[go: up one dir, main page]

KR840005447A - 밀베마이신 d 유도체의 제조방법 - Google Patents

밀베마이신 d 유도체의 제조방법 Download PDF

Info

Publication number
KR840005447A
KR840005447A KR1019830003387A KR830003387A KR840005447A KR 840005447 A KR840005447 A KR 840005447A KR 1019830003387 A KR1019830003387 A KR 1019830003387A KR 830003387 A KR830003387 A KR 830003387A KR 840005447 A KR840005447 A KR 840005447A
Authority
KR
South Korea
Prior art keywords
acid
compound
general formula
reactive derivative
group
Prior art date
Application number
KR1019830003387A
Other languages
English (en)
Other versions
KR900008698B1 (ko
Inventor
준야(외 5) 이데
Original Assignee
가와무라 요시부미
상꾜 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가와무라 요시부미, 상꾜 가부시끼가이샤 filed Critical 가와무라 요시부미
Publication of KR840005447A publication Critical patent/KR840005447A/ko
Application granted granted Critical
Publication of KR900008698B1 publication Critical patent/KR900008698B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

밀베마이신 D 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 식(I)의 화합물을 일반식 HOOC-R-COOH의 이염기산 또는 상기 산의 반응성 유도체와 반응시킴을 특징으로 하는 일반식(II)의 화합물의 제조방법.
  3. [식 중, R은 1∼4 탄소원자를 갖는 직쇄 알킬렌기, 비닐렌기 또는 일반식(식중, X는 수소원자 또는 1∼6 탄소원자를 갖는 알킬기이다)의 기를 나타낸다.]
  4. 제1항에 있어서, 산의 반응성 유도체가 산할라이드, 모노카르복실산과의 혼합 무수물 또는 내부 무수물인 방법.
  5. 제1항에 있어서, 산의 반응성 유도체가 일반식의 화합물 또는 일반식 Y-CO-R-COOH(식 중, Y는 히드록시기, 할로겐원자 또는 C2∼C5S/SB> 알킬 카르보닐기이다)의 화합물인 방법.
  6. 제1항에 있어서, 반응기 염기 및 불활성 용매의 존재하에 수행되는 방법.
  7. 제1항에 있어서, 반응이 -10℃∼+50℃의 온도에서 수행되는 방법.
  8. 제1항에 있어서, 반응성 유도체는 R이 에틸렌인 내부 무수물이며, 반응이 4-디메틸아미노피리딘 및 피리딘의 존재하에 수행되는 방법.
  9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003387A 1982-07-23 1983-07-22 밀베마이신 d 유도체의 제조방법 KR900008698B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57128472A JPS5920285A (ja) 1982-07-23 1982-07-23 ミルベマイシンｄの５−二塩基酸エステル誘導体及びその塩
JP128472 1982-07-23

Publications (2)

Publication Number Publication Date
KR840005447A true KR840005447A (ko) 1984-11-12
KR900008698B1 KR900008698B1 (ko) 1990-11-27

Family

ID=14985570

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003387A KR900008698B1 (ko) 1982-07-23 1983-07-22 밀베마이신 d 유도체의 제조방법

Country Status (15)

Country Link
EP (1) EP0102721B1 (ko)
JP (1) JPS5920285A (ko)
KR (1) KR900008698B1 (ko)
AU (1) AU559048B2 (ko)
BR (1) BR8303940A (ko)
CA (1) CA1202967A (ko)
DE (1) DE3361293D1 (ko)
DK (1) DK337783A (ko)
ES (1) ES524399A0 (ko)
IE (1) IE55552B1 (ko)
IL (1) IL69295A0 (ko)
NZ (1) NZ205003A (ko)
SE (1) SE8304067L (ko)
ZA (1) ZA835354B (ko)
ZW (1) ZW16583A1 (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60126289A (ja) * 1983-11-14 1985-07-05 Sankyo Co Ltd ミルベマイシン類の５−カ−ボネ−ト誘導体
DE3519834C2 (de) * 1984-06-05 1993-12-16 American Cyanamid Co Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen
US5169956A (en) * 1984-06-05 1992-12-08 American Cyanamid Company Macrolide antibiotic compounds
US5317030A (en) * 1984-06-05 1994-05-31 American Cyanamid Company Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
US5198464A (en) * 1984-06-05 1993-03-30 American Cyanamid Company Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
US4778809A (en) * 1985-08-23 1988-10-18 Ciba-Geigy Corporation 5-esters of milbemycins for controlling parasitic pests
EP0237339B1 (en) * 1986-03-12 1993-06-02 American Cyanamid Company Macrolide compounds
GB8803836D0 (en) * 1988-02-18 1988-03-16 Glaxo Group Ltd Compositions
US5428034A (en) * 1988-09-02 1995-06-27 Sankyo Co., Ltd. Milbemycin derivatives, their preparation and their use
JP2622197B2 (ja) * 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US6495591B1 (en) 1997-10-02 2002-12-17 Essential Therapeutics, Inc. Fungal efflux pump inhibitors
DE60116615T2 (de) 2000-04-27 2006-09-07 Sankyo Lifetech Co.Ltd. 13-substituierte milbemycinderivate, ihre herstellung und ihre verwendung gegen insekten und andere schadorganismen
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions

Also Published As

Publication number Publication date
SE8304067L (sv) 1984-01-24
EP0102721B1 (en) 1985-11-21
BR8303940A (pt) 1984-02-28
ES8502126A1 (es) 1984-12-16
SE8304067D0 (sv) 1983-07-20
DK337783A (da) 1984-01-24
KR900008698B1 (ko) 1990-11-27
ES524399A0 (es) 1984-12-16
IL69295A0 (en) 1983-11-30
DE3361293D1 (en) 1986-01-02
IE55552B1 (en) 1990-10-24
CA1202967A (en) 1986-04-08
NZ205003A (en) 1986-06-11
JPS5920285A (ja) 1984-02-01
DK337783D0 (da) 1983-07-22
ZA835354B (en) 1984-04-25
ZW16583A1 (en) 1984-02-15
IE831709L (en) 1984-01-23
AU1716883A (en) 1984-01-26
AU559048B2 (en) 1987-02-19
EP0102721A1 (en) 1984-03-14

Similar Documents

Publication Publication Date Title
KR840005447A (ko) 밀베마이신 d 유도체의 제조방법
KR840004712A (ko) 벤조퀴논 유도체의 제조방법
KR950701902A (ko) 리그난계 화합물의 제조방법(process for producing lignan compound)
KR830007654A (ko) 1,2-디히드로-3H-피롤로[1,2-a]피톤-1-카르복실 에스테르의 5-아로일화 방법
KR860000243A (ko) 아민유도체의 제조방법
KR860007201A (ko) 항생 작용을 갖는 악타가르딘의 염기성 모노카르복시아미드 유도체의 제조방법
KR850005845A (ko) 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법
KR840006482A (ko) 디히드로피라졸로 [3,4-b]피리딘 유도체의 제조방법
KR830004263A (ko) 신규 소염제 및 면역 조절제인 피리딘과 피리미딘의 제조방법
KR840004065A (ko) 2-시아노-2-프로페노산 및 그 유도체의 제조방법
KR840007556A (ko) 방향족 히드록시카르복시산 벤질 에스테르의 제조방법
KR850005838A (ko) 1,3,2-디옥사보리난의 제조방법
KR840009059A (ko) 1,8-디하이드록시-10-아실-9-안트론류의 제조방법
KR840005455A (ko) 세팔로스포린 유도체류의 제조방법
KR920008054A (ko) 4-에톡시페닐-3-아릴프로필(디메틸)실란의 제조방법
KR840005107A (ko) 피리미디온 및 그의 산부가염의 제조방법
GB1351525A (en) Binuclear n-heterocyclic n,n-diglycidyl compounds processes for their manufacture and their use
KR840008647A (ko) 대칭 1,4-디하이드로피리딘디카복실 에스테르의 제조방법
KR870001208A (ko) 에르골린의 n-메틸 유도체 제조방법
KR840006208A (ko) 7-아닐리노이소퀴놀린-5,8-퀴논의 제조방법
KR840007010A (ko) 설타미실린 및 동족체의 제조방법
KR850006397A (ko) 치환된 이소크로만 및 옥세핀의 제조방법
KR910016673A (ko) 히드록시페닐프로피오네이트의 제조방법
KR830007672A (ko) 페니실란산술폰의 에스테르 제조 방법
KR880011114A (ko) 치환된 아세틸렌 화합물의 제조방법

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19830722

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19880701

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19830722

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19900731

Patent event code: PE09021S01D

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19901031

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19910220

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19910312

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19910312

End annual number: 3

Start annual number: 1

PR1001 Payment of annual fee

Payment date: 19931027

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 19941011

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 19951024

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 19961022

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 19961022

Start annual number: 7

End annual number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee