KR880700856A - 조직 플라스미노겐 활성화인자(tpa)상사체 - Google Patents

조직 플라스미노겐 활성화인자(tpa)상사체

Info

Publication number: KR880700856A
Authority: KR; South Korea
Prior art keywords: compound; region; regions; protein; tpa
Prior art date: 1985-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

KR870700754A

Other languages

English (en)

Korean (ko)

Inventor

아아르 마로티 키이스

에프 레버그 에드워드

와이 더리아울트 니콜

Original Assignee

로버어트 에이 아미테이지

디 옆죤 캄파니

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-20

Filing date

1986-12-12

Publication date

1988-04-12

1986-12-12 Application filed by 로버어트 에이 아미테이지, 디 옆죤 캄파니 filed Critical 로버어트 에이 아미테이지

1988-04-12 Publication of KR880700856A publication Critical patent/KR880700856A/ko

Status Granted legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

KR870700754A 1985-12-20 1986-12-12 조직 플라스미노겐 활성화인자(tpa)상사체 Granted KR880700856A (ko)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US81160785A	1985-12-20	1985-12-20
US811607		1985-12-20
US90948286A	1986-09-19	1986-09-19
US909482		1986-09-19
PCT/US1986/002684 WO1987003906A1 (en)	1985-12-20	1986-12-12	Tissue plasminogen activator (tpa) analogs

Publications (1)

Publication Number	Publication Date
KR880700856A true KR880700856A (ko)	1988-04-12

Family

ID=27123502

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
KR1019870700754A Expired - Fee Related KR950000303B1 (ko)	1985-12-20	1986-12-12	조직 플라스미노겐 활성화 인자(tpa) 상사체를 제조하는 방법
KR870700754A Granted KR880700856A (ko)	1985-12-20	1986-12-12	조직 플라스미노겐 활성화인자(tpa)상사체

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
KR1019870700754A Expired - Fee Related KR950000303B1 (ko)	1985-12-20	1986-12-12	조직 플라스미노겐 활성화 인자(tpa) 상사체를 제조하는 방법

Country Status (12)

Country	Link
EP (2)	EP0289508A1 (de)
JP (1)	JPH0659223B2 (de)
KR (2)	KR950000303B1 (de)
AT (1)	ATE85081T1 (de)
AU (1)	AU600463B2 (de)
DE (1)	DE3687651T2 (de)
DK (1)	DK431887A (de)
ES (1)	ES2053449T3 (de)
FI (1)	FI97809C (de)
GR (1)	GR3007280T3 (de)
NO (1)	NO176921C (de)
WO (1)	WO1987003906A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5501853A (en) *	1985-12-23	1996-03-26	Chiron Corporation	Peptide plasminogen activators
ATE70301T1 (de) *	1986-02-17	1991-12-15	Stichting Centraal Lab	Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
DE3786317T2 (de) *	1986-03-28	1994-02-03	Creative Biomolecules Inc	Proteinanaloge des gewebs-plasminogenaktivators.
US5047241A (en) *	1986-07-11	1991-09-10	American Home Products Corporation	Tris-Kringle plasminogen activator with novel K2 insert
US5242819A (en) *	1986-12-05	1993-09-07	Ciba-Geigy Corporation	DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) *	1986-12-05	1996-12-03	Ciba-Geigy Corporation	Hybrid plasminogen activator
GB2200640B (en) *	1987-01-30	1991-07-10	American Home Prod	Des-epidermal growth factor plasminogen activators
US5149533A (en) *	1987-06-04	1992-09-22	Zymogenetics, Inc.	Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) *	1987-06-18	1988-12-19	Kabigen Ab	Nya fibrinolytiska enzymer
US5037752A (en) *	1987-10-09	1991-08-06	Monsanto Company	Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US4963357A (en) *	1987-10-09	1990-10-16	Monsanto Company	Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5100666A (en) *	1987-10-09	1992-03-31	Monsanto Company	Modified tissue plasminogen activator K2K2SP
US5244676A (en) *	1987-10-09	1993-09-14	Monsanto Company	Modified tissue plasminogen activator with modified glycosylation site
DE3888619D1 (de) *	1987-10-09	1994-04-28	Monsanto Co	Modifizierter Gewebeplasminogenaktivator.
JP2534332B2 (ja) *	1987-10-29	1996-09-11	山之内製薬株式会社	ポリペプチド化合物
US5648254A (en) *	1988-01-15	1997-07-15	Zymogenetics, Inc.	Co-expression in eukaryotic cells
WO1989007146A1 (en) *	1988-02-05	1989-08-10	Integrated Genetics, Inc.	Rearranged tissue plasminogen activators and method for producing same
AU619803B2 (en) *	1988-02-05	1992-02-06	Genzyme Corporation	Rearranged tissue plasminogen activators and method for producing same
EP0400054A1 (de) *	1988-02-05	1990-12-05	Genzyme Corporation	Für modifizierte tpa-moleküle kodierende gensequenzen und deren produkte
US5346824A (en) *	1988-05-20	1994-09-13	Genentech, Inc.	DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) *	1988-05-20	1993-12-14	Genentech, Inc.	DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3823805A1 (de) *	1988-07-14	1990-01-18	Basf Ag	Neue polypeptide, ihre herstellung und verwendung
DE3825253A1 (de) *	1988-07-25	1990-02-01	Boehringer Mannheim Gmbh	T-pa-derivat und seine herstellung
US5714145A (en) *	1988-09-02	1998-02-03	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) *	1988-09-02	1993-11-16	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3836200A1 (de) *	1988-10-24	1990-04-26	Boehringer Mannheim Gmbh	Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
ATE123057T1 (de) *	1988-10-27	1995-06-15	Tno	Trombolytischer wirkstoff mit modifikation der domäne der kringle.
CA2007364A1 (en) *	1989-01-17	1990-07-17	David J. Livingston	Gene sequences encoding modified residues situated in the protease domain of tpa
DE3927865A1 (de) *	1989-08-23	1991-02-28	Boehringer Mannheim Gmbh	T-pa-mutante gk1l
EP0643772B1 (de) *	1992-06-03	1997-07-23	Genentech, Inc.	Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US5795975A (en) *	1993-01-10	1998-08-18	Yeda Research And Development Co. Ltd.	TNF receptor promoter
IL104355A (en) *	1993-01-10	2006-08-20	Yeda Res & Dev	Tnf receptor promoter
US6706504B1 (en)	1996-11-12	2004-03-16	The Scripps Research Institute	Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR79202B (de)	1982-05-05	1984-10-22	Genentech Inc
ZA837173B (en)	1982-11-08	1984-05-30	Univ Case Western Reserve	Genomic bovine growth hormone
US4511502A (en)	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
US4511503A (en)	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
NZ215660A (en) *	1985-04-04	1990-03-27	Beecham Group Plc	Tissue plasminogen activator modified in the growth factor domain
US4916071A (en) *	1985-08-14	1990-04-10	American Home Products Corporation	Poly-kringle plasminogen activator
NZ217331A (en) *	1985-08-26	1989-05-29	Lilly Co Eli	Tissue plasminogen activator derivatives and genetically engineered product

1986
- 1986-12-12 EP EP87900529A patent/EP0289508A1/de active Pending
- 1986-12-12 ES ES86309704T patent/ES2053449T3/es not_active Expired - Lifetime
- 1986-12-12 EP EP86309704A patent/EP0231624B1/de not_active Expired - Lifetime
- 1986-12-12 KR KR1019870700754A patent/KR950000303B1/ko not_active Expired - Fee Related
- 1986-12-12 AU AU67701/87A patent/AU600463B2/en not_active Ceased
- 1986-12-12 AT AT86309704T patent/ATE85081T1/de active
- 1986-12-12 KR KR870700754A patent/KR880700856A/ko active Granted
- 1986-12-12 DE DE8686309704T patent/DE3687651T2/de not_active Expired - Fee Related
- 1986-12-12 WO PCT/US1986/002684 patent/WO1987003906A1/en active IP Right Grant
1987
- 1987-08-19 DK DK431887A patent/DK431887A/da not_active Application Discontinuation
- 1987-08-20 NO NO873517A patent/NO176921C/no not_active IP Right Cessation
1988
- 1988-06-17 FI FI882922A patent/FI97809C/fi not_active IP Right Cessation
1993
- 1993-02-15 JP JP5025188A patent/JPH0659223B2/ja not_active Expired - Lifetime
- 1993-03-09 GR GR930400502T patent/GR3007280T3/el unknown

Also Published As

Publication number	Publication date
JPH05344892A (ja)	1993-12-27
NO873517D0 (no)	1987-08-20
GR3007280T3 (de)	1993-07-30
DE3687651D1 (de)	1993-03-11
EP0289508A1 (de)	1988-11-09
JPH0659223B2 (ja)	1994-08-10
DE3687651T2 (de)	1993-06-24
FI882922L (fi)	1988-06-17
FI97809B (fi)	1996-11-15
WO1987003906A1 (en)	1987-07-02
NO873517L (no)	1987-08-20
NO176921C (no)	1995-06-21
FI882922A0 (fi)	1988-06-17
EP0231624B1 (de)	1993-01-27
AU600463B2 (en)	1990-08-16
DK431887D0 (da)	1987-08-19
NO176921B (no)	1995-03-13
ES2053449T3 (es)	1994-08-01
AU6770187A (en)	1987-07-15
KR950000303B1 (ko)	1995-01-13
FI97809C (fi)	1997-02-25
DK431887A (da)	1987-08-19
ATE85081T1 (de)	1993-02-15
EP0231624A1 (de)	1987-08-12

Publication	Publication Date	Title
KR880700856A (ko)	1988-04-12	조직 플라스미노겐 활성화인자(tpa)상사체
DE69232725D1 (de)	2002-09-12	Synthetische dna-sequenz mit verstärkter isektizider aktivität in mais
ES2137931T3 (es)	2000-01-01	Proteinas gdf-1 y uog-1.
DE59711812D1 (de)	2004-09-02	Rekombinante collagenase typ i aus clostridium histolyticum und ihre verwendung zur isolierung von zellen und zellverbänden
BR9406998A (pt)	1996-09-10	Construção de DNA vetor de expressão recombinante célula processo para produzir uma enzima demonstrando atividade proteolítica enzima enzima com atividade protease preparação de enzima e uso de uma enzima
KR970707153A (ko)	1997-12-01	카텝신 02 프로테아제(cathepsin 02 protease)
ATE352626T1 (de)	2007-02-15	Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
ATE293696T1 (de)	2005-05-15	Mutierte alpha-amylase enzyme mit erhöhter stabilität
DE69434612D1 (de)	2006-04-06	Monoklonale Antikörper gegen recombinantes Stratum Corneum chymotryptisches Enzym (SCCE)
ATE284954T1 (de)	2005-01-15	Hyaluronan synthase gen und seine verwendung
DE69333067D1 (de)	2003-07-31	Enzym mit endoglukanase wirkung
ATE319818T1 (de)	2006-03-15	Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren
GEP20022619B (en)	2002-01-25	Novel Cell Systems Having Specific Interaction of Peptide Binding Pairs
DK0749444T3 (da)	2001-11-26	Human/dyre-faktor VIII-hybrid
BR9911549A (pt)	2001-03-20	Processo de produção de fitase em levedura
KR960701899A (ko)	1996-03-28	인자 viii:c활성을 갖는 단백질 복합체 및 그의 제조
Sage et al.	1981	Susceptibility of type V collagen to neutral proteases: evidence that the major molecular species is a thrombin-sensitive heteropolymer,[. alpha. 1 (V)] 2. alpha. 2 (V)
ATE450603T1 (de)	2009-12-15	Polypeptide mit verzweigungsenzym-aktivität und für diese kodierende nukleinsäuren
DE69535696D1 (de)	2008-03-13	Tripeptidyl-aminopeptidase
KR960010863A (ko)	1996-04-20	재조합 머사시딘 및 이의 제조방법
ATE90967T1 (de)	1993-07-15	Proteinanaloge des gewebs-plasminogenaktivators.
KR880001816A (ko)	1988-04-27	변이 인간 프로유로키나제 및 이의 제조방법
Ebisu et al.	1992	Production of human epidermal growth factor by Bacillus brevis increased with use of a stable plasmid from B. brevis 481
Bowles et al.	1981	Cleavage of colicin Ia by the Escherichia coli K-12 outer membrane is not mediated by the colicin Ia receptor
AU7843101A (en)	2001-12-17	Furin polypeptides with improved characteristics

Legal Events

Date	Code	Title	Description
1987-08-19	PA0109	Patent application	Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19870819
1988-04-12	PG1501	Laying open of application
1991-09-11	A201	Request for examination
1991-09-11	PA0201	Request for examination	Patent event code: PA02012R01D Patent event date: 19910911 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19870819 Comment text: Patent Application
1994-05-27	E902	Notification of reason for refusal
1994-05-27	PE0902	Notice of grounds for rejection	Comment text: Notification of reason for refusal Patent event date: 19940527 Patent event code: PE09021S01D
1994-12-19	G160	Decision to publish patent application
1995-01-13	PG1605	Publication of application before grant of patent	Comment text: Decision on Publication of Application Patent event code: PG16051S01I Patent event date: 19941219
1995-03-28	E701	Decision to grant or registration of patent right
1995-03-28	PE0701	Decision of registration	Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19950328
1995-05-08	GRNT	Written decision to grant
1995-05-08	PR0701	Registration of establishment	Comment text: Registration of Establishment Patent event date: 19950508 Patent event code: PR07011E01D
1995-05-08	PR1002	Payment of registration fee	Payment date: 19950508 End annual number: 3 Start annual number: 1
1997-12-30	PR1001	Payment of annual fee	Payment date: 19971230 Start annual number: 4 End annual number: 4
1998-12-30	FPAY	Annual fee payment	Payment date: 19981230 Year of fee payment: 5
1998-12-30	PR1001	Payment of annual fee	Payment date: 19981230 Start annual number: 5 End annual number: 5
2000-01-14	LAPS	Lapse due to unpaid annual fee
2000-01-14	PC1903	Unpaid annual fee