KR20030036862A - 시클린 의존성 키나아제 억제용 조성물 - Google Patents
시클린 의존성 키나아제 억제용 조성물 Download PDFInfo
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- KR20030036862A KR20030036862A KR10-2003-7004561A KR20037004561A KR20030036862A KR 20030036862 A KR20030036862 A KR 20030036862A KR 20037004561 A KR20037004561 A KR 20037004561A KR 20030036862 A KR20030036862 A KR 20030036862A
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- alkyl
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- cycloalkyl
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- heteroaryl
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
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Abstract
Description
Claims (29)
- 약리적으로 허용 가능한 담체와 결합된 다음의 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염 및 고정된 복용량으로 배합된 항암제로 이루어진 항암제 조성물:화학식 (1)식 중, R1및 R2는 독립적으로 히드로겐, 플루오린 또는 알킬;R3는 아릴 또는 헤테로아릴R4는 알킬, 시클로알킬, 아릴, 시클로알킬알킬, 아릴알킬, 헤테로아릴, 헤테로아릴알킬, 헤테로시클로알킬, 헤테로시클로알킬알킬; 또는CO-알킬, CO-시클로알킬, CO-아릴, CO-알킬-시클로알킬, CO-알킬-아릴, CO-헤테로아릴, CO-알킬-헤테로아릴, CO-헤테로시클로알킬, CO-알킬-헤테로시클로알킬; 또는CONH-알킬, CONH-시클로알킬, CONH-아릴, CONH-알킬-시클로알킬, CONH-알킬-아릴, CONH-헤테로아릴, CONH-알킬-헤테로아릴, CONH-헤테로시클로알킬, CONH-알킬-헤테로시클로알킬; 또는COO-알킬, COO-시클로알킬, COO-아릴, COO-알킬-시클로알킬, COO-알킬-아릴, COO-헤테로아릴, COO-알킬-헤테로아릴, COO-헤테로시클로알킬, COO-알킬-헤테로시클로알킬; 또는SO2-시클로알킬, SO2-아릴, SO2-알킬-시클로알킬, SO2-알킬-아릴, SO2-헤테로아릴, SO2-알킬-헤테로아릴, SO2-헤테로시클로알킬, SO2-알킬-헤테로시클로알킬; 또는C(NCN)NH-알킬, C(NCN)NH-시클로알킬, C(NCN)NH-아릴, C(NCN)NH-알킬-시클로알킬, C(NCN)NH-알킬-아릴, C(NCN)NH-헤테로아릴, C(NCN)NH-알킬-헤테로아릴, C(NCN)NH-헤테로시클로알킬, C(NCN)NH-알킬-헤테로시클로알킬; 또는C(NNO2)NH-알킬, C(NNO2)NH-시클로알킬, C(NNO2)NH-아릴, C(NNO2)NH-알킬-시클로알킬, C(NNO2)NH-알킬-아릴, C(NNO2)NH-헤테로아릴, C(NNO2)NH-알킬-헤테로아릴, C(NNO2)NH-헤테로시클로알킬, C(NNO2)NH-알킬-헤테로시클로알킬; 또는C(NH)NH-알킬, C(NH)NH-시클로알킬, C(NH)NH-아릴, C(NH)NH-알킬-시클로알킬, C(NH)NH-알킬-아릴, C(NH)NH-헤테로아릴, C(NH)NH-알킬-헤테로아릴, C(NH)NH-헤테로시클로알킬, C(NH)NH-알킬-헤테로시클로알킬; 또는C(NH)NHCO-알킬, C(NH)NHCO-시클로알킬, C(NH)NHCO-아릴, C(NH)NHCO-알킬-시클로알킬, C(NH)NHCO-알킬-아릴, C(NH)NHCO-헤테로아릴, C(NH)NHCO-알킬-헤테로아릴, C(NH)NHCO-헤테로시클로알킬, C(NH)NHCO-알킬-헤테로시클로알킬; 또는C(NOR6)NH-알킬,C(NOR6)NH-시클로알킬, C(NOR6)NH-아릴, C(NOR6)NH-알킬-시클로알킬, C(NOR6)NH-알킬-아릴, C(NOR6)NH-헤테로아릴, C(NOR6)NH-알킬-헤테로아릴, C(NOR6)NH-헤테로시클로알킬, C(NOR6)NH-알킬-헤테로시클로알킬;R5는 히드로겐 또는 알킬;R6는 히드로겐, 알킬, 시클로알킬, 아릴, 시클로알킬알킬, 아릴알킬, 헤테로아릴, 헤테로아릴알킬, 헤테로시클로알킬 또는 헤테로시클로알킬알킬;m은 0에서 2의 정수;n은 1에서 3의 정수;상기 중 "알킬"은 탄소원자 1 내지 12개를 포함하는 알킬을 의미하고;"아릴"은 6개 이상의 원자를 갖는 고리를 1 내지 5개 포함하는 모노시클릭 또는 비시클릭 방향족 고리를 의미하며;"헤테로아릴"은 한개 이상의 헤테로원자 O, S, 또는 N을 포함하는 5 또는 6개의 고리원자를 갖는 모노시클릭 방향족 히드로카본기 또는 8 내지 10개의 원자를 갖는 비시클릭방향족기를 의미하며;"시클로알킬"은 3 내지 15개의 탄소원자를 포함하는 시클로알킬이고;"헤테로시클로알킬"은 고리에 존재하는 하나의 탄소 원자가 O, S, 또는 N에서 선택된 헤테로원자에 의해 대체되고 부가로 세개의 탄소 원자까지 상기 헤테로원자로 대체될 수 있는 비방향족 시클로알킬기를 의미한다.
- 약리적으로 허용 가능한 담체와 제 1 항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염으로 이루어지고, 항암치료 또는 항암제와 차례로 투여되는 항암제 조성물.
- 제 2 항에 있어서, 상기 항암치료 또는 항암제 투여에 앞서 투여되는 항암제 조성물.
- 제 2 항에 있어서, 상기 항암치료 또는 항암제 투여 이후에 투여되는 항암제 조성물.
- 단백질 키나아제를 억제하는데 효과적인 양의 제 1 항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 단백질 키나아제 억제용 조성물.
- 시클린 의존성 키나아제를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 시클린 의존성 키나아제 억제용 조성물.
- cdc2를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdc2(cdk1) 억제용 조성물.
- cdk2를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdk2 억제용 조성물.
- cdk3를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdk3 억제용 조성물.
- cdk4를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdk4 억제용 조성물.
- cdk5를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdk5 억제용 조성물.
- cdk6를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdk6 억제용 조성물.
- cdk7를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdk7 억제용 조성물.
- cdk8를 억제하는데 효과적인 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 cdk8 억제용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 증식성 질병 치료용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 암 치료용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 염증, 염증성 장의질병 또는 이식 거부반응 치료용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 관절염 치료용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 HIV에 의한 감염의 치료 또는 AIDS의 치료 및 발생 억제용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 바이러스성 감염 치료용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 진균성 감염 치료용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 암 또는 종양 재발발생 억제용 조성물.
- 치료학적으로 유효한 양의 제 1항에서 정의된 화학식 (1)로 표현되는 화합물 또는 그의 약리적으로 허용 가능한 염을 유효성분으로 함유하는 신경변성 질병 치료용 조성물.
- 제 1 항에 있어서, 증식성 질병의 치료에 사용되는 조성물.
- 제 1 항에 있어서, 암의 치료에 사용되는 조성물.
- 제 1 항에 있어서, 암 또는 종양 재발 발생을 억제하는데 사용되는 조성물.
- 제 2 항에 있어서, 증식성 질병의 치료에 사용되는 조성물.
- 제 2 항에 있어서, 암의 치료에 사용되는 조성물.
- 제 2 항에 있어서, 암 또는 종양 재발 발생을 억제하는데 사용되는 조성물.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6519597P | 1997-11-12 | 1997-11-12 | |
US60/065,195 | 1997-11-12 | ||
PCT/US1998/023197 WO1999024416A1 (en) | 1997-11-12 | 1998-11-02 | Aminothiazole inhibitors of cyclin dependent kinases |
Related Parent Applications (1)
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KR10-2000-7004995A Division KR100454426B1 (ko) | 1997-11-12 | 1998-11-02 | 시클린 의존성 키나아제의 아미노티아졸 억제제 |
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KR20030036862A true KR20030036862A (ko) | 2003-05-09 |
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KR10-2000-7004995A Expired - Fee Related KR100454426B1 (ko) | 1997-11-12 | 1998-11-02 | 시클린 의존성 키나아제의 아미노티아졸 억제제 |
KR10-2003-7004561A Ceased KR20030036862A (ko) | 1997-11-12 | 1998-11-02 | 시클린 의존성 키나아제 억제용 조성물 |
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KR10-2000-7004995A Expired - Fee Related KR100454426B1 (ko) | 1997-11-12 | 1998-11-02 | 시클린 의존성 키나아제의 아미노티아졸 억제제 |
Country Status (32)
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US (1) | US6040321A (ko) |
EP (1) | EP1042307B1 (ko) |
JP (1) | JP4344084B2 (ko) |
KR (2) | KR100454426B1 (ko) |
CN (1) | CN1160343C (ko) |
AR (1) | AR017182A1 (ko) |
AT (1) | ATE374771T1 (ko) |
AU (1) | AU730607B2 (ko) |
BR (1) | BR9814124A (ko) |
CA (1) | CA2309551C (ko) |
CO (1) | CO4990957A1 (ko) |
CY (1) | CY1107509T1 (ko) |
CZ (1) | CZ297907B6 (ko) |
DE (1) | DE69838515T2 (ko) |
DK (1) | DK1042307T3 (ko) |
EG (1) | EG24028A (ko) |
ES (1) | ES2296347T3 (ko) |
HU (1) | HUP0004559A3 (ko) |
ID (1) | ID23983A (ko) |
IL (1) | IL135589A (ko) |
MY (1) | MY120779A (ko) |
NO (1) | NO316773B1 (ko) |
NZ (1) | NZ503828A (ko) |
PE (1) | PE131699A1 (ko) |
PL (1) | PL204642B1 (ko) |
PT (1) | PT1042307E (ko) |
RU (1) | RU2211839C2 (ko) |
TR (1) | TR200001344T2 (ko) |
TW (1) | TW593292B (ko) |
UY (1) | UY25239A1 (ko) |
WO (1) | WO1999024416A1 (ko) |
ZA (1) | ZA9810332B (ko) |
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2000
- 2000-04-27 NO NO20002153A patent/NO316773B1/no not_active IP Right Cessation
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2007
- 2007-12-27 CY CY20071101633T patent/CY1107509T1/el unknown
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