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KR870006906A - 피부투과식 약물투여장치 - Google Patents

피부투과식 약물투여장치 Download PDF

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Publication number
KR870006906A
KR870006906A KR1019860005668A KR860005668A KR870006906A KR 870006906 A KR870006906 A KR 870006906A KR 1019860005668 A KR1019860005668 A KR 1019860005668A KR 860005668 A KR860005668 A KR 860005668A KR 870006906 A KR870006906 A KR 870006906A
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KR
South Korea
Prior art keywords
extension
stress reduction
active agent
reinforcement
substrate
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Granted
Application number
KR1019860005668A
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English (en)
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KR930001081B1 (ko
Inventor
에쓰. 캠프벨 파트리씨아
비. 에켄호프 제임스
에이. 플레이스 버길
Original Assignee
알자 코포레이숀
에드워드 엘. 맨델
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Publication of KR870006906A publication Critical patent/KR870006906A/ko
Application granted granted Critical
Publication of KR930001081B1 publication Critical patent/KR930001081B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/14—Topical contraceptives and spermacides

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

피부투과식 약물투여장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 생물학적 활성제를 장시간 동안 피부투과식으로 투여하는 치료장치로서, 투여할 전술한 활성제를 포함하는 기질을 포함하며, 전술한 기질사이에 끼워넣은 직물보강장치를 가지는 전술한 기질의 말초표면인 의도한 몸체를 포함하며, 피부에 견고하게 접착되면서도 불쾌감없이 떼어낼 수 있는 충분히 낮은 탈피력을 가진 전술한 기질을 포함하며, 보강장치가 모든 방향으로 실제로 균등하게 변형될 수 있는 등방성의 웨브 또는 연속의 중복성으로 형성된 비-등방성의 웨브를 형성하는 임의방향으로 결합된 섬유로 형성된 신축성 있는 직물을 포함하고, 또한 임의방향으로 된 두 번째 섬유가 가로방향으로 결합되어 일차적으로 연속섬유에 대해 직각으로 변형될 수 있도록 된 일반적으로 평행의 섬유를 포함하는 것을 특징으로 하는 장치.
  2. 제1항에 있어서, 보강장치가 비-등방성일 때 장치가 약 5% 연장에서 1000-15000g/㎠의 범위의 연장율 및 전술한 연장의 5분내에 약 25-45% 범위의 응력감소로 형성되는 것을 특징으로 하는 장치.
  3. 제2항에 있어서, 장치의 2cm 폭의 스트립이 15% 연장되기 위하여 30-300gms 의 신장력을 요하는 것을 특징으로 하는 장치.
  4. 제1항에 있어서, 보강장치가 15% 연장에서 800-60,000g/㎠의 연장율을 가지며 15% 연장에서 5분내에 30-45%의 응력감소를 가지는 것을 특징으로 하는 장치.
  5. 전술한 항중 어느 한항에 있어서, 전술한 기질을 전술한 보강장치에 결합시키는 결합층을 특징으로 하는 장치로서, 전술한 결합층이 활성제가 실제로 투과안되는 재질로서 형성되어서 장치의 몸체 말초포던을 통해 배출돗는 약제의 양을 감소시키는 장치.
  6. 제5항에 있어서, 결합층이 보강장치/결합제의 조성물의 연장율이나 응력감소가 보강장치 단독의 연장율이나 응력감소보다 5%이상으로 변하지 않게 하는 것을 특징으로 하는 장치.
  7. 제2항 내지 제6항중 어느 한항에 있어서, 저장기가 1500g/㎠이하의 연장율과 15% 연장에서 5분내에 25% 이하의 응력감소를 가지는 것을 특징으로 하는 장치.
  8. 전술한 항중 어느 한항에 있어서, 저장기가 28-61%의 VA함량을 가지는 EVA 고분자를 형성되는 것을 특징으로 하는 장치.
  9. 전술한 항중 어느 한항에 있어서, 활성제를 테스토테를 에스타디올, 인터페론, 아시클리비트, 페놀프탈레인, 안티안토로겐(antiantrogon) 및 LHRH가 있거나 없는 시프로페론에서 선택하는 것을 특징으로 하는 장치.
  10. 제1항에 있어서, 전술한 실시예에 참고로 기술한 것과 실제로 같은 피부투과식 치료장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860005668A 1986-01-13 1986-07-14 피부투과식 약품 투여장치 Expired - Fee Related KR930001081B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US818561 1986-01-13
US818.561 1986-01-13
US06/818,561 US4725439A (en) 1984-06-29 1986-01-13 Transdermal drug delivery device

Publications (2)

Publication Number Publication Date
KR870006906A true KR870006906A (ko) 1987-08-13
KR930001081B1 KR930001081B1 (ko) 1993-02-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860005668A Expired - Fee Related KR930001081B1 (ko) 1986-01-13 1986-07-14 피부투과식 약품 투여장치

Country Status (8)

Country Link
US (2) US4725439A (ko)
EP (1) EP0232580B1 (ko)
JP (1) JPH0811726B2 (ko)
KR (1) KR930001081B1 (ko)
CA (1) CA1257819A (ko)
DE (1) DE3687067T2 (ko)
ES (1) ES8706455A1 (ko)
GB (1) GB2185187B (ko)

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Also Published As

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US4725439A (en) 1988-02-16
ES556380A0 (es) 1987-07-01
GB8615106D0 (en) 1986-07-23
CA1257819A (en) 1989-07-25
JPS62167724A (ja) 1987-07-24
ES8706455A1 (es) 1987-07-01
DE3687067T2 (de) 1993-05-06
GB2185187A (en) 1987-07-15
DE3687067D1 (de) 1992-12-10
GB2185187B (en) 1989-10-25
US4867982A (en) 1989-09-19
KR930001081B1 (ko) 1993-02-15
JPH0811726B2 (ja) 1996-02-07
EP0232580A3 (en) 1989-06-21
EP0232580A2 (en) 1987-08-19
EP0232580B1 (en) 1992-11-04

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