ATE90967T1 - Proteinanaloge des gewebs-plasminogenaktivators. - Google Patents

Proteinanaloge des gewebs-plasminogenaktivators.

Info

Publication number: ATE90967T1
Authority: AT; Austria
Prior art keywords: tpa; analogues; fragment; fibrin binding; natural
Prior art date: 1986-03-28

Application number

AT87903044T

Other languages

English (en)

Inventor

Roberto Crea

Roy Ho Loi Pang

Hermann Oppermann

Peter C Keck

Gabriel Alvarado-Urbina

Gay-May Wu

Charles M Cohen

Original Assignee

Creative Biomolecules Inc

Menarini Farma Ind

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-28

Filing date

1987-03-26

Publication date

1993-07-15

1987-03-26 Application filed by Creative Biomolecules Inc, Menarini Farma Ind filed Critical Creative Biomolecules Inc

1993-07-15 Application granted granted Critical

1993-07-15 Publication of ATE90967T1 publication Critical patent/ATE90967T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT87903044T 1986-03-28 1987-03-26 Proteinanaloge des gewebs-plasminogenaktivators. ATE90967T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US84554186A	1986-03-28	1986-03-28
US2933687A	1987-03-23	1987-03-23
EP87903044A EP0263172B1 (de)	1986-03-28	1987-03-26	Proteinanaloge des gewebs-plasminogenaktivators
PCT/US1987/000760 WO1987005934A1 (en)	1986-03-28	1987-03-26	Protein analogues of tissue plasminogen activator

Publications (1)

Publication Number	Publication Date
ATE90967T1 true ATE90967T1 (de)	1993-07-15

Family

ID=26704839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87903044T ATE90967T1 (de)	1986-03-28	1987-03-26	Proteinanaloge des gewebs-plasminogenaktivators.

Country Status (5)

Country	Link
EP (1)	EP0263172B1 (de)
AT (1)	ATE90967T1 (de)
AU (1)	AU7282687A (de)
DE (1)	DE3786317T2 (de)
WO (1)	WO1987005934A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2031826T3 (es) *	1985-12-23	1993-01-01	Chiron Corporation	Procedimiento para producir nuevos peptidos activadores del plasminogeno.
CA1339445C (en) *	1986-11-12	1997-09-09	The General Hospital Corporation	Recombinant hybrid immunoglobulin molecules and method of use
GB8705377D0 (en) *	1987-03-07	1987-04-08	Beecham Group Plc	Compounds
GB8711957D0 (en) *	1987-05-20	1987-06-24	Beecham Group Plc	Compounds
US5149533A (en) *	1987-06-04	1992-09-22	Zymogenetics, Inc.	Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) *	1987-07-01	1994-04-12	Beecham Group Plc	Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
EP0316068A1 (de) *	1987-10-09	1989-05-17	Collaborative Research Inc.	Modifizierter Plasminogenaktivator mit niedrigem Molekulargewicht und Verfahren zu seiner Herstellung
US5372812A (en) *	1988-04-04	1994-12-13	The General Hospital Corporation	Composition and method for acceleration of clot lysis
US5582862A (en)	1988-04-04	1996-12-10	General Hospital Corporation	Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
JPH02504472A (ja) *	1988-06-03	1990-12-20	セルテック　リミテッド	ハイブリッド蛋白
IE69054B1 (en) *	1988-07-20	1996-08-07	Schering Ag	Vampire bat salivary plasminogen activators
US5609869A (en) *	1988-08-19	1997-03-11	The General Hospital Corporation	Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5811265A (en) *	1988-08-19	1998-09-22	The General Hospital Corporation	Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
DE3942580A1 (de) *	1989-12-22	1991-06-27	Basf Ag	Verfahren zur herstellung von hirudin
AU741338B2 (en) *	1996-09-20	2001-11-29	Bristol-Myers Squibb Company	Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL68561A (en) *	1982-05-05	1991-01-31	Genentech Inc	Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
KR950000303B1 (ko) *	1985-12-20	1995-01-13	디 엎죤 캄파니	조직 플라스미노겐 활성화 인자(tpa) 상사체를 제조하는 방법
DE3682891D1 (de) *	1986-02-17	1992-01-23	Stichting Centraal Lab	Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.

1987
- 1987-03-26 AT AT87903044T patent/ATE90967T1/de not_active IP Right Cessation
- 1987-03-26 EP EP87903044A patent/EP0263172B1/de not_active Expired - Lifetime
- 1987-03-26 WO PCT/US1987/000760 patent/WO1987005934A1/en active IP Right Grant
- 1987-03-26 AU AU72826/87A patent/AU7282687A/en not_active Abandoned
- 1987-03-26 DE DE87903044T patent/DE3786317T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU7282687A (en)	1987-10-20
EP0263172A1 (de)	1988-04-13
WO1987005934A1 (en)	1987-10-08
DE3786317D1 (de)	1993-07-29
EP0263172B1 (de)	1993-06-23
DE3786317T2 (de)	1994-02-03

Publication	Publication Date	Title
ATE90967T1 (de)	1993-07-15	Proteinanaloge des gewebs-plasminogenaktivators.
AU605124B2 (en)	1991-01-10	Novel peptide plasminogen activators
ATE282087T1 (de)	2004-11-15	Modifiziertes enzym mit lipolytischer aktivität
ES2187527T3 (es)	2003-06-16	Estructura de orden superior y enlace de acidos nucleicos peptidicos.
Matsuda et al.	1972	A simple, large scale method for preparation of plasminogen-free fibrinogen
DE69929886D1 (de)	2006-04-20	Überexpression von phytase in hefesystemen
BG100771A (en)	1997-08-29	Hematopoeic protein and ways and methods for its preparation
IE831024L (en)	1983-11-05	Human tissue plasminogen activator
DK0618976T3 (da)	2002-12-02	Syntetisk DNA-sekvens med forbedret insekticid virkning i majs
DK0941318T5 (da)	2002-02-18	Håndvægtformede konstruerede ekspressionssystemer til genterapi
IL114118A0 (en)	1995-10-31	Novel cell systems having specific interaction of peptide binding pairs
KR970707153A (ko)	1997-12-01	카텝신 02 프로테아제(cathepsin 02 protease)
AU1207301A (en)	2001-04-30	Stabilized proteins
SE9602496D0 (sv)	1996-06-20	Method and means for producing a fibrinogen binding protein and its use in biotechnology
DE69731463D1 (de)	2004-12-09	Rekombinante ribonuklease proteine
WO1994021800A3 (en)	1994-11-10	Protein tyrosine phosphatase ptp-s31
WO1994003611A3 (en)	1994-03-31	Ptp-d subfamily of protein tyrosine phosphatases
ATE282327T1 (de)	2004-12-15	Modifizierung von schaumeigenschaften von proteinen
DK0901526T3 (da)	2007-09-10	Cortistatin: neuropeptider, sammensætninger og metoder
KR900702017A (ko)	1990-12-05	혼성 단백질(bybrid proteins)
DE69634757D1 (de)	2005-06-23	Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
Williams et al.	1993	Dye-ligand affinity purification of human complement factor B and β2 glycoprotein I
DE60023933D1 (en)	2005-12-15	Hybrid-toxine von bacillus thuringiensis
PT1379639E (pt)	2005-10-31	A glucuranilo epimerase c5 o dna que a codifica e as suas utilizacoes
Medved' et al.	1988	The cleavage of β‐chain in bovine fibrinogen DH fragment (95 kDa) leads to a significant increase in its anticlotting activity

Legal Events

Date	Code	Title	Description
1994-02-15	UEP	Publication of translation of european patent specification
1996-12-15	REN	Ceased due to non-payment of the annual fee