모-1α,25-디히드록시-22-데히드로 비타민 D3인 방법.
  14. 종양 질병에 걸린 대상에 제1항에 정의한 1α-히드록시비타민 D동족체 유효 투여량을 투여하는 것을 특징으로하는 종양 질병의 치료 방법.
  15. 제14항에 있어서, 투여되는 상기 1α-히드록시비타민 D동족체가 24-디호모-1α,25-디히드록시-22-데히드로비타민 D3인 방법.
  16. 제14항에 있어서, 투여되는 상기 1α-히드록시비타민 D동족체가 24-트리호모-1α,25-디히드록시-22-데히드로비타민 D3인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890702480A 1988-04-29 1989-04-18 불포화 측쇄를 갖는 1α-히드록시비타민 D동족체 KR940003360B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18767588A 1988-04-29 1988-04-29
US187,675 1988-04-29
PCT/US1989/001632 WO1989010352A1 (en) 1988-04-29 1989-04-18 SIDE CHAIN UNSATURATED 1alpha-HYDROXYVITAMIN D HOMOLOGS

Publications (2)

Publication Number Publication Date
KR900700448A true KR900700448A (ko) 1990-08-13
KR940003360B1 KR940003360B1 (ko) 1994-04-21

Family

ID=22689977

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702480A KR940003360B1 (ko) 1988-04-29 1989-04-18 불포화 측쇄를 갖는 1α-히드록시비타민 D동족체

Country Status (13)

Country Link
EP (1) EP0374219A1 (ko)
JP (1) JPH0699454B2 (ko)
KR (1) KR940003360B1 (ko)
AU (1) AU629831B2 (ko)
FR (1) FR2630739A1 (ko)
GB (1) GB2217716A (ko)
HU (1) HU206316B (ko)
IE (1) IE67953B1 (ko)
IL (1) IL90065A (ko)
IN (1) IN169818B (ko)
NL (1) NL8920392A (ko)
RU (1) RU2057117C1 (ko)
WO (1) WO1989010352A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225579A (en) * 1988-03-16 1993-07-06 Hoxan Corporation Method of manufacturing vitamin D2, Vitamin D3, activated type vitamin D2, activated type vitamin D3, and their derivatives
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
JPH0325053A (ja) * 1989-06-23 1991-02-01 Takata Kk プリテンショナー装置
GB8914963D0 (en) * 1989-06-29 1989-08-23 Leo Pharm Prod Ltd Chemical compounds
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
DE69508895T2 (de) * 1994-12-14 1999-10-21 Duphar International Research B.V., Weesp Vitamin-D-Derivate und Verfahren zur Herstellung dieser Verbindungen
US8377913B2 (en) 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0197949A1 (en) * 1984-10-04 1986-10-22 Wisconsin Alumni Research Foundation Vitamin d derivatives and methods for preparing same
KR910004337B1 (ko) * 1985-01-17 1991-06-26 위스콘신 알럼니 리서치 화운데이션 비타민 d 유도체 및 이를 함유하는 약제
AU614372B2 (en) * 1988-04-21 1991-08-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues

Also Published As

Publication number Publication date
IE891407L (en) 1989-10-29
FR2630739A1 (fr) 1989-11-03
HUT52476A (en) 1990-07-28
JPH02504149A (ja) 1990-11-29
IL90065A0 (en) 1989-12-15
IE67953B1 (en) 1996-05-15
NL8920392A (nl) 1990-04-02
IN169818B (ko) 1991-12-28
JPH0699454B2 (ja) 1994-12-07
IL90065A (en) 1996-05-14
RU2057117C1 (ru) 1996-03-27
AU629831B2 (en) 1992-10-15
GB2217716A (en) 1989-11-01
HU894747D0 (en) 1990-06-28
EP0374219A1 (en) 1990-06-27
WO1989010352A1 (en) 1989-11-02
KR940003360B1 (ko) 1994-04-21
HU206316B (en) 1992-10-28
AU3553389A (en) 1989-11-24
GB8909573D0 (en) 1989-06-14

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