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KR880002508A - 세포내 지방입자(리포솜)의 제조방법 및 조성물 - Google Patents

세포내 지방입자(리포솜)의 제조방법 및 조성물 Download PDF

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Publication number
KR880002508A
KR880002508A KR1019860006446A KR860006446A KR880002508A KR 880002508 A KR880002508 A KR 880002508A KR 1019860006446 A KR1019860006446 A KR 1019860006446A KR 860006446 A KR860006446 A KR 860006446A KR 880002508 A KR880002508 A KR 880002508A
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KR
South Korea
Prior art keywords
liposome
pharmaceutically acceptable
composition
hydrating agent
acceptable salt
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Granted
Application number
KR1019860006446A
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KR900007185B1 (ko
Inventor
박 죤와이.
톰프슨 쉴에이.
Original Assignee
제임스 엠. 카나지
앨러겐 파마슈티칼, 인크
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Application filed by 제임스 엠. 카나지, 앨러겐 파마슈티칼, 인크 filed Critical 제임스 엠. 카나지
Publication of KR880002508A publication Critical patent/KR880002508A/ko
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Publication of KR900007185B1 publication Critical patent/KR900007185B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Materials For Medical Uses (AREA)

Abstract

내용 없음

Description

세포내 지방입자(리포솜)의 제조방법 및 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 리포솜을 형성하기에 적합한 방법으로, a.리포솜-형성물질;b.수화제가 리포솜-형성물질에 대하여 1:20과 1:0.05사이의 몰농도 비율로 존재하는 수화제와 ;c.캡슐화할 물질을 수용액에 분산시켜서 제조한 리포솜 조성물.
  2. 수화제가 카복실산염, 아미노, 구아니디노 기능인 오메가 치환제를 갖는 알파아미노산이거나 제약상 허용되는 이것들의 염, 또는 다음 일반식의 화합물 또는 이것의 제약상 허용염인 제 1 항의 조성물.
    이식에서, X는또는이며, 여기에서 Z는 H이거나 무기나 유기양이온이고 ; Y는나이며 여기서Z는 상기 정의한 것과 같으며 ; n은 정수 1-10이다.
  3. 수화제가 리포솜-형성물질에 대하여 1 : 2 내지 1:0.5사이의 몰농도 비율의 양으로 존재하는 제 2 항의 조성물.
  4. 상기 수화제가 아르기닌, 호모아르기닌 또는 이것들의 N-아실유도체, 감마-아미노부틸산, 아스파라긴, 리신, 오르니틴, 글루타민산, 아스파라긴산 또는 다음 일반식의 화합물이나 이것들의 제약상 허용염인 제 3 항의 조성물.
    이들식에서 n은 2-4이다.
  5. 상기 수화제가 아르기닌, 호모아르기닌, 감마-아미노부틸산, 리신, 또는 오르니틴 또는 이것들의 제약상 허용염인 제 4 항의 생성물.
  6. 상기 수화제가 글루타민산이나 아스파라긴산 또는 이것들의 제약적 허용염인 제 5 항의 조성물.
  7. 조성물이, a.리포솜-형성물질 b.수화제가 리포솜-형성물질에 대하여 1:20 및 1:0.05 사이의 몰농도비로 존재하는 수화제, c. 임의로 캡슐화할 물질과 ; d 고체에 대하여 300몰까지의 양인 물로 이루어지며, 수용액에 분산시켰을 때 리포솜을 형성할 수 있는 조성물 및 그 조성물로 부터 제조된 리포솜.
  8. 수화제가 카복실산 염, 아미노 또는 구아니디노 기능인 오메가 치환제를 갖는 알파 아미노산이나 이것들의 제약상 허용염 또는 다음 일반식의 화합물이나 이것의 제약상 허용염.
    이식에서, X는또는이며 여기에서 Z는 H이거나 무기나 유기 양이온이고 ; Y는또는이며 여기서 Z는 상기한 바와 같고 ; n은 정수 1-10이다.
  9. 상기 수화제가 아르기닌,호모아르기닌, 또는 그것들의 N-아실유도체, 감마-아미노부틸산, 아스파라긴, 리신, 오르니틴, 글루타민산, 아스파라긴산 또는 일반식의 화합물이나 이것들의 제약적 허용염.
    이들식에서 n은 2-4이다.
  10. 수화제가 리포솜-형성물질에 대하여 1 : 2내지 1 :0.5몰농도 사이의 양으로 존재하는 제 2 항의 조성물.
  11. 상기 수화제가 아르기닌, 호모아르기닌, 감마-아미노부틸산, 리신 또는 오르니틴 또는 이것들의 제약상 허용염인 제10항의 조성물.
  12. 상기 수화제가 글루타민산이나 아스파라긴산 또는 이것들의 제약적 허용염인 제10항인 조성물.
  13. 리포솜-형성물질에 대하여 1 : 20내지 1 : 0.05의 몰농도 비율로 수화제를, 리포솜-형성물질을 수용액에 분산시키기 전이나 분산시킴과 동시에, 그 리포솜-형성물질에 첨가하는 것으로 이루어지는 안정된 리포솜을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860006446A 1985-08-07 1986-08-05 리포솜 조성물 Expired KR900007185B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76348485A 1985-08-07 1985-08-07
US763.484 1985-08-07
US763484 1985-08-07

Publications (2)

Publication Number Publication Date
KR880002508A true KR880002508A (ko) 1988-05-09
KR900007185B1 KR900007185B1 (ko) 1990-09-29

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KR1019860006446A Expired KR900007185B1 (ko) 1985-08-07 1986-08-05 리포솜 조성물

Country Status (19)

Country Link
EP (1) EP0211647B1 (ko)
JP (1) JP2511417B2 (ko)
KR (1) KR900007185B1 (ko)
CN (1) CN1027491C (ko)
AT (1) ATE94754T1 (ko)
AU (1) AU601154B2 (ko)
CA (1) CA1280975C (ko)
DE (1) DE3689056T2 (ko)
DK (1) DK362786A (ko)
ES (1) ES8801118A1 (ko)
FI (1) FI863227A7 (ko)
GR (1) GR862020B (ko)
HU (1) HU198836B (ko)
IE (1) IE61445B1 (ko)
IL (1) IL79114A (ko)
NO (1) NO863176L (ko)
NZ (1) NZ216768A (ko)
PT (1) PT83130B (ko)
ZA (1) ZA864541B (ko)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79114A (en) * 1985-08-07 1990-09-17 Allergan Pharma Method and composition for making liposomes
IT1214540B (it) * 1986-10-23 1990-01-18 Vincenzo Zappia Mario De Rosa Formulazioni idrosolubili di ubidecarenoni, procedimento per laloro preparazione e composizioni farmaceutiche che li compongono.
EP0287646B1 (en) * 1986-10-23 1992-05-20 Arval S.P.A. Cosmetic preparations containing ubidecarenones
WO1989003679A1 (en) * 1987-10-19 1989-05-05 The Liposome Company, Inc. Aqueous preparation of liposome composition
FR2631234B1 (fr) * 1988-05-10 1990-09-14 Dior Christian Parfums Composition cosmetique ou dermatologique, notamment a action amincissante ou anti-cellulitique contenant des extraits de cola sous forme libre ou sous forme liposomale
JP2786482B2 (ja) * 1988-06-29 1998-08-13 第一製薬株式会社 脂質膜構造体
BE1001869A3 (fr) * 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US5741513A (en) * 1990-02-08 1998-04-21 A. Natterman & Cie. Gmbh Alcoholic aqueous gel-like phospholipid composition, its use and topical preparations containing it
JP3218637B2 (ja) * 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
US6165500A (en) * 1990-08-24 2000-12-26 Idea Ag Preparation for the application of agents in mini-droplets
CA2067754C (en) * 1990-08-24 2002-06-04 Gregor Cevc Preparation for the application of agents in mini-droplets
DE4038075C1 (en) * 1990-11-29 1992-03-19 B. Braun Melsungen Ag, 3508 Melsungen, De Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
CA2087691A1 (en) * 1992-01-23 1993-07-24 Peter Critchley Cosmetic compositon
GB9224502D0 (en) * 1992-11-23 1993-01-13 New Roger R C Method of preparing a lipid-containing formulation
CA2156525A1 (en) * 1993-02-19 1994-09-01 Susan Dillon Influenza vaccine compositions containing 3-o-deacylated monophosphoryl lipid a
SG65599A1 (en) * 1993-03-24 1999-06-22 Collaborative Lab Inc Cosmetic delivery system for salicylic acid and process for preparation of same
CA2120197A1 (en) * 1993-04-02 1994-10-03 Kenji Endo Stable aqueous dispersions containing liposomes
JPH0757826A (ja) * 1993-08-18 1995-03-03 Nec Corp 端子台
TW520294B (en) * 1998-01-08 2003-02-11 Res Dev Foundation Stabilization of lipid: DNA formulations during nebulization
US6375980B1 (en) * 1998-01-08 2002-04-23 Research Development Foundation Stabilization of lipid:DNA formulations during nebulization
TR200101790T2 (tr) 1998-12-23 2001-10-22 Idea Ag. Yayılgan olmayan in vivo topik uygulamalar için geliştirilmiş formül
EP1031347B1 (en) 1999-01-27 2002-04-17 Idea Ag Transnasal transport/immunisation with highly adaptable carriers
PT1031346E (pt) 1999-01-27 2002-09-30 Idea Ag Vacinacao nao invasiva atraves da pele
MXPA02000053A (es) 1999-07-05 2003-07-21 Idea Ag Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables.
US6248353B1 (en) * 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
EP1138310A1 (de) * 2000-03-28 2001-10-04 Primacare S.A. Pro-liposomen
PT1347743E (pt) 2000-12-07 2006-06-30 Univ Utrecht Holding Bv Composicao para o tratamento de doencas inflamatorias
US6610322B1 (en) 2000-12-20 2003-08-26 Brian Charles Keller Self forming, thermodynamically stable liposomes and their applications
US20040105881A1 (en) 2002-10-11 2004-06-03 Gregor Cevc Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
GB0404993D0 (en) * 2004-03-05 2004-04-07 Univ Liverpool John Moores Method and apparatus for producing carrier complexes
MX2007012121A (es) * 2005-03-31 2007-11-20 Unilever Nv Entrega intensificada de agentes de beneficio para la piel.
PL2081551T3 (pl) * 2006-10-06 2013-06-28 Scil Tech Gmbh Wytworzenie wysuszonego rekonstytuowanego pęcherzyka do zastosowania farmaceutycznego
JP5112673B2 (ja) * 2006-10-16 2013-01-09 株式会社コーセー セラミド含有組成物及びこれを配合する皮膚外用剤
CN103327965B (zh) 2011-01-25 2017-07-18 宝洁公司 脂质体和包含脂质体的个人护理组合物
US10159646B2 (en) * 2013-08-12 2018-12-25 Altum-Avro Pharma Partnership Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery
US8986732B2 (en) 2013-08-12 2015-03-24 Helix Biopharma Corporation Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery
IT201700086879A1 (it) * 2017-07-28 2019-01-28 Univ Degli Studi Cagliari Vescicole lipidiche a doppio strato contenenti adrenalina, per uso nel trattamento delle emergenze cardiache
CN109224879B (zh) * 2018-09-17 2021-04-27 南京工业大学 一种cha分子筛膜的制备方法
CN113995852B (zh) * 2021-11-08 2024-01-30 河北大学 Arg-脂质体微囊、微囊包封的鱼精蛋白-siRNA复合体及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK116528A (ko) * 1966-09-30
US3932657A (en) * 1973-11-12 1976-01-13 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome encapsulation of chelating agents
US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
AT356278B (de) * 1976-07-12 1980-04-25 Hoffmann La Roche Verfahren zur herstellung von injektions- loesungen
JPS5323872A (en) * 1976-08-17 1978-03-04 Takeda Chem Ind Ltd Preparation of microcapsule
DE2656333C2 (de) * 1976-12-13 1985-08-08 Karl Prof. Dr.med. 7302 Ostfildern Theurer Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten
IT1110989B (it) * 1979-01-19 1986-01-13 Erba Farmitalia Forme farmaceutiche costitutite da liposomi e procedimenti relativi
DE2856333C2 (de) * 1978-12-27 1983-09-22 A. Nattermann & Cie GmbH, 5000 Köln Oral einnehmbare Arzneimittel mit entzündungshemmender Wirkung
US4174296A (en) * 1978-12-04 1979-11-13 American Lecithin Company Water soluble lecithin composition
US4528193A (en) * 1978-12-27 1985-07-09 A. Natterman & Cie. Gmbh Inflammation-preventing pharmaceutical composition of oral administration
DE2914789A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Injizierbare arzneimittel mit entzuendungshemmender wirkung
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
JPS574913A (en) * 1980-06-11 1982-01-11 Green Cross Corp:The Urokinase preparation for oral administration
JPS5746921A (en) * 1980-09-02 1982-03-17 Green Cross Corp:The Oral preparation of human blood coagulation factor
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
WO1983003383A1 (en) * 1982-03-29 1983-10-13 Liposome Co Inc Stable plurilamellar vesicles
EP0102324A3 (de) * 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
FR2540381B1 (fr) * 1983-02-08 1986-05-30 Dior Sa Parfums Christian Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede
JPS607934A (ja) * 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソ−ムの製造方法
JPS607932A (ja) * 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソーム懸濁液およびその製法
IL79114A (en) * 1985-08-07 1990-09-17 Allergan Pharma Method and composition for making liposomes

Also Published As

Publication number Publication date
CN1027491C (zh) 1995-01-25
HK1004530A1 (en) 1998-11-27
JP2511417B2 (ja) 1996-06-26
CA1280975C (en) 1991-03-05
FI863227A0 (fi) 1986-08-06
ATE94754T1 (de) 1993-10-15
NO863176L (no) 1987-02-09
PT83130A (en) 1986-09-01
DE3689056T2 (de) 1994-01-27
NO863176D0 (no) 1986-08-06
ES556651A0 (es) 1987-12-16
DE3689056D1 (de) 1993-10-28
HUT43487A (en) 1987-11-30
JPS6242733A (ja) 1987-02-24
EP0211647B1 (en) 1993-09-22
DK362786A (da) 1987-02-08
IE61445B1 (en) 1994-11-02
AU601154B2 (en) 1990-09-06
IE862103L (en) 1987-02-07
GR862020B (en) 1986-12-24
KR900007185B1 (ko) 1990-09-29
IL79114A0 (en) 1986-09-30
ZA864541B (en) 1987-02-25
FI863227L (fi) 1987-02-08
PT83130B (pt) 1989-03-30
FI863227A7 (fi) 1987-02-08
CN86104874A (zh) 1987-02-04
NZ216768A (en) 1989-11-28
DK362786D0 (da) 1986-07-30
IL79114A (en) 1990-09-17
ES8801118A1 (es) 1987-12-16
AU5914186A (en) 1987-12-24
EP0211647A1 (en) 1987-02-25
HU198836B (en) 1989-12-28

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