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KR850005396A - 1,4-벤조퀴논 유도체 및 벤제유도체의 제조방법 - Google Patents

1,4-벤조퀴논 유도체 및 벤제유도체의 제조방법 Download PDF

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KR850005396A
KR850005396A KR1019850000496A KR850000496A KR850005396A KR 850005396 A KR850005396 A KR 850005396A KR 1019850000496 A KR1019850000496 A KR 1019850000496A KR 850000496 A KR850000496 A KR 850000496A KR 850005396 A KR850005396 A KR 850005396A
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lower alkoxy
lower alkyl
hydrogen atom
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KR910007075B1 (ko
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히데유끼 이와끼 (외 2)
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오오쓰까 아끼히꼬
오오쓰까세이야꾸 가부시끼 가이샤
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Priority claimed from JP59013037A external-priority patent/JPS60156610A/ja
Priority claimed from JP59143858A external-priority patent/JPS6122041A/ja
Priority claimed from JP14487684A external-priority patent/JPS6124536A/ja
Priority claimed from JP59230683A external-priority patent/JPS61109714A/ja
Application filed by 오오쓰까 아끼히꼬, 오오쓰까세이야꾸 가부시끼 가이샤 filed Critical 오오쓰까 아끼히꼬
Publication of KR850005396A publication Critical patent/KR850005396A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/30—Quinones containing groups having oxygen atoms singly bound to carbon atoms with polycyclic non-condensed quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C07C46/08—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring with molecular oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

1,4-벤조퀴논 유도체 및 벤제유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(6)으로 표시되는 페놀 유도체를 산화제로 산화시킴을 특징으로 하는 하기 일반식(Ⅰ)로 표시되는 1,4-벤조퀴논 유동체의 제조방법.
    {상기 식중, R1은 저급 알킬기, 저급 알콕시기, 아미노기, 히드록실기, 또는 저급 알카노일옥시기이고 : R2는 수소원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 저급 알콕시카르보닐기, 저급 알킬티오기 또는 히드록시-저급 알킬기이고 : R3는 히드록실기, 저급 알킬기, 저급 알콕시기, 아미노기 또는 저급 알카노일옥시기이며 :A및D는 각각 탄소원자 1∼10의 알킬렌기이고 : B는 일반식 -CH=CH-,, -C≡C-, 또는 -CH(OH)-CH(OH)-의 기이고 :l및m는 각각 0 또는 1이고 :E는 일반식
    [식중, R4는 저급 알킬기, 저급 알콕시기, 아미노기, 히드록실기 또는 저급 알카노일옥시기이고, : R5는 수소원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 저급 알콕시-카르보닐기, 저급 알킬티오기, 히드록시-저급 알킬기, 일반식 -G-C≡C-R7(식중G는 저급 알킬렌기이고 : R7는 저급 알킬기임)의 기 또는 일반식
    (식중 L은 저급 알킬렌기이고 : R8및 R9는 각각 저급 알콕시기임)의 기이고 : R6는 저급 알킬기, 히드록실기, 저급 알콕시기, 아미노기 또는 저급 알카노일옥시기임]의 기 또는 일반식
    (식중 R10은 수소원자 또는 메틸기임)의 기이며, ℓ가 0일 때는 기호A및D로 표시된 1∼10 탄소원자의 알킬렌기 중 하나 또는 둘다는 알킬렌쇄내에 헤테로 원자로서 산소원자, 황 원자 또는 일반식 -S-S-의 기를 가질 수도 있으나, 단,E가 일반식
    의 기일 때는A및D는 각각 헵타 메틸렌기이고 ℓ및m은 각각 1이며 B는 일반식 -CH=CH-의 기이고 R1은 메톡시기이며 R2는 수소원자이고 R3는 히드록실기이고 : 나아가m이 1일때는 ℓ은 0 또는 1이며,m이 0이면ℓ은 0이다 : 단 (ⅰ) ℓ이 0이면A및D의 알킬렌기내의 탄소원자수의 총합은 1∼12이고 :(ii)B가 일반식 -C≡C-의 기이면, (a) R1및 R4는 저급 알콕시기이어서는 안되고, (b) R2, R3, R5및 R6는 수소원자이어서는 안되며, (c)A및 D는 각각 헵타메틸렌기이어서는 안되고,(iii) B가 일반식 -CH=CH-의 기이면, (a) R1및 R4중 어느 하나가 저급 알콕시기일 경우에는 다른 하나는 저급 알콕시기, 히드록실기 또는 저급 알카노일옥시기이어서는 안되고, (b) R2및 R5중 어느 하나가 수소원자 또는 저급 알킬기일 경우에는 다른 하나는 수소원자이어서는 안되며, (c) R3및 R6중 어느 하나가 히드록실기, 저급 알콕시기 또는 저급 알카노일옥시기일 경우에는 다른 하나는 히드록실기 또는 저급 알카노일옥실기이어서는 안되고, 나아가 (d)A및D는 각각 헵타메틸렌기이어서는 안된다.
    {상기 식중, R1, R2, R3, B, ℓ,D및m은 상기에서 정의한 바와 같으며 : E3는 일반식
    [식중, R4및R6는 상기에서 정의한 바와 같으며 : R5c는 수소원자, 할로겐 원자, 저급 알킬기, 저급 알콕시기, 저급 알콕시카르보닐기, 저급 알킬티오기, 히드록시-저급 알킬기, 또는 일반식 -G-C≡C-R7(식중, G 및 R7은 상기에서 정의한 바와 같음)의 기, 또는 일반식
    (식중, L, R8, 및 R9는 상기에서 정의한 바와 같음)의 기이다]의 기이다}
  2. 하기 일반식(8)로 표시되는 페닐 유도체를 산화제로 산화시킴을 특징으로 하는 하기 일반식로 (2) 표시되는 1,4-벤조퀴논 유도체의 제조 방법.
    {상기 식중, R11은 저급 알콕시기 또는 히드록실기이고 : R12는 수소원자, 히드록실기 또는 저급 알콕시기이고 : R13은 수소원자 또는 탄소원자 1∼8의 알킬기이며 : M은 탄소원자 1∼10의 알킬렌기이고 : Q는 일반식 -CH=CH-, -C≡C-,, 또는 -CH2-CH2-의 기이다 : 단,(i) R11이 저급 알콕시기 또는 히드록실기이고 R12가 히드록실기 또는 수소원자이면, 일반식 -M-Q-R13의 기는n-펜틸기, 트리데케닐기 또는 운데실기이어서는 안되며,(ii) R11이 저급 알콕시기이고 R12가 히드록실기이면, 일반식 -M-Q-R13의 기는 8-헵타데케닐기 또는 10-펜타데세닐기이어서는 안된다,}
    (상기 식중, R11, R12, R13, M 및 Q는 상기에서 정의한 바와 같다.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000496A 1984-01-26 1985-01-26 1,4-벤조퀴논 유도체의 제조방법 Expired KR910007075B1 (ko)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP143858 1980-10-15
JP59013037A JPS60156610A (ja) 1984-01-26 1984-01-26 アラキドン酸５−リポキシゲナ−ゼ阻害剤
JP13037/84 1984-01-26
JP13037 1984-01-26
JP59143858A JPS6122041A (ja) 1984-07-10 1984-07-10 １，４−ベンゾキノン誘導体
JP143858/84 1984-07-10
JP144876/84 1984-07-11
JP14487684A JPS6124536A (ja) 1984-07-11 1984-07-11 １，４−ベンゾキノン誘導体
JP144876 1984-07-11
JP230683/84 1984-10-31
JP230683 1984-10-31
JP59230683A JPS61109714A (ja) 1984-10-31 1984-10-31 アラキドン酸５−リポキシゲナ−ゼ阻害剤

Publications (2)

Publication Number Publication Date
KR850005396A true KR850005396A (ko) 1985-08-24
KR910007075B1 KR910007075B1 (ko) 1991-09-16

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KR1019850000496A Expired KR910007075B1 (ko) 1984-01-26 1985-01-26 1,4-벤조퀴논 유도체의 제조방법

Country Status (5)

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EP (1) EP0151995B1 (ko)
KR (1) KR910007075B1 (ko)
DE (1) DE3586910T2 (ko)
DK (1) DK34185A (ko)
ES (1) ES8702330A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100325798B1 (ko) * 1998-01-14 2002-02-25 한병훈 암전이 억제작용 및 항혈전 작용이 있는 벤조퀴논류 화합물

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2835523B1 (fr) * 2002-02-06 2004-04-16 Servier Lab Nouveaux derives de 3-aryl-2,5-dihydroxy-1,4-benzoquinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393075A (en) * 1980-04-14 1983-07-12 Takeda Chemical Industries, Ltd. Quinone compounds and their use in suppressing the production of SRS-A in mammals
JPS56150014A (en) * 1980-04-21 1981-11-20 Takeda Chem Ind Ltd Antiallergic agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100325798B1 (ko) * 1998-01-14 2002-02-25 한병훈 암전이 억제작용 및 항혈전 작용이 있는 벤조퀴논류 화합물

Also Published As

Publication number Publication date
EP0151995A3 (en) 1987-04-22
DK34185A (da) 1985-07-27
EP0151995B1 (en) 1992-12-23
DE3586910T2 (de) 1993-05-19
DE3586910D1 (de) 1993-02-04
DK34185D0 (da) 1985-01-25
EP0151995A2 (en) 1985-08-21
KR910007075B1 (ko) 1991-09-16
ES8702330A1 (es) 1986-12-16
ES539878A0 (es) 1986-12-16

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