KR101761929B1 - 인간 ox40에 대한 특이성을 갖는 항체 분자 - Google Patents
인간 ox40에 대한 특이성을 갖는 항체 분자 Download PDFInfo
- Publication number
- KR101761929B1 KR101761929B1 KR1020117021615A KR20117021615A KR101761929B1 KR 101761929 B1 KR101761929 B1 KR 101761929B1 KR 1020117021615 A KR1020117021615 A KR 1020117021615A KR 20117021615 A KR20117021615 A KR 20117021615A KR 101761929 B1 KR101761929 B1 KR 101761929B1
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- South Korea
- Prior art keywords
- antibody
- seq
- set forth
- sequence set
- heavy chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15303809P | 2009-02-17 | 2009-02-17 | |
| US61/153,038 | 2009-02-17 | ||
| PCT/US2010/024377 WO2010096418A2 (en) | 2009-02-17 | 2010-02-17 | Antibody molecules having specificity for human ox40 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20110128301A KR20110128301A (ko) | 2011-11-29 |
| KR101761929B1 true KR101761929B1 (ko) | 2017-07-26 |
Family
ID=42634416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117021615A Expired - Fee Related KR101761929B1 (ko) | 2009-02-17 | 2010-02-17 | 인간 ox40에 대한 특이성을 갖는 항체 분자 |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US8614295B2 (ja) |
| EP (1) | EP2398498B1 (ja) |
| JP (2) | JP5782385B2 (ja) |
| KR (1) | KR101761929B1 (ja) |
| CN (1) | CN102741287B (ja) |
| AR (1) | AR075504A1 (ja) |
| AU (1) | AU2010216152B2 (ja) |
| BR (1) | BRPI1008692B8 (ja) |
| CA (1) | CA2751477C (ja) |
| CL (1) | CL2011001994A1 (ja) |
| CO (1) | CO6410312A2 (ja) |
| CY (1) | CY1121431T1 (ja) |
| DK (1) | DK2398498T3 (ja) |
| EA (1) | EA037792B1 (ja) |
| ES (1) | ES2699716T3 (ja) |
| HR (1) | HRP20181932T1 (ja) |
| HU (1) | HUE042114T2 (ja) |
| IL (1) | IL214282A (ja) |
| LT (1) | LT2398498T (ja) |
| MA (1) | MA33122B1 (ja) |
| MX (1) | MX2011008697A (ja) |
| MY (1) | MY157473A (ja) |
| NZ (1) | NZ594315A (ja) |
| PE (1) | PE20120211A1 (ja) |
| PL (1) | PL2398498T3 (ja) |
| PT (1) | PT2398498T (ja) |
| SG (3) | SG173620A1 (ja) |
| SI (1) | SI2398498T1 (ja) |
| TN (1) | TN2011000374A1 (ja) |
| TW (1) | TWI476281B (ja) |
| UA (1) | UA107341C2 (ja) |
| UY (1) | UY32451A (ja) |
| WO (1) | WO2010096418A2 (ja) |
| ZA (1) | ZA201105500B (ja) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011008697A (es) * | 2009-02-17 | 2011-11-18 | Ucb Pharma Sa | Moleculas de anticuerpos que tiene especificidad para ox40 humano. |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| NZ716369A (en) | 2010-08-23 | 2017-05-26 | Univ Texas | Anti-ox40 antibodies and methods of using the same |
| CA2860170C (en) | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| EA036047B1 (ru) | 2011-07-11 | 2020-09-18 | Икнос Сайенсиз Са | Антитела, которые связываются с ox40, и их применение |
| CA2845810C (en) * | 2011-08-23 | 2017-03-28 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
| UA112203C2 (uk) | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
| CN103946237B (zh) | 2011-11-11 | 2017-04-12 | Ucb医药有限公司 | 白蛋白结合抗体及其结合片段 |
| WO2013086419A1 (en) * | 2011-12-09 | 2013-06-13 | California Institute Of Technology | Polymer scaffolds and their use in the treatment of vision loss |
| CN104968364A (zh) | 2012-12-03 | 2015-10-07 | 百时美施贵宝公司 | 强化免疫调变性Fc融合蛋白的抗癌活性 |
| EP2976361B1 (en) | 2013-03-18 | 2018-07-18 | BiocerOX Products B.V. | Humanized anti-cd134 (ox40) antibodies and uses thereof |
| CN105722860A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-2融合蛋白及其应用 |
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