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KR970025615A - 암 전이 억제제 - Google Patents

암 전이 억제제 Download PDF

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Publication number
KR970025615A
KR970025615A KR1019960054598A KR19960054598A KR970025615A KR 970025615 A KR970025615 A KR 970025615A KR 1019960054598 A KR1019960054598 A KR 1019960054598A KR 19960054598 A KR19960054598 A KR 19960054598A KR 970025615 A KR970025615 A KR 970025615A
Authority
KR
South Korea
Prior art keywords
cancer metastasis
metastasis inhibitor
injection
active ingredient
ursolic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019960054598A
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English (en)
Other versions
KR100424503B1 (ko
Inventor
히로미찌 이시까와
도모꼬 와따나베
사또시 니시무로
미쓰루 히로따
Original Assignee
아시다 신
닛뽕 케미카루 리사치 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아시다 신, 닛뽕 케미카루 리사치 가부시끼가이샤 filed Critical 아시다 신
Publication of KR970025615A publication Critical patent/KR970025615A/ko
Application granted granted Critical
Publication of KR100424503B1 publication Critical patent/KR100424503B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 유효 성분으로 우르솔릭산(ursolic acid) 또는 그의 염으로 이루어지며, 환자에게 경구적으로 또는 주사를 통하여 투여되어 수술 후 통원 치료를 가능하게 하는 낮은 독성을 갖는 신규한 암 전이 억제제를 제공한다.

Description

암 전이 억제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 유효 성분으로 우르솔릭산 또는 피의 염으로 이루어지는 암 전이 억제제.
  2. 제1항에 있어서, 경구 투여 또는 주사용을 목적으로 하는 암 전이 억제제.
  3. 제2항에 있어서, 성인 환자에 있어서의 1인 투여량이 10mg-3,000mg의 범위인 암 전이 억제제.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019960054598A 1995-11-16 1996-11-15 암전이억제제 Expired - Fee Related KR100424503B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP95-323710 1995-11-16
JP7323710A JP3041232B2 (ja) 1995-11-16 1995-11-16 癌転移抑制剤
JP92-323710 1995-11-16

Publications (2)

Publication Number Publication Date
KR970025615A true KR970025615A (ko) 1997-06-24
KR100424503B1 KR100424503B1 (ko) 2004-06-04

Family

ID=18157744

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960054598A Expired - Fee Related KR100424503B1 (ko) 1995-11-16 1996-11-15 암전이억제제

Country Status (7)

Country Link
US (1) US5985924A (ko)
EP (1) EP0774255B1 (ko)
JP (1) JP3041232B2 (ko)
KR (1) KR100424503B1 (ko)
CN (1) CN1073843C (ko)
AT (1) ATE206914T1 (ko)
DE (1) DE69615984T2 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2775686B1 (fr) * 1998-03-09 2006-07-28 Pascal Commenil Exploitation industrielle et commerciale des lipides cuticulaires de la baie de raisin en pharmacologie et cosmetologie
DE60102402T2 (de) * 2000-02-10 2005-03-10 Loders Croklaan B.V. Fettmischungen mit Kristallmodifikatoren
CN1450900A (zh) * 2000-07-31 2003-10-22 日清奥利友株式会社 抗肿瘤剂
WO2002009720A1 (en) * 2000-07-31 2002-02-07 University Of Virginia Patent Foundation Inhibitors of dna polymerase sigma
EP1349559B1 (en) * 2000-12-15 2008-04-16 Naturalendo Tech Co., Ltd. Compositions for inducing secretion of insulin-like growth factor-1
US6979470B2 (en) * 2001-07-17 2005-12-27 Metaproteomics, Llc Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2
US20040029906A1 (en) * 2001-07-31 2004-02-12 Michael Christman Inhibitors of dna polymerase sigma
AU2003248555A1 (en) * 2002-05-24 2003-12-12 Greystone Medical Group, Inc. Anti-cancer formulation
CN1243538C (zh) * 2002-11-21 2006-03-01 武汉利元亨药物技术有限公司 熊果酸豆磷脂纳米粒冻干粉针及制备方法
WO2005034958A1 (en) * 2003-10-10 2005-04-21 Sk Chemicals, Co., Ltd. Triterpene compounds which are effective on improvement of brain function
JP4810642B2 (ja) * 2004-11-30 2011-11-09 秋田県 癌転移抑制用トリテルペン誘導体及び該トリテルペン誘導体を用いた癌転移抑制用組成物
US11090313B2 (en) 2010-05-20 2021-08-17 University Of Iowa Research Foundation Methods for inhibiting muscle atrophy
WO2014022772A1 (en) 2012-08-03 2014-02-06 University Of Iowa Research Foundation Tomatidine, analogs thereof, compositions comprising same, and uses for same
CN104688745B (zh) * 2010-05-20 2019-11-12 爱荷华大学研究基金会 用于抑制肌萎缩的方法
JP6001060B2 (ja) 2011-06-06 2016-10-05 ユニバーシティ オブ アイオワ リサーチ ファウンデーション 筋萎縮を阻害するための方法
CA2877338C (en) 2012-07-05 2022-10-11 Nutramax Laboratories, Inc. Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder
JP6211380B2 (ja) * 2012-10-17 2017-10-11 丸善製薬株式会社 Ｔｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤
KR102155125B1 (ko) * 2015-07-17 2020-09-11 경희대학교 산학협력단 악성 중피종 예방 또는 치료용 조성물
CN105534991A (zh) * 2015-12-24 2016-05-04 上海交通大学医学院 五环三萜类化合物在制备usp7抑制剂中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE707409A (ko) * 1967-12-01 1968-04-16
JPS6439973A (en) * 1987-08-06 1989-02-10 Taiyo Kagaku Kk Drink composition
JPH03287530A (ja) * 1990-03-31 1991-12-18 Snow Brand Milk Prod Co Ltd 免疫抑制剤
US5519008A (en) * 1992-09-10 1996-05-21 Glycomed Incorporated Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)
JPH0748250A (ja) * 1993-06-04 1995-02-21 Sekisui Chem Co Ltd 眠気防止用テープ
US5643884A (en) * 1993-08-09 1997-07-01 Glycomed Incorporated Lupane triterpenoid derivatives

Also Published As

Publication number Publication date
CN1073843C (zh) 2001-10-31
EP0774255A1 (en) 1997-05-21
JP3041232B2 (ja) 2000-05-15
CN1157716A (zh) 1997-08-27
US5985924A (en) 1999-11-16
JPH09143076A (ja) 1997-06-03
KR100424503B1 (ko) 2004-06-04
ATE206914T1 (de) 2001-11-15
DE69615984D1 (de) 2001-11-22
DE69615984T2 (de) 2002-07-04
EP0774255B1 (en) 2001-10-17

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